Associate Professor Jeffrey Looi

MBBS(Syd), MD(ANU), DMedSc(Melb), FRANZCP, AFRACMA, AMA(M)
Associate Professor, Psychiatry, Old Age Psychiatry, Neuropsychiatry & A/g Discipline Lead, Academic Unit of Psychiatry & Addiction Medicine, School of Clinical Medicine, Canberra Hospital, ANU Medical School
ANU College of Health and Medicine
T: 61-2-51243500

Areas of expertise

  • Neurosciences 1109
  • Psychiatry (Incl. Psychotherapy) 110319
  • Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) 170101
  • Biostatistics 010402
  • Image Processing 080106
  • Public Health And Health Services 1117

Research interests

  • Neuropsychiatry of movement disorders, cognitive impairment and dementia
  • Structural-functional correlative magnetic resonance neuroimaging in neurodegenerative and neuropsychiatric disease: endophenotype characterisation
  • Subcortical neuroimaging biomarkers for neurodegenerative and neuropsychiatric disease
  • Manual and automated segmentation of neuroanatomic structures in brain magnetic resonance images: computational neuroanatomy
  • MRI processing, data analysis and computer visualisation
  • Cognitive neuroscience and neuroanatomy of neurodegenerative disease
  • Translational neuroimaging measures for clinical practice

Biography

Associate Professor Jeffrey Looi is a clinical academic neuropsychiatrist, leading an international research network on cognitive neuroscience and structural neuroimaging biomarkers in neurodegenerative and neuropsychiatric disease. As an active clinician, he also comments on and conducts mental health service as well as population mental health research. He qualified MBBS (1992), and has been awarded two research higher doctorates, MD (2011) from the ANU and DMedSc (2018) from the University of Melbourne. He is board certified as a consultant physician in psychiatry (FRANZCP, 1999) and has qualifications in medical administration (AFRACMA, 2006). A Foundation Faculty member since 2003, he was appointed (2006) and continues as Associate Professor and Acting Discipline Lead (08/2016-), Academic Unit of Psychiatry & Addiction Medicine, ANU Medical School. He was appointed as a Clinical Associate Professor at the Melbourne Neuropsychiatry Centre, University of Melbourne 2015-2019 and a Visiting Guest Researcher, Karolinska Institute, Stockholm, Sweden 2006-2016. He works in clinical practice two days per week.

Professor Looi has received multiple international research and leadership awards, including: a Fulbright Scholarship at the Laboratory of Neuro Imaging, UCLA Medical School (2005); Australian Davos Connection Future Summit Leadership award (2006); and a Young Psychiatrist Award from the Pacific Rim College of Psychiatrists (2012). He has been a senior medico-political representative with the Australian Medical Association and Royal Australian and New Zealand College of Psychiatrists for nearly two decades; and is an author/co-author on more than 120 peer-reviewed papers and 100+ other publications (Google Scholar h-index:24, i10-index:40, citations: 2740).

The international research network he leads is AUSSIE, the Australian United States Scandinavian/Spanish Imaging Exchange. This network focuses on mentoring medical researchers in clinical neuropsychiatry and neuroscience research: especially medical students, medical scientists and physicians in training, as well as collaborative interdisciplinary research (neuroscience, computational science/engineering, medical physics, psychology, neurology, neuroradiology and psychiatry). The network is a platform for developing early career research and collaborative skills, as well as for international scientific exchange. A number of students, graduates and start-up collaborators have received local, national and international awards for their research excellence.

Researcher's projects

Clinical Research

  • Tracking disease progression in Parkinson’s Disease using postural sway, eye movements, electrophysiological measures and MRI (Chief Investigators: D. Apthorp, C. Lueck, N. Cherbuin, T. Maddess, J.C.L. Looi and H.Suominen)
  • Mental Health Services and Population Mental Health: governance, service delivery and resource allocation in mental health services, population suicide rates and aetiological factors, leadership and psychiatric/medical expertise (T. Bastiampillai, S. Allison, S.R. Kisely, B. Cartledge,  C.S. Yong, P.Keightley, P.A. Maguire, D.Bonner, J.C.L. Looi)

Neuroimaging Analysis Network

  • Australian United States Scandinavian/Spanish Imaging Exchange (AUSSIE)
  • Current collaborators: University of Melbourne; Karolinska Institute Huddinge, Stockholm; University of North Carolina, Chapel Hill; Lund University & Skane University Hospital, Lund; University of Southern California; University of Wollongong; University of Western Australia; University of Notre Dame, Fremantle; University of New South Wales; Complutense University Madrid & Hospital Clinico San Carlos Madrid.

Design, Methodology, Analysis & Project Management

  • Design and project management of international clinical neuroimaging research projects
  • Manual and automated segmentation of brain magnetic resonance imaging (MRI) datasets
  • MRI processing, data analysis and computer visualisation
  • Correlation of clinical, neuropsychological and behavioural measurements with structural MRI data
  • Translational neuroimaging measures for clinical practice

Available student projects

Structural-functional correlative neuroimaging analysis of:

  • mild cognitive impairment and dementias (frontotemporal lobar degeneration, age-related vascular disease, Alzheimer's disease),
  • movement disorders (Parkinson's and Huntington's disease, progressive supranuclear palsy),
  • & other neuropsychiatric disorders

Current student projects

 


 

Vacation Scholars

  • No vacation scholar positions will be available for summer 2019-2020.

 


 

Graduate Scholars (MChD program, ANU)

MChD Project 2018-2019

  • Nicola Marshall - Systematic narrative review of treatment in Parkinson's disease (Co-supervised by Dr Zain Hindawi)
  • Aiden Brumby - Thalamaic morphology and correlates in Parkinson's disease and related disorders

MChD Project 2019-2020 (co-supervised by Dr Zain Hindawi)

  • Maddison Brian - Systematic narrative review
  • Ned Cotter - Systematic narrative review
  • Anneka Jolly - Systematic narrative review
  • Sheraz Majoka - Systematic narrative review

Undergraduate Honours Students

Neuroscience Honours

  • Opportunities available

Supervised Postgraduate Scholars

PhD

  • Opportunities available
  • Structural-functional correlative neuroimaging of Huntington's disease - multimodal morphology (MChD/PhD [ANU], Dr Fiona Wilkes, BSc (Psychol) [Hons] & MChD[2014] - with Monash University & University of Melbourne - RANZCP New Investigator Grant Awardee 2013; Registrar in Psychiatry, Canberra Health Services)
  • Novel neuroimaging biomarkers in Parkinson’s Disease: subcortical morphology and correlation with neuropsychiatric manifestations, {PhD [ANU] Mr Conor Owens-Walton, BA, BSc [Psychol, Internat. Relations], MNeurosci(Research) with Lund University, Sweden} Thesis submitted July 2019.

Masters Degree

  • Opportunities available 
  • Striatal morphology and clinical correlates in elderly bipolar disorder (Master of Science [Affective Neuroscience], Maastricht University - Dr Bjorn Cartledge, BMBS, BA, BInternat.Stud. - with UNSW & University of Melbourne)
  • Striatal morphology in neurodegenerative disease and schizophrenia (Master of Neuroscience - Advanced, JCSMR, ANU - Ms Catherine Yiru Guo - with University of Melbourne)

Co-supervised Postgraduate Scholars

PhD

  • Psychological and cognitive outcomes of delirium in intensive care units (co-supervisor for UNSW, PhD - Ms Daniella Bulic, BSc [Hons], BaSW, MEc - Thesis submitted 30 May 2019

 


 

Other research supervision/start-up collaborators

Academic Psychiatrist (ANU Medical School)

  • Fatigue in Inflammatory Bowel Disease (Dr Philip Keightley BMed FRANZCP, Associate Lecturer & Consultant Psychiatrist, ANU Medical School - with the Gastroenterology Department, Canberra Hospital)

Early Career Collaborators

  • Multimodal analysis of cortico-striatal-thalamic loops in bvFTD [Dr David Jakabek, BSc, MPsych (Clinical), MBBS, University of Wollongong, FRACP Trainee - with Lund University, Sweden and University of Notre Dame, Fremantle, WA]

 


 

Recent Alumni from the AUSSIE network

MChD Postgraduate Medical Research Project Students

  • Measurement of intercaudate distance on MRI as a potential clinical biomarker in Parkinson's disease (MChD [ANU], Mr Conan Hall)
  • Structural-functional correlative neuroimaging of treatment-resistant temporal lobe epilepsy prior to hippocampal resection: hippocampal and related morphology (MChD [ANU],  Dr Jae-Gon Yoo, BPharm [Hons] - with Lund University, Monash University & University of Melbourne - former Canberra Hospital PPF Vacation Scholar -Awarded Best Presentation MBBS Project Night 2014 - now Radiology Registrar, Adelaide)

MChD Project 2017-2018

  • Striatal Morphology in Parkinsonian Disorders: subcortical morphology and correlation with neuropsychiatric manifestations, (Daniel Cordas & Michael Hunter with Hospital Clinico San Carlos, Madrid, Spain)

Undergraduate Honours Students (2016)

  • Striatal morphology in mild cognitive impairment: corrrelation with clinicopathological features (PhB Honours, Class I [RSB, ANU], Mr Vlad Marinov with RSB, ANU and Lund University, Sweden, currently Medical student)
  • Striatal morphology in vascular dementia and subjective cognitive impairment: case-control study and corrrelatiive analysis (BSc(Adv) RSB, ANU], Mr Morgan See with RSB and CRAHW, ANU and Karolinska Institute, Sweden)

Masters Graduates

  • Investigation of 3 Dimensional shape analysis of the thalamus in the IMAGE-HD cohort - 2017 Master of Neuroscience Advanced [JCSMR, ANU] (Ms Lisa Furlong, BPsyc[Hons] - now PhD student, Melbourne Neuropsychiatry Centre, University of Melbourne)
  • Longitudinal volumetry and shape analysis of the striatum in a cohort with leukoaraiosis - a pilot study - 2014 (MPhil [ANU] - A/Prof Matthew Macfarlane, BHB, MBChB, FRANZCP, Clinical Associate Professor, University of Wollongong Graduate School of Medicine - with the EU, Karolinska Institute & University of Melbourne - RANZCP Early Psychiatrist Career Award 2014)
  • Striatal morphology and clinical correlates in Parkinson's disease -2014 (Master of Neuroscience-Research [JCSMR, ANU]  - Mr Conor Owens-Walton, BA, BSc [Psychol, Internat. Relations] - with Lund University & University of Melbourne - Research Scholarship 2014)

PhD

  • PhD cum laude: Un estudio de neuroimagen en Trastornos de la Conducta Alimentaria: análisis del procesamiento emocional en relación con los antecedentes traumáticos (A neuroimaging study of eating disorders: analysis of emotional processing in relation to traumatic events) - 2014 (co-director for Complutense University Madrid, PhD - Dr Rosa Molina-Ruiz, MD, Consultant Psychiatrist & Clinical Academic)
  • Motor electrophysiology and striatal morphology in Huntington disease (co-supervisor for ANU, PhD - 2016 - Dr Lauren Turner BSc (Psychol) [Hons], MChD student, ANU [currently]; Registered Psychologist & Medical Student)

Past student projects

Selected MBBS Research Projects (20+ students supervised since 2004)

  • Caudate nucleus volumes in stroke and vascular dementia (Drs Vanessa Tatham and Ellen Millard - MBBS Research Project)
  • Validation of manual segmentation protocol for the putamen for MRI (Dr Huong Nguyen - MBBS Research Project)
  • Caudate nucleus volumes in eating disorders (Ms Lujing Liu - MBBS Research Project)
  • Structural-functional correlative neuroimaging of temporal lobe epilepsy - hippocampal morphology (MBBS Research Project, Mr Jae-Gon Yoo)
  • Structural-functional correlative neuroimaging in a neurodegenerative disease cohort - caudate nucleus morphology (MBBS Research Project, Mr Sam Norman)
  • Structural-functional correlative neuroimaging of progressive supranuclear palsy - thalamic morphology (MChD Research Project, Mr Mitchell Hunter-Dickson - with Lund University & University of Melbourne)

Vacation Scholars

  • Bicaudate and other subcortical measurement profiles on MRI as clinical translational diagnostic aids in neurodegenerative disease - (Mr Conor Owens-Walton - Canberra Hospital PPF Vacation Scholarship)
  • Structural-functional correlative neuroimaging of PSP - striatal morphology (Ms Suhaila Kamrani & Ms Carla Borg-Caruana - Canberra Hospital PPF Vacation Scholarship)
  • Striatal volumes in Niemann-Pick C Disease (Mr Vivek Baskaran - Canberra Hospital Private Practice Fund Vacation Scholarship)
  • Cerebellar vermis volumes in progressive supranuclear palsy (Ms Sandy Ye-Gi Kim - Canberra Hospital Private Practice Fund Vacation Scholarship)
  • Reliability of Hippocampal Segmentation in MRI for Temporal Lobe Epilepsy (Mr Jae-Gon Yoo - Canberra Hospital Private Practice Fund Vacation Scholarship)

Publications

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Updated:  16 November 2019 / Responsible Officer:  Director (Research Services Division) / Page Contact:  Researchers