Dr Woei Ming Steve Lee

Postdoc-Biomed (Harvard Med Sch), PhD - Optics (St Andrews Uni), B.Eng- EE (Nanyang Tech Uni)
Group Leader
College of Health & Medicine
T: +6126125 6166

Areas of expertise

  • Biological Physics 029901
  • Medical Physics 029903
  • Fluidisation And Fluid Mechanics 091504
  • Optical Physics 0205
  • Biomedical Instrumentation 090303
  • Biomedical Engineering 0903
  • Photonics, Optoelectronics And Optical Communications 020504
  • Medical Biotechnology Diagnostics (Incl. Biosensors) 100402
  • Cardiovascular Medicine And Haematology 1102

Research interests

Imaging science and technology, much like data science, is increasingly important in discovery and quantification of many field of biological and medical sciences.

My team's expertises in machine learning (HoloUNET) "Restore a hologram to close to perfect condition at almost pitch black at sub-millisecond imaging speeds -featured in Laser Focus World’s ‘Top 20 inventions in 2020’) alongside with Coded Lightsheet from HKU, computational super resolution SOFI - EPFL, Single molecule 1 nm localisation- UNSW.

Steve leads the ANU Optical Biofluidics Imaging Group that looks to develop and apply novel optical imaging techniques and instruments for biofluidic sciences. Biological fluidic flows in vasculature, microfluidics and in the interstitial space possess important physical traits that drive cellular mechanics and tissue remodelling. Steve's interest is to unravel hidden biological fluidic transport and 4D cellular network in the extracellular matrix (ECM), cellular networks and platelet aggregates using advanced bioimaging tools, especially in the interstitial spaces that is largely unknown. His group's work has been reported interdisciplinary biomethods journals such as Nature Protocols, Lab On Chip, Biophys J, Cell, Biomed Opt Exp, Blood Advances, Sci Rep, Advanced Biosyst as well as specialised physical sciences journals such Opt Lett, Physical Review A, Opt Express, App Phys Lett etc.

Steve has assembled a team of multi-disciplinary imaging scientists (optics, biochemistry, machine learning) that can build cutting edge 4D, 5D optical microscopy tools  (non-commerically available) so as to tailor each to investigate fluid flow in a biological relevant models (microfluidics, organiods and mice model). For example, his team developed Raster Adaptive Optics (RAO, patent pending- 2019904929) formed the basis for 2x National in vivo Imaging Initiatives (ACRF InCite and ARC-LIEF) to study immune and cancer cells in ECM in mice models. His label-free high resolution imaging of blood thrombus (COSI) is used by National Platelet Referral Centre for early diagnosis in embolisment using microchips.

Video summary: https://youtu.be/N6NryTr-5fU 

Biography

As an interdisciplinary imaging scientist, Steve completed undergraduate training in Electronics Engineering at the Nanyang Tech University (Singapore) and a PhD in Optics at the University of St Andrews (UK) with Kishan Dholakia and Ewan Wright. From 2010-2012, his postdoctoral fellowship was on bioimaging (NIH, NCI-PSOC) at Harvard Medical School (USA) with Seok-Hyun Andy Yun, that is followed a Vice Chancellor Fellowship (UNSW- NanoOptics). Prior to his PhD studies, Steve developed commercial laser instruments (Einst Tech Pte Ltd)  

As a highly collaborative biomedical imaging scientist, he developed wide collaborative network across medical biosciences and imaging scientists. His interdisciplinary work have been reported biomethod journals: Nature Protocol, Lab On Chip, Biophys J, Cell, Biomed Opt Exp, Blood Advances, Sci Rep, Advanced Biosyst. More notably, his 2014 ANSTO Eureka Prize was awarded for the development of low cost elastomer optics for mobile microscopy. Since 2015, he was awarded major advanced bioimaging project grants with total amount ~ $16.3 million; as ANU lead-Chief Investigator- on major competitive project grants (ARC, NHMRC, Industry) ~ $2.67 million, as co-Chief Investigator (ACRF, ARC, Industry) worth $3.85 million and participant (industry) ~ $8.75 million. In 2021, he is the Director of Technology and a Chief Investigator of ACRF (InCite) Centre and will serve on the Advisory Editorial Board of Biomicrofluidics-AIP.  

As an educator, he was a finalist for 2015 ANU Last lecture finalist- nominated by student society, convenor of Biomedical Imaging and ANU MIT-Harvard (HST)-BioOptics summer school from 2014-2018. He has trained >30 junior researchers (postdoc, PhD, honours).

As a communicator, he delivered invited oral presentations at over 20 international and national conferences, as invited, plenary, keynote, public lectures organised by Google, ANSTO, Royal Society-NSW, TedXCanberra and Optical Societies (OSA, EOS, AOS) and Fraunhofer institute and Czech Academy of Sciences. His work received media coverage in TIME, ABC News, Sunrise (Ch7) ,SMH, The Australian, CBS News and Smithsonian.  

Researcher's projects

oBIGGoogle Scholar , ORCID

  1. Imaging Science for biomedicine: develop new imaging tools for life Science
  2. Biofluidic Imaging: cellular morphodynamics (cell adhesion, trafficking, migration) under fluid shear  

Available student projects

Highly motivated students with keen interest in interdisciplinary imaging research are welcome to join our highly multidisciplinary and growing research laboratory at the Australian National University to invent, develop new optical imaging solutions to discover new molecular and structural mechanisms of blood cells trafficking, aggregate, migrate under fluid shear 

 

Current student projects

  • ANU Imaging Scientist (to be filled)
  • Dr Daniel Lim - ANU BioImaging Postdoctoral FellowAdvanced 4D Imaging of blood cells, Collaborator – Gardiner, JCSMRPhan, Garvan
  • Ms Yujie Zheng- PhD student, Label- Free Multimodal Biofluidic Imaging Collaborator – Gardiner, JCSMR
  • Mr Avinash Upadhya- PhD studentStructured beams for super-res nanoscopy Collaborator – Shroff NIH
  • Mr Tienan Xu- PhD student,  Novel Lightsheet Imaging, Collaborator – Gaus UNSW
  • Mr Zhiduo Zhang- Research AssistantMachine learning for Microscopy, Collaborator – Xie, CS
  • Mr Hanqi Lin - Honour student, Advanced image deconvolution,
  • Mr Junxiang Zhang- Visiting Research studentImmersive Display Technology for Optical Holograms

Past student projects

Junior Research Staff (Supervisor)

2017 - 2020:     Mr Tao Xu ,                            Toyota Graduate Training Program    

2018 - 2019:     *Dr Yuanqing (Alex) Ma ,        EMBO Fellow, Marseille France    

2017 - 2018:      Dr Samantha Montague,        Research Fellow,             

2016 - 2017:      Dr Roland Fleddermann,         Research Fellow,                          

2014 - 2015:      Mr Zijian Cen,                       Senior Product Analytics                              

Graduate students (Primary supervisor)

2015 -  2019:     Mr Yongxiao Li, PhD Candidate, Postdoctoral Researcher, Rockefeller Uni

2014 -  2018:     Miss Xuefei (Sherry) He, PhD Candidate  Imaging Engineer, HiSilicon

2014 -  2018:     Miss Tahseen Kamal, PhD Candidate Research Associate UNSW

2016 -  2017:    *Miss Wei Zhong, Master Student (Uni Twente, Netherlands)  Research Scientist, Science Sport

2013 -  2016:     Mr Niko Eckerskorn, PhD Candidate (Australian National University)  Analytics Engineer - CoreLogic RP Data

2015 -  2016:    *Mr Wengou Zhu, Visiting PhD candidate(Sun Yat University, China)        Lecturer

2014 – 2015:    *Mr Redmar Vileg, Visiting Master Student (Uni Twente, Netherlands) PhD student, Leiden Uni 

2013 – 2014:     Mr Huang Longyao, Master by Research  (Australian National University)

2013 – 2014:    *Miss Sjoukje Schoustra, Visiting Master Student (Uni Twente, Netherlands)   PhD student, Twente Uni

2013 – 2014 :   *Miss Li Li,Visiting PhD candidate(Sun Yat University, China) Research Engineering Huawei

Undergraduate

2018           :    *Ms Hui Wang Undergraduate, Tsinghua University

2017-  2018:     Mr Yonglin Ren

2017-  2017:     Mr Oliver Johnson, University Medal  | ANU-HST-MIT summer scholar

2016 - 2016 :    Ms Emily Campbell  Tillyard prize recipient | ANU-HST-MIT Summer scholar

2016-  2017:     Mr Tienan Xu  ANU-PhD student

2015 - 2016:     Mr Thomas McMenamin  ANU-MPhil student

2015 - 2016:     Mr Avinash Upadhya, University Medal  | ANU-HST-MIT summer scholar ANU-PhD student

2015 - 2016:     Mr Yang Lu  CSIRO-PhD student 

2015 - 2016:     Mr Tao Xu    ANU-MSc student

2014 - 2015:     Mr Misha Petkovic System Engineer, Seeing Machine

2015 - 2016      Miss Yi Du

2015 - 2016      Miss Yujie Zheng   ANU-PhD student

2015 - 2016      Mr Lyle Halliday,  University Medal, IET Medal  System Engineer, S Medical

2014 - 2015      Mr Zachary Shafron,  Honorable mention(undergraduate project) System Engineer, Thales

2013 –2015      Mr Avinash Upadhya, Yao Su Student Research Award ANU-PhD student

2014 2015      Ms Rachel Watkins,YouFab Global Creative Awards, Finalist Teacher (STEM)

2014 2015      Mr David Wright

2014 2015      Mr Jaden Rubstein

2014 –2015      Mr Zi Cen (Kenny) Senior Product Analytics Engineer ResMed

2014 2015      Mr Alan Harrison 

2013 2014      Miss Siti Mohd Shariaf   

* visiting

Publications

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

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Updated:  14 May 2021 / Responsible Officer:  Director (Research Services Division) / Page Contact:  Researchers