Areas of expertise

• Cellular Immunology 110704
• Gene Expression (Incl. Microarray And Other Genome Wide Approaches) 060405

Research interests

Publications

• McNamara, H, Cai, Y, Wagle, M, Sontani, I, Roots, CM, Misoge, LA, O'Connor, JH, Sutton, HJ, Ganusov, VV, Heath, WR, Bertolino, P, Goodnow, CC, Parish, IA, Enders, A and I. Cockburn. 2017, 'Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids', Science Immunology, vol. 2, no. 9, pp. 1-10pp.
• Miosge, L, Sontani, Y, Chuah, A, Horikawa, K, Russel, TA, Mei, Y, Wagle, M, Howard, DR, Enders, A, Tscharke, DC, Goodnow, CC and IA Parish. 2017, 'Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.', PNAS, Online, pp. 1-10pp..
• Parish, I, Stamp, L, Lorenzo, A et al 2016, 'A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy', American Journal of Pathology, vol. 186, no. 9, pp. 2254-2261.
• Wagle, M & Parish, I 2016, 'FOXO3 is differentially required for CD8(+) T-cell death during tolerance versus immunity', Immunology and Cell Biology, vol. 94, no. 9, pp. 895-899pp.
• Ramiscal, R, Parish, I, Lee-Young, R et al. 2015, 'Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation', eLife, vol. 4, pp. e08698-e08698.
• Xin, G, Schauder, D, Lainez, B et al 2015, 'A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control', Cell Reports, vol. 13, no. 6, pp. 1118-1124.
• Chen JH, Perry CJ, Tsui YC, Staron MM, Parish IA, Dominguez CX, Rosenberg DW and Kaech SM, 2015, 'Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection', Nature Medicine, vol. 21, no. 4, pp. 327-334.
• Staron, M, Gray, S, Marshall, H et al 2014, 'The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8(+) T Cells during Chronic Infection', Immunity, vol. 41, no. 5, pp. 802-814.
• Tay, S, Wong, Y, Roediger, B et al 2014, 'Intrahepatic Activation of Naive CD4(+) T Cells by Liver-Resident Phagocytic Cells', Journal of Immunology, vol. 193, no. 5, pp. 2087-2095.
• Parish, I, Marshall, H, Staron, M et al 2014, 'Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1', Journal of Clinical Investigation, vol. 124, no. 8, pp. 3455-3468.
• Parish, I 2013, 'Cell cycle control of T cell memory Non-T cells KIP T cell memory under control', Immunology and Cell Biology, vol. 91, no. 2, pp. 117-119.
• D'Souza, AD, Parish, IA, Krause, DS, Kaech, SM, Shadel, GS 2013, 'Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia', Molecular Therapy, vol. 21, pp. 42-48.
• Lang, PA, Lang, KS, Xu, HC, Grusdat, M, Parish, IA, Recher, M, Elford, AR, Dhanji, S, Shaabani, N, Tran, CW, Dissanayake, D, Rahbar, R, Ghazarian, M, Brüstle, A, Fine, J, Chen, P, Weaver, CT, Klose, C, Diefenbach, A, Häussinger, D, Carlyle, JR, Kaech, SM, Mak, TW, Ohashi, PS 2012, 'Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 109, pp. 1210-1215.
• Marshall, HD, Chandele, A, Jung, YW, Meng, H, Poholek, AC, Parish, IA, Rutishauser, R, Cui, W, Kleinstein, SH, Craft, J, Kaech, SM 2011, 'Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection', Immunity, vol. 35, pp. 633-646.
• D'Souza, AD, Parish, IA*, McKay, SE, Kaech, SM, Shadel, GS 2011, 'Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling', American Journal of Pathology, vol. 178, pp. 2740-2751. * joint first author
• Parish, IA & Kaech, SM 2011, 'IL-7 Knocks the Socs Off Chronic Viral Infection', Cell, vol. 144, pp. 467-468.
• Rutishauser, RL, Martins, GA, Kalachikov, S, Chandele, A, Parish, IA et al 2009, 'Transcriptional Repressor Blimp-1 Promotes CD8⁺ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties', Immunity, vol. 31, pp. 296-308.
• Parish, IA & Kaech, SM 2009, 'Diversity in CD8⁺ T cell differentiation', Current Opinion in Immunology, vol. 21, pp. 291-297.
• Parish, IA, Rao, S, Smyth, GK, Juelich, T, Denyer, GS, Davey, GM, Strasser, A, Heath, WR 2009, 'The molecular signature of CD8+ T cells undergoing deletional tolerance', Blood, vol. 113, pp. 4575-4585.
• Parish, IA, Waithman, J, Davey, GM et al 2009, 'Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 10, pp. 3901-3906.
• Yu, D, Rao, S, Tsai, LM, Lee, SK, He, YQ, Sutcliffe, EL, Srivastava, M, Linterman, M, Zheng, L, Simpson, N, Ellyard,JI, Parish, IA, Ma, CS, Li, QJ, Parish, CR, Mackay, CR, Vinuesa, CG, 2009, 'The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment', Immunity, vol. 31, pp. 457-468.
• Sutcliffe, EL, Parish, IA, He, YQ et al 2009, 'Dynamic histone variant exchange accompanies gene induction in T cells', Molecular and Cellular Biology, vol. 29, no. 7, pp. 1972-1986.
• Parish, IA & Heath, WR 2008, 'Too dangerous to ignore: self-tolerance and the control of ignorant autoreactive T cells', Immunology and Cell Biology, vol. 86, pp. 146-152.
• Heath, WR, Belz, GT, Behrens, GM, Smith, CM, Forehan, SP, Parish, IA, Davey, GM, Wilson, NS, Carbone, FR, Villadangos, JA 2004, 'Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens', Immunological Reviews, vol. 199, pp. 9-26.

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

• Regulation of CD8 T cell dysfunction during tolerance and chronic viral infection (Primary Investigator)