Associate Professor Dipti Talaulikar

MBBS, PhD, FRACP, FRCPA
Associate Professor, ANU Medical School; Visiting Fellow, JCSMR, ANU
College of Health & Medicine
T: 612 6244 2487

Areas of expertise

  • Pathology (Excl. Oral Pathology) 110316
  • Haematology 110202
  • Cancer Cell Biology 111201
  • Cancer Diagnosis 111202
  • Haematological Tumours 111206

Research interests

The Haematology Translational Research Unit at the Canberra Hospital is mainly involved with translational research projects in lymphoproliferative disorders including lymphoma and myeloma. Our particular areas of interest lie in

1. determining the cellular origin of lymphoma using a combination of sophisticated flow cytometry and cell sorting, genotyping and ultra deep sequencing techniques, 

2. etsablishing links between autoimmunity and lymphoma and

3. determining mechanisms of spread of lymphoproliferative disorders to extranodal tissues especially the bone marrow.

Most of our projects involve work on archived human tissue samples stored at the Haematology Research Tissue Bank.

Biography

I am a physician scientist working full time as staff specialist in the department of Haematology at Canberra Hospital. I obtained my fellowships for RACP and RCPA in 2006-07 and completed a PhD at ANU (2006-2009). I have a Specialist Certificate in Clinical Research from Melbourne University.

I effectively set up the Haematology Research Tissue Bank, a repository of peripheral blood, bone marrow and primary tissue samples from patients with haematological and related disorders, and have been managing this for 6 years.

Over the last 2 years I have gradually built a team of staff and collaborators to support a lymphoma research program. Our Haematology Translational Research Unit at Canberra Hospital supports medical and research students.

 

Available student projects

1. Cellular origin of non-Hodgkin lymphoma: Recent studies have elucidated recurrent somatic mutations in several subtypes of non-Hodgkin lymphoma. However, it is not yet known at what stage in ontogeny these mutations arise. Our group is studying the disease heterogeneity within subtypes of non-Hodgkin lymphoma using sophisticated multicolour flow cytometry, genotyping and ultra deep sequencing techniques. The project involves use of human samples archived in the Haematology research tissue bank, and direct translation of research findings into the diagnostic laboratory and clinic.

2. Does autoimmunity drive development of lymphoproliferative disorders?

3. Mechanisms of tumour spread in diffuse large B-cell lymphoma

Current student projects

1. Analysis of BCR and Driver Mutations in Non-Hodgkin Lymphoma Patients with Autoimmune Disease

2. Characterisation of the lymphoid and myeloid cells in the tumour microenvironment in diffuse large B-cell lymphoma

3. The Impact of high body mass index on innate immune cells in the microenvironment and on clinical outcome in patients with Diffuse Large B-cell Lymphoma.

Publications

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

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Updated:  11 May 2021 / Responsible Officer:  Director (Research Services Division) / Page Contact:  Researchers