Areas of expertise
- Infectious Agents 060502
- Bacteriology 060501
- Receptors And Membrane Biology 060110
- Basic Pharmacology 111501
- Enzymes 060107
- Medical Parasitology 110803
Publications
- Lopes, E, Mestre, R, Fontinha, D et al. 2022, 'Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity', European Journal of Medicinal Chemistry, vol. 236.
- Qiu, D, Pei, J, Rosling, J et al. 2022, 'A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin', Nature Communications, https://www.nature.com/articles/s41467-022-33403-9
- Tse, E, Aithani, L, Anderson, M et al. 2021, 'An open drug discovery competition: Experimental validation of predictive models in a series of novel antimalarials', Journal of Medicinal Chemistry, 64, 16450-16463.
- Zeng, J, Hapuarachchi, S, Shafik, S et al. 2021, 'Identifying the major lactate transporter of Toxoplasma gondii tachyzoites', Scientific Reports, 11, 1-11.
- Gilson, P, Kumarasingha, R, Thompson, J et al. 2019, 'A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4', Scientific Reports, 9, 1-15.
- Lehane, A, Dennis, A, Bray, K et al. 2019, 'Characterization of the ATP4 ion pump in Toxoplasma gondii', Journal of Biological Chemistry, 294, 5720-5734.
- Lawrence, N, Dennis, A, Lehane, A et al 2018, 'Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption', Cell Chemical Biology, vol. 25, pp. 1140-1150pp.
- Uboldi, A, Wilde, M, McRae, E et al 2018, 'Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii', PLoS Biology, vol. 16, no. 9, pp. 1-32.
- Dennis, A, Lehane, A, Ridgway, M et al. 2018, 'Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials', Antimicrobial Agents and Chemotherapy, 62, 1-17.
- Dennis, A, Rosling, J, Lehane, A et al. 2018, 'Diverse antimalarials from whole cell phenotypic screens disrupt malaria parasite ion and volume homeostasis', Scientific Reports, 8, 1-15.
- Rosling, J, Ridgway, M, Summers, R et al 2018, 'Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes', Journal of Biological Chemistry, 293, 13327-13337.
- McCoy, J, Stewart, R, Uboldi, A et al 2017, 'A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii', Journal of Biological Chemistry, vol. 292, no. 18, pp. 7662-7674pp.
- Hapuarachchi, S, Cobbold, S, Shafik, S et al 2017, 'The malaria parasite's lactate transporter PfFNT is the target of antiplasmodial compounds identified in whole cell phenotypic screens', PLoS Pathogens, 13:e1006180. doi: 10.1371/journal.ppat.1006180
- Nakazawa Hewitt, S, Dranow, D, Horst, B et al 2016, 'Biochemical and structural characterization of selective allosteric inhibitors of the Plasmodium falciparum drug target, Prolyl-tRNA-synthetase', ACS Infectious Diseases, 3, 34-44.
- Veiga, M, Dhingra, S, Henrich, P et al. 2016, 'Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies', Nature Communications, vol. 7, no. 11553.
- Richards, S (co-first author), Nash, M (co-first author), Baker, E et al 2016, 'Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter', PLoS Pathogens, vol. 12, no. 7.
- Van Schalkwyk, D (co-first author), Nash, M (co-first author), Shafik, S (co-first author) et al 2016, 'Verapamil-sensitive transport of quinacrine and methylene blue via the plasmodium falciparum chloroquine resistance transporter reduces the parasite's susceptibility to these tricyclic drugs', Journal of Infectious Diseases, vol. 212, no. 11, pp. 800-810.
- Van Voorhis, W, Adams, J, Adelfio, R et al 2016, 'Open source drug discovery with the Malaria Box compound collection for neglected diseases and beyond', PLoS Pathogens, 12: e1005763. doi:10.1371/journal.ppat.1005763
- Petersen, I, Gabryszewski, S, Johnston, G et al 2015, 'Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter', Molecular Microbiology, vol. 97, no. 2, pp. 381-395.
- Marchetti, R, Lehane, A, Shafik, S et al 2015, 'A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum'. Nature Communications, 6, 6721.
- Deane, K (co-first author), Summers, R (co-first author), Lehane, A, Martin R. E. (co-senior author), Barrow R. A (co-senior author). 2014, Chlorpheniramine analogues reverse chloroquine resistance in Plasmodium falciparum by inhibiting PfCRT, ACS Medicinal Chemistry Letters, 5, 576-581.
- Hrycyna, C, Summers, R, Lehane, A et al 2014, 'Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum', ACS Chemical Biology, 9, 722-730.
- Jimenez-Diaz, M, Ebert, D, Salinas, Y et al 2014, '(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium', Proceedings of the National Academy of Sciences USA, 111, E5455-E5462.
- Kirk, K & Lehane, A 2014, 'Membrane transport in the malaria parasite and its host erythrocyte', Biochemical Journal, 457, 1-18.
- Lehane, A, Ridgway, M, Baker, E et al 2014, 'Diverse chemotypes disrupt ion homeostasis in the malaria parasite', Molecular Microbiology, 94, 327-339.
- Teng, R, Lehane, A, Winterberg, M et al 2014, '1H-NMR metabolite profiles of different strains of Plasmodium falciparum', Bioscience Reports, 34, 685-699.
- Ecker, A, Lehane, A & Fidock, D 2012, 'Molecular markers of Plasmodium resistance to antimalarials', in Henry M. Staines, Sanjeev Krishna (ed.), Treatment and Prevention of Malaria. Antimalarial Drug Chemistry, Action and Use, Springer, Basel, pp. 249-280.
- Ecker, A, Lehane, A, Clain, J et al 2012, 'PfCRT and its role in antimalarial drug resistance', Trends in Parasitology, vol. 28, no. 11, pp. 504-514.
- Lehane, A, McDevitt, C, Kirk, K et al 2012, 'Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?', International Journal for Parasitology: Drugs & Drug Resistance, 2, 47-57.
- Lehane, A, Van Schalkwyk, D, Valderramos, S et al 2011, 'Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT', Antimicrobial Agents and Chemotherapy, 55, 2310-2318.
- Henry, R, Cobbold, S, Allen, R et al 2010, 'An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum', Journal of Biological Chemistry, 285, 18615-18626.
- Lehane, A & Kirk, K 2010, 'Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT', Molecular Microbiology, 77, 1039-1051.
- Saliba, K, Lehane, A & Kirk, K 2008, 'A polymorphic drug pump in the malaria parasite', Molecular Microbiology, vol. 70, no. 4, pp. 775-779.
- Lehane, A & Saliba, K 2008, 'Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite', BMC Research Notes, vol. 1, no. 26, p. 5.
- Lehane, A, Hayward, R, Saliba, K et al 2008, 'A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites', Journal of Cell Science, vol. 121, no. 10, pp. 1624-1632.
- Lehane, A & Kirk, K 2008, 'Chloroquine-resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.', Antimicrobial Agents and Chemotherapy, vol. 52, no. 12, pp. 4374-4380.
- Lehane, A, Marchetti, R, Spry, C et al 2007, 'Feedback Inhibition of Pantothenate Kinase Regulates Pantothenol Uptake by the Malaria Parasite', Journal of Biological Chemistry, vol. 282, no. 35, pp. 25395-25405.
- Lehane, A, Korres, H & Verma, N 2005, 'Bacteriophage-encoded glucosyltransferase Gtrll of Shigella flexneri: membrane topology and identification of critical residues', Biochemical Journal, vol. 389, pp. 137-143.
- Lehane, A, Saliba, K, Allen, R et al 2004, 'Choline uptake into the malaria parasite is engergized by the membrane potential', Biochemical and Biophysical Research Communications, vol. 320, no. 2, pp. 311-317.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- How do apicomplexan parasites steal amino acids from their hosts? (Secondary Investigator)
- PfATP4 screening - A pH-based 'fingerprint' screen to simultaneously identify inhibitors of multiple validated and potential antimalarial drug targets (Primary Investigator)
- Understanding high-level resistance to antimalarial PfATP4 inhibitors (Primary Investigator)
- Determining the mechanistic basis of the patterns of inverse drug susceptibility induced by two key drug resistance proteins of the malaria parasite. (Secondary Investigator)
- Ion regulation in Apicomplexan parasites (Primary Investigator)
- PfATP4 Compounds Screening (Secondary Investigator)
- Factors affecting the susceptibility of the malaria parasite to quinoline drugs (Primary Investigator)