Professor Thomas Preiss
Dipl Chem (Marburg University, Germany) PhD (University of Newcastle upon Tyne, UK), Habilitation (Heidelberg University, Germany)
Leader - RNA Biology Group
ANU College of Health and Medicine
Areas of expertise
- Gene Expression (Incl. Microarray And Other Genome Wide Approaches) 060405
- Epigenetics (Incl. Genome Methylation And Epigenomics) 060404
- Systems Biology 060114
- Proteomics And Intermolecular Interactions (Excl. Medical Proteomics) 060109
- Cell Metabolism 060104
- Bioinformatics 060102
- Mycology 060505
- Cell Development, Proliferation And Death 060103
- Enzymes 060107
- Cardiology (Incl. Cardiovascular Diseases) 110201
- Cancer Cell Biology 111201
Research interests
Prof Preiss is a molecular biologist determining the mechanisms and transcriptome-wide patterns of eukaryotic mRNA translation as one of life’s core processes and its regulation by RNA-binding proteins and non-coding RNA as a means of controlling gene activity. He joined the translational control field in 1995 as a postdoctoral scientist and has since had a particular focus on mechanisms of translation initiation using yeast and mammalian cells and cell-free translation systems as his preferred models. In addition to his mechanistic work, he also studies global patterns of post-transcriptional control using microarray and next gen sequencing-based methods. After starting his own group he continued to investigate the role of the mRNA cap and poly(A) tail and associated protein factors in determining mRNA utilisation. These studies overlap with work on the discovery of miRNA targets and the unravelling of their mechanism of action. Employing next gen sequencing technology (RNAseq) his group is further pursuing interests in the area of RNA (mRNA, miRNA, tRNA, other noncoding RNA) processing, modification, polyadenylation and utilisation.
Biography
From 1986-91 Thomas Preiss studied Chemistry at the Philipps-Universität, Marburg (Germany) and the University of Bristol (UK), followed by PhD work (1992-95) at the University of Newcastle upon Tyne (UK). He spent the next seven years (1995-2002) as a postdoctoral scientist at the European Molecular Biology Laboratories (EMBL), Heidelberg (Germany), in parallel also completing his Habilitation in Biochemistry [Permission to teach at the professorial level] at the Medical Faculty of the Universität Heidelberg (Germany). In 2002 he became a laboratory head at the Victor Chang Cardiac Research Institute in Sydney and held conjoint appointments at the University of New South Wales (Senior Lecturer, then Associate Professor). In 2011 he accepted a position as Professor of RNA Biology at ANU/JCSMR. Since 2022 he is the inaugural Director of the ANU Shine-Dalgarno Centre for RNA Innovation.
Researcher's projects
1. microRNAs are gene regulators with critical roles in heart disease. We focus on how interactions between microRNAs and their messenger RNA targets change during disease with a particualr emphasis on analysing the contribution of processing of microRNAs and targets.
2. The research successes of Molecular Biology and Biochemistry have given us detailed pictures of the regulatory and metabolic states of cells and tissues, yet we know little about how these states affect each other. We use next generation sequencing (NGS) and mass spectrometry to investigate the possible existence of regulatory interactions between ribonucleic acids, enzymes and metabolites to connect gene expression and metabolism.
3. The role of the modified base 5-methylcytosine (m5C) as an epigenetic mark in DNA is well appreciated and intensely studied. By comparison, the cellular functions of the same base modification in RNA molecules are poorly understood. We are applying NGS technology to chart the occurrence of m5C in eukaryotic cellular RNAs and endeavour to unravel its function(s) for different classes of RNA.
4. Messenger ribonucleic acids (mRNA) act as templates for protein synthesis by ribosomes. Much like the DNA of genes, eukaryotic mRNA molecules do not exist as ‘naked’ nucleic acid. They interact with RNA-binding proteins, ribosomes and translation factors, and adopt dynamic structures that determine the precise outcome of translation. We combine NGS technology with isolation of polyribosomal complexes from living cells, to generate transcriptome-wide snapshots of the distribution of translation complexes along mRNAs. Such systems-level data will allow unprecedented insight into the mechanism, dynamics and regulation of protein synthesis.
Available student projects
The RNA Biology Lab focuses on understanding the mechanisms and transcriptome-wide patterns of eukaryotic mRNA translation and its regulation by RNA-binding proteins and non-coding RNA. Central to the work is the ‘closed-loop’ model of translation, which posits that the cap and poly(A) tail ends of the mRNA come together for efficient initiation. We were the first to discover that miRNAs target key components of the mRNA closed-loop for repression and we continue to investigate the molecular componentry of the miRNA mechanism. We are further applying next generation sequencing methods to study transcriptome-wide patterns of mRNA and miRNA expression, processing, as well as mRNA translation state, tail length and nucleoside modification.
Openings for Honours and PhD projects exist in several of these programmes and students joining the lab will have the opportunity to develop their research together with Prof Preiss and senior members of his group.
Current student projects
1. Messenger RNA and microRNA processing diversity in cardiac biology
2. Gene regulation through interactions between RNA, enzymes and metabolites
3. The role of 5-methylcytosine as a modification of RNA in cancer
4. Tracking factor footprints to reveal the intricacy and control of translation initiation
Projects can be devised to suit PhD or Honours/Masters level students.
Publications
- Hayashi, J, Ton, J, Negi, S et al. 2021, 'The effect of oxidized dopamine on the structure and molecular chaperone function of the small heat-shock proteins, αB-crystallin and hsp27', International Journal of Molecular Sciences, vol. 22, no. 7, pp. 1-20.
- Janapala, Y, Woodward, K, Kim, J et al. 2021, 'Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells', Journal of Visualized Experiments, vol. 178 e62639
- Schumann, U, Zhang, H, Sibbritt, T et al. 2020, 'Multiple links between 5-methylcytosine content of mRNA and translation', BMC Biology, vol. 18, pp. 40.
- Wagner, S, Herrmannová, A, Hronová, V et al. 2020, 'Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes', Molecular Cell, vol. 79, no. 4, pp. 546-560.
- Sen, N, Gupta, N, Archer, S et al. 2019, 'Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo', Nucleic Acids Research, vol. 47, no. 16, pp. 8785-8806.
- Swaminathan, A, Harrison, P, Preiss, T et al. 2019, 'PAT-Seq: A method for simultaneous quantitation of gene expression, poly(A)-site selection and poly(A)-length distribution in yeast transcriptomes', in Stephen G Oliver & Juan I Castrillo (ed.), Yeast System Biology: Methods and Protocols, Humana Press, New York, pp. 141-164.
- Preiss, T & Bommer, U 2019, 'New RNA molecules and the regulation of gene expression at the translational level (Neue RNA-Molek�le und die Regulation der Genexpression auf Translationsebene)', BioSpektrum, vol. 25, no. 3, pp. 350-351.
- Janapala, Y, Preiss, T & Shirokikh, N 2019, 'Control of Translation at the Initiation Phase During Glucose Starvation in Yeast', International Journal of Molecular Sciences, vol. 20, no. 16, pp. 4043.
- Janin, M, Ortiz-Barahona, V, Castro de Moura, M et al. 2019, 'Epigenetic loss of RNA‑methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program', Acta Neuropathologica, vol. 138, no. 6, pp. 1053-1074.
- Ragan PhD, C, Goodall, G, Shirokikh, N et al. 2019, 'Insights into the biogenesis and potential functions of exonic circular RNA', Scientific Reports, vol. 9, no. 1, pp. 2048.
- Shirokikh, N, Dutikova, Y et al 2019, 'Migration of Small Ribosomal Subunits on the 5' Untranslated Regions of Capped Messenger RNA', International Journal of Molecular Sciences, vol. 20, no. 18. pp. 4464
- Faunce, T, Ray, A, Gardiner, C et al 2018, 'Regulating RNA Research and CRISPR Gene Drives to Combat Biosecurity Threats', https://www.ncbi.nlm.nih.gov/pubmed/30302983
- Hentze, MW, Castello, A, Schwarzl, T et al 2018, 'A brave new world of RNA-binding proteins', Nature Reviews: Molecular Cell Biology, vol. 19, no. 5, pp. 327-341.
- Rasko, J & Preiss, T 2018, 'Diversity of transcripts emanating from protein-coding genes', Seminars in Cell & Developmental Biology, vol. 75, pp. 1-2.
- Shirokikh, N & Preiss, T 2018, 'Cover Image, Volume 9, Issue 4 WIREs RNA', Wiley Interdisciplinary Reviews: RNA , vol. 9, no. 4.
- Shirokikh, N & Preiss, T 2018, 'Translation initiation by cap-dependent ribosome recruitment: Recent insights and open questions', Wiley Interdisciplinary Reviews: RNA , vol. 9, no. 4, pp. e1473 (1-45).
- David, R, Burgess, A, Parker, B et al 2017, 'Transcriptome-wide mapping of RNA 5-methylcytosine in arabidopsis mRNAs and noncoding RNAs', The Plant Cell, vol. 29, no. 3, pp. 445-460.
- Shirokikh, N, Archer, S, Beilharz, T et al 2017, 'Translation complex profile sequencing to study the in vivo dynamics of mRNA-ribosome interactions during translation initiation, elongation and termination', Nature Protocols, vol. 12, no. 4, pp. 697-731.
- Evers, M, Shafik, A, Schumann, U et al 2016, 'RNAModR: Functional analysis of mRNA modifications in R'. bioRxiv - 080051, not peer-reviewed.
- Schumann, U, Shafik, A & Preiss, T 2016, 'METTL3 Gains R/W Access to the Epitranscriptome', Molecular Cell, vol. 62, no. 3, pp. 323-324.
- Reichel, M, Liao, Y, Rettel, M et al. 2016, 'In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings', The Plant Cell, vol. 28, no. 10, pp. 2435-2452.
- Shafik, A, Schumann, U, Evers, M et al 2016, 'The emerging epitranscriptomics of long noncoding RNAs', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1859, no. 1, pp. 59-70.
- Preiss, T 2016, 'All Ribosomes Are Created Equal. Really?', Trends in Biochemical Sciences, vol. 41, no. 2, pp. 121-123.
- Soetanto, R, Hynes, C, Patel, H et al. 2016, 'Role of miRNAs and alternative mRNA 3 '-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1859, no. 5, pp. 744-756.
- Liao, Y, Castello, A, Fischer, B et al. 2016, 'The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease', Cell Reports, vol. 16, no. 5, pp. 1456-1469.
- Liepelt, A, Naarmann-de Vries, I, Simons, N et al 2016, 'Identification of RNA-binding proteins in macrophages by interactome capture', Molecular and Cellular Proteomics, vol. 15, no. 8, pp. 2699-2714.
- Archer, S•, Shirokikh, N•, Beilharz, T et al 2016, 'Dynamics of ribosome scanning and recycling revealed by translation complex profiling', Nature, vol. 535, no. 7613, pp. 570-574.
- Singhania, R, Pavey, S, Payne, E et al 2016, 'Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediates', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1859, no. 8, pp. 1034-1042.
- Wong, QWL, Lee, Q, Vaz, C et al 2016, 'Embryonic stem cells exhibit mRNA isoform specific translational regulation', PLOS ONE (Public Library of Science), vol. 11, no. 1, e0143235.
- Castello, A, Hentze, M & Preiss, T 2015, 'Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins', Trends in Endocrinology and Metabolism, vol. 26, no. 12, pp. 746-757.
- Fu, N, Rios, A, Pal, B et al 2015, 'EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival', Nature Cell Biology, vol. 17, no. 4, pp. 365-375.
- Archer, S, Shirokikh, N, Hallwirth, C et al 2015, '"Probing the closed-loop model of mRNA translation in living cells"', RNA Biology, vol. 12, no. 3, pp. 248-254.
- Archer, S•, Shirokikh, N• & Preiss, T 2015, 'Probe-directed degradation (PDD) for flexible removal of unwanted cDNA sequences from RNA-seq libraries', in A. Boyle, J.L Haines, B. R Korf (ed.), Current Protocols in Human Genetics, John Wiley & Sons Inc., New Jersey, USA, pp. 11.15.1-11.15.36.
- Harrison, P, Powell, D, Clancy, J et al 2015, 'PAT-seq: A method to study the integration of 3'-UTR dynamics with gene expression in the eukaryotic transcriptome', RNA, vol. 21, no. 8, pp. 1502-1510.
- Sibbritt, T, Shafik, A, Clarke, S et al 2016, 'Nucleotide-Level Profiling of m5C RNA Methylation', in Methods Mol Biol, Erik Dassi (ed.), Post-Transcriptional Gene Regulation, Humana Press, New York, vol. 1358, pp. 269-284.
- Srivastava, M, Duan, G, Kershaw, NJ et al 2015, 'Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.', Nature Communications, vol. 6, no. 6253.
- Keam, S, Young, P, McCorkindale, A et al 2014, 'The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells', Nucleic Acids Research, vol. 42, no. 14, pp. 8984-8995.
- Murat, P, Zhong, J, Lekieffre, L et al 2014, 'G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation', Nature Chemical Biology, vol. 10, no. 5, pp. 358-U64.
- Liang, B, Soka, M, Christensen, A et al 2014, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis', Journal of Molecular and Cellular Cardiology, vol. 67, pp. 69-76.
- Archer, S, Shirokikh, N & Preiss, T 2014, 'Selective and flexible depletion of problematic sequences from RNA-seq libraries at the cDNA stage', BMC Genomics, vol. 15, pp. 401.
- Clancy, JL, Patel, HR, Hussein, SMI et al 2014, 'Small RNA changes en route to distinct cellular states of induced pluripotency', Nature Communications, vol. 5, p. 5522.
- Hussein, SMI, Puri, MC, Tonge, PD et al 2014, 'Genome-wide characterization of the routes to pluripotency', Nature, vol. 516, no. 7530, pp. 198-206.
- Lee, D-S, Shin, J-Y, Tonge, PD et al 2014, 'An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator', Nature Communications, vol. 5, p. 5619.
- Tonge, PD, Corso, AJ, Monetti, C et al 2014, 'Divergent reprogramming routes lead to alternative stem-cell states', Nature, vol. 516, no. 7530, pp. 192-197.
- Vinuesa, CG & Preiss, T 2014, 'Inflammation: Gone with Translation', PLoS Genetics, vol. 10, no. 6, pp. e1004442
- Hentze, M & Preiss, T 2013, 'Circular RNAs: splicing's enigma variations', The EMBO Journal, vol. 32, no. 7, pp. 923-925.
- Ohanian, M, Humphreys, D, Anderson, E et al 2013, 'A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance', BMC Genetics, vol. 14, no. 18, pp. 18-18.
- Olesen, M, Liang, B, Soka, M et al 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', European Heart Journal, vol. 34, no. 1, pp. 642-642.
- Castello, A, Fischer, B, Hentze, M et al 2013, 'RNA-binding proteins in Mendelian disease', Trends in Genetics, vol. 29, no. 5, pp. 318-327.
- Li, C, Young, P, Maloney, C et al 2013, 'Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice', Epigenetics, vol. 8, no. 6, pp. 602-611.
- Lai, X, Beilharz, T, Au, W et al 2013, 'Yeast hEST1A/B (SMG5/6)-Like Proteins Contribute to Environment-Sensing Adaptive Gene Expression Responses', G3: Genes, Genomes, Genetics, vol. 3, no. 10, pp. 1649-1659.
- Sibbritt, T, Patel, H & Preiss, T 2013, 'Mapping and significance of the mRNA methylome', Wiley Interdisciplinary Reviews: WIREs RNA, vol. 4, no. 4, pp. 397-422.
- Hernandez, G, Proud, C, Preiss, T et al 2012, 'On the diversification of the translation apparatus across eukaryotes', Comparative and Functional Genomics, vol. 2012, pp. 256848-256848.
- Hynes, C, Clancy, J & Preiss, T 2012, 'miRNAs in cardiac disease: Sitting duck or moving target?', IUBMB Life, vol. 64, no. 11, pp. 872-878.
- Gebauer, F, Preiss, T & Hentze, M 2012, 'From cis-regulatory elements to complex RNPs and back', Cold Spring Harbor Perspectives in Biology, vol. 4, no. 7, pp. 1-14.
- Castello, A, Fischer, B, Eichelbaum, K et al 2012, 'Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins', Cell, vol. 149, no. 6, pp. 1393-1406.
- Humphreys, D, Clancy, J, Patel, H et al. 2012, 'Complexity of Murine Cardiomyocyte miRNA Biogenesis, Sequence Variant Expression and Function', PLoS ONE, vol. 7, no. 2, pp. 1-18.
- Schonrock, N, Humphreys, D, Preiss, T et al 2011, 'Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-beta', Journal of Molecular Neuroscience, vol. 46, no. 2, pp. 324-335.
- Squires, J, Patel, H, Nousch, M et al 2012, 'Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA', Nucleic Acids Research, vol. 40, no. 11, pp. 5023-33.
- Clancy, J, Wei, G, Echner, N et al 2011, 'mRNA isoform diversity can obscure detection of miRNA-mediated control of translation', RNA, vol. 17, no. 6, pp. 1025-1031.
- Squires, J & Preiss, T 2011, '5-methylcytosine as a modification in RNA', in J Craig & N Wong (ed.), Epigenetics: A Reference Manual, Horizonpress, USA, pp. 227-236.
- Li, C, Cropley, J, Cowley, M et al 2011, 'A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice', PLoS Genetics, vol. 7, no. 4, pp. e1001380-e1001380.
- Beilharz, T & Preiss, T 2011, 'Polyadenylation state microarray (PASTA) analysis', in Castrillo JI & Oliver SG, (eds.), Methods in Molecular Biology: Yeast Systems Biology (vol 759), Springer, New York, pp. 133-148.
- Squires, J & Preiss, T 2010, 'Function and detection of 5-methylcytosine in eukaryotic RNA', Epigenomics, vol. 2, no. 5, pp. 709-715.
- Swarbrick, A, Woods, S, Shaw, A et al 2010, 'miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma', Nature Medicine, vol. 16, no. 10, pp. 1134-U113.
- Larance, M, Rowland, A, Loehn, K et al 2010, 'Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3', Molecular and Cellular Proteomics, vol. 9, no. 4, pp. 682-694.
- Beilharz, T, Humphreys, D & Preiss, T 2010, 'miRNA effects on mRNA closed-loop formation during translation initiation', in Robert E. Rhoads (ed.), miRNA Regulation of the Translational Machinery, Springer-Verlag Berlin Heidelberg, London United Kingdom, pp. 99-112.
- Clancy, J & Preiss, T 2010, 'Getting to the heart of microRNA control of ribosome function', Australian Biochemist, vol. 41, no. 3, pp. 12-15.
- Hentze, MW & Preiss, T 2010, 'The REM phase of gene regulation', Trends in Biochemical Sciences, vol. 35, no. 8, pp. 423-426.
- Schonrock, N, Ke, Y, Humphreys, D et al 2010, 'Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β', PLoS ONE (Public Library of Science), vol. 5, no. 6, pp. e11070.
- Beilharz, T, Humphreys, D, Clancy, J et al 2009, 'microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells', PLOS ONE (Public Library of Science), vol. 4, no. 8, pp. e6783, 12.
- Beilharz, T & Preiss, T 2009, 'Transcriptome-wide measurement of mRNA polyadenylation state', Methods, vol. 48, no. 3, pp. 294-300.
- Traven, A, Beilharz, T, Lo, T et al 2009, 'The Ccr4-Pop2-NOT mRNA deadenylase contributes to septin organization in Saccharomyces cerevisiae', Genetics (online), vol. 182, no. 4, pp. 955-966.
- Zdanowicz, A, Thermann, R, Kowalska, J et al 2009, 'Drosophila miR2 primarily targets the 7GpppN cap structure for translational repression', Molecular Cell, vol. 35, no. 6, pp. 881-8.
- Humphreys, D, Westman, B, Martin, D et al 2008, 'Inhibition of translation initiation by a miRNA', in Appasani K (ed.), MicroRNAs: from Basic Science to Disease Biology, Cambridge University Press, UK, pp. 85-101.
- Butt, A, Sergio, C, Inman, C et al 2008, 'The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome', Breast Cancer Research (Online edition), vol. 10, no. 2, pp. R28.
- Beilharz, T & Preiss, T 2007, 'Widespread use of poly(A) tail length control to accentuate expression of the yeast transcriptome', RNA, vol. 13, no. 7, pp. 982-97.
- Muckenthaler, M & Preiss, T 2007, 'Mechanismen der Translationskontrolle in Eukaryonten [Mechanisms of translational control in eukaryotes]', in Ruckpaul K and Ganten D (ed.), Mechanisms of translational control in eukaryotes, Springer, Heidelberg, pp. 139-158.
- Gao, L, Kwan, J, Macdonald, P et al 2007, 'Improved Poststorage Cardiac Function by Poly (ADP-ribose) Polymerase Inhibition: Role of Phosphatidylinositol 3-Kinase Akt Pathway', Transplantation, vol. 84, no. 3, pp. 380-6.
- Lackner, D, Beilharz, T, Marguerat, S et al 2007, 'A Network of Multiple Regulatory Layers Shapes Gene Expression in Fission Yeast', Molecular Cell, vol. 26, no. 1, pp. 145-155.
- Nousch, M, Reed, V, Bryson-Richardson, R et al 2007, 'The eIF4G-homolog p97 can activate translation independent of caspase cleavage', RNA, vol. 13, no. 3, pp. 374-84.
- Hentze, M, Gebauer, F & Preiss, T 2007, 'Cis-regulatory sequences and trans-acting factors in translation control', in Mathews MB, Sonenberg N, Hershey JWB (ed.), Translational Control in Biology and Medicine (2nd ed), Cold Spring Harbor Laboratory Press, New York, USA, pp. 269-295.
- Clancy, J, Nousch, M, Humphreys, D et al 2007, 'Methods to analyze microRNA-mediated control of mRNA translation', Methods in Enzymology, vol. 431, pp. 83-111.
- Clancy, JL, Nousch, M, Rodnina, M & Preiss, T. 2007. The ins and outs of translation. Genome Biology, vol. 8, p. 321.
- Muckenthaler, M & Preiss, T 2006, 'Translational Control in Eukaryotes', in Ruckpaul K and Ganten D (ed.), Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, Springer, Heidelberg, pp. 1904-1909.
- Woolstencroft, R, Beilharz, T, Cook, M et al 2006, 'Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length', Journal of Cell Science, vol. 119, no. Pt24, pp. 5178-92.
- Westman, B, Beeren, L, Grudzien, E et al 2005, 'The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro', RNA, vol. 11, no. 10, pp. 1505-13.
- Humphreys, D, Westman, B, Martin, D et al 2005, 'MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 47, pp. 16961-6.
- Preiss, T & Beilharz, T 2004, 'Translational profiling: The genome-wide measure of the nascent proteome', Briefings in Functional Genomics, vol. 3, no. 2, pp. 103-111.
- PREISS, T. 2004. Functional genomics: strict tempo and hierarchical vocabularies. Genome Biol, 5, 307.
- BARON-BENHAMOU, J., FORTES, P., INADA, T., PREISS, T. & HENTZE, M. W. 2003. The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast. RNA, 9, 654-62.
- PREISS, T. & HENTZE, M. W. 2003. Starting the protein synthesis machine: eukaryotic translation initiation. Bioessays, 25, 1201-11.
- PREISS, T., BARON-BENHAMOU, J., ANSORGE, W. & HENTZE, M. W. 2003. Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock. Nat Struct Biol, 10, 1039-47.
- DE GREGORIO, E., BARON, J., PREISS, T. & HENTZE, M. W. 2001. Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure. RNA, 7, 106-13.
- BERGAMINI, G., PREISS, T. & HENTZE, M. W. 2000. Picornavirus IRESes and the poly(A) tail jointly promote cap- independent translation in a mammalian cell-free system. RNA, 6, 1781-90.
- FORTES, P., INADA, T., PREISS, T., HENTZE, M. W., MATTAJ, I. W. & SACHS, A. B. 2000. The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation. Mol Cell, 6, 191-6.
- HEMMINGS-MIESZCZAK, M., HOHN, T. & PREISS, T. 2000. Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders. Mol Cell Biol, 20, 6212-23.
- DE GREGORIO, E., PREISS, T. & HENTZE, M. W. 1999. Translation driven by an eIF4G core domain in vivo. Embo J, 18, 4865-74.
- GEBAUER, F., CORONA, D. F., PREISS, T., BECKER, P. B. & HENTZE, M. W. 1999. Translational control of dosage compensation in Drosophila by Sex- lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail. Embo J, 18, 6146-54.
- PREISS, T. & HENTZE, M. W. 1999. From factors to mechanisms: translation and translational control in eukaryotes. Curr Opin Genet Dev, 9, 515-21.
- DE GREGORIO, E., PREISS, T. & HENTZE, M. W. 1998. Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent. RNA, 4, 828-836.
- LAFONTAINE, D. L., PREISS, T. & TOLLERVEY, D. 1998. Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? Mol Cell Biol, 18, 2360-70.
- PREISS, T. & HENTZE, M. W. 1998. Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast. Nature, 392, 516-520.
- PREISS, T., MUCKENTHALER, M. & HENTZE, M. W. 1998. Poly(A)-tail-promoted translation in yeast: implications for translational control. RNA, 4, 1321-1331.
- PREISS, T., CHRZANOWSKA-LIGHTOWLERS, Z. M. & LIGHTOWLERS, R. N. 1997. Glutamate dehydrogenase: an organelle-specific mRNA-binding protein. Trends Biochem Sci, 22, 290.
- LIGHTOWLERS, R. N., SANG, A. E., PREISS, T. & CHRZANOWSKA-LIGHTOWLERS, Z. M. 1996. Targeting proteins to mitochondria: is there a role for mRNA localization? Biochem Soc Trans, 24, 527-31.
- PREISS, T., LOWERSON, S. A., WEBER, K. & LIGHTOWLERS, R. N. 1995. Human mitochondria: distinct organelles or dynamic network? Trends Genet, 11, 211-2.
- PREISS, T., SANG, A. E., CHRZANOWSKA-LIGHTOWLERS, Z. M. & LIGHTOWLERS, R. N. 1995. The mRNA-binding protein COLBP is glutamate dehydrogenase. FEBS Lett, 367, 291-6.
- CHRZANOWSKA-LIGHTOWLERS, Z. M., PREISS, T. & LIGHTOWLERS, R. N. 1994. Inhibition of mitochondrial protein synthesis promotes increased stability of nuclear-encoded respiratory gene transcripts. J Biol Chem, 269, 27322-8.
- MOWS, C. C., PREISS, T., SLATER, E. P., CAO, X., VERRIJZER, C. P., VAN DER VLIET, P. C. & BEATO, M. 1994. Two independent pathways for transcription from the MMTV promoter. J Steroid Biochem Mol Biol, 51, 21-32.
- PREISS, T., CHRZANOWSKA-LIGHTOWLERS, Z. M. & LIGHTOWLERS, R. N. 1994. The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis. Biochim Biophys Acta, 1221, 286-9.
- SCHILLACE, R., PREISS, T., LIGHTOWLERS, R. N. & CAPALDI, R. A. 1994. Developmental regulation of tissue-specific isoforms of subunit VIa of beef cytochrome c oxidase. Biochim Biophys Acta, 1188, 391-7.
- CAO, X., PREISS, T., SLATER, E. P., WESTPHAL, H. M. & BEATO, M. 1993. Expression and functional analysis of steroid receptor fragments secreted from Staphylococcus aureus. J Steroid Biochem Mol Biol, 44, 1-11.
- MACKENZIE, K., HOWARD, J. A. K., MASON, S., GRAVETT, E. C., ASTIN, K. B., SHIXIONG, L., BATSANOV, A. S., VLAOVIC, D., MAHER, J. P., MURRAY, M., KENDREW, D., WILSON, C., JOHNSON, R. E., PREISS, T. & GREGORY, R., J. 1993. On intramolecular dyotropy: structural effects on reaction-rates, crystal structure-molecular mechanics correlations and primary deuterium kinetic isotope effects. J Chem Soc-Perkin Trans, 2, 1211-1228.
- PREISS, T. & LIGHTOWLERS, R. N. 1993. Post-transcriptional regulation of tissue-specific isoforms. A bovine cytosolic RNA-binding protein, COLBP, associates with messenger RNA encoding the liver-form isopeptides of cytochrome c oxidase. J Biol Chem, 268, 10659-67.
- PREISS, T., HALL, A. G. & LIGHTOWLERS, R. N. 1993. Identification of bovine glutamate dehydrogenase as an RNA-binding protein. J Biol Chem, 268, 24523-6.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- RNA-level gene regulation (Primary Investigator)
- NHMRC Small Equipment Grant 2022 - Luna FX7 Automated Cell Counter - Link to ARIES 41237 (Secondary Investigator)
- How novel ribosomal RNA gene repeat variants drive cellular function (Secondary Investigator)
- NSW RNA Production and Research Network - Support and Services Pillar (Secondary Investigator)
- How and why cells decorate their genetic messages (Primary Investigator)
- Mechanisms and Patterns of Post-Transcriptional Gene Control (Primary Investigator)
- Genome-wide discovery of translation control mechanisms (Primary Investigator)
- Mechanisms and targets of protein synthesis dysregulation in cancer (Primary Investigator)
- Role of RNA-binding proteins in cardiomyocyte physiology (Primary Investigator)
- Functions of circular RNAs (Secondary Investigator)
- SW-41Ti Swinging Bucket Rotor Package (Beckman-Coulter) (See 32537) (Primary Investigator)
- RNA binding metabolic enzymes orchestrate gene transcript organizations and functions (Secondary Investigator)
- Characterising the topology and function of the human m5C RNA methylome (Primary Investigator)
- Patterns of mRNA translation in mammalian cells under stress (fellowship for Nikolay Shirokikh) (Primary Investigator)
- Charting the interface between cellular metabolic states and gene regulation (Primary Investigator)
- Tracking factor footprints to reveal the intricacy and control of translation initiation (Primary Investigator)
- Exploring the role of miRNA and target processing variability in cardiac hypertrophy (Primary Investigator)
- Role of mRNA polyadenylation control in gene expression (Primary Investigator)
- Designer RNA-binding proteins for research and therapeutic purposes (Secondary Investigator)
- RNA interference and the Immune System (Secondary Investigator)
- NHMRC Research Fellowship (Primary Investigator)
