Associate Professor Giel van Dooren
ANU College of Science
Publications
- Hayward, J, Rajendran, E, Zwahlen, S et al. 2021, 'Divergent features of the coenzyme Q: Cytochrome c oxidoreductase complex in Toxoplasma gondii parasites', PLoS Pathogens, vol. 17, no. 2.
- Smith, N, Goulart, C, Hayward, J et al. 2021, 'Control of human toxoplasmosis', International Journal for Parasitology, vol. 51, no. 2-3, pp. 95-121.
- Fairweather, S, Rajendran, E, Blume, M et al. 2021, 'Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii, PLoS Pathogens, 17, https://doi.org/10.1371/journal.ppat.1009835
- Zeng, J, Hapuarachchi, S, Shafik, S et al. 2021, 'Identifying the major lactate transporter of Toxoplasma gondii tachyzoites', Scientific Reports, 11, 1-11.
- Tjhin, E, Hayward, J, McFadden, G et al 2020, 'Characterization of the apicoplast-localized enzyme TgUroD in Toxoplasma gondii reveals a key role of the apicoplast in heme biosynthesis', Journal of Biological Chemistry, vol. 295, no. 6, pp. 1539-1550.
- Aw, Y, Seidi, A, Hayward, J et al. 2020, 'A key cytosolic iron-sulfur cluster synthesis protein localizes to the mitochondrion of Toxoplasma gondii', Molecular Microbiology, no. 00, pp. 1-18.
- Rajendran, E, Kirk, K & van Dooren, G 2020, 'Measuring Solute Transport in Toxoplasma gondii Parasites', in Christopher J. Tonkin (ed.), Toxoplasma gondii: Methods and Protocols, Humana Press, New York, NY, pp. 245-268.
- Katris, N, Ke, H, McFadden, G et al 2019, 'Calcium negatively regulates secretion from dense granules in Toxoplasma gondii', Cellular Microbiology, vol. 2019, no. e13011, pp. 1-9.
- Hayward, J, Hayward, J, van Dooren, G et al 2019, 'Same same, but different: Uncovering unique features of the mitochondrial respiratory chain of apicomplexans', Molecular and Biochemical Parasitology, vol. 232, pp. 1-8.
- Hayward, J, Hayward, J, van Dooren, G et al 2019, 'Same same, but different: Uncovering unique features of the mitochondrial respiratory chain of apicomplexans', Molecular and Biochemical Parasitology, vol. 232, pp. 1-8.
- Lehane, A, Dennis, A, Bray, K et al. 2019, 'Characterization of the ATP4 ion pump in Toxoplasma gondii', Journal of Biological Chemistry, 294, 5720-5734.
- Parker, K *, Fairweather, S *, Rajendran, E et al. 2019, 'The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family', PLoS Pathogens, 15, e1007577. * Co-first authors
- Huet, D, Rajendran, E, van Dooren, G et al 2018, 'Identification of cryptic subunits from an apicomplexan ATP synthase', eLife, vol. 7, pp. 24pp.
- Seidi, A, Muellner-Wong, L, Rajendran, E et al 2018, 'Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase', eLife, vol. 7, pp. 1-36.
- van Dooren, G & Hapuarachchi, S 2017, 'The Dark Side of the Chloroplast: Biogenesis, Metabolism and Membrane Biology of the Apicoplast', Advances in Botanical Research, vol. 84, pp. 145-185.
- Rajendran, E, Hapuarachchi, S, Miller, C et al 2017, 'Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites', Nature Communications, 8:14455. doi: 10.1038/ncomms14455.
- Amiar, S, MacRae, J, Callahan, D et al 2016, 'Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase', PLoS Pathogens, vol. 12, no. 8, pp. e1005765-e1005765.
- van Dooren, G, Yeoh, L, Striepen, B et al 2016, 'The Import of Proteins into the Mitochondrion of Toxoplasma gondii', Journal of Biological Chemistry, vol. 291, no. 37, pp. 19335-19350.
- Yeoh, L, Goodman, C, Hall, N et al 2015, 'A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii', Nucleic Acids Research, vol. 43, no. 9, pp. 4661-4675.
- Smith, C, Jerkovic, A, Puy, H et al 2015, 'Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites' http://www.ncbi.nlm.nih.gov/pubmed/25414439
- Katris, N, van Dooren, G, McMillan, P et al 2014, 'The Apical Complex Provides a Regulated Gateway for Secretion of Invasion Factors in Toxoplasma', PLoS Pathogens, vol. 10, no. 4, pp. e1004074-e1004074.
- Warring, S, Dou, Z, Carruthers, V et al 2014, 'Characterization of the chloroquine resistance transporter homologue in Toxoplasma gondii', Eukaryotic Cell, vol. 13, no. 11, pp. 1360-1370.
- Agrawal, S, Chung, D, Ponts, N et al 2013, 'An Apicoplast Localized Ubiquitylation System Is Required for the Import of Nuclear-encoded Plastid Proteins', PLoS Pathogens, vol. 9, no. 6.
- van Dooren, G & Striepen, B 2013, 'The algal past and parasite present of the apicoplast', Annual Review of Microbiology, vol. 67, pp. 271-289.
- Ramakrishnan, S, Docampo, M, MacRae, J et al 2012, 'Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii', Journal of Biological Chemistry, vol. 287, no. 7, pp. 4957-4971.
- Glaser, S, van Dooren, G, Agrawal, S et al 2012, 'Tic22 is an essential chaperone required for protein import into the apicoplast', Journal of Biological Chemistry, vol. 287, no. 47, pp. 39505-39512.
- McCoy, J, Whitehead, L, van Dooren, G et al 2012, 'TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells', PLoS Pathogens, vol. 8, no. 12.
- van Dooren, G, Kennedy, A & McFadden, G 2012, 'The Use and Abuse of Heme in Apicomplexan Parasites', Antioxidants & redox signaling, vol. 17, no. 4, pp. 634-656.
- Gould, S, Kraft, L, van Dooren, G et al 2011, 'Ciliate pellicular proteome identifies novel protein families with characteristic repeat motifs that are common to alveolates', Molecular Biology and Evolution, vol. 28, no. 3, pp. 1319-1331.
- van Dooren, G & Ralph, S 2010, 'Novel vacuoles in Toxoplasma', Molecular Microbiology, vol. 76, no. 6, pp. 1335-1339.
- Brooks, C, Johnsen, H, van Dooren, G et al 2010, 'The Toxoplasma Apicoplast Phosphate Translocator Links Cytosolic and Apicoplast Metabolism and Is Essential for Parasite Survival', Cell Host and Microbe, vol. 7, no. 1, pp. 62-73.
- Chtanova, T, Han, S, Schaeffer, M et al 2009, 'Dynamics of T Cell, Antigen-Presenting Cell, and Pathogen Interactions during Recall Responses in the Lymph Node', Immunity, vol. 31, no. 2, pp. 342-355.
- Agrawal, S, van Dooren, G, Beatty, W et al 2009, 'Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins', Journal of Biological Chemistry, vol. 284, no. 48, pp. 33683-33691.
- van Dooren, G, Reiff, S, Tomova, C et al 2009, 'A Novel Dynamin-Related Protein Has Been Recruited for Apicoplast Fission in Toxoplasma gondii', Current Biology, vol. 19, no. 4, pp. 267-276.
- Breinich, M, Ferguson, D, Foth, B et al 2009, 'A Dynamin Is Required for the Biogenesis of Secretory Organelles in Toxoplasma gondii', Current Biology, vol. 19, no. 4, pp. 277-286.
- Schaeffer, M, Han, S, Chtanova, T et al 2009, 'Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii', Journal of Immunology, vol. 182, no. 10, pp. 6379-6393.
- Chtanova, T, Schaeffer, M, Han, S et al 2008, 'Dynamics of Neutrophil Migration in Lymph Nodes during Infection', Immunity, vol. 29, no. 3, pp. 487-496.
- van Dooren, G, Tomova, C, Agrawal, S et al 2008, 'Toxoplasma gondii Tic20 is essential for apicoplast protein import', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 36, pp. 13574-13579.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Targeting the mitochondrial electron transport chain of apicomplexan parasites (Primary Investigator)
- Regulating nutrient uptake in intracellular parasites (Primary Investigator)
- A novel family of amino acid transporters in Apicomplexan parasites (Secondary Investigator)
- Biogenesis of the relict plastid of Apicomplexan parasites: the role of a dynamin-related protein in apicoplast division (Primary Investigator)