Associate Professor Rachel W. Li
MD, PhD.
Associate Professor, Group Leader, Trauma and Orthopaedic Research Laboratory
ANU College of Health and Medicine
Areas of expertise
- Orthopaedics 110314
- Biomaterials 090301
- Rheumatology And Arthritis 110322
- Pharmacology And Pharmaceutical Sciences 1115
- Immunology Not Elsewhere Classified 110799
Biography
Short Bio: Associate Professor Rachel W. Li was a clinician, liver diseases specialist. She created an Endoscopic Drug Delivery device which was used in the stomach and liver cancer patients with acute haemorrhage. She received a National Innovation Award from Chinese Medical Association. She completed PhD in Southern Cross University and postdoctoral fellowship in USA, then an Assistant Professor of Clinical Pathology, University of Hawaii. She started her laboratory research focusing on the interplay among orthopaedic implant, bone and immune system after returning to Australia. She pinioned orthopaedic laboratory research in ACT region, which has not only produced high level science and emerging scientists, but all resulted in her being awarded funding from ARC, NHMRC, and CORE.
Researcher's projects
Osteo-immunology: Interplay of osteoblasts and inflammatory cells in primary and revision total joint arthroplasty
Clinical trial: athrofibrosis - interplay of ECM fibroblasts with inflammatory cells post total knee arthroplasty
Personalised medicine: Exosome miRNAs as regulators of mRNAs in osteolysis of the patients undergoing revision total joint replacement.
Bio material development: Biomimetic gels for co-growth of osteoblasts and osteoclasts
Bio material development: Magnesium alloys for biodegradable, resorbable and antibacterial implants. This project requires in vitro and in vivo experiment.
Available student projects
- Biomaterials, metal and polyethylene, for orthopaedic implants in vitro testing
- Biomaterials for orthopaedic implants preclinical trial (surgery) in vivo on medium/large animals
- Patient recruitment, sampling and mRNA and miRNA sequencing (for clinical PhD researchers)
- Natural compounds in vitro testing for anti-inflammatory and antibacterial activity
Current student projects
The osseointegration and antimicrobial properties of AgSrPO4Mg
Circulating miRNA and osteolysis around hip and knee arthroplasty
Bioresorbable metals for osteosynthesis in maxillofacial surgery
Athrofibrosis - interplay of ECM fibroblasts with inflammatory cells post total knee arthroplasty
Publications
- Song, M, Li, R, Qiu, Y et al. 2022, 'Gallium-Strontium Phosphate Conversion Coatings for Promoting Infection Prevention and Biocompatibility of Magnesium for Orthopedic Applications', ACS Biomaterials Science & Engineering, vol. 8, pp. 2709 - 2723.
- Diggle, B, Jiang, Z, Li, R et al. 2021, 'Self-Healing Polymer Network with High Strength, Tunable Properties, and Biocompatibility', Chemistry of Materials, vol. 33, no. 10, pp. 3712ââ¬â3720.
- Deng, Y, Li, R, Yang, Y et al. 2021, 'Pharmacological prevention of renal ischemia-reperfusion injury in a rat model', ANZ Journal of Surgery, vol. 92, no. 3, pp. 518-525.
- Chai, Y, Chen, X, Zhang, D et al. 2020, 'Laser polished fused deposition poly-lactic acid objects for personalized orthopaedic application', SN Applied Sciences, vol. 2, pp. 1-10.
- Li, R, Deng, Y, Pham, H et al. 2020, 'Riluzole protects against skeletal muscle ischaemia-reperfusion injury in a porcine model', Injury: international journal of the care of the injured, vol. 51, pp. 178-184.
- Ratnadiwakara, M, Rooke, M, Ohms, S et al. 2019, 'The SuprMam1 breast cancer susceptibility locus disrupts the vitamin D/ calcium/ parathyroid hormone pathway and alters bone structure in congenic mice', Journal of Steroid Biochemistry and Molecular Biology, vol. 188, pp. 48-58.
- Lee, S, Mastronardi, C, Li, R et al 2019, 'Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats', Translational Psychiatry, vol. 9, no. 10, pp. 1-12.
- Song, M, Zeng, R, Ding, Y et al 2019, 'Recent advances in biodegradation controls over Mg alloys for bone fracture management: A review', Journal of Materials Science and Technology, vol. 35, no. 4, pp. 535-544pp.
- Smith, P, Yang, Y, Weiss, S et al. 2018, 'Surgical Technique for Establishment of a Multiple-Organ Ischemia and Reperfusion (I/R) Injury Model in Rat ', Journal of Orthopedics and Muscular System Research, vol. 2018, no. 01.
- Lin, D & Li, R 2018, 'Natural Products Targeting Inflammation Processes and Multiple Mediators', in C M Subhash (ed.), Natural Products and Drug Discovery: An Integrated Approach, Elsevier, Netherlands, pp. 277-308pp.
- Chai, Y, Li, R, Perriman, D, Chen, S, Qin QH, et al 2018, 'Laser polishing of thermoplastics fabricated using fused deposition modelling', International Journal of Advanced Manufacturing Technology, vol. 96, no. 9-12, pp. 4295-4302.
- Chen, W, Foo, S, Zaid, A et al 2017, 'Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation', Nature Microbiology, vol. 2, no. 10, pp. 1435-1445.
- Chen, S, Lee, C, Li, R, Smith, P, Qin QH, 2017, 'Modelling osteoblast adhesion on surface-engineered biomaterials: optimisation of nanophase grain size', Computer Methods in Biomechanics and Biomedical Engineering, vol. 20, no. 8, pp. 905-914.
- Ding, Y, Li, R, Nakai, M et al 2016, 'Osteoanabolic Implant Materials for Orthopedic Treatment', Advanced Healthcare Materials, vol. 5, no. 14, pp. 1740-1752pp..
- Chen, W, Foo, S, Li, R et al 2014, 'Osteoblasts from osteoarthritis patients show enhanced susceptibility to Ross River virus infection associated with delayed type I interferon responses', Virology Journal, vol. 11, no. 189, pp. 189-189.
- Li, R, Patel, H, Perriman, D et al 2014, 'MICRORNA PROFILING IN WEAR PARTICLE ASSOCIATED OSTEOLYSIS', Bone and Joint Journal, vol. 96-B, no. SUPP 11 43.
- Chen, W, Foo, S, Rulli, N et al. 2014, 'Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 16, pp. 6040-6045.
- Li, R, Kirkland, N, Truong, J et al 2014, 'The influence of biodegradable magnesium alloys on the osteogenic differentiation of human mesenchymal stem cells', Journal of Biomedical Materials Research. Part A, vol. 102, no. 12, pp. 4346-4357.
- Chen, X, Nisbet, D, Li, R et al 2014, 'Controlling initial biodegradation of magnesium by a biocompatible strontium phosphate conversion coating', Acta Biomaterialia, vol. 10, no. 3, pp. 1463-1474.
- Lee, S, Mastronardi, C, Li, R et al 2013, 'Understanding the Long Term Effect of Weight Gain Induced By Short Term Exposure of Antidepressants', Endo 2013, The Endocrine Society, Chevy Chase, Maryland, pp. 1pp.
- Li, M, Zhang, Q, Liu, L et al 2013, 'Expression of the Mismatch Repair Gene hMLH1 Is Enhanced in Non-Small Cell Lung Cancer with EGFR Mutations', PLOS ONE (Public Library of Science), vol. 8, no. 10, pp. e78500-e78500.
- Noret, M, Herrero, L, Rulli, N et al 2012, 'Interleukin 6, RANKL, and Osteoprotegerin Expression by Chikungunya Virus-Infected Human Osteoblasts', Journal of Infectious Diseases, vol. 206, no. 3, pp. 455-U183.
- Fisher, A, Southcott, E, Li, R et al 2011, 'Serum resistin in older patients with hip fracture: Relationship with comorbidity and biochemical determinants of bone metabolism', Cytokine, vol. 56, no. 2, pp. 157-166.
- Yang, Y, Fu, B, Li, R et al 2011, 'Anterior single screw fixation of odontoid fracture with intraoperative Iso-C 3-dimensional imaging', European Spine Journal, vol. 20, no. 11, pp. 1899-1907.
- Lin, G, Li, R, Myersc, S et al 2008, 'A method of selecting plants with anti-inflammatory potential for pharmacological study', Natural Product Communications, vol. 3, no. 1, pp. 71-76.
- Pal, N, Quah, B, Smith, PN, Gladkis, LL, Timmers H, Li, RW. 2011. Nano-osteoimmunology as an important consideration in the design of future implants. Acta Biomaterialia, vol. 7, no. 7, pp. 2926-2934.
- Yang YL, Fu BS, Li RW, Smith PN, Mu WD, Li LX, Zhou DS. 2011. Anterior single screw fixation of odontoid fracture with intraoperative iso-C 3-dimensional imaging. Eur Spine J, Published online, June 04
- Smith PN, Freeman C, Yu D, Chen M, Gatenby PA, Parish CR, Li RW. 2010. Heparanase in primary human osteoblasts. J Orthop Res, 28:1315-1322.
- Gladkis LG, Li RW, Scarvell JM, Smith PN, Timmers H. 2009. Exploration of the size, shape and abundance of UHMWPE wear particles using atomic force microscopy. Wear, 267:632-638.
- Li M, Liu L, Liu Z, Yue S, Zhou L, Zhang Q, Cheng S, Li RW, Smith PN, Lu S. 2009. The status of KRAS mutations in patients with non-small cell lung cancers from mainland China. Oncol Rep, 22:1013-1020.
- Xu Q, Yuan Y, Sun LP, Gong YH, Xu Y, Yu XW, Dong NN, Lin GD, Smith PN, Li RW. 2009. Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism. Int J Oncol, 35:1313-1320.
- Li RW, Freeman C, Yu D, Hindmarsh EJ, Tymms KE, Parish CR, Smith PN. 2008. Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis. Arthritis Rheum, 58:1590-1600.
- Lin GD, Li RW, Myers SP, Leach DN. 2008. A method of selecting plants with anti-inflammatory potential for pharmacological study. Nat Prod Commun, 3:71-76.
- Smith PN, Leditschke A, McMahon D, Sample RR, Perriman D, Prins A, Brussel T, Li RW. 2008. Monitoring and controlling intramedullary pressure increase in long bone instrumentation: a study on sheep. J Orthop Res, 26:1327-1333.
- Smith, P, Perriman, D, Sample, R et al 2007, 'An Effective Method of Monitoring and Controlling Intramedullary Pressure Increase during Instrumentation', Injury Extra, vol. 38, pp. 422-426.
- Seely D, Kennedy DA, Myers SP, Cheras PA, Lin D, Li R, Cattley T, Brent PA, Mills E, Leonard BJ. 2007. In vitro analysis of the herbal compound Essiac. Anticancer Res, 27:3875-3882.
- Li, R, Theriault, A, Au, K et al 2006, 'Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters', Life Sciences, vol. 79, no. 4, pp. 365-373.
- Li, R, Lin, D, Leach, D et al 2006, 'Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae)', Journal of ethnopharmacology, vol. 104, pp. 138-143.
- Li, R, Douglas, T, Maiyoh, G et al 2006, 'Green tea leaf extract improves lipid and glucose homeostasis in a fructose-fed insulin-resistant hamster model', Journal of ethnopharmacology, vol. 104, pp. 24-31.
- Li, R, Leach, D, Myers, S et al 2004, 'A new anti-inflammatory glucoside from Ficus racemosa', Planta Medica, vol. 70, no. 5, pp. 421-426.
- Li, R, Myers, S, Leach, D et al 2004, 'Anti-inflammatory activity, cytotoxicity and active compounds of Tinospora smilacina', Phytotherapy Research, vol. 18, no. 1, pp. 78-83.
- Casaschi, A, Maiyoh, G, Rubio, B et al 2004, 'The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells', Journal of Nutrition, vol. 134, no. 6, pp. 1340-6.
- Li, R, Lin, D, Myers, S et al 2003, 'Anti-inflammatory activity of Chinese medicinal vine plants', Journal of ethnopharmacology, vol. 85, no. 1, pp. 61-67.
- Li, R, Myers, S, Leach, D et al 2003, 'A cross-cultural study: anti-inflammatory activity of Australian and Chinese plants', Journal of ethnopharmacology, vol. 85, no. 1, pp. 25-32.
- Li, R, Lin, G & Myers, S 2001, 'In vitro Cytotoxicity of Anti-inflammatory Vine Plants. P3E26 (abstract)', Toxicology, vol. 164, no. 1-3, pp. 172-3.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Friction Stir Hybrid Machine for Welding, Processing and 3D Printing (Secondary Investigator)
- Novel biomarkers for arthrofibrosis after total knee arthroplasty (TKA) (Primary Investigator)
- NHMRC Equipment Grant 2021: Colony Counter and Spiral Plating System - Linked to ARIES ID 39296 (Secondary Investigator)
- Bioinspired artificial tissues for trauma injury - skin, ligament and cartilage repair (Primary Investigator)
- Orthopaedic Biological Research Grant Fund (Primary Investigator)
- ARC Training Centre for Multiscale 3D Imaging, Modelling and Manufacturing (Secondary Investigator)
- Research Consultancy Service Agreement 2018 (Primary Investigator)
- Surface modifications to prevent infection and promote osseointegration of orthopaedic implants (Secondary Investigator)
- Functional Strontium Phosphate Coated Magnesium Alloys For Orthopaedic Use (Secondary Investigator)
- Novel Insights into the Pathobiology of Alphavirus Infections (Secondary Investigator)
- Osteomics: A breakthrough integrated research system using mathematical and computational methods to replace animal models of human bone disease and bone repair (Secondary Investigator)
- Dendritic Cell Activation by Nanoparticles of Ultra-high Molecular Weight Polyethylene (UHMWPE) - How and Why (Secondary Investigator)
- Does A New Formula, Combination of Heparanase and OP-1, Synergistically Promote Bone Growth? Running Title: Synergistic effect of heparanase and OP-1 (Secondary Investigator)
