Associate Professor Lara Malins
BA in Chemistry (Boston University), PhD (The University of Sydney)
Associate Professor, Westpac Research Fellow
ANU College of Science
T:
+61 2 6125 9106
Areas of expertise
- Organic Chemistry 0305
- Medicinal And Biomolecular Chemistry 0304
- Proteins And Peptides 030406
- Natural Products Chemistry 030502
Biography
Lara Malins completed her undergraduate studies in chemistry at Boston University in 2009. She relocated to The University of Sydney as an International Postgraduate Research Scholar to undertake her PhD with Professor Richard Payne on the development of new peptide ligation strategies. Upon completion of her postgraduate work, Lara served as a National Institutes of Health (NIH) postdoctoral research fellow in the laboratory of Professor Phil Baran at The Scripps Research Institute, developing synthetic methods for the targeted modification of peptides. She began her independent career at the Research School of Chemistry in November 2017 and is currently an Associate Professor and Westpac Research Fellow. Her research focuses on the development of new synthetic methods for drug discovery, natural product synthesis, and chemical biology.
Publications
- White, A, Palombi, I & Malins, L 2022, 'Umpolung strategies for the functionalization of peptides and proteins', Chemical Science, vol. 13, no. 10, pp. 2809-2823.
- Lin, Y & Malins, L 2021, 'An Electrochemical Approach to Designer Peptide alpha-Amides Inspired by alpha-Amidating Monooxygenase Enzymes', Journal of the American Chemical Society, vol. 143, no. 30, pp. 11811-11819.
- VO, Y, Schwartz, B, Onagi, H et al. 2021, 'A Rapid and Mild Sulfation Strategy Reveals Conformational Preferences in Therapeutically Relevant Sulfated Xylooligosaccharides', Chemistry, A European Journal, vol. 27, no. 38, pp. 9830-9838.
- Schwartz, B, Zhang, M, Attard, R et al 2020, 'Structurally Diverse Acyl Bicyclobutanes: Valuable Strained Electrophiles', Chemistry, A European Journal, vol. 26, no. 13, pp. 2808-2812.
- Lin, Y & Malins, L 2020, 'Total synthesis of biseokeaniamides A-C and late-stage electrochemically-enabled peptide analogue synthesis', Chemical Science, vol. 11, no. 39, pp. 10752-10758.
- Noisier, A, Johansson, M, Knerr, L et al. 2019, 'Late-Stage Functionalization of Histidine in Unprotected Peptides', Angewandte Chemie, vol. 58, no. 52, pp. 19096-19102.
- Malins, L 2018, 'Decarboxylative couplings as versatile tools for late-stage peptide modifications', Peptide Science, vol. 110, no. 3, pp. 1-16pp.
- Zhang, M, Malins, L, Ward, J et al 2018, 'Total Synthesis of Suillusin', Organic Letters, vol. 20, no. 22, pp. 7304-7307.
- Malins, L 2018, 'Hitting the sweet spot', Nature Chemistry, vol. 10, no. 6, pp. 578-580pp.
- Malins, L 2018, 'Peptide modification and cyclization via transition-metal catalysis', Current Opinion in Chemical Biology, vol. 46, pp. 25-32.
- Malins, L, de Gruyter, J, Robbins, K et al. 2017, 'Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products', Journal of the American Chemical Society, vol. 139, no. 14, pp. 5233-5241.
- Mitchell, N, Kulkarni, S, Malins, L et al. 2017, 'One�Pot Ligation–Oxidative Deselenization at Selenocysteine and Selenocystine', Chemistry, A European Journal, vol. 23, no. 4, pp. 946-952.
- de Gruyter, J, Malins, L & Baran, P 2017, 'Residue-Specific Peptide Modification: A Chemist’s Guide', Biochemistry, vol. 56, no. 30, pp. 3863-3873.
- Edwards, J, Merchant, R, McClymont, K et al. 2017, 'Decarboxylative alkenylation', Nature, vol. 545, pp. 213-218.
- Smith, J, Qin, T, Merchant, R et al. 2017, 'Decarboxylative Alkynylation', Angewandte Chemie International Edition, vol. 56, no. 39, pp. 11906-11910.
- de Gruyter, J, Malins, L, Wimmer, L et al. 2017, 'CITU: A Peptide and Decarboxylative Coupling Reagent', Organic Letters, vol. 19, no. 22, pp. 6196-6199.
- Qin, T, Malins, L, Edwards, J et al. 2017, 'Nickel�Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms', Angewandte Chemie International Edition, vol. 56, no. 1, pp. 260-265.
- Lopchuk, J, Fjelbye, K, Kawamata, Y et al. 2017, 'Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity', Journal of the American Chemical Society, vol. 139, no. 8, pp. 3209-3226.
- Isahak, N, Gody, G, Malins, L et al. 2016, 'Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation', Chemical Communications, vol. -, no. 52, pp. 12952-12955.
- Gianatassio, R, Lopchuk, J, Wang, J et al. 2016, 'Strain-release amination', Science, vol. 351, no. 6270, pp. 241-246.
- Tian, Q, Cornella, J, Li, C et al. 2016, 'A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents', Science, vol. 352, no. 6287, pp. 801-805.
- Malins, L 2016, 'Transition Metal-Promoted Arylation: An Emerging Strategy for Protein Bioconjugation', Australian Journal of Chemistry, vol. 69, no. 12, pp. 1360-1364.
- Gianatassio, R, Lopchuk, J, Wang, J et al. 2016, 'Organic chemistry: Strain-release amination', Science, vol. 351, no. 6270, pp. 241-246.
- Wilkinson, B, Day, S, Malins, L et al 2011, 'Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer', Angewandte Chemie International Edition, vol. 50, pp. 1635-1639.
- Wilkinson, B, Malins, L, Chun, C et al 2010, 'Synthesis of MUC1-Lipopeptide Chimeras', Chemical Communications, vol. 46, pp. 6249-6251.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Advances in Peptide Synthesis: Exploiting Underutilised Functional Groups (Primary Investigator)
- Harnessing molecular strain for drug discovery and bioconjugation (Primary Investigator)
- Mining the microbiome: Next-generation antibiotics from gut bacteria (Primary Investigator)
- ARC Centre of Excellence for Innovations in Peptide and Protein Science (Secondary Investigator)
- Developing targeted antimalarial drug leads from host defence peptide-drug conjugates (Secondary Investigator)
- Next generation facility for investigating thermodynamics and kinetics (Secondary Investigator)
- A radical approach to unnatural amino acids and peptide-based antibiotics (Primary Investigator)
