Areas of expertise

• Biochemistry And Cell Biology 0601
• Proteomics And Intermolecular Interactions (Excl. Medical Proteomics) 060109

Research interests

Publications

• Soboleva, T, Parker, B, Nekrasov, M et al 2017, 'A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B', PLoS Genetics, vol. 13, no. 2, pp. e1006633-e1006633.
• Domaschenz, R, Kurscheid, S, Nekrasov, M et al 2017, 'The Histone Variant H2A.Z Is a Master Regulator of the Epithelial-Mesenchymal Transition', Cell Reports, vol. 21, no. 4, pp. 943-952.
• Soboleva, T, Nekrasov, M, Ryan, D et al 2014, 'Histone variants at the transcription start-site', Trends in Genetics, vol. 30, no. 5, pp. 199-209.
• Nekrasov, M, Soboleva, T, Jack, C et al 2013, 'Histone variant selectivity at the transcription start site H2A.Z or H2A.Lap1', Nucleus, vol. 4, no. 6, pp. 431-437.
• Nekrasov, M, Amrichova, J, Parker, B et al., 'Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics', Nature Structural and Molecular Biology. 2012, vol. 19, no. 11, pp. 1076-1083.
• Soboleva TA, Nekrasov M, Pahwa A, Williams R, Huttley GA, Tremethick DJ. 'A unique H2A histone variant occupies the transcriptional start site of active genes', Nature Structural and Molecular Biology. 2012 Jan; 19(1): 25-30.
• Fiedler, M, Sanchez-Barrena, M, Nekrasov, M et al 2008, 'Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex', Molecular Cell, vol. 30, no. 4, pp. 507-18.
• Nekrasov, M, Klymenko, T, Fraterman, S et al 2007, 'Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes', The EMBO Journal, vol. 26, no. 18, pp. 4078-88.
• Nekrasov, M, Wild, B & Muller, J 2005, 'Nucleosome binding and histone methyltransferase activity of Drosophila PRC2', EMBO Reports, vol. 6, no. 4, pp. 348-353.
• Nekrasov MP, Ivshina MP, Chernov KG, Kovrigina EA, Evdokimova VM, Thomas AA, Hershey JW, Ovchinnikov LP. 'The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage.' J Biol Chem. 2003 Apr 18;278(16):13936-43

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

• The special role of histone variants in regulating the inheritance and 3-dimensional organisation of the epigenome (Secondary Investigator)