Associate Professor Di Yu

PhD
Group Leader

Areas of expertise

  • Autoimmunity 110703
  • Structural Biology (Incl. Macromolecular Modelling) 060112
  • Genetic Immunology 060406
  • Cellular Immunology 110704
  • Rheumatology And Arthritis 110322
  • Biochemistry And Cell Biology 0601
  • Immunology 1107

Research interests

The immune system strikes a kaleidoscope way to eliminate different types of infections and cancerous cells. While immune deficiency leads to susceptibility to infections and cancers, the trade-off of “strong” immune responses is the risk of autoimmune diseases and inflammation. Maintenance of a competent but balanced immune system is the cornerstone of health. The sophisticated immune defence mechanisms are essentially orchestrated by T cells. Not only can T cells directly kill infected and cancerous cells, but they also, through multiple subsets, fundamentally control the activation and function of other immune cell types. Therefore, targeted regulation of T cells subsets can efficiently modulate immune responses to treat many human diseases.

In the lab of T-cell Immune Mechanism, Monitoring and Modulation (TIM3), Dr Di Yu and his team are investigating the molecular mechanisms by which T cells control the competence and balance of the immune system, with the aim to design new strategies to modulate the immune system to treat autoimmune disease, infection and cancer.

Three major approaches are used in our research. First, we use gene-targeted mice to investigate basic molecular mechanisms of the adaptive immunity, particularly for T cells and cytokines. Second, we phenotype immune cells using methods such as multi-colour flow cytometry to monitor the immune system of patients to understand the dysregulated immune responses associated with diseases and the immunological changes responding to therapies. Third, based on biochemical and structural knowledge of cytokines, we design and optimize cytokine-based immunotherapies to modulate the immune system to treat human diseases.

 

Publications

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

Return to top

Updated:  20 September 2020 / Responsible Officer:  Director (Research Services Division) / Page Contact:  Researchers