Dr Arno Mullbacher
Professor
Visiting Professor
ANU College of Health and Medicine
T:
+61(0)415334652
Areas of expertise
- Medical Virology 110804
- History And Philosophy Of Science (Incl. Non Historical Philosophy Of Science) 220206
- Cellular Immunology 110704
- Veterinary Immunology 070705
- Clinical Pharmacology And Therapeutics 111502
- Transplantation Immunology 110708
- Cellular Nervous System 110902
- Genetic Immunology 060406
- Cell Metabolism 060104
- Animal Physiology Cell 060602
- Infectious Diseases 110309
- Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics) 110106
- Cell Development, Proliferation And Death 060103
- Biochemistry And Cell Biology 0601
- Nutrition And Dietetics 1111
- Immunology 1107
- Medical Microbiology 1108
Publications
- Rezende Melo Da Silva, C, Tscharke, D, Lobigs, M et al 2017, 'Ectromelia virus N1L is essential for virulence but not dissemination in a classical model of mousepox', Virus Research, vol. 228, pp. 61-65.
- Mangan, M, Rezende Melo Da Silva, C, Luu, J et al. 2017, 'A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection', Immunology and Cell Biology, vol. 95, no. 10, pp. 884-894pp.
- Furuya, Y, Ludewick, H & Mullbacher, A 2015, 'Mysteries of type I IFN response: benefits versus detriments', Frontiers in Immunology, vol. 6, no. Article 21, pp. 1-2.
- Furuya, Y & Mullbacher, A 2013, 'Type I IFN Exhaustion is a Host Defence Protecting Against Secondary Bacterial Infections', Scandinavian Journal of Immunology, vol. 78, no. 5, pp. 395-400.
- Alsharifi, M, Koskinen, A, Wijesundara, D et al 2013, 'MHC Class II-Alpha Chain Knockout Mice Support Increased Viral Replication That Is Independent of Their Lack of MHC Class II Cell Surface Expression and Associated Immune Function Deficiencies', PLOS ONE (Public Library of Science), vol. 8, no. 6, pp. 1-8.
- Domingo, M, Colmenarejo, C, MartÃnez-Lostao, L et al 2012, 'Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis', Diagnostic Microbiology and Infectious Disease, vol. 73, no. 1, pp. 57-64.
- Furuya, Y, Chan, J, Wan, E et al 2011, 'Gamma-Irradiated Influenza Virus Uniquely Induces IFN-I Mediated Lymphocyte Activation Independent of the TLR7/MyD88 Pathway', PLOS ONE (Public Library of Science), vol. 6, no. 10, pp. e25765-e25765.
- Hansen, A, Regner, M, Bonefeld, C et al 2011, 'TCR down-regulation boosts T-cell-mediated cytotoxicity and protection against poxvirus infections', European Journal of Immunology, vol. 41, no. 7, pp. 1948-1957.
- Regner, M, Pavlinovic, L, Regner, N et al 2011, 'In Vivo Elimination of MHC-I-Deficient Lymphocytes by Activated Natural Killer Cells Is Independent of Granzymes A and B', PLOS ONE (Public Library of Science), vol. 6, no. 8, pp. e23252-e23252.
- Melo-Silva, CR, Tscharke, DC, Lobigs, M, Koskinen, A, Wong, YC, Buller, RM, Mullbacher, M, Regner, M 2011, 'The Ectromelia Virus SPI-2 Protein Causes Lethal Mousepox by preventing NK Cell Responses', Journal of Virology. Vol. 81, No. 21, pp. 11170–11182.
- Alsharifi, M & Mullbacher, A 2010, 'The gamma-irradiated influenza vaccine and the prospect of producing safe vaccines in general', Immunology and Cell Biology, vol. 88, no. 2, pp. 103-104.
- Wijesundara, D, Kumar, S, Alsharifi, M et al 2010, 'Antigen-specific activation thresholds of CD8+ T cells are independent of IFN-I-mediated partial lymphocyte activation', International Immunology, vol. 22, no. 9, pp. 757-767.
- Furuya, Y, Regner, M, Lobigs, M et al 2010, 'Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations', Journal of General Virology, vol. 91, pp. 1450-1460.
- Furuya, Y, Chan, J, Regner, M et al 2010, 'Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses', Journal of Virology, vol. 84, no. 9, pp. 4212-4221.
- Lobigs, M, Mullbacher, A & Regner, M 2009, 'CD4+ and CD8+ T-Cell Immune Responses in the West Nile Virus Infection', in Michael S. Diamond (ed.), West Nile Encephalitis Virus Infection; viral pathogenesis and the host immune response, Springer, USA, pp. 287-303.
- Pardo, J, Galvez, E, Koskinen, A et al 2009, 'Caspase-Dependent Inhibition of Mousepox Replication by gzmB', PLoS ONE (Public Library of Science), vol. 4, no. 10, pp. 7512 - 7522.
- Alsharifi, M, Furuya, Y, Bowden, T et al 2009, 'Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections', PLoS ONE (Public Library of Science), vol. 4, no. 4, pp. e5336.
- Pardo, J, Aguilo, J, Anel, A et al 2009, 'The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation', Microbes and Infection, vol. 11, pp. 452-459.
- Anel, A, Bleackley, C, Borner, C et al 2009, 'EMBO workshop on cytotoxicity, cell death and the immune system', Cell Death and Differentiation, vol. 16, pp. 790-793.
- Regner, M, Pavlinovic, L, Koskinen, A et al 2009, 'Cutting edge: Rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B', Journal of Immunology, vol. 183, no. 1, pp. 37-40.
- Alsharifi, M, Mullbacher, A & Regner, M 2008, 'Interferon type 1 responses in primary and secondary infections', Immunology and Cell Biology, vol. 86, pp. 239-245.
- Alsharifi, M, Lobigs, M, Bettadapura, J et al 2008, 'Restricted Semliki Forest virus replication inperforin and Fas-ligand double-deficient mice', Journal of General Virology, vol. 89, no. 8, pp. 1942-1944.
- Regner, M, Fenner, F & Mullbacher, A 2008, 'Mousepox and Rabbitpox viruses', in B.W.J. Mahy & M.H.V. van Regenmortel (ed.), Encyclopedia of Virology (3rd ed), Elsevier, USA, pp. 342-348.
- Pardo, J, Wallich, R, Martin, P et al. 2008, 'Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs', Cell Death and Differentiation, vol. 15, pp. 567-579.
- Sugui, J, Pardo, J, Chang, Y et al 2007, 'Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone', Eukaryotic Cell, vol. 6, no. 9, pp. 1562-1569.
- Sugui, J, Pardo, J, Chang, Y et al 2007, 'Role of laeA in the regulation of alb1, gliP, Conidial Morphology and Virulence in Aspergillus fumigatus', Eukaryotic Cell, vol. 6, no. 9 (Sept), pp. 1552-1561.
- Budd, A, Alleva, L, Alsharifi, M et al. 2007, 'Increased survival after gemfibrozil treatment of severe mouse influenza', Antimicrobial Agents and Chemotherapy, vol. 51, no. 8, pp. 2965-2968.
- de Jersey, J, Snelgrove, S, Palmer, S et al 2007, 'Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 4, pp. 1295-1300.
- Sutton, V, Waterhouse, N, Browne, K et al 2007, 'Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis', Journal of Cell Biology, vol. 176, no. 4, pp. 425-433.
- Pardo, J, Wallich, R, Ebnet, K et al 2007, 'Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin', Cell Death and Differentiation, vol. 14, pp. 1768-1779.
- Wang, Y, Lobigs, M, Lee, E et al 2006, 'CD8+ T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon', Journal of General Virology, vol. 87, pp. 3599-3609.
- Patterson, J, Chandrasekara, A, Bao, S et al 2006, 'Prebiotic supplementation with resistant starch alters health indices associated with metabolic changes and intestinal dysbiosis', International Journal of Probiotics and Prebiotics, vol. 1, no. 3/4, pp. 181-192.
- Alsharifi, M, Lobigs, M, Simon, M et al 2006, 'NK cell-mediated immunopathology during an acute viral infection of the CNS', European Journal of Immunology, vol. 36, pp. 887-896.
- Pardo, J, Urban, C, Galvez, E et al 2006, 'The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice', Journal of Cell Biology, vol. 174, no. 4, pp. 509-519.
- Alsharifi, M, Regner, M, Blanden, R et al 2006, 'Exhaustion of Type I interferon response following an acute viral infection', Journal of Immunology, vol. 177, pp. 3235-33241.
- Mullbacher, A, Lobigs, M, Alsharifi, M et al 2006, 'Cytotoxic T-cell immunity as a target for influenza vaccines', The Lancet Infectious Diseases, vol. 6, pp. 255-256.
- Alsharifi, M, Lobigs, M, Regner, M et al 2005, 'Type I interferons trigger systemic, partial lymphocyte activation in response to viral infection', Journal of Immunology, vol. 175, pp. 4635-4640.
- Pao, L, Sumaria, N, Kelly, J et al 2005, 'Functional analysis of granzyme M and its role in immunity to infection', Journal of Immunology, vol. 175, pp. 3235-3243.
- Martin, P, Wallich, R, Pardo, J et al 2005, 'Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?', Blood, vol. 106, no. 8, pp. 2871-2878.
- Lobigs, M, Mullbacher, A & Lee, E 2004, 'Evidence that a mechanism for efficient flavivirus budding upregulates MHC class 1', Immunology and Cell Biology, vol. 82, pp. 184-188.
- Wang, Y, Lobigs, M, Lee, E et al 2004, 'Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice', Immunology and Cell Biology, vol. 82, pp. 170-173.
- Pardo, J, Bosque, A, Brehm, R et al 2004, 'Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis', Journal of Cell Biology, vol. 167, no. 3, pp. 457-468.
- Xu, D, Regner, M, Smith, D et al. 2004, 'The multidrug resistance gene mdrla influences resistance to ectromelia virus infection by mechanisms other than conventional immunity', Immunology and Cell Biology, vol. 82, pp. 462-470.
- Regner, M & Mullbacher, A 2004, 'Granzymes in cytolytic lymphocytes to kill a killer?', Immunology and Cell Biology, vol. 82, pp. 161-169.
- Mullbacher, A & Blanden, R 2004, 'T-cell mediated control of poxvirus infection in mice', in Covadonga Alonso (ed.), Viruses and Apoptosis, Springer, Germany, pp. 39-55.
- Mullbacher, A, Regner, M, Wang, Y et al 2004, 'Can we really learn from model pathogens?', Trends in Immunology, vol. 25, no. 10, pp. 524-528.
- Rode, M, Balkow, S, Sobek, V et al 2004, 'Perforin and Fas act together in the inductin of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection', Journal of Virology, vol. 78, no. 22, pp. 12395-12405.
- Muller, U, Sobek, V, Balkow, S et al 2003, 'Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway', European Journal of Immunology, vol. 33, pp. 70-78.
- Wang, Y, Lobigs, M, Lee, E et al 2003, 'CD8+ T Cells Mediate Recovery and Immunopathology in West Nile Virus Encephalitis', Journal of Virology, vol. 77, no. 24, pp. 13323-13334.
- Chin, J & Mullbacher, A 2003, 'Immune activation versus hyporesponsiveness and tolerance in the gut', in Roy Fuller & Gabriela Perdigón (ed.), Gut Flora, Nutrition, Immunity and Health, Blackwell Publishing Ltd, United Kingdom, pp. 178-200.
- Mullbacher, A, Lobigs, M & Lee, E 2003, 'Immunobiology of mosquito-borne encephalitic flaviviruses', in Chambers T.J. and Monath T.P. (ed.), The Flaviviruses: Pathogenesis and Immunity, Academic Press, San Diego, USA, pp. 87-120.
- Lobigs, M, Mullbacher, A, Wang, Y et al 2003, 'Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus', Journal of General Virology, vol. 84, no. 3, pp. 567-572.
- Mullbacher, A 2003, 'Cell-mediated cytotoxicity in recovery from poxvirus infections', Reviews in Medical Virology, vol. 13, pp. 223-232.
- Lobigs, M, Mullbacher, A & Regner, M 2003, 'MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen', Immunology and Cell Biology, vol. 81, pp. 217-223.
- Licon-Luna, R, Lee, E, Mullbacher, A et al. 2002, 'Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice', Journal of Virology, vol. 76, no. 7, pp. 3202-3211.
- Mullbacher, A, Lobigs, M, Tha Hla, R et al. 2002, 'Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis', Journal of Immunology, vol. 169, pp. 145-150.
- Laver, W & Mullbacher, A 2001, 'How commercialization puts a blight on research', Nature, vol. 412, p. 765.
- Momburg, F, Mullbacher, A & Lobigs, M 2001, 'Modulation of transporter associated with antigen processing (TAP)-mediated peptide import into the endoplasmic reticulum by flavivirus infection', Journal of Virology, vol. 75, no. 12, pp. 5663-5671.
- Waring, P & Mullbacher, A 2001, 'Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycle', Immunology and Cell Biology, vol. 79, no. 3, pp. 264-273.
- Hamilton-Williams, E, Serreze, D, Charlton, B et al 2001, 'Transgenic rescue implicates β2-Microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 20, pp. 11533-11538.
- Mullbacher, A & Lobigs, M 2001, 'Creation of killer pox virus could have been predicted', Journal of Virology, vol. 75, no. 18, pp. 8353-8355.
- Balkow, S, Kersten, A, Tran, T et al 2001, 'Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection', Journal of Virology, vol. 75, no. 18, pp. 8781-8791.
- Regner, M, Lobigs, M, Blanden, R et al 2001, 'Antiviral cytotoxic T cells cross-reactively recognize disparate peptide determinants from related viruses but ignore more similar self- and foreign determinants', Journal of Immunology, vol. 166, no. 6, pp. 3820-3828.
- Regner, M, Mullbacher, A, Blanden, R et al 2001, 'Immunogenicity of two peptide determinants in the cytolytic T-cell response to flavivirus infection: Inverse correlation between peptide affinity for MHC class I and T-cell precursor frequency', Viral Immunology, vol. 14, no. 2, pp. 135-149.
- Regner, M, Lobigs, M, Blanden, R et al 2001, 'Effector cytolotic function but not IFN-γ production in cytotoxic T cells triggered by virus-infected target cells in vitro', Scandinavian Journal of Immunology, vol. 54, pp. 366-374.
- Wallich, R, Simon, M & Mullbacher, A 2001, 'Virulence of mousepox is independent of serpin-mediated control of cellular cytotoxicity', Viral Immunology, vol. 14, no. 1, pp. 71-81.
- Mullbacher, A & Lobigs, M 2001, 'Creation of Killer Poxvirus Could Have Been Predicted', Journal of Virology, vol. 75, no. 18, pp. 8353-8355.
- Riera, L, Gariglio, M, Valente, G et al 2000, 'Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection', European Journal of Immunology, vol. 30, no. 5, pp. 1350-5.
- Mullbacher, A & Blanden, R 2000, 'Cytotoxic T cell memory', in Sitkovsky, M.V.; Henkart, P.A. (ed.), Cytotoxic Cells: Basic Mechanisms and Medical Applications, Lippincott Williams & Wilkins, Philadelphia, pp. 317-325.
- Simon, M & Mullbacher, A 2000, 'Role of granzymes in target cell lysis and viral infections', in Sitkovsky, M.V.; Henkart, P.A. (ed.), Cytotoxic Cells: Basic Mechanisms and Medical Applications, Lippincott Williams & Wilkins, Philadelphia, pp. 197-211.
- Lobigs, M, Chelvanayagam, G & Mullbacher, A 2000, 'Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class 1', European Journal of Immunology, vol. 30, no. 5, pp. 1496-1506.
- Simon, M, Waring, P, Lobigs, M et al. 2000, 'Cytotoxic T cells specifically induce Fas on target cells thereby facilitating exocytosis-independent induction of apoptosis', Journal of Immunology, vol. 165, pp. 3663-3672.
- Waring, P & Mullbacher, A 1999, 'Cell death induced by the Fas/FasL pathway and its role in pathology', Immunology and Cell Biology, vol. 77, pp. 312-317.
- Mullbacher, A, Lobigs, M, Kos, F et al. 1999, 'Alloreactive cytotoxic T-cell function, peptide nonspecific', Scandinavian Journal of Immunology, vol. 49, pp. 563-569.
- Mullbacher, A, Tha Hla, R, Museteanu, C et al. 1999, 'Perforin is essential for the control of ectromelia virus but not related poxviruses in mice', Journal of Virology, vol. 73, pp. 1665-1667.
- Mullbacher, A, Waring, P, Tha Hla, R et al. 1999, 'Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 24, pp. 13950-13955.
- Lobigs, M, Mullbacher, A, Blanden, R et al. 1999, 'Antigen presentation in Syrian hamster cells: substrate selectivity of TAP controlled by polymorphic residues in TAP1 and differential requirements for loading of H2 class l molecules', Immunogenetics, vol. 49, pp. 931-941.
- Mullbacher, A, Wallich, R, Moyer, R et al 1999, 'Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections', Journal of Immunology, vol. 162, pp. 7315-7321.
- Hayder, H, Blanden, R, Korner, H et al 1999, 'Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin', Journal of Immunology, vol. 163, pp. 1516-1520.
- Mullbacher, A, Lobigs, M, Yewdell, J et al. 1999, 'Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infection', European Journal of Immunology, vol. 29, pp. 1228-1234.