Professor Carola Garcia de Vinuesa
MD (MBBS) PhD FAA
Co-Director, Centre for Personalised Immunology, NHMRC Centre of Research Excellence
ANU College of Health and Medicine
Areas of expertise
- Cellular Immunology 110704
- Immunogenetics (Incl. Genetic Immunology) 110706
- Rheumatology And Arthritis 110322
- Humoural Immunology And Immunochemistry 110705
- Medical Genetics (Excl. Cancer Genetics) 110311
- Autoimmunity 110703
- Biochemistry And Cell Biology 0601
- Immunology 1107
Research interests
Carola Vinuesa’s research aims to unravel the complex interaction of cells and molecules that regulate the production of potent, long-lasting antibody responses and to identify genetic abnormalities that interfere with this process and contribute to the development of autoimmunity.
Her group has identified genes, cell types and checkpoints important to prevent autoantibody-mediated diseases. Her team is also working towards connecting genetic variation in humans to autoimmune disease with the goal of identifying more targeted treatments. She directs the Centre for Personalised immunology (CPI), an NHMRC Centre for Research Excellence that is sequencing whole genomes from patients with immune-mediated diseases to uncover mutations that cause disease. She also co-directs the China Australia Centre for Personalised Immunology (CACPI) based in Shanghai Renji Hospital (Jiaotong University). The ultimate aim of her research is to understand autoimmune disease pathogenesis, refine diagnosis and develop improved approaches to therapy.
Biography
Carola Vinuesa was born in Spain and obtained a medical degree at the University Autonoma of Madrid. She undertook specialist clinical training in the UK and in 2000 was awarded a PhD by the University of Birmingham. A year later she was the recipient of a Wellcome Trust International Travelling prize Fellowship to do postdoctoral work at The John Curtin School for Medical Research in The Australian National University. Since 2006 she has been a group leader. She has been the recipient of several prestigious awards including the Science Minister’s Prize for Life Scientist of the year (2008), the Gottschalk Medal of the Australian Academy of Sciences (2009). In 2015, she was elected as a Fellow of the Australian Academy of Science. She is currently Professor of Immunology at the Australian National University and Director of the Centre for Personalised Immunology (CPI), an NHMRC Centre for Research Excellence.
ORCID ID 000-0001-9799-0298
Web of Science researcher ID B-1108-2010
Publications
- Hicks, S, Pohl, K, Neeman, T et al. 2021, 'A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting', Journal of Infectious Diseases, vol. 223, no. 1, pp. 10-14.
- Brohus, M, Arsov, T, Wallace, D et al. 2020, 'Infanticide vs. inherited cardiac arrhythmias', Europace, vol. 23, no. 3, pp. 441-450.
- Jiang, S, Stanley, M & Garcia de Vinuesa, C 2020, 'Rare genetic variants in systemic autoimmunity', Immunology and Cell Biology, vol. 98, no. 5.
- Wirasinha, R, Davies, A, Srivastava, M et al. 2020, 'Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility', Journal of Experimental Medicine, vol. 218, no. 2.
- Roco Alegre, J, Mesin, L, Binder, S et al. 2019, 'Class-Switch Recombination Occurs Infrequently in Germinal Centers', Immunity, vol. 51, no. 2, pp. 337-350.
- Fernandez De Canete Nieto, P, Sweet, R, Gonzalez Figueroa, P et al 2019, 'Regulatory roles of IL-10 producing human follicular T cells', Journal of Experimental Medicine, vol. 216, no. 8, p. 14.
- Tavernier, S, Athanasopoulos, V, Verloo, P et al. 2019, 'A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation', Nature Communications, vol. 10, no. 4779, pp. 1-16.
- Ellyard, J, Tunningley, R, Lorenzo, A et al. 2019, 'Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders', Frontiers in Immunology, vol. 10, no. 2134, pp. 1-13.
- Arsov, T, Sestan, M, Cekada, N et al. 2019, 'Systemic lupus erythematosus: A new autoimmune disorder in Kabuki syndrome', European Journal of Medical Genetics, vol. 62, no. 6, pp. 1-4.
- Arsov, T, Xie, C, Shen, N et al. 2019, 'Genomic test ends a long diagnostic odyssey in a patient with resistance to thyroid hormones', Thyroid Research, vol. 12, no. 7, pp. 1-5.
- Jiang, S, Athanasopoulos, V, Ellyard, J et al. 2019, 'Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus', Nature Communications, vol. 10, no. 2201, pp. 1-12.
- Alshekaili, J, Chand, R, Lee, E et al. 2018, 'STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles', Scientific Reports, vol. 8, no. 3529, pp. 1-11.
- Cardinez, C, Miraghazadeh, B, Tanita, K et al 2018, 'Gain-of-function IKBKB mutation causes human combined immune deficiency', https://www.ncbi.nlm.nih.gov/pubmed/30337470
- Prabhu, S, Cockburn, I & Garcia de Vinuesa, C 2018, 'HIV Immunogens: Affinity Is Key', Immunity, vol. 48, no. 1, pp. 11-13pp.
- Kara, E, Bastow, C, McKenzie, D et al. 2018, 'Atypical chemokine receptor 4 shapes activated B cell fate', Journal of Experimental Medicine, vol. 215, no. 3, pp. 801-813pp.
- Miraghazadeh, B, Cardinez, C, da Silva, E et al. 2018, 'Modelling human immune deficiency from novel missense mutations with orthologous heterozygous mutations engineered in mice by CRISPR/Cas9', CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference, IMDDNAC 2018, Springer New York LLC, United States, pp. 440-440.
- Papa, I & Garcia de Vinuesa, C 2018, 'Synaptic Interactions in Germinal Centers', Frontiers in Immunology, vol. 9, no. 1858, pp. 1-10.
- Papa, I, Saliba, D, Ponzoni, M et al. 2017, 'TFH-derived dopamine accelerates productive synapses in germinal centres', Nature, vol. 547, no. 7663, pp. 318+.
- Gonzalez-Figueroa, P, Roco Alegre, J & Garcia de Vinuesa, C 2017, 'Germinal Center Lymphocyte Ratios and Successful HIV Vaccines', Trends in Molecular Medicine, vol. 23, no. 2, pp. 95-97pp.
- Yan, H, Wu, L, Shih, C et al. 2017, 'Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center', Cell Reports, vol. 19, no. 5, pp. 995-1007pp.
- Nagalingam, G, Garcia de Vinuesa, C, Britton, W et al. 2017, 'Modulation of roquin function in myeloid cells reduces mycobacterium tuberculosis-induced inflammation', Journal of Immunology, vol. 199, no. 5, pp. 1796-1804.
- Gorosito, M, Tosello Boari, J, Fiocca Vernengo, F et al. 2017, 'Unconventional pro-inflammatory CD4+ T cell response in B cell-deficient mice infected with Trypanosoma cruzi', Frontiers in Immunology, vol. 8, no. NOV, pp. -.
- Fernandez De Canete Nieto, P, Sweet, R, Papa, I et al. 2016, 'Human Foxp3-negative follicular regulatory T cells control IgE responses', European Journal of Immunology, vol. 46, no. S1, pp. 13-13.
- Garcia de Vinuesa, C, Linterman, M, Yu, D et al. 2016, 'Follicular Helper T Cells', Annual Review of Immunology, vol. 34, pp. 335-368.
- Walters, G & Garcia de Vinuesa, C 2016, 'T Follicular Helper Cells in Transplantation', Transplantation, vol. 100, no. 8, pp. 1650-1655.
- Tan, J, McKenzie, C, Vuillermin, P et al. 2016, 'Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways', Cell Reports, vol. 15, no. 12, pp. 2809-2824.
- Athanasopoulos, V, Ramiscal, R & Garcia de Vinuesa, C 2016, 'ROQUIN signalling pathways in innate and adaptive immunity', European Journal of Immunology, vol. 46, no. 5, pp. 1082-1090.
- Garcia de Vinuesa, C, Linterman, M, Yu, D et al. 2016, 'Follicular Helper T Cells', Annual Review of Immunology, vol. 34, pp. 335-368.
- Vijayan, D, Mohd Redzwan, N, Avery, D et al. 2016, 'IL-27 directly enhances germinal center b cell activity and potentiates lupus in sanroque mice', Journal of Immunology, vol. 197, no. 8, pp. 3008-3017.
- Pratama, A, Srivastava, M, Hawley, N et al. 2015, 'MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres', Nature Communications, vol. 6, pp. 6436-6436.
- Srivastava, M, Duan, G, Kershaw, NJ et al 2015, 'Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.', Nature Communications, vol. 6, no. 6253.
- Ueno, H, Banchereau, J & Garcia de Vinuesa, C 2015, 'pathophysiology of t follicular helper cells in humans and mice', Nature Immunology, vol. 16, no. 2, pp. 142-152.
- Jiang, S, Mercan, S, Papa, I et al. 2015, 'Vangl1 copy number variation predisposes to nephritis in systemic lupus erythmatosus'.
- Mino, T, Murakawa, K, Fukao, A et al. 2015, 'Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms', Cell, vol. 161, no. 5, pp. 1058-1073.
- Chang, P & Garcia de Vinuesa, C 2015, 'Detection of Mouse Natural Killer T Follicular Helper (NKTFH) Cells by Flow Cytometry', in Marion Espeli & Michelle Linterman (ed.), T Follicular Helper Cells, Humana Press, New York, pp. 135-141.
- Ramiscal, R, Parish, I, Lee-Young, R et al. 2015, 'Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation', eLife, vol. 4, pp. e08698-e08698.
- Jiang, S, Shen, N & Garcia de Vinuesa, C 2015, 'Posttranscriptional T cell gene regulation to limit Tfh cells and autoimmunity', Current Opinion in Immunology, vol. 37, pp. 21-27.
- Garcia de Vinuesa, C & Cook, M 2015, The promise and challenges of genomic medicine, pp. 17-18pp.
- Field, M.A., Cho, V., Cook, M.A., Enders, A., Vinuesa, C.G., Whittle, B., Andrews, T.D. and C.C. Goodnow 2015, 'Reducing the search space for causal genetic variants with VASP', Bioinformatics, pp. 1-3.
- Ellyard, J, Jerjen, R, Martin, J et al. 2014, 'Identification of a Pathogenic Variant in TREX1 in Early-Onset Cerebral Systemic Lupus Erythematosus by Whole-Exome Sequencing', Arthritis & Rheumatism, vol. 66, no. 12, pp. 3382-3386.
- Pratama, A & Garcia de Vinuesa, C 2014, 'Control of TFH cell numbers: Why and how?', Immunology and Cell Biology, vol. 92, no. 1, pp. 40-48.
- Chew, G, Gatenby, P, Mercan, S et al. 2014, 'TNFRSF13B Variants in SLE and Immunodeficiency', Journal of Clinical & Cellular Immunology, vol. 5, no. 4, pp. 1-8.
- Vinuesa, CG & Preiss, T 2014, 'Inflammation: Gone with Translation', PLoS Genetics, vol. 10, no. 6, pp. e1004442
- Pratama, A, Ramiscal, R, Silva-Galindo, D et al. 2013, 'Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation', Immunity, vol. 38, no. 4, pp. 669-680.
- Ramiscal, R & Garcia de Vinuesa, C 2013, 'T-cell subsets in the germinal center', Immunological Reviews, vol. 252, no. 1, pp. 146-155.
- He, J, Tsai, L, Leong, Y et al. 2013, 'Circulating precursor CCR7loPD-1hi CXCR5+ CD4+ T cells indicate tfh cell activity and promote antibody responses upon antigen reexposure', Immunity, vol. 39, no. 4, pp. 770-781.
- Lee, J, Espeli, M, Anderson, C et al. 2013, 'Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway', Cell, vol. 155, no. 1, pp. 57-69.
- Garcia de Vinuesa, C & Chang, P 2013, 'Innate B cell helpers reveal novel types of antibody responses', Nature Immunology, vol. 14, no. 2, pp. 119-126.
- Garcia de Vinuesa, C, Fagarasan, S & Dong, C 2013, 'New Territory for T Follicular Helper Cells', Immunity, vol. 39, no. 3, pp. 417-420.
- Ramiscal, RR, Vinuesa, CG, 2013, 'T-cell subsets in the germinal center', Immunological Reviews, vol.252, no.1, pp.146-55.
- Teh, C. E., Horikawa, K., Arnold, C. N., Beutler, B., Kucharska, E. M., Vinuesa, C. G., Bertram, E. M., Goodnow, C. C. & Enders, A. 2013. Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation. Genes and immunity, vol. 14, no. 4, pp. 223-233.
- Vinuesa, CG, Chang, PP, 2013, 'Innate B cell helpers reveal novel types of antibody responses', Nature Immunology, vol.14, no.2, pp.119-26.
- Lee, S, Silva-Galindo, D, Martin, J et al. 2012, 'Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers', Immunity, vol. 37, no. 5, pp. 880-892.
- Lee, SK, Silva, DG, Martin, JL, Pratama, A, Hu, X, Chang, PP, Walters, G, Vinuesa, CG, 2012, 'Interferon-y excess leads to pathogenic accumulation of follicular helper T cells and germinal centers', Immunity, vol.37, no.5, pp.880-92.
- Chang, PP, Barral, P, Fitch, J, Pratama, A, Ma, CS, Kallies, A, Hogan, JJ, Cerundolo, V, Tangye, SG, Bittman, R, Nutt, SL, Brink, R, Godfrey, DI, Batista, FD, Vinuesa, CG, 2012, 'Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses', Nature Immunology, vol. 13, no. 1, pp. 35-43.
- Ellyard, J, Chia, T, Rodriguez-Pinilla, S et al. 2012, 'Heterozygosity for Roquin(san) leads to angioimmunoblastic T-cell lymphoma-like tumors in mice', Blood, vol. 120, no. 4, pp. 812-821.
- Linterman, M, Liston, A & Garcia de Vinuesa, C 2012, 'T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells', Immunological Reviews, vol. 247, no. 1, pp. 143-159.
- Garcia de Vinuesa, C 2012, 'HIV and T follicular helper cells: a dangerous relationship', Journal of Clinical Investigation, vol. 122, no. 9, pp. 3059-3062.
- Kuchroo, V, Ohashi, P, Sartor, R et al. 2012, 'Dysregulation of immune homeostasis in autoimmune diseases', Nature Medicine, vol. 18, no. 1, pp. 42-47.
- Chang, P, Lee, C, Hu, X et al 2012, 'Breakdown in Repression of IFN-y mRNA Leads to Accumulation of Self-Reactive Effector CD8+ T Cells', Journal of Immunology, vol. 189, pp. 701-710.
- Sweet, RA, Lee, SK & Vinuesa, CG 2012, 'Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity', Current Opinion in Immunology, vol. 24, pp. 658-664.
- Sweet, RA, Lee, SK, Vinuesa, CG, 2012, 'Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity', Current Opinion in Immunology, vol.24, no.6, pp.658-64.
- Vinuesa, CG, 2012, 'HIV and T follicular helper cells: a dangerous relationship', Journal of Clinical Investigation', vol.122, no.9, pp.3059-62.
- Ellyard, JI, Chia, T, Rodriguez-Pinilla, SM, Martin, JL, Hu, X, Navarro-Gonzalez, M, Garcia, JF, Delfau-Larue, MH, Montes-Moreno, S, Gaulard, P, Cook, MC, Walters, G, Piris, MA, Vinuesa, CG, 2012, 'Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice', Blood, vol.120, no.4, pp.812-821.
- Chang, PP, Lee, SK, Davey, G, Duan, G, Cho, JH, Karupiah, G, Sprent, J, Heath, WR, Bertram, EM, Vinuesa, CG, 2012, 'Breakdown in repression of IFN-y mRNA leads to accumulation of self-reactive effector CD8+T', Journal of Immunology, vol.189, no.2, pp.701-710.
- Linterman, MA, Liston, A, Vinuesa, CG, 2012, 'T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells', Immunological Reviews, vol.247, no.1, pp.143-159.
- Kuchroo, VK, Ohashi, PS, Sartor, RB, Vinuesa, CG, 2012, 'Dysregulation of immune homeostasis in autoimmune diseases', Nature Medicine, vol.18, no. 1, pp.42-47.
- Linterman, MA, Pierson, W, Lee, SK, Kallies, A, Kawamoto, S, Rayner, TF, Srivastava, M, Divekar, DP, Beaton, L, Hogan, JJ, Fagarasan, S, Liston, A, Smith, KG, Vinuesa,, CG, 2011, 'Foxp3+ follicular regulatory T cells control the germinal center response', Nature Medicine, vol. 17, no. 8, pp. 975-982.
- Lee, SK, Rigby, RJ, Zotos, D,, Tsai, LM, Kawamoto, S, Marshall, JL, Ramiscal, RR, Chan, TD, Gatto, D, Brink, R, Yu, D, Fagarasan, S, Tarlinton, DM, Cunningham, AF, Vinuesa, CG, 2011, 'B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells', Journal of Experimental Medicine, vol. 208, no. 7, pp. 1377-88.
- Vinuesa, CG, M & Cyster, J 2011, 'How T Cells Earn the Follicular Rite of Passage', Immunity, vol. 35, no. 5, pp. 671-680.
- Silva DG#, DALEY SR#, Hogan J, Lee SK, Teh CE, Hu DY, Lam KP, Goodnow CC*, Vinuesa CG*, 2011, Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells, Diabetes, vol. 60, no. 8, pp. 2102-2111. #* Equal contributors
- Ellyard, JI, Vinuesa, CG, 2011, 'A BATF-ling connection between B cells and follicular helper T cells', Nature Immunology, vol. 12, no. 6, pp. 519-520.
- Vinuesa, C.G. & Cook, M 2011, 'Blood Relatives of Follicular Helper T Cells', Immunity, vol. 34, no. 1, pp. 10-12.
- Simpson, N, Gatenby, P, Wilson, A, Malik, S, Fulcher, DA, Tangye, SG, Manku, H,Vyse, TJ, Roncador, G, Huttley, G, Goodnow, CC, Vinuesa, CG, Cook, MC, 2010, 'Expansion of Circulating T Cells Resembling Follicular Helper T Cells Is a Fixed Phenotype That Identifies a Subset of Severe Systemic Lupus Erythematosus', Arthritis & Rheumatism, vol. 62, no. 1, pp. 234-244.
- Linterman, MA, Beaton, L, Yu, D, Ramiscal, R, Srivastava, M, Hogan, J, Verma, NK, Smyth, MJ, Rigby, RJ, Vinuesa, CG, 2010, 'IL-21 acts directly on B cells to regulate Bc1-6 expression and germinal center responses', Journal of Experimental Medicine, vol. 207, no. 2, pp. 353-363.
- Goodnow, C, Vinuesa, C.G., Randall, K et al 2010, 'Control systems and decision making for antibody production', Nature Immunology, vol. 11, no. 8, pp. 681-688.
- Linterman, M & Vinuesa, C.G. 2010, 'Signals that influence T follicular helper cell differentiation and function', Seminars in Immunopathology, vol. 32, no. 2, pp. 183-196.
- Linterman, M & Vinuesa, C.G., 2010, 'T Follicular Helper Cells During Immunity and Tolerance', in Adrian Liston (ed.), Progress in Molecular Biology and Translational Science, Elsevier Academic Press Inc., USA, pp. 207-248.
- Vinuesa, C.G, Linterman, M, Goodnow, C et al 2010, 'T cells and follicular dendritic cells in germinal center B-cell formation and selection', Immunological Reviews, vol. 237, no. 1, pp. 72-89.
- Yu, D & Vinuesa, C.G., 2010, 'Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity', Cellular and Molecular Immunology, vol. 7, pp. 198-203.
- Yu, D & Vinuesa, C.G., 2010, 'The elusive identity of T follicular helper cells', Trends in Immunology, vol. 31, no. 10, pp. 377-383.
- Athanasopoulos, V, Barker, A, Yu, D, Tan, AH, Srivastava, M, Contreras, N, Wang, J, Lam, KP, Brown, SH, Goodnow, CC, Dixon, NE, Leedman, PJ, Saint, R, Vinuesa, CG, 2010, 'The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs', The FEBS Journal, vol. 277, pp. 2109-2127.
- Vinuesa, C.G., Sanz, I & Cook, M 2009, 'Dysregulation of germinal centres in autoimmune disease', Nature Reviews, Immunology, vol. 9, pp. 845-857.
- Yu, D, Rao, S, Tsai, LM, Lee, SK, He, YQ, Sutcliffe, EL, Srivastava, M, Linterman, M, Zheng, L, Simpson, N, Ellyard,JI, Parish, IA, Ma, CS, Li, QJ, Parish, CR, Mackay, CR, Vinuesa, CG, 2009, 'The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment', Immunity, vol. 31, pp. 457-468.
- Linterman, M, Rigby, R, Wong, R, Yu, D, Brink, R, Cannons, JL, Schwartzberg, PL, Cook, MC, Walters, GD, Vinuesa, CG, 2009, 'Follicular helper T cells are required for systemic autoimmunity', Journal of Experimental Medicine, vol. 206, no. 3, pp. 561-576.
- Linterman, M, Rigby, R, Wong, R, Silva, D, Withers, D, Anderson, G, Verma, NK, Brink, R, Hutloff, A, Goodnow, CC, Vinuesa, CG, 2009, 'Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos', Immunity, vol. 30, pp. 228-241.
- Johnson, A, Aravind, L, Schulzhenko, N, Morgun, A, Choi, SY, Crockford, YL, Lambe, T, Domaschenz, H, Kucharska, EM, Zheng, LX, Vinuesa, CG, Lenardo, MJ, Goodnow, CC, Cornall, RJ, Schwartz, RH, 2009, 'Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection', Nature Immunology, vol. 10, no. 8, pp. 831-839.
- Randall, K. L., Lambe, T., Johnson, A., Treanor, B., Kucharska, E. M., Domaschenz, H., Whittle, B., Tze, L. E., Enders, A., Crockford, T. L., Bouriez-Jones, T., Alston, D., Cyster, J. G., Lenardo, M. J., Mackay, F., Deenick, E. K., Tangye, S. G., Chan, T. D., Camidge, T., Brink, R., Vinuesa, C. G., Batista, F. D., Cornall, R. J. & Goodnow, C. C. 2009. 'Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production', Nature Immunology, vol. 10, no. 12, pp. 1283-1291.
- Vinuesa, C.G., & Yu, D 2009, 'Roquin Defects Reveal a Role for the microRNA Machinery in Regulating Autoimmunity', in Moncef Zouali (ed.), The Epigenetics of Autoimmune Disease, John Wiley & Sons Inc, UK, pp. 261-274.
- Vinuesa, C.G., Rigby, R & Yu, D 2009, 'Logic and extent of miRNA-mediated control of autoimmune gene expression', International Reviews of Immunology, vol. 28, no. 3-4, pp. 112-138.
- Liu, M, Duke, J, Richter, D, Vinuesa, CG, Goodnow, CC, Kleinstein, SH, Schatz, DG, 2008, 'Two levels of protection for the B cell genome during somatic hypermutation', Nature, vol. 451, pp. 841-845.
- Yu, D, Cook, M, Shin, D, Silva, DG, Marshall, J, Toellner, KM, Havran, WL, Caroni, P, Cooke, MP, Morse, HC, MacLennan, ICM, Goodnow, CC, Vinuesa, CG, 2008, 'Axon growth and guidance genes identify T-dependent germinal centre B cells', Immunology and Cell Biology, vol. 86, pp. 3-14.
- Rigby, R & Vinuesa, C.G., 2008, 'SiLEncing SLE: the power and promise of small noncoding RNAs', Current Opinion in Rheumatology, vol. 20, pp. 526-531.
- Yu, D, Tan, A, Hu, X, Athanasopoulos, V, Simpson, N, Silva, DG, Hutloff, A, Giles, KM, Leedman, PJ, Lam, KP, Goodnow, CC, Vinuesa, CG, 2007, 'Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA', Nature, vol. 450, no. 8 November, pp. 299-304.
- Goodnow, C, Campbell, J, Rui, L, Vinuesa, CG, 2007, 'Tolerance mechanisms in the late phase of the antibody response', in Gupta S; Alt FW; Cooper MD; Melchers F;Rajewsky K (ed.), Mechanisms of Lymphocyte Activation and Immune Regulation Xl B Cell Biology, Springer, USA, pp. 163-168.
- Vinuesa, C.G., & Cook, M 2007, 'Genetic analysis of systemic autoimmunity', in George Bock and Jamie Goode (ed.), Decoding the genomic control of immune reactions: Novartis Foundation Symposium, No 281, John Wiley & Sons Inc, Chichester, U.K., pp. 103-120.
- Vinuesa, C.G., & Cook, M 2007, 'The Molecular Basis of Lymphoid Architecture in the Mouse', in James Fox,S Barthold,M Davisson.C Newcomer,F Quimby,A Smith (ed.), The Mouse in Biomedical Research (2nd ed), Academic Press, USA, pp. 57-108.
- Arsov, T, Silva-Galindo, D, O'Bryan, M, Sainsbury, A, Lee, NJ, Kennedy, C, Manji, SSM, Nelms, K, Liu, CN, Vinuesa, CG, de Kretser, DM, 2006, 'Fat Aussie - A new alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis', Molecular Endocrinology, vol. 20, no. 7, pp. 1610-1622.
- Cook, M, Vinuesa, C.G., & Goodnow, C 2006, 'ENU-mutagenesis: insight into immune function and pathology', Current Opinion in Immunology, vol. 18, pp. 627-633.
- Hsu, M, Toellner, K, Vinuesa, C.G., et al 2006, 'B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responses', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 15, pp. 5905-5910.
- Jayasekera, J, Vinuesa, C.G., Karupiah, G et al 2006, 'Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice', Journal of General Virology, vol. 87, pp. 3361-3371.
- Vinuesa, C.G., Cook, M, Angelucci, C et al 2005, 'A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity', Nature, vol. 435, pp. 452-458.
- Vinuesa, C.G., Tangye, S, Moser, B et al 2005, 'Follicular B helper T cells in antibody responses and autoimmunity', Nature Reviews, Immunology, vol. 5, pp. 853-865.
- Linterman, M & Vinuesa, C.G., 2005, 'Roquin: a novel immune regulator that represses ICOS expression and differentiation of self-reactive T cells', Inmunologia, vol. 24, pp. 326-333.
- Goodnow, C, Sprent, J, Fazekas de St Groth, B, Vinuesa, CG, 2005, 'Cellular and genetic mechanisms of self tolerance and autoimmunity', Nature, vol. 435, pp. 590-597.
- Vinuesa, C.G., & Goodnow, C 2004, 'Illuminating autoimmune regulators through controlled variation of the mouse genome sequence', Immunity, vol. 20, no. 6, pp. 669-679.
- Jun, J, Wilson, L, Vinuesa, C.G., et al 2003, 'Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis', Immunity, vol. 18, pp. 751-762.
- MacLennan, ICM, Toellner, KM, Cunningham, AF, Serre, K, Sze, DMY, Zuniga, E, Cook, MC, Vinuesa, CG, 2003, 'Extrafollicular antibody responses', Immunological Reviews, vol. 194, pp. 8-18.
- Rui, L, Vinuesa, C.G., Blasioli, J et al 2003, 'Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling', Nature Immunology, vol. 4, no. 6, pp. 594-600.
- Vinuesa, C.G., & MacLennan, I 2003, 'Antibody responses to Polysaccharides', in Simon Y.C. Wong and Gemma Arsequell (ed.), Immunobiology of Carbohydrates, Landes Bioscience, Austin, Texas, pp. 128-147.
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Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Cells, soluble factors, and genes that control pathogenic antibody responses in humans (Primary Investigator)
- How BANK1 pathway defects in B cells cause human lupus (Primary Investigator)
- Regulation of Haemopoietic and Immune Cells in Health and Disease (Secondary Investigator)
- The ACRF Department of Cancer Biology and Therapeutics (Secondary Investigator)
- Novel therapeutic for autoimmune disease (DTF212) (Primary Investigator)
- Novel pathways that regulate T cells (Primary Investigator)
- AutoMACS Pro (See 30857) (Primary Investigator)
- Centre for Personalised Immunology (Primary Investigator)
- The role of microRNA in a novel mouse model of vasculitis (Primary Investigator)
- Understanding pathogenicity and immunity in an encephalitic mouse model of Hendra virus infection (external led) (Secondary Investigator)
- T lymphocytes: from basic biology to immunotherapy (Primary Investigator)
- Molecular and Cellular basis of inflammatory and immunodeficiency diseases (Secondary Investigator)
- 2011 Research Fellowship SRF B (Primary Investigator)
- The role of Roquin in microRNA function and decay (Primary Investigator)
- Specialised subsets of T follicular helper cells in the control of infection and immune pathology (Primary Investigator)
- Genetic pathology of Roquin in human autoimmune disease (Primary Investigator)
