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Researchers

Dr Lisa Miosge

ANU College of Health and Medicine

E: lisa.miosge@anu.edu.au

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Areas of expertise

Autoimmunity 110703
Cellular Immunology 110704
Immunogenetics (Incl. Genetic Immunology) 110706
Genetic Immunology 060406
Immunology 1107

Publications

Boast, B, Miosge, L, Kuehn, H et al. 2021, 'A point mutation in IKAROS ZF1 causes a B cell deficiency in mice', Journal of Immunology, vol. 206, no. 7, pp. 1505-1514.
Kayagaki, N, Kornfeld, O, Stowe, I et al. 2021, 'NINJ1 mediates plasma membrane rupture during lytic cell death', Nature, vol. 591, no. 7848, pp. 131-136.
Wagle, M, Vervoort, S, Kelly, M et al. 2021, 'Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance', Nature Communications, vol. 12, no. 1.
Wirasinha, R, Davies, A, Srivastava, M et al. 2020, 'Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility', Journal of Experimental Medicine, vol. 218, no. 2.
Koay, H, Su, S, Amman-Zalcenstein, D et al. 2019, 'A divergent transcriptional landscape underpins the development and functional branching of MAIT cells', Science Immunology, vol. 4, no. 41, pp. -.
Skvortsova, K, Masle-Farquhar, E, Luu, P et al. 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, vol. 35, no. 2, pp. 297-314.
Jiang, S, Athanasopoulos, V, Ellyard, J et al. 2019, 'Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus', Nature Communications, vol. 10, no. 2201, pp. 1-12.
McNamara, H, Cai, Y, Wagle, M, Sontani, I, Roots, CM, Misoge, LA, O'Connor, JH, Sutton, HJ, Ganusov, VV, Heath, WR, Bertolino, P, Goodnow, CC, Parish, IA, Enders, A and I. Cockburn. 2017, 'Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids', Science Immunology, vol. 2, no. 9, pp. 1-10pp.
Miosge, L, Sontani, Y, Chuah, A, Horikawa, K, Russel, TA, Mei, Y, Wagle, M, Howard, DR, Enders, A, Tscharke, DC, Goodnow, CC and IA Parish. 2017, 'Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.', PNAS, Online, pp. 1-10pp..
Parish, I, Stamp, L, Lorenzo, A et al 2016, 'A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy', American Journal of Pathology, vol. 186, no. 9, pp. 2254-2261.
Siggs, O, Miosge, L, Daley, S et al 2015, 'Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation', Journal of Immunology, vol. 194, no. 6, pp. 2587-2595.
Flesch, I. E. A., K. L. Randall, N. A. Hollett, H. Di Law, L. A. Miosge, Y. Sontani, C. C. Goodnow, and D. C. Tscharke. 2015, 'Delayed control of herpes simplex virus infection and impaired CD4+ T-cell migration to the skin in mouse models of DOCK8 deficiency', Immunology and Cell Biology, vol. 93, no. 2015, pp. 517-521.
Miosge, L. A., M. A. Field, Y. Sontani, V. Cho, S. Johnson, A. Palkova, B. Balakishnan, R. Liang, Y. Zhang, S. Lyon, B. Beutler, B. Whittle, E. M. Bertram, A. Enders, C. C, Goodnow and T. D. Andrews. 2015, 'Comparison of predicted and actual consequences of missense mutations', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 37, pp. E5189-E5198.
Enders, A., Short, A., Miosge, L. A., Bergmann, H., Sontani, Y., Bertram, E. M., Whittle, B., Balakishnan, B., Yoshida, K., Sjollema, G., Field, M. A., Andrews, T. D., Hagiwara, H. & Goodnow, C. C. 2014. 'Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 12, pp. 4513-4518.
Bergmann, H., Yabas, M., Short, A., Miosge, L., Barthel, N., Teh, C.E., Roots, C.M., Bull, K.R., Jeelall, Y., Horikawa, K., Whittle, B., Balakishnan, B., Sjollema, G., Bertram, E.M. Mackay, F., Rimmer, A.J., Cornall, R.J., Field, M.A., Andrews, T.D., Goodnow, C.C. and A. Enders 2013, 'B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPl2A', Journal of Experimental Medicine, vol. 210, no. 1, pp. 31-40.
Bull, K. R., Rimmer, A. J., Siggs, O. M., Miosge, L. A., Roots, C. M., Enders, A., Bertram, E. M., Crockford, T. L., Whittle, B., Potter, P. K., Simon, M. M., Mallon, A.-M., Brown, S. D. M., Beutler, B., Goodnow, C. C., Lunter, G. & Cornall, R. J. 2013, 'Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations', PLoS Genetics, vol. 9, no. 1, pp. e1003219/1-12.
Myers, D. R., Polakos, N. K., Enders, A., Roots, C. M., Balakishnan, B., Miosge, L. A., Sjollema, G., Bertram, E. M., Field, M. A., Shao, Y., Andrews, T. D., Whittle, B., Barnes, S. W., Walker, J. R., Cyster, J. G., Goodnow, C. C. & Roose, J. P. 2013, 'Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies', eLife, vol. 2013, no. 2, pp. 1-26.
Stepensky, P., Keller, B., Buchta, M., Kienzler, A.-K., Elpeleg, O., Somech, R., Cohen, S., Shachar, I., Miosge, L. A., Schlesier, M., Fuchs, I., Enders, A., Eibel, H., Grimbacher, B. & Warnatz, K. 2013. Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects. The Journal of allergy and clinical immunology, vol. 131, no. 2, pp. 477-485.e1.
Brownlie, R, Miosge, L, Vassilakos, D et al 2012, 'Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function', Science Signaling, vol. 5, no. 252, pp. 1-11.
Siggs, O, Miosge, L, Yates, A et al. 2007, 'Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions', Immunity, vol. 27, no. 6, pp. 912-916.
BLERY, M, Tze, L, Miosge, L et al. 2006, 'Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kB in B cell clonal anergy', Journal of Experimental Medicine, vol. 203, no. 7, pp. 1773-1783.
Miosge, L & Goodnow, C 2005, 'Genes, pathways and checkpoints in lymphocyte development and homeostasis', Immunology and Cell Biology, vol. 83, pp. 318-335.
Jun, J, Wilson, L, Vinuesa, C.G., et al 2003, 'Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis', Immunity, vol. 18, pp. 751-762.
Miosge, L, Blasioli, J, BLERY, M et al. 2002, 'Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kB2 in regulating circulating B cell numbers', Journal of Experimental Medicine, vol. 196, no. 8, pp. 1113-1119.
Goodnow, C, Glynne, R, Akkaraju, S et al. 2001, 'Autoimmunity, self-tolerance and immune homeostasis: from whole animal phenotypes to molecular pathways', Advances in Experimental Medicine and Biology, vol. 490, pp. 33-40.

Updated: 03 December 2023 / Responsible Officer: Director (Research Services Division) / Page Contact: Researchers