Areas of expertise
- Autoimmunity 110703
- Cellular Immunology 110704
- Immunogenetics (Incl. Genetic Immunology) 110706
- Genetic Immunology 060406
- Immunology 1107
Publications
- Wirasinha, R, Davies, A, Srivastava, M et al. 2020, 'Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility', Journal of Experimental Medicine, vol. 218, no. 2.
- Skvortsova, K, Masle-Farquhar, E, Luu, P et al. 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, vol. 35, no. 2, pp. 297-3.14E+10.
- Jiang, S, Athanasopoulos, V, Ellyard, J et al 2019, 'Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus', Nature Communications, vol. 10, no. 2201, pp. 1-12.
- McNamara, H, Cai, Y, Wagle, M, Sontani, I, Roots, CM, Misoge, LA, O'Connor, JH, Sutton, HJ, Ganusov, VV, Heath, WR, Bertolino, P, Goodnow, CC, Parish, IA, Enders, A and I. Cockburn. 2017, 'Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids', Science Immunology, vol. 2, no. 9, pp. 1-10pp.
- Miosge, L, Sontani, Y, Chuah, A, Horikawa, K, Russel, TA, Mei, Y, Wagle, M, Howard, DR, Enders, A, Tscharke, DC, Goodnow, CC and IA Parish. 2017, 'Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.', PNAS, Online, pp. 1-10pp..
- Siggs, O, Miosge, L, Daley, S et al 2015, 'Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation', Journal of Immunology, vol. 194, no. 6, pp. 2587-2595.
- Miosge, L. A., M. A. Field, Y. Sontani, V. Cho, S. Johnson, A. Palkova, B. Balakishnan, R. Liang, Y. Zhang, S. Lyon, B. Beutler, B. Whittle, E. M. Bertram, A. Enders, C. C, Goodnow and T. D. Andrews. 2015, 'Comparison of predicted and actual consequences of missense mutations', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 37, pp. E5189-E5198.
- Bergmann, H., Yabas, M., Short, A., Miosge, L., Barthel, N., Teh, C.E., Roots, C.M., Bull, K.R., Jeelall, Y., Horikawa, K., Whittle, B., Balakishnan, B., Sjollema, G., Bertram, E.M. Mackay, F., Rimmer, A.J., Cornall, R.J., Field, M.A., Andrews, T.D., Goodnow, C.C. and A. Enders 2013, 'B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPl2A', Journal of Experimental Medicine, vol. 210, no. 1, pp. 31-40.
- Bull, K. R., Rimmer, A. J., Siggs, O. M., Miosge, L. A., Roots, C. M., Enders, A., Bertram, E. M., Crockford, T. L., Whittle, B., Potter, P. K., Simon, M. M., Mallon, A.-M., Brown, S. D. M., Beutler, B., Goodnow, C. C., Lunter, G. & Cornall, R. J. 2013, 'Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations', PLoS Genetics, vol. 9, no. 1, pp. e1003219/1-12.
- Myers, D. R., Polakos, N. K., Enders, A., Roots, C. M., Balakishnan, B., Miosge, L. A., Sjollema, G., Bertram, E. M., Field, M. A., Shao, Y., Andrews, T. D., Whittle, B., Barnes, S. W., Walker, J. R., Cyster, J. G., Goodnow, C. C. & Roose, J. P. 2013, 'Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies', eLife, vol. 2013, no. 2, pp. 1-26.
- Brownlie, R, Miosge, L, Vassilakos, D et al 2012, 'Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function', Science Signaling, vol. 5, no. 252, pp. 1-11.
- Siggs, O, Miosge, L, Yates, A et al 2007, 'Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions', Immunity, vol. 27, no. 6, pp. 912-916.
- BLERY, M, Tze, L, Miosge, L et al 2006, 'Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kB in B cell clonal anergy', Journal of Experimental Medicine, vol. 203, no. 7, pp. 1773-1783.
- Miosge, L & Goodnow, C 2005, 'Genes, pathways and checkpoints in lymphocyte development and homeostasis', Immunology and Cell Biology, vol. 83, pp. 318-335.
- Jun, J, Wilson, L, Vinuesa, C.G., et al 2003, 'Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis', Immunity, vol. 18, pp. 751-762.
- Miosge, L, Blasioli, J, BLERY, M et al 2002, 'Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kB2 in regulating circulating B cell numbers', Journal of Experimental Medicine, vol. 196, no. 8, pp. 1113-1119.
- Goodnow, C, Glynne, R, Akkaraju, S et al 2001, 'Autoimmunity, self-tolerance and immune homeostasis: from whole animal phenotypes to molecular pathways', Advances in Experimental Medicine and Biology, vol. 490, pp. 33-40.
