Associate Professor Jiayu (Jean) Wen
Areas of expertise
- Genome Structure And Regulation 060407
- Bioinformatics 060102
- Genomics 060408
- Biostatistics 010402
- Bioinformatics Software 080301
- Artificial Intelligence And Image Processing 0801
Publications
- Jiang, X, Wen, J, Paver, E et al. 2021, 'H2A.B is a cancer/testis factor involved in the activation of ribosome biogenesis in Hodgkin lymphoma', EMBO Reports, vol. 22, no. 8.
- Lee, S, Wei, L, Zhang, B et al. 2021, 'ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing', PLoS Genetics, vol. 17, no. 4.
- Regadas, I, Dahlberg, O, Vaid, R et al. 2021, 'A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation', Molecular Cell, vol. 81, no. 8, pp. 1766-1780.
- Vaid, R, Wen, J & Mannervik, M 2020, 'Release of promoter-proximal paused Pol II in response to histone deacetylase inhibition', Nucleic Acids Research, vol. 48, no. 9, pp. 4877-4890.
- Somasiri, P, Behm, C, Adamski, M et al. 2020, 'Transcriptional response of Caenorhabditis elegans when exposed to Shigella flexneri', Genomics, vol. 112, pp. 774-781.
- Uebersch�r, M, Wang, H, Zhang, C et al. 2019, 'BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila', Nature Communications, vol. 10, no. 0.
- Jee, D, Yang, J, Park, S et al. 2018, 'Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals', Molecular Cell, vol. 69, no. 2, pp. 265-278pp.
- Lin, C, Hu, F, Dubruille, R et al. 2018, 'The hpRNA/RNAi Pathway Is Essential to Resolve Intragenomic Conflict in the Drosophila Male Germline', Developmental Cell, vol. 46, no. 3, pp. 316-326.e1-e5 (16pp).
- Lin, C, Wen, J, Bejarano, F et al. 2017, 'Characterization of a TUTase/RNase complex required for Drosophila gametogenesis', RNA, vol. 23, no. 3, pp. 284-296.
- Sanfilippo, P, Wen, J & Lai, E 2017, 'Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species', Genome Biology, vol. 18, pp. 229 (22pp).
- Garaulet, D, Sun, K, Li, W et al. 2016, 'miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila', Journal of Neuroscience, vol. 36, no. 12, pp. 3414-3421.
- Wen, J, Bejarano, F, Duan, H et al. 2015, 'Adaptive regulation of testis gene expression and control of male fertility by the Drosophila hairpin RNA pathway', Molecular Cell, vol. 57, no. 1, pp. 165-178.
- Wen, J, Ladewig, E, Shenker, S et al. 2015, 'Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates', PLOS Computational Biology, vol. 11, no. 9, pp. 1-29.
- Bortolamiol-Becet, D, Hu, F, Jee, D et al. 2015, 'Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor', Molecular Cell, vol. 59, no. 2, pp. 217-228.
- Brown, J, Boley, N, Eisman, R et al. 2014, 'Diversity and dynamics of the Drosophila transcriptome', Nature, vol. 512, pp. 393-399pp.
- Frankel, L, Di Malta, C, Wen, J et al. 2014, 'A non-conserved miRNA regulates lysosomal function and impacts on a human lysosomal storage disorder', Nature Communications, vol. 5, no. 5840, pp. 1-11.
- Gerstein, M, Rozowsky, J, Yan, K et al. 2014, 'Comparative analysis of the transcriptome across distant species', Nature, vol. 512, pp. 445-448.
- Wen, J, Mohammed, J, Bortolamiol-Becet, D et al. 2014, 'Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines', Genome Research, vol. 24, no. 7, pp. 1236-1250.
- Stadthagen, G, Tehler, D, Høyland-Kroghsbo, N et al 2013, 'Loss of miR-10a Activates Lpo and Collaborates with Activated Wnt Signaling in Inducing Intestinal Neoplasia in Female Mice', PLoS Genetics, vol. 9, no. 10, pp. e1003913(12pp).
- Gregersen, L, Jacobsen, A, Frankel, L et al. 2012, 'MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells', BMC Cancer, vol. 12, no. 232, pp. 1-10.
- Chen, Y, Jorgensen, M, Kolde, R et al. 2011, 'Prediction of RNA Polymerase II recruitment, elongation and stalling from histone modification data', BMC Genomics, vol. 12, no. 544, pp. 1-16.
- Frankel, L, Wen, J, Lees, M et al. 2011, 'microRNA‐101 is a potent inhibitor of autophagy', The EMBO Journal, vol. 30, no. 22, pp. 4628-4641.
- Lindblad-Toh, K, Garber, M, zuk, O et al. 2011, 'A high-resolution map of human evolutionary constraint using 29 mammals', Nature, vol. 478, no. 7370, pp. 476-4782.
- Parker, B, Moltke, I, Roth, A et al 2011, 'New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes', Genome Research, vol. 21, no. 11, pp. 1929-1943pp.
- Wen, J, Parker, B, Jacobsen, A et al 2011, 'MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action', RNA, vol. 17, no. 5, pp. 820-834.
- Gregersen, L, Jacobsen, A, Frankel, L et al 2010, 'MicroRNA-145 Targets YES and STAT1 in Colon Cancer Cells', PLOS ONE (Public Library of Science), vol. 5, no. 1, pp. e8836 (1-10).
- Jacobsen, A, Wen, J, Marks, D et al 2010, 'Signatures of RNA binding proteins globally coupled to effective microRNA target sites', Genome Research, vol. 20, no. 8, pp. 1010-1019pp.
- Parker, B, Wen, J & Parker, B 2009, 'Predicting microRNA targets in time-series microarray experiments via functional data analysis', BMC Bioinformatics, vol. 10, no. Suppl 1, pp. 1-10.
- Wen, J, Weiller, G & Parker, B 2008, 'Analysis of Structural Strand Asymmetry in Non-coding RNAs', Asia-Pacific Bioinformatics Conference (APBC 2008), ed. Alvis Brazma, Satoru Miyamo and Tatsuya Akutsu, Imperial College Press, London, UK, pp. 187-198.
- Wen, J, Frickey, T & Weiller, G 2008, 'Computational prediction of candidate miRNAs and their targets from Medicago truncatula non-protein-coding transcripts', In Silico Biology, vol. 8, no. 24, pp. 1-11.
- Wen, J, Parker, B & Weiller, G 2007, 'In silico identification and characterization of mRNA-like noncoding transcripts in Medicago truncatula.', In Silico Biology, vol. 7, pp. 0034 1-22.
- Steele, E, Lindley, R, Wen, J et al 2006, 'Computational analyses show A-to-G mutations correlate with nascent mRNA hairpins at somatic hypermutation hotspots', DNA Repair, vol. 5, pp. 1346-1363.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- RNA-binding proteins rewire transcriptomes in immune cell differentiation (Primary Investigator)
- Evolution and functional impact of gene silencing by hairpin derived RNAs (Primary Investigator)