Areas of expertise
- Physical Organic Chemistry 030505
- Proteins And Peptides 030406
- Characterisation Of Biological Macromolecules 030403
- Synthetic Biology 060113
- Molecular Medicine 030405
- Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics) 110106
- Structural Chemistry And Spectroscopy 030606
- Organic Chemical Synthesis 030503
- Genetic Immunology 060406
- Structural Biology (Incl. Macromolecular Modelling) 060112
- Organometallic Chemistry 039904
- Cellular Immunology 110704
- Analytical Biochemistry 060101
- Enzymes 060107
- Chemical Characterisation Of Materials 030301
- Analytical Spectrometry 030101
- Biological Physics 029901
- Analytical Chemistry 0301
- Other Biological Sciences 0699
- Environmental Biotechnology 1002
- Medicinal And Biomolecular Chemistry 0304
- Organic Chemistry 0305
- Biochemistry And Cell Biology 0601
Biography
Born 1958 in Heidelberg, Germany
1977-1984 Study of Chemistry in Heidelberg and Freiburg, Germany
1984-1987 PhD (biomolecular NMR) at the ETH-Zürich in the group of Prof. Kurt Wüthrich (Nobel Prize winner in Chemistry 2002)
1987-1992 Academic position with Prof. Kurt Wüthrich
1992-2002 Professor of Molecular Biophysics at the Karolinska Institute in Stockholm, Sweden
2002-2007 ARC Federation Fellow at the Australian National University (ANU) in Canberra, Australia
from 2007 Professor at the ANU
2017-2022 ARC Australian Laureate Fellow at the ANU
President of the Australian and New Zealand Magnetic Resonance Society (ANZMAG) 2006-08
Awards: ETH silver medal for PhD thesis (1987), Latsis Prize of the ETH-Zürich (1992), FEBS Anniversary Prize of the Gesellschaft für Biologische Chemie (1993), Wallmarkska Prize of the Royal Swedish Academy of Sciences (1996), foreign member of the Latvian Academy of Sciences (2005), Humboldt Research Award (2010), Medal of the Australian and New Zealand Society of Magnetic Resonance (2013), ISMAR Fellow (2016)
Combined citations of publications: >15000
h-index: > 70
Researcher's projects
.
- development of NMR techniques in view of pharmaceutical applications. This involves (i) rapid structure determinations of small molecules bound to target proteins and (ii) the determination of three-dimensional structures of protein-protein complexes.
- implementation and development of selective labelling strategies for proteins, including in vitro expression, site-directed labelling techniques established by Prof. Peter Schultz, Scripps.
- determination of the three-dimensional structure of medically important proteins and protein domains. Many projects result from a long-standing collaboration with Prof. Nicholas E. Dixon (University of Wollongong).
- 3D structure determinations of protein domains of unknown structure
Available student projects
See the publication list for past and current interests of the group. Collaboration with pharmaceutical industry and visits at collaborating groups for practical work is encouraged.
Postdocs
There are no possbilities in the moment to pay for an additional postdoctoral salary. Anyone coming with his/her own fellowship, however, will be more than welcome!
For Honours and PhD scholarships, the right persons are
- physicists or chemists with interdisciplinary interest, ready to learn molecular biological and biochemical techniques (protein cloning, expression and purification)
- physicists or chemists, ready to learn NMR spectroscopy
Any applicant is expected to have university degrees significantly above average.
Tuition fee waivers can be arranged for highly performing overseas applicants for PhD studies.
To send an application
Please include a CV, information about your university degrees, and subjects of study and expertise.
Direct enquiries to Gottfried Otting.
Publications
- Nekouei, F, Wen, X, Zheng, Z et al. 2022, 'InOOH-mediated intergrown heterojunctions for enhanced photocatalytic Performance: Assembly and interfacial charge carrier transferring', Chemical Engineering Journal, vol. 442, no. 2.
- Judd, M, Abdelkader Ali, E, Qi, M et al. 2022, 'Short-range ENDOR distance measurements between Gd(iii) and trifluoromethyl labels in proteins', Physical Chemistry Chemical Physics, vol. 24, no. 41, pp. 25214-25226.
- Orton, H, Qianzhu, H, Abdelkader Ali, E et al. 2021, 'Through-Space Scalar 19F-19F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins', Journal of the American Chemical Society, vol. 143, no. 46, pp. 19587-19598.
- Maleckis, A, Herath, I & Otting, G 2021, 'Synthesis of C-13/F-19/H-2 labeled indoles for use as tryptophan precursors for protein NMR spectroscopy', Organic and Biomolecular Chemistry, vol. 19, no. 23, pp. 5133-5147.
- Herath, I, Breen, C, Hewitt, S et al. 2021, 'A Chiral Lanthanide Tag for Stable and Rigid Attachment to Single Cysteine Residues in Proteins for NMR, EPR and Time-Resolved Luminescence Studies', Chemistry, A European Journal, vol. 27, no. 51, pp. 13009ââ¬â13023.
- Abdelkader, E & Otting, G 2021, 'NT*-HRV3CP: An optimized construct of human rhinovirus 14 3C protease for high-yield expression and fast affinity-tag cleavage', Journal of Biotechnology, vol. 325, pp. 145-151.
- Abdelkader, E, Qianzhu, H, Tan, Y et al. 2021, 'Genetic Encoding of N6-(((Trimethylsilyl)methoxy)carbonyl)- l -lysine for NMR Studies of Protein-Protein and Protein-Ligand Interactions', Journal of the American Chemical Society, vol. 143, no. 2, pp. 1133-1143.
- Qianzhu, H, Welegedara, A, Williamson, H et al. 2020, 'Genetic Encoding of para-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions', Journal of the American Chemical Society, vol. 142, no. 41, pp. 17277-17281.
- Kaczmarski, J, Mahawaththage Don, M, Feintuch, A et al. 2020, 'Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme', Nature Communications, vol. 11, no. 1.
- Siddiquee, R, Choi, S, Lam, S et al 2020, 'Cell-free expression of natively folded hydrophobins', Protein Expression and Purification, vol. 170.
- Orton, H, Huber, T & Otting, G 2020, 'Paramagpy: software for fitting magnetic susceptibility tensors using paramagnetic effects measured in NMR spectra', Magnetic Resonance, vol. 1, no. 1, pp. 1-12.
- Qi, R & Otting, G 2019, 'Mutant T4 DNA polymerase for easy cloning and mutagenesis', PLOS ONE (Public Library of Science), vol. 14, no. 1, pp. 1-14.
- Nitsche, C, Passioura, T, Varava, P et al 2019, 'De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease', ACS Medicinal Chemistry Letters, vol. 10, no. 2, pp. 168-174.
- Nitsche, C, Onagi, H, Quek, J et al 2019, 'Biocompatible Macrocyclization between Cysteine and 2-Cyanopyridine Generates Stable Peptide Inhibitors', Organic Letters, vol. 21, no. 12, pp. 4709-4712.
- Bahramzadeh, A, Huber, T & Otting, G 2019, 'Three-Dimensional Protein Structure Determination Using Pseudocontact Shifts of Backbone Amide Protons Generated by Double-Histidine Co2+-Binding Motifs at Multiple Sites', Biochemistry, vol. 58, no. 30, pp. 3243-3250.
- Dalaloyan, A, Martorana, A, Barak, Y et al 2019, 'Tracking Conformational Changes in Calmodulin in vitro, in Cell Extract, and in Cells by Electron Paramagnetic Resonance Distance Measurements', ChemPhysChem, vol. 20, no. 14, pp. 1860-1868.
- Prokopiou, G, Lee, M, Collauto, A et al 2018, 'Small Gd(III) Tags for Gd(III)-Gd(III) Distance Measurements in Proteins by EPR Spectroscopy', Inorganic Chemistry, vol. 57, no. 9, pp. 5048-5059.
- Orton, H & Otting, G 2018, 'Accurate Electron-Nucleus Distances from Paramagnetic Relaxation Enhancements', Journal of the American Chemical Society, vol. 140, no. 24, pp. 7688-7697.
- Welegedara, A, Adams, L, Huber, T et al 2018, 'Site-Specific Incorporation of Selenocysteine by Genetic Encoding as a Photocaged Unnatural Amino Acid', Bioconjugate Chemistry, vol. 29, no. 7, pp. 2257-2264.
- Mahawaththage Don, M, Lee, M, Giannoulis, A et al 2018, 'Small neutral Gd(iii) tags for distance measurements in proteins by double electron-electron resonance experiments', Physical Chemistry Chemical Physics, vol. 20, no. 36, pp. 23535-23545pp.
- Bahramzadeh, A, Jiang, H, Huber, T et al 2018, 'Two Histidines in an α�Helix: A Rigid Co2+�Binding Motif for PCS Measurements by NMR Spectroscopy', Angewandte Chemie International Edition, vol. 57, no. 21, pp. 6226-6229pp.
- Loh, C, Adams, L, Graham, B et al 2018, 'Genetically encoded amino acids with tert-butyl and trimethylsilyl groups for site-selective studies of proteins by NMR spectroscopy', Journal of Biomolecular NMR, vol. 71, no. 4, pp. 287-293pp.
- Wang, X, Chen, J, Otting, G et al 2018, 'Conversion of an amide to a high-energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium', Scientific Reports, vol. 8, no. 16371, pp. 1-9pp.
- Becker, W, Adams, L, Graham, B et al 2018, 'Trimethylsilyl tag for probing protein-ligand interactions by NMR', Journal of Biomolecular NMR, vol. 70, no. 4, pp. 211-218.
- Chen, W & Otting, G 2018, 'Using tert-Butyl Groups in a Ligand to Identify Its Binding Site on a Protein', ACS Medicinal Chemistry Letters, vol. 9, no. 2, pp. 109-113.
- Nitsche, C & Otting, G 2018, 'NMR studies of ligand binding', Current Opinion in Structural Biology, vol. 48, pp. 16-22.
- Watson, E, Liu, X, Thompson, R et al 2018, 'Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics', ACS Central Science, vol. 4, no. 4, pp. 468-476.
- Nitsche, C & Otting, G 2017, 'Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags', Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 98-99, pp. 20-49pp.
- Pearce, B, Jabar, S, Loh, C et al 2017, 'Structure restraints from heteronuclear pseudocontact shifts generated by lanthanide tags at two different sites', Journal of Biomolecular NMR, vol. 68, no. 1, pp. 19-32.
- Wu, Z, Lee, M, Carruthers, T et al 2017, 'New Lanthanide Tag for the Generation of Pseudocontact Shifts in DNA by Site-Specific Ligation to a Phosphorothioate Group', Bioconjugate Chemistry, vol. 28, no. 6, pp. 1741-1748pp.
- Mahawaththage Don, M, Pearce, B, Szabo, M et al 2017, 'Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease', Antiviral Research, vol. 142, pp. 141-147.
- Welegedara, A, Yang, Y, Lee, M et al 2017, 'Double-Arm Lanthanide Tags Deliver Narrow Gd3+-Gd3+ Distance Distributions in Double Electron-Electron Resonance (DEER) Measurements', Chemistry, A European Journal, vol. 23, no. 48, pp. 11694-11702.
- Nitsche, C, Mahawaththage Don, M, Becker, W et al 2017, 'Site-selective tagging of proteins by pnictogen-mediated self-assembly', Chemical Communications, vol. 53, no. 79, pp. 10894-10897pp.
- Wu, Z, Feintuch, A, Collauto, A et al 2017, 'Selective Distance Measurements Using Triple Spin Labeling with Gd3+, Mn2+, and a Nitroxide', Journal of Physical Chemistry Letters, vol. 8, no. 21, pp. 5277-5282pp.
- Jabar, S, Adams, L, Wang, Y et al 2017, 'Chemical Tagging with tert-Butyl and Trimethylsilyl Groups for Measuring Intermolecular Nuclear Overhauser Effects in a Large Protein-Ligand Complex', Chemistry, A European Journal, vol. 23, no. 53, pp. 13033-13036pp.
- Pilla, K, Otting, G & Huber, T 2017, 'Protein Structure Determination by Assembling Super-Secondary Structure Motifs Using Pseudocontact Shifts', Structure, vol. 25, no. 3, pp. 559-568.
- Pilla, K, Otting, G & Huber, T 2017, '3D Computational Modeling of Proteins Using Sparse Paramagnetic NMR Data', in Jonathan Keith (ed.), Methods in Molecular Biology - Bioinformatics: Structure, Function and Applications, Humana Press Inc., USA, pp. 3-21pp.
- Pilla, K, Otting, G & Huber, T 2016, 'Pseudocontact Shift-Driven Iterative Resampling for 3D Structure Determinations of Large Proteins', Journal of Molecular Biology, vol. 428, no. 2, pp. 522-532.
- Orton H, Kuprov, I, Loh, C et al 2016, 'Using Paramagnetism to Slow Down Nuclear Relaxation in Protein NMR', Journal of Physical Chemistry Letters, vol. 7, no. 23, pp. 4815-4818.
- Chen, J, Yang, Y, Zhang, L et al. 2016, 'Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy', Physical Chemistry Chemical Physics, vol. 18, no. 8, pp. 5850-5859.
- Cohen, M, Frydman, V, Milko, P et al 2016, 'Overcoming artificial broadening in Gd3+-Gd3+ distance distributions arising from dipolar pseudo-secular terms in DEER experiments', Physical Chemistry Chemical Physics, vol. 18, no. 18, pp. 12847-12859.
- Collauto, A, Frydman, V, Lee, M et al 2016, 'RIDME distance measurements using Gd(III) tags with a narrow central transition', Physical Chemistry Chemical Physics, vol. 18, no. 28, pp. 19037-19049.
- Chen, J, Wang, X, Yang, F et al 2016, '3D Structure Determination of an Unstable Transient Enzyme Intermediate by Paramagnetic NMR Spectroscopy', Angewandte Chemie International Edition, vol. 55, no. 44, pp. 13744-13748.
- Abdelkader, E, O'Malley, W, Aulsebrook, M et al 2016, 'Luminescent Alkyne-Bearing Terbium(III) Complexes and Their Application to Bioorthogonal Protein Labeling', Inorganic Chemistry, vol. 55, no. 4, pp. 1674-1682.
- Abdelkader, E, Yao, X, Feintuch, A et al 2016, 'Pulse EPR-enabled interpretation of scarce pseudocontact shifts induced by lanthanide binding tags', Journal of Biomolecular NMR, vol. 64, no. 1, pp. 39-51.
- Chen, W, Nitsche, C, Pilla, K et al 2016, 'Sensitive NMR Approach for Determining the Binding Mode of Tightly Binding Ligand Molecules to Protein Targets', Journal of the American Chemical Society, vol. 138, no. 13, pp. 4539-4546.
- Lee, M, Loh, C, Shin, J et al 2015, 'Compact, hydrophilic, lanthanide-binding tags for paramagnetic NMR spectroscopy', Chemical Science, vol. 6, no. 4, pp. 2614-2624.
- Chen, W, Kuppan, K, Lee, M et al. 2015, 'O-tert-Butyltyrosine, an NMR Tag for High-Molecular-Weight Systems and Measurements of Submicromolar Ligand Binding Affinities', Journal of the American Chemical Society, vol. 137, no. 13, pp. 4581-4586.
- Pilla, K, Leman, J, Otting, G et al. 2015, 'Capturing Conformational States in Proteins Using Sparse Paramagnetic NMR Data', PLOS ONE (Public Library of Science), vol. 10, no. 5, pp. e0127053-e0127053.
- Feintuch, A, Otting, G & Goldfarb, D 2015, 'Gd3+ Spin Labeling for Measuring Distances in Biomacromolecules: Why and How?', Methods in Enzymology, vol. 563, pp. 415-457.
- Abdelkader, E, Feintuch, A, Yao, X et al 2015, 'Protein conformation by EPR spectroscopy using gadolinium tags clicked to genetically encoded p-azido-L-phenylalanine', Chemical Communications, vol. 51, no. 88, pp. 15898-15901.
- Abdelkader, E, Lee, M, Feintuch, A et al 2015, 'A New Gd3+ Spin Label for Gd3+-Gd3+ Distance Measurements in Proteins Produces Narrow Distance Distributions', Journal of Physical Chemistry Letters, vol. 6, pp. 5016-5021.
- Loh, C, Graham, B, Abdelkader, E et al 2015, 'Generation of pseudocontact shifts in proteins with lanthanides using small "clickable" nitrilotriacetic acid and iminodiacetic acid tags', Chemistry, A European Journal, vol. 21, no. 13, pp. 5084-5092.
- Chen, W, Loscha, K, Nitsche, C et al. 2014, 'The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI', FEBS Letters, vol. 588, no. 14, pp. 2206-2211.
- Cao, C, Chen, J, Yang, Y et al 2014, 'Selective 15N-labeling of the side-chain amide groups of asparagine and glutamine for applications in paramagnetic NMR spectroscopy', Journal of Biomolecular NMR, vol. 59, no. 4, pp. 251-261.
- Shishmarev, D, Wang, Y, Mason, C et al. 2014, 'Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy', Nucleic Acids Research, vol. 42, no. 4, pp. 2750-2757.
- Su, X, Wang, Y, Yagi, H et al. 2014, 'Bound or free: interaction of the C-terminal domain of Escherichia coli single-stranded DNA-binding protein (SSB) with the tetrameric core of SSB', Biochemistry, vol. 53, no. 12, pp. 1925-1934.
- Carruthers, T, Carr, P, Loh, C et al 2014, 'Iron(III) located in the dinuclear metallo-beta-lactamase IMP-1 by pseudocontact shifts', Angewandte Chemie International Edition, vol. 53, no. 51, pp. 14269-14272.
- de la Cruz, L, Chen, W, Graham, B et al 2014, 'Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease', FEBS Journal, vol. 281, no. 6, pp. 1517-1533.
- Shishmarev, D, Wang, Y, Mason, C et al. 2014, 'Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy', Nucleic Acids Research, vol. 42, no. 4, pp. 2750-2757.
- Shishmarev, D & Otting, G 2013, 'How reliable are pseudocontact shifts induced in proteins and ligands by mobile paramagnetic metal tags? A modelling study', Journal of Biomolecular NMR, vol. 56, no. 3, pp. 203-216.
- Arthur, I, Hennessy, J, Padmakshan, D et al. 2013, 'In situ deprotection and incorporation of unnatural amino acids during cell-free protein synthesis', Chemistry, A European Journal, vol. 19, no. 21, pp. 6824-6830.
- Zhang, W, Otting, G & Jackson, C 2013, 'Protein engineering with unnatural amino acids', Current Opinion in Structural Biology, vol. 23, no. 4, pp. 581-587.
- Matalon, E, Huber, T, Hagelueken, G et al 2013, 'Gadolinium(III) spin labels for high-sensitivity distance measurements in transmembrane helices', Angewandte Chemie International Edition, vol. 52, no. 45, pp. 11831-11834.
- Loscha, K & Otting, G 2013, 'Biosynthetically directed 2H labelling for stereospecific resonance assignments of glycine methylene groups', Journal of Biomolecular NMR, vol. 55, no. 1, pp. 97-104.
- Loh, C, Ozawa, K, Tuck, K et al 2013, 'Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins', Bioconjugate Chemistry, vol. 24, no. 2, pp. 260-268.
- Kaminker, I, Tkach, I, Manukovsky, N et al 2013, 'W-band orientation selective DEER measurements on a Gd3+/nitroxide mixed-labeled protein dimer with a dual mode cavity', Journal of Magnetic Resonance, vol. 227, pp. 66-71.
- Ozawa, K, Horan, N, Robinson, A et al 2013, 'Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits alpha, epsilon, theta and beta reveals a highly flexible arrangement of the proofreading domain', Nucleic Acids Research, vol. 41, no. 10, pp. 5354-5367.
- Pasfield, L, De La Cruz Rodriguez, L et al 2013, 'Synthesis of (±)-panduratin A and related natural products using the high pressure Diels-Alder reaction', Asian Journal of Organic Chemistry, vol. 2, no. 1, pp. 60-63.
- Yagi, H, Maleckis, A & Otting, G 2013, 'A systematic study of labelling an alpha-helix in a protein with a lanthanide using IDA-SH or NTA-SH tags', Journal of Biomolecular NMR, vol. 55, no. 2, pp. 157-166.
- Yagi, H, Pilla, K, T, Maleckis, A et al 2013, 'Three-dimensional protein fold determination from backbone amide pseudocontact shifts generated by lanthanide tags at multiple sites', Structure, vol. 21, no. 6, pp. 883-890.
- Marchetti, A, Jehle, S, Felletti, M et al. 2012, 'Backbone assignment of fully protonated solid proteins by 1H detection and ultrafast magic-angle-spinning NMR spectroscopy', Angewandte Chemie International Edition, vol. 51, no. 43, pp. 10756-10759.
- Banerjee, D, Yagi, H, Huber, T et al 2012, 'Nanometer-range distance measurement in a protein using Mn2+ tags', Journal of Physical Chemistry Letters, vol. 3, no. 2, pp. 157-160.
- Schmitz, C, Vernon, R, Otting, G et al 2012, 'Protein structure determination from pseudocontact shifts using ROSETTA', Journal of Molecular Biology, vol. 416, no. 5, pp. 668-677.
- Li, Q, Yang, Y, Maleckis, A et al. 2012, 'Thiol-ene reaction: a versatile tool in site-specific labelling of proteins with chemically inert tags for paramagnetic NMR', Chemical Communications, vol. 48, no. 21, pp. 2704-2706.
- Loscha, K, Herlt, A, Qi, R et al 2012, 'Multiple-site labeling of proteins with unnatural amino acids', Angewandte Chemie International Edition, vol. 51, no. 9, pp. 2243-2246.
- Ozawa, K, Loscha, K, Kuppan, K et al. 2012, 'High-yield cell-free protein synthesis for site-specific incorporation of unnatural amino acids at two sites', Biochemical and Biophysical Research Communications, vol. 418, no. 4, pp. 652-656.
- Kaminker, I, Yagi, H, Huber, T et al 2012, 'Spectroscopic selection of distance measurements in a protein dimer with mixed nitroxide and Gd3+ spin labels', Physical Chemistry Chemical Physics, vol. 14, no. 13, pp. 4355-4358.
- Jaudzems, K, Jia, X, Yagi, H et al 2012, 'Structural basis for 5'-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2', Journal of Molecular Biology, vol. 424, no. 1-2, pp. 42-53.
- Marchetti, A, Jehle, S, Felletti, M et al. 2012, 'Backbone assignment of fully protonated solid proteins by 1H detection and ultrafast magic-angle-spinning NMR spectroscopy', Angewandte Chemie International Edition, vol. 51, no. 43, pp. 10756-10759.
- Graham, B, Loh, C, Swarbrick, J et al 2011, 'DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra', Bioconjugate Chemistry, vol. 22, no. 10, pp. 2118-2125.
- Ugwumba, I, Ozawa, K, Xu, Z et al. 2011, 'Improving a natural enzyme activity through incorporation of unnatural amino acids', Journal of the American Chemical Society, vol. 133, no. 2, pp. 326-333.
- Su, X, Loh, C, Qi, R et al. 2011, 'Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enzymes for selective 15N-labelling and production of perdeuterated proteins in H2O', Journal of Biomolecular NMR, vol. 50, no. 1, pp. 35-42.
- Jia, X, Maleckis, A, Huber, T et al 2011, '4,4 '-Dithiobisdipicolinic Acid: A Small and Convenient Lanthanide Binding Tag for Protein NMR Spectroscopy', Chemistry, A European Journal, vol. 17, no. 24, pp. 6830-6836.
- Swarbrick, J, Ung, P, Su, X et al. 2011, 'Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy', Chemical Communications, vol. 47, no. 26, pp. 7368-7370.
- Yagi, H, Banerjee, D, Graham, B et al 2011, 'Gadolinium tagging for high-precision measurements of 6 nm distances in protein assemblies by EPR', Journal of the American Chemical Society, vol. 133, no. 27, pp. 10418-10421.
- Jia, X, Yagi, H, Su, X et al. 2011, 'Engineering [Ln(DPA)3]3- binding sites in proteins: a widely applicable method for tagging proteins with lanthanide ions', Journal of Biomolecular NMR, vol. 50, no. 4, pp. 411-420.
- Shishmarev, D & Otting, G 2011, 'Radiation damping on cryoprobes', Journal of Magnetic Resonance, vol. 213, no. 1, pp. 76-81.
- de la Cruz, L, Nguyen, T, Ozawa, K et al 2011, 'Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts', Journal of the American Chemical Society, vol. 133, no. 47, pp. 19205-19215.
- Nguyen T. H. D.; Ozawa K.; Stanton-Cook M.; Barrow R.; Huber T.; Otting G.; 2011, Generation of pseudocontact shifts in protein NMR spectra with a genetically encoded cobalt(II)-binding amino acid, Angewandte Chemie International Edition, 50, 692-694.
- Ugwumba, I, Ozawa, K, De La Cruz, L, et al 2011, 'Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular-weight compounds', Assay and Drug Development Technologies, vol. 9, no. 1, pp. 50-57.
- Yagi, H, Loscha, K, Su, X et al. 2010, 'Tunable paramagnetic relaxation enhancements by [Gd(DPA)3]3- for protein structure analysis', Journal of Biomolecular NMR, vol. 47, no. 2, pp. 143-153.
- Man, B, Su, X, Liang, H et al. 2010, '3-Mercapto-2,6-Pyridinedicarboxylic Acid: A Small Lanthanide-Binding Tag for Protein Studies by NMR Spectroscopy', Chemistry, A European Journal, vol. 16, no. 12, pp. 3827-3832.
- Su, X, McAndrew, K, Huber, T et al. 2008, 'Lanthanide-Binding Peptides for NMR Measurements of Residual Dipolar Couplings and Paramagnetic Effects from Multiple Angles', Journal of the American Chemical Society, vol. 130, no. 5, pp. 1681-1687.
- Schmitz, C, Stanton-Cook, M, Su, X et al. 2008, 'Numbat: an iteractive sotware tool for fitting Δχ-tensors to molecular coordinates using pseudocontact shifts', Journal of Biomolecular NMR, vol. 41, no. 3, pp. 179-189.
- Su, X, Man, B, Beeren, S et al. 2008, 'A Dipicolinic Acid Tag for Rigid Lanthanide Tagging of Proteins and Paramagnetic NMR Spectroscopy', Journal of the American Chemical Society, vol. 130, no. 32, pp. 10486-10487.
- John, M, Schmitz, C, Park, A et al. 2007, 'Sequence-Specific and Stereospecific Assignment of Methyl Groups Using Paramagnetic Lanthanides', Journal of the American Chemical Society, vol. 129, no. 44, pp. 13749-13757.
- Su, X, Huber, T, Dixon, N et al. 2006, 'Site-Specific Labelling of Proteins with a Rigid Lanthanide-Binding Tag', ChemBioChem, vol. 7, no. 10, pp. 1599-1604.
- Schmitz, C, John, M, Park, A et al. 2006, 'Efficient χ-tensor determination and NH assignment of paramagnetic proteins', Journal of Biomolecular NMR, vol. 35, no. 2, pp. 79-87.
- Ozawa, K, Headlam, M, Mouradov, D et al. 2005, 'Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins', The FEBS Journal, vol. 272, no. 12, pp. 3162-3171.
- Su, X & Otting, G 2010, 'Paramagnetic labelling of proteins and oligonucleotides for NMR', Journal of Biomolecular NMR, vol. 46, no. 1, pp. 101-112.
- Man, B, Su, X, Liang, H et al. 2010, '3-Mercapto-2,6-Pyridinedicarboxylic Acid: A Small Lanthanide-Binding Tag for Protein Studies by NMR Spectroscopy', Chemistry, A European Journal, vol. 16, no. 12, pp. 3827-3832.
- Tanaka, S, Kawata, Y, Otting, G et al 2010, 'Chaperonin-encapsulation of proteins for NMR', Biochimica et Biophysica Acta: Proteins & Proteomics, vol. 1804, no. 4, pp. 866-871.
- Yagi, H, Loscha, K, Su, X et al. 2010, 'Tunable paramagnetic relaxation enhancements by [Gd(DPA)3]3- for protein structure analysis', Journal of Biomolecular NMR, vol. 47, no. 2, pp. 143 - 153.
- Potapov, A, Yagi, H, Huber, T et al 2010, 'Nanometer-Scale Distance Measurements in Proteins Using Gd3+ Spin Labeling', Journal of the American Chemical Society, vol. 132, no. 26, pp. 9040-9048.
- Otting, G 2010, 'Protein NMR Using Paramagnetic Ions', Annual Review of Biophysics, vol. 39, pp. 387 - 405.
- Jia, X, Ozawa, K, Loscha, K et al 2009, 'Glutarate and N-acetyl-L-glutamate buffers for cell-free synthesis of selectively 15N-labelled proteins', Journal of Biomolecular NMR, vol. 44, no. 2, pp. 59-67.
- Su, X, Ozawa, K, Qi, R et al. 2009, 'NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease', PLoS Neglected Tropical Diseases, vol. 3, no. 12, pp. e561 1-9.
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- John, M, Pintacuda, G, Park, A et al. 2006, 'Structure determination of protein-ligand complexes by transferred paramagnetic shifts', Journal of the American Chemical Society, vol. 128, no. 39, pp. 12910-12916.
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- Su, X, Huber, T, Dixon, N et al. 2006, 'Site-specific labelling of proteins with a rigid lanthanide-binding tag', ChemBioChem, vol. 7, no. 10, pp. 1599-1604.
- Keniry, M, Park, A, Owen, E et al. 2006, 'Structure of the θ subunit of Escherichia coli DNA polymerase III in complex with the ε subunit.', Journal of Bacteriology, vol. 188, no. 12, pp. 4464-4473.
- Schmitz, C, John, M, Park, A et al. 2006, 'Efficient χ-tensor determination and NH assignment of paramagnetic proteins', Journal of Biomolecular NMR, vol. 35, no. 2, pp. 79-87.
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- Liepinsh, E, Banyai, L, Patthy, L et al 2006, 'NMR structure of the WIF domain of the human Wnt-inhibitory factor-1', Journal of Molecular Biology, vol. 357, no. 3, pp. 942-950.
- Wu, P & Otting, G 2005, 'Rapid pulse length determination in high-resolution NMR', Journal of Magnetic Resonance, vol. 176, no. 1, pp. 115-119.
- John, M, Park, A, Pintacuda, G et al. 2005, 'Weak alignment of paramagnetic proteins warrants correction for residual CSA effects in measurements of pseudocontact shifts', Journal of the American Chemical Society, vol. 127, no. 49, pp. 17190-17191.
- Hastings, A, Otting, G, Folmer, R et al 2005, 'Interaction of the replication terminator protein of Bacillus subtilis with DNA probed by NMR spectroscopy', Biochemical and Biophysical Research Communications, vol. 335, no. 2, pp. 361-366.
- Oakley, A, Loscha, K, Schaeffer, P et al 2005, 'Crystal and solution structures of the helicase-binding domain of Escherichia coli primase', Journal of Biological Chemistry, vol. 280, no. 12, pp. 11495-11504.
- Williams, N, Liepinsh, E, Watt, S et al 2005, 'Stabilization of native protein fold by intein-mediated covalent cyclization', Journal of Molecular Biology, vol. 346, no. 4, pp. 1095-1108.
- Robinson, A, Wu, P, Harrop, S et al 2005, 'Integron-associated mobile gene cassettes code for folded proteins: the structure of Bal32a, a new member of the adaptable α+β barrel family', Journal of Molecular Biology, vol. 346, no. 5, pp. 1229-1241.
- Moriya, M, Taniguchi, S, Wu, P et al. 2005, 'Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC', Biochemistry, vol. 44, no. 2, pp. 575-583.
- Ozawa, K, Headlam, M, Mouradov, D et al. 2005, 'Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins', The FEBS Journal, vol. 272, no. 12, pp. 3162-3171.
- Ozawa, K, Jergic, S, Crowther, J et al 2005, 'Cell-free protein synthesis in an autoinduction system for NMR studies of protein-protein interactions', Journal of Biomolecular NMR, vol. 32, no. 3, pp. 235-241.
- Wu, P & Otting, G 2005, 'SWET for secure water suppression on probes with high quality factor', Journal of Biomolecular NMR, vol. 32, no. 3, pp. 243-250.
- Ozawa, K, Dixon, N & Otting, G 2005, 'Cell-free synthesis of 15N-labeled proteins for NMR studies', IUBMB Life, vol. 57, no. 9, pp. 615-622.
- Liepinsh, E, Rakonjac, M, Boissonneault, V et al 2004, 'Letter to the Editor: NMR structure of human coactosin-like protein', Journal of Biomolecular NMR, vol. 30, no. 3, pp. 353-356.
- Pintacuda, G, Keniry, M, Huber, T et al. 2004, 'Fast structure-based assignment of 15N HSQC spectra of selectively 15N-labeled paramagnetic proteins', Journal of the American Chemical Society, vol. 126, no. 9, pp. 2963-2970.
- Pintacuda, G, Moshref, A, Leonchiks, A et al 2004, 'Site-specific Labelling with a Metal Chelator for Protein-structure Refinement', Journal of Biomolecular NMR, vol. 29, no. 3, pp. 351-361.
- Loscha, K, Oakley, A, Bancia, B et al 2004, 'Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase', Protein Expression and Purification, vol. 33, no. 2, pp. 304-310.
- Ozawa, K, Headlam, M, Schaeffer, P et al 2004, 'Optimization of an Escherichia coli system for cell-free synthesis of selectively 15N-labelled proteins for rapid analysis by NMR spectroscopy', European Journal of Biochemistry, vol. 271, no. 20, pp. 4084-4093.
- Hoshino, M & Otting, G 2004, 'Sensitivity-enhanced double-TROSY experiment for simultaneous measurement of one-bond 15N-1H, 15N-13C and two-bond 1H-13C couplings', Journal of Magnetic Resonance, vol. 171, no. 2, pp. 270-276.
- Pintacuda, G, Kaikkonen, A & Otting, G 2004, 'Modulation of the distance dependence of paramagnetic relaxation enhancements by CSAxDSA cross-correlation', Journal of Magnetic Resonance, vol. 171, no. 2, pp. 233-243.
- Loscha, K, Oakley, A, Bancia, B et al 2004, 'Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase', Protein Expression and Purification, vol. 33, no. 2, pp. 304-310.
- Usami, S, Takahashi, K, Yuge, I et al 2003, 'Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Menieres disease', European Journal of Human Genetics, vol. 11, no. 10, pp. 744-748.
- Pintacuda, G, Hohenthanner, K, Otting, G et al 2003, 'Angular dependence of dipole-dipole-Curie-spin cross-correlation effects in high-spin and low-spin paramagnetic myoglobin', Journal of Biomolecular NMR, vol. 27, no. 2, pp. 115-132.
- Liepinsh, E, Gastaud, J, Dehareng, D et al 2003, 'NMR Structure of Citrobacter freundii AmpD, Comparison with Bacteriophage T7 Lysozyme and Homology with PGRP Domains', Journal of Molecular Biology, vol. 327, no. 4, pp. 833-842.
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- Liepinsh, E, Leonchiks, A, Sharipo, A et al 2003, 'Solution Structure of the R3H Domain from Human Sμbp-2', Journal of Molecular Biology, vol. 326, no. 1, pp. 217-223.
- Liepinsh, E, Banyai, L, Pintacuda, G et al 2003, 'NMR Structure of the Netrin-like Domain (NTR) of Human Type I Procollagen C-Proteinase Enhancer Defines Structural Consensus of NTR Domains and Assesses Potential Proteinase Inhibitory Activity and Ligand Binding', Journal of Biological Chemistry, vol. 278, no. 28, pp. 25982-25989.
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- Bellanda, M, Peggion, E, Otting, G et al 2002, 'Backbone 1H, 13C and 15N resonance assignment of the N-terminal 24 kDa fragment of the gyrase B subunit from E. coli', Journal of Biomolecular NMR, vol. 22, no. 4, pp. 369-370.
- Pintacuda, G & Otting, G 2002, 'Identification of protein Surfaces by NMR Measurements with a paramagnetic Gd(III) Chelate', Journal of the American Chemical Society, vol. 124, no. 3, pp. 372-373.
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- Liepinsh, E, Trexler, M, Kaikkonen, A et al 2001, 'NMR Structure of the LCCL domain and implications for DFNA9 deafness disorder', The EMBO Journal, vol. 20, no. 19, pp. 5347-5353.
- Kaikkonen, A, Otting, G & Otting, G 2001, 'Residual Dipolar 1H-1H Couplings of Methyl Groups in Weakly Aligned Proteins', Journal of the American Chemical Society, vol. 123, no. 8, pp. 1770-1771.
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Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Non-Canonical Amino Acids for Protein Analysis and Peptide Inhibitors (Secondary Investigator)
- Enhanced high-field nuclear magnetic resonance spectroscopy (Primary Investigator)
- Methods for Protein Structure Analysis by Electron Paramagnetic Resonance (Secondary Investigator)
- ARC Centre of Excellence for Innovations in Peptide and Protein Science (Secondary Investigator)
- Ultrafast magic angle spinning solid-state NMR capability (Primary Investigator)
- Proteins in motion - new tools for biotechnology (Primary Investigator)
- Australian High Field EPR Facility (Secondary Investigator)
- New methods for drug discovery and structural biology by NMR spectroscopy (Primary Investigator)
- New methods for structural biology and drug discovery by nuclear magnetic resonance spectroscopy (Primary Investigator)
- Visualization of large functional structural changes in proteins by electron paramagnetic resonance spectroscopy using gadolinium tags and bifunctional spin labeling (Primary Investigator)
- Multinuclear 700 MHz NMR Spectrometer for Advanced Molecular Analysis (Primary Investigator)
- 3D structure determination of biomolecular assemblies from sparse data of different length scales (Secondary Investigator)
- New methods for structure analysis of proteins and protein interactions (Primary Investigator)
- Advanced EPR Facilities for Chemical, Biological and Materials Sciences (Secondary Investigator)
- New fragment-based drug design technology by NMR spectroscopy (Primary Investigator)
- New Methods for Structural Biology in Solution (Primary Investigator)
