Emeritus Professor Helen O'Neill
Areas of expertise
- Immunology 1107
- Cellular Immunology 110704
- Regenerative Medicine (Incl. Stem Cells And Tissue Engineering) 100404
- Gene Expression (Incl. Microarray And Other Genome Wide Approaches) 060405
Publications
- Petvises, S, Periasamy, P & O'Neill, H 2018, 'MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis', BMC Immunology, vol. 19, no. 21, pp. 1-13.
- Petvises, S, Talaulikar, D & O'Neill, H 2016, 'Delineation of a novel dendritic-like subset in human spleen', Cellular and Molecular Immunology, vol. 13, no. 4, pp. 443-450.
- Abbey, J, Karsunky, H, Serwold, T et al 2015, 'Expression of TCR-Vβ peptides by murine bone marrow cells does not identify T-cell progenitors', Journal of Cellular and Molecular Medicine, vol. 19, no. 8, pp. 1956-1964.
- Petvises, S & O'Neill, H 2014, 'Distinct progenitor origin distinguishes a lineage of dendritic-like cells in spleen', Frontiers in Immunology, vol. 4, no. JAN, pp. -.
- O'Neill, H, Kallapur, K, Periasamy, P et al. 2014, 'Spleen stroma maintains progenitors and supports long-term hematopoiesis', Current Stem Cell Research & Therapy, vol. 9, no. 4, pp. 354-363.
- Hinton, R & O'Neill, H 2014, 'Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen', Journal of Stem Cells, vol. 9, no. 3, pp. 199-208.
- Kallapur, K, Tan, J & O'Neill, H 2014, 'Characterization of the effect of LPS on dendritic cell subset discrimination in spleen', Journal of Cellular and Molecular Medicine, vol. 18, no. 9, pp. 1908-1912.
- Petvises, S & O'Neill, H 2014, 'Characterisation of dendritic cells arising from progenitors endogenous to murine spleen', PLOS ONE (Public Library of Science), vol. 9, no. 2, e88311, pp. 1-10.
- Periasamy, P & O'Neill, H 2013, 'Stroma-dependent development of two dendritic-like cell types with distinct antigen presenting capability', Experimental Hematology, vol. 41, no. 3, pp. 281-292.
- Periasamy, P, Petvises, S & O'Neill, H 2013, 'Development of two distinct dendritic-like APCs in the context of splenic stroma', Frontiers in Immunology, vol. 4, no. MAR (Article 73), pp. 1-11.
- Periasamy, P & O'Neill, H 2013, 'In vitro hematopoiesis reveals a novel dendritic-like cell present in murine spleen', Current Stem Cell Research & Therapy, vol. 8, no. 5, pp. 365-369.
- Periasamy, P, Tan, J & O'Neill, H 2013, 'Novel splenic antigen-presenting cells derive from a Lin(-)c-kit(lo) progenitor', Journal of Leukocyte Biology, vol. 93, no. 1, pp. 63-69.
- Kallapur, K, Tan, J & O'Neill, H 2013, 'Investigation into the prevalence of a novel dendritic-like cell subset in vivo', Journal of Cellular and Molecular Medicine, vol. 17, no. 12, pp. 1608-1618.
- Hinton, R, Papathanasiou, P & O'Neill, H 2012, 'Distinct in vitro myelopoiesis is dependent on the self-renewal of hematopoietic progenitors', Scandinavian Journal of Immunology, vol. 75, no. 2, pp. 168-175.
- Hinton, R & O'Neill, H 2012, 'Technical Advance: In vitro production of distinct dendritic-like antigen-presenting cells from self-renewing hematopoietic stem cells', Journal of Leukocyte Biology, vol. 91, no. 2, pp. 341-346.
- Hey, Y & O'Neill, H 2012, 'Murine spleen contains a diversity of myeloid and dendritic cells distinct in antigen presenting function', Journal of Cellular and Molecular Medicine, vol. 16, no. 11, pp. 2611-2619.
- Tan, J & O'Neill, H 2012, 'Myelopoiesis in spleen-producing distinct dendritic-like cells', Journal of Cellular and Molecular Medicine, vol. 16, no. 8, pp. 1924-1933.
- O'Neill, H 2012, 'Niches for Extramedullary Hematopoiesis in the Spleen', Invited review. Niche: Journal of Cellular Therapy and Regenerative Medicine, 1, 12-16. [DOI:10.5152/niche.2012.03]
- Petvises, S & O'Neill, H 2012, 'Hematopoiesis leading to a diversity of dendritic antigen-presenting cell types', Immunology and Cell Biology, vol 90, no 4, pp. 372-378.
- Hinton, R, Petvises, S & O'Neill, H 2011, 'Myelopoiesis related to perinatal spleen', Immunology and Cell Biology, vol. 89, no. 6, pp. 689-695.
- Tan, J, Quah, B, Kallapur, K et al. 2011, 'Identification of a novel antigen cross-presenting cell type in spleen', Journal of cellular and molecular medicine, vol. 15, no. 5, pp. 1189-1199.
- O'Neill, H, Kallapur, K, Periasamy, P et al 2011, 'Spleen as a site for hematopoiesis of a distinct antigen presenting cell type', Stem Cells International, vol. 2011, no. 954275, pp. 1-8.
- Tan, J & O'Neill, H 2010, 'Investigation of murine spleen as a niche for hematopoiesis', Transplantation, vol. 89, no. 2, pp. 140-145.
- Tan, J & O'Neill, H 2010, 'Authors' Reply: The Spleen as a Site for Hematopoiesis', Transplantation, vol. 90, no. 9, pp. 1041-1042.
- Tan, J & O'Neill, H 2010, 'Spleen as a distinct site for dendritic cell haematopoiesis', in Lorraine C Welles (ed.), Dendritic Cells: Types, Life Cycles and Biological Functions, Nova Science Publishers Inc., New York, pp. 95-108.
- Tan, J & O'Neill, H 2010, 'In vitro haematopoiesis of a novel dendritic-like cell present in murine spleen', Current Stem Cell Research & Therapy, vol. 5, no. 4, pp. 367-371.
- Tan, J, Periasamy, P & O'Neill, H 2010, 'Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells', Blood, vol. 115, no. 18, pp. 3678-3685.
- Cheng, X & O'Neill, H 2009, 'Oncogenesis and cancer stem cells: current opinions and future directions', Journal of Cellular and Molecular Medicine, vol. 13, pp. 4377-84.
- Tan, J & O'Neill, H 2009, 'Haematopoietic stem cells in spleen have distinct differentiative potential for antigen presenting cells', Journal of Cellular and Molecular Medicine, vol. Online First 3 Oct 09, pp. 2144-2150.
- Periasamy, P, Tan, J, Kallapur, K et al. 2009, 'Splenic stromal niches support hematopoiesis of dendritic-like cells from precursors in bone marrow and spleen', Experimental Hematology, vol. 37, pp. 1060-1071.
- O'Neill, H & Quah, B 2008, 'Exosomes Secreted by Bacterially Infected Macrophages Are Proinflammatory', Science Signaling, vol. 1, no. 6, pp. 6p.
- Kallapur, K & O'Neill, H 2008, 'Dendritic cells as immune regulators: the mouse model', Journal of cellular and molecular medicine, vol. 12, no. 5B, pp. 1909-1914.
- Abbey, J & O'Neill, H 2008, 'Expression of T-cell receptor genes during early T-cell development', Immunology and Cell Biology, vol. 86, pp. 166-174.
- Despars, G, Periasamy, P, Tan, J et al 2008, 'Gene signature of Stromal Cells which support Dendritic Cell Development', Stem Cells and Development, vol. 17, pp. 917-928.
- Abbey, J & O'Neill, H 2008, 'Detection of spliced and unspliced forms of germlineTCR-VB transcripts in extrathymic lymphoid sites', Molecular Immunology, vol. 45, no. 4, pp. 1099-1111.
- Tan, J & O'Neill, H 2007, 'Dendritic Cell Development in the Context of the Spleen Microenvironment', Stem Cells, vol. 25, pp. 2139-2145.
- Despars, G, Tan, J, Periasamy, P et al 2007, 'The Role of Stroma in Hematopoiesis and Dendritic Cell Development', Current Stem Cell Research & Therapy, vol. 2, no. 1, pp. 23-29.
- Tan, J, Ni, K, Le, F et al 2007, 'Hematopoiesis of immature myeloid dendritic cells in stroma-dependent spleen longterm cultures occurs independently of NF-kB/RelB function', Experimental Hematology, vol. 35, pp. 1580-1593.
- Quah, B & O'Neill, H 2007, 'Mycoplasma contaminants present in exosome preparations induce polyclonal B cell responses', Journal of Leukocyte Biology, vol. 82, pp. 1070-1082.
- Despars, G, O'Neill, T & O'Neill, H 2007, 'Use of gene profiling to describe a niche for dendritic cell development', Immunology and Cell Biology, vol. 85, pp. 567-570.
- Periasamy, P & O'Neill, H 2007, 'Role of the splenic microenvironment in dendritic cell hematopoiesis', Trends in Developmental Biology, vol. 2, pp. 51-59.
- Abbey, J, Hulett, M & O'Neill, H 2006, 'Cell surface expression of a peptide encoded by the unrearranged TCR-VÃ?8.2 gene', Molecular Immunology, vol. 43, no. 9, pp. 1408-1417.
- Despars, G & O'Neill, H 2006, 'Splenic Endothelial Cell Lines Support Development of Dendritic Cells from Bone Marrow', Stem Cells, vol. 24, pp. 1496-1504.
- O'Neill, H 2006, 'Dendritic Cell Therapy for Tolerance Induction to Stem Cell Transplantation', Current Stem Cell Research & Therapy, vol. 1, pp. 121-125.
- Despars, G & O'Neill, H 2006, 'Heterogeneity amongst splenic stromal cell lines which support dendritic cell hematopoiesis', In Vitro Cellular and Developmental Biology - Animal, vol. 42, no. 7, pp. 208-215.
- Tan, J & O'Neill, H 2005, 'Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity', Journal of Leukocyte Biology, vol. 78, no. 2, pp. 319-324.
- Quah, B & O'Neill, H 2005, 'Maturation of function in dendritic cells for tolerance and immunity', Journal of cellular and molecular medicine, vol. 9, no. 3, pp. 643-654.
- Quah, B & O'Neill, H 2005, 'The Immunogenicity of dendritic cell-derived exosomes', Blood cells, Molecules and Diseases, vol. 35, no. 2, pp. 94-110.
- Despars, G & O'Neill, H 2005, 'Splenic Endothelial Cell Lines Support Dendritic Cell Development from Bone Marrow', Tissue Antigens, vol. 66, no. 5, pp. 397-398.
- Quah, B, Ni, K & O'Neill, H 2004, 'In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity', International Immunology, vol. 16, no. 4, pp. 567-577.
- O'Neill, H & Wilson, H 2004, 'Limitations with in vitro production of dendritic cells using cytokines', Journal of Leukocyte Biology, vol. 75, pp. 600-603.
- Despars, G & O'Neill, H 2004, 'A role for niches in the development of a multiplicity of dendritic cell subsets', Experimental Hematology, vol. 32, no. 3, pp. 235-243.
- O'Neill, H, Wilson, H, Quah, B et al. 2004, 'Dendritic Cell Development in Long-Term Spleen Stromal Cultures', Stem Cells, vol. 22, no. 4, pp. 475-486.
- Despars, G, Ni, K, Bouchard, A et al 2004, 'Molecular definition of an in vitro niche for dendritic cell development', Experimental Hematology, vol. 32, no. 12, pp. 1182-1193.
- Wilson, H & O'Neill, H 2004, 'Preparation of Label from Small Cell Numbers for Microarray Screening', OMICS: A Journal of Integrative Biology, vol. 8, no. 3, pp. 190-196.
- Abbey, J & O'Neill, H 2004, 'Germline transcription of multiple TCR-Vbeta genes in cloned T-cell lines', Immunology and Cell Biology, vol. 82, no. 4, pp. 393-399.
- Wilson, H & O'Neill, H 2003, 'Dynamics of dendritic cell development from precursors maintained in stroma-dependant long-term cultures', Immunology and Cell Biology, vol. 81, no. 2, pp. 144-151.
- Wilson, H & O'Neill, H 2003, 'GENE EXPRESSION DURING DENDTRITIC CELL DEVELOPMENT IN VITRO', Experimental Hematology, vol. 31, p. 86.
- Wilson, H & O'Neill, H 2003, 'Identification of differentially expressed genes representing dendritic cell precursors and their progeny', Blood, vol. 102, no. 5, pp. 1661-1669.
- Wilson, H & O'Neill, H 2003, 'Murine dendritic cell development: Difficulties associated with subset analysis', Immunology and Cell Biology, vol. 81, no. 4, pp. 239-246.
- O'Neill, H 2002, 'Estimating Disease Risk with Genetic Screening', Agenda: a journal of policy analysis and reform, vol. 9, no. 4, pp. 355-364.
- O'Neill, H, Quah, B, Wilson, H et al. 2002, 'In vitro production and analysis of dendritic cells which stimulate B lymphocyte immunity via production of exosomes', Experimental Hematology, vol. 30, p. 55.
- Ni, K & O'Neill, H 2001, 'Development of Dendritic Cells from GM-CSF-/- Mice in vitro : GM-CSF Enhances Production and Survival of Cells', Developmental Immunology, vol. 8, no. 2, pp. 133-146.
- O'Neill, H, Jonas, N, Wilson, H et al. 2000, 'Immunotherapeutic Potential of Dendritic Cells Generated in Long Term Stroma-Dependent Cultures', Cancer Biotherapy and Radiopharmaceuticals, vol. 14, pp. 263-276.
- Ni, K & O'Neill, H 2000, 'Spleen stromal cells support haemopoiesis and in vitro growth of dendritic cells from bone marrow', British Journal of Haematology, vol. 105, pp. 58-67.
- Quah, B & O'Neill, H 2000, 'The Application of Dendritic Cell-derived Exomes in Tumour Immunotherapy', Cancer Biotherapy and Radiopharmaceuticals, pp. 185-194.
- Ni, K & O'Neill, H 2000, 'Improved FACS analysis confirms generation of immature dendritic cells in long-term stromal-dependent spleen cultures', Immunology and Cell Biology, vol. 78, pp. 196-204.
- Wilson, H, Ni, K & O'Neill, H 2000, 'Proliferation of dendritic cell progenitors in long term culture is not dependent on granulocyte macrophage-colony stimulating factor', Experimental Hematology, vol. 28, pp. 193-202.
- Wilson, H, Ni, K & O'Neill, H 2000, 'Identification of progenitor cells in long-term spleen stromal cultures that produce immature dendritic cells', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 97, pp. 4784-4789.
