Professor Trevor Lamb
B.E. (Electronics, Melb.), Sc.D. (Physiology, Cantab.), FRS, FAA
Emeritus Professor of Neuroscience
College of Science
Areas of expertise
- Sensory Systems 110906
- Vision Science 111303
Research interests
Transduction and adaptation in vertebrate rod and cone photoreceptors.
Evolution of photoreceptors, the retina, and the eye.
Biography
Professor Trevor Lamb is Emeritus Professor of Neuroscience at the John Curtin School of Medical Research in the Australian National University. He obtained a degree in Electronic Engineering from the University of Melbourne, and then a PhD in Physiology from the University of Cambridge, where he remained for over 30 years before returning to Australia in 2003 as a Federation Fellow. His research involves the cellular and molecular mechanisms by which retinal rod and cone photoreceptors respond to light, and, more recently, the evolution of these cells and of our eye. His 77 publications have received over 6000 citations. He was elected a Fellow of the Royal Society in 1993, and a Fellow of the Australian Academy of Science in 2005, following his return to Australia. Despite taking early retirement in 2011, he actively continues his research.
Publications
- Lamb, T & Kraft, T 2020, 'A quantitative account of mammalian rod phototransduction with PDE6 dimeric activation: Responses to bright flashes', Open Biology, vol. 10.
- Lukowski, S, Lo, C, Sharov, A et al. 2019, 'A single-cell transcriptome atlas of the adult human retina', The EMBO Journal, vol. 38, no. 18, pp. 1-15.
- Lamb, T & Hunt, D 2018, 'Evolution of the calcium feedback steps of vertebrate phototransduction', Open Biology, vol. 8, 180119.
- Lamb, T, Heck, M & Kraft, T 2018, 'Implications of dimeric activation of PDE6 for rod phototransduction', Open Biology, vol. 8, 180076.
- Qureshi BM, Behrmann E, Schöneberg J et al. 2018, 'It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods', Open Biology, vol. 8, 180076.
- Lamb, T, Patel, H, Chuah, A et al 2018, 'Evolution of the shut-off steps of vertebrate phototransduction', Open Biology, vol. 8, 170232.
- Lamb, T & Hunt, D 2017, 'Evolution of the vertebrate phototransduction cascade activation steps', Developmental Biology, vol. 431, no. 1, pp. 77-92.
- Lamb, T, Patel, H, Chuah, A et al 2016, 'Evolution of Vertebrate Phototransduction: Cascade Activation', Molecular Biology and Evolution, vol. 33, no. 8, pp. 2064-2087.
- Lamb, T 2016, 'Why rods and cones?', Eye, vol. 30, no. 2, pp. 179-185pp.
- Lamb, T & Kraft, T 2016, 'Quantitative modeling of the molecular steps underlying shut-off of rhodopsin activity in rod phototransduction', Molecular Vision, vol. 22, pp. 674-696.
- Lamb, T, Corless, R & Pananlos, A 2015, 'The kinetics of regeneration of rhodopsin under enzyme-limited availability of 11-cis retinoid', Vision Research, vol. 110, no. Part A, pp. 23-33.
- Lamb, T 2013, 'Evolution of phototransduction, vertebrate photoreceptors and retina', Progress in Retinal and Eye Research, vol. 36, pp. 52-119.
- Mahroo, O & Lamb, T 2012, 'Slowed recovery of human photopic ERG a-wave amplitude following intense bleaches: A slowing of cone pigment regeneration?', Documenta Ophthalmologica, vol. 125, no. 2, pp. 137-147.
- Mahroo, O, Ban, V, Bussman, B et al 2012, 'Modelling the initial phase of the human rod photoreceptor response to the onset of steady illumination', Documenta Ophthalmologica, vol. 124, no. 2, pp. 125-131.
- Ruseckaite, R, Lamb, T, Pianta, M et al 2011, 'Human scotopic dark adaptation: Comparison of recoveries of psychophysical threshold and ERG b-wave sensitivity', Journal of Vision, vol. 11, no. 8, pp. 1-16.
- Vogalis, F, Shiraki, T, Kojima, D et al 2011, 'Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses', Journal of Physiology, vol. 589, no. 9, pp. 2321-2348.
- Lamb, T 2011, 'Evolution of the eye. Scientists now have a clear vision of how our notoriously complex eye came to be.', Scientific American, vol. 305, no. 1, pp. 64-69.
- Lamb, T 2009, 'Evolution of vertebrate retinal photoreception', Philosophical Transaction of the Royal Society: B- Biological Sciences, vol. 364, no. 2009, pp. 2911-2924.
- Lamb, T, Arendt, D & Collin, S, eds, 2009, The evolution of phototransduction and eyes, 364.
- Cameron, A, Miao, L, Ruseckaite, R et al 2008, 'Dark adaptation recovery of human rod bipolar cell response kinetics estimated from scotopic b-wave measurements', Journal of Physiology, vol. 586, no. 22, pp. 5419-5436.
- Lamb, T, Pugh, E & Collin, S 2008, 'The origin of the vertebrate eye', Evolution: Education and Outreach, vol. 1, no. 4, pp. 415-426.
- Lamb, T, Collin, S & Pugh, E 2007, 'Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup.', Nature Reviews Neuroscience, vol. 8, no. (December), pp. 960-975.
- Cameron, A, Mahroo, O & Lamb, T 2006, 'Dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogram', Journal of Physiology, vol. 575, no. 2, pp. 507-526.
- Lamb, T & Pugh, E 2006, 'Phototransduction, dark adaption, and rhodopsin regeneration', Investigative Ophthalmology and Visual Science, vol. 47, no. 12, pp. 5138-5153.
- van Hateren, J & Lamb, T 2006, 'The photocurrent response of human cones in fast and monophasic', BMC Neuroscience, vol. 7, no. 34, pp. 1-8.
- Hamer, R, Nicholas, S, Tranchina, D et al 2005, 'Towards a unified model of verebrate rod phototransduction', Visual Neuroscience, vol. 22, pp. 417-436.
- Kenkre, J, Moran, N, Lamb, T et al 2005, 'Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposures', Journal of Physiology, vol. 567, no. 1, pp. 95-112.
- Jaervinen, J & Lamb, T 2005, 'Inverted photocurrent responses from amphibian rod photoreceptors: role of membrane voltage in response recovery', Journal of Physiology, vol. 566, no. 2, pp. 455-466.
- Wenzel, A, Oberhauser, V, Pugh, E et al 2005, 'The Retinal G Protein-coupled Receptor (RGR) Enhances Isomerohydrolase Activity Independent of Light', Journal of Biological Chemistry, vol. 280, no. 33, pp. 29874-29884.
- Lamb, T & Burns, M 2004, 'Visual transduction by rod and cone photoreceptors', in Leo Chalupa & J.S.Werner (ed.), The Visual Neurosciences, MIT Press, Cambridge, USA, pp. 215-233.
- Lamb, T & Pugh, E 2004, 'Dark adaptation and the retinoid cycle of vision', Progress in Retinal and Eye Research, vol. 23, no. 3, pp. 307-380.
- Mahroo, O & Lamb, T 2004, 'Recovery of the human photopic electroretinogram after bleaching exposures: estimation of pigment regeneration kinetics', Journal of Physiology, vol. 554, no. 2, pp. 417-437.
- Friedburg, C, Allen, C, Mason, P et al 2004, 'Contribution of cone photoreceptors and post-receptoral mechanisms to the human photopic electroretinogram', Journal of Physiology, vol. 556, no. 3, pp. 819-834.
- Hamer, R, Nicholas, S, Tranchina, D et al 2003, 'Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses', Journal of General Physiology, vol. 122, no. 4, pp. 419-444.
- Arshavsky, V, Lamb, T & Pugh, E 2002, 'G Proteins and Phototransduction.', Annual Review of Physiology, vol. 64, pp. 153-187.
- Friedburg, C, Thomas, M & Lamb, T 2001, 'Time course of the flash response of dark-and-light adapted human rod photoreceptors derived from the electroretinogram', Journal of Physiology, vol. 534, no. 1, pp. 217 - 242.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Comprehensive quantification of cone dynamics (Secondary Investigator)
- Short-term adaptations in photoreceptors - CFDA 93.687 (Primary Investigator)
- The evolution of light detection and its impact on early vertebrate evolution (Secondary Investigator)
