Dr Farzaneh Kordbacheh
Research interests
- Characterising and elucidating the mode of action of polyanions that can neutralise the cytotoxic properties of histones involved in neutrophil extracellular traps (NETs) formed in response to pathogens and tissue injury.
- Cancer Immunotherapy.
Biography
Dr Farzaneh Kordbacheh is an early career researcher in Cancer and Vascular Biology Group, ACRF Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research, ANU.
She completed her PhD at the Australian National University in 2013, on a joint project between Research School of Biology (Prof. Djordjevic) and John Curtin School of Medical Research (Prof. Parish), discovering angiogenic modulating small molecules from natural products using a bioassay-directed discovery approach. Using high resolution accurate mass spectrometry (LC-MS Q-TOF) and NMR data she was then able to elucidate the structure of two pro-angiogenic molecules. She then investigated the cellular mode of action of these molecules by looking at their effect on endothelial cell proliferation, migration, tube formation and adhesion to extra-cellular matrix components. These molecules may have therapeutic value where the formation of new blood vessels may be used to treat diseases, such as cardiovascular disease, and for wound healing.
During her first postdoctoral research experience in the Oral Oncology Research Program at the University of Queensland Centre for Clinical Research (UQCCR), she focused on identifying the molecular actions driving cancer development and progression under the direction of Prof. Farah. Farzaneh has analysed more than hundred whole transcriptome libraries from pre-cancerous and malignant oral lesions and utilised gene ontology enrichment in order to identify druggable target genes as well as developing a genomic diagnostic tool for early cancer detection. She has co-authored publications including original cancer research, an invited cancer review and an invited book chapter.
In early 2015, she went back to ANU to pursue her drug discovery journey under direction of Prof. Parish. Her current research interests include characterising and elucidating the mode of action of polyanions that can neutralise the cytotoxic properties of histones involved in neutrophil extracellular traps (NETs) formed in response to pathogens and tissue injury as well as cancer immunotherapy.
Farzaneh is also a member of Board of Directors and State Convener at the Australian Society for Madical Research (ASMR), CHM Early Career Academic Staff Development Committee member and NECTAR custodian.
Researcher's projects
- Characterising and elucidating the mode of action of polyanions that can neutralise the cytotoxic properties of histones involved in neutrophil extracellular traps (NETs) formed in response to pathogens and tissue injury.
- Cancer Immunotherapy.
Publications
- Momeny, M, Esmaeili, F, Hamzehlou, S et al 2019, 'The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells', Cellular oncology (Dordrecht), vol. 42, no. 4, pp. 491-504.
- Kordbacheh, F, Carruthers, T, Orlov, A et al 2018, 'Promotion of mammalian angiogenesis by neolignans derived from soybean extracellular fluids', PLOS ONE (Public Library of Science), vol. 13, no. 5, pp. 21pp.
- Kordbacheh, F, O'Meara, C, Coupland, L et al 2017, 'Extracellular histones induce erythrocyte fragility and anemia', Blood, vol. 130, no. 26, pp. 2884-2888.
- Buckler, J, Banwell, M, Kordbacheh, F et al 2017, 'Developing neolignans as proangiogenic agents: Stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4'-coniferyl ethers', ACS Omega, vol. 2, no. 10, pp. 7375-7388.
- Kordbacheh, F, Bhatia, N & Farah, C 2016, 'Patterns of differentially expressed genes in oral mucosal lesions visualised under autofluorescence (VELscope (TM))', Oral Diseases, vol. 22, no. 4, pp. 285-296.
- Farah, C, Dalley, A, Nguyen, P et al 2016, 'Improved surgical margin definition by narrow band imaging for resection of oral squamous cell carcinoma: A prospective gene expression profiling study', Head and Neck, vol. 38, no. 6, pp. 832-839.
- Farah, C, Jessri, M, Kordbacheh, F et al 2015, 'Next-generation sequencing applications in Head and Neck Oncology', in Wei Wu and Hani Choudhry (ed.), Next Generation Sequencing in Cancer Research, Volume 2. From Basepairs to Bedsides, Springer International Publishing Switzerland, Switzerland, pp. 401-422.
- Djordjevic, M, Orlov, A, Susanti, . et al 2014, 'Lipo-chitin oligosaccharides, plant symbiosis signalling molecules that modulate mammalian angiogenesis in vitro', PLOS ONE (Public Library of Science), vol. 9, no. 12, pp. e112635-e112635.
- Buer, C, Kordbacheh, F, Truong, T et al 2013, 'Alteration of flavonoid accumulation patterns in transparent testa mutants disturbs auxin transport, gravity responses, and imparts long-term effects on root and shoot architecture', Planta, vol. 238, no. 1, pp. 171-189.
- James, G, Hocart, C, Hillier, W et al. 2011, 'Fatty acid profiling of Chlamydomonas reinhardtii under nitrogen deprivation', Bioresource Technology, vol. 102, no. 3, pp. 3343-3351.
- Kordbacheh, F, Ofoghi, H, Akbarzadeh, A et al 2011, 'High level expression and chloroplast targeting of human calcitonin (hCT) in Transgenic tobacco plants', Transgenic Plant Journal, vol. 5, no. 1, pp. 57-61.
- Akbarzadeh, A, Kordbacheh, F, Jafari, M et al 2010, 'A Binary Vector for Agrobacterium Mediated Plant Transformation with New Glyphosate Tolerant Gene as a Selectable Marker', Biharean Biologist, vol. 4, no. 1, pp. 19-29.
