Professor Kiaran Kirk
Areas of expertise
- Microbiology 0605
- Biochemistry And Cell Biology 0601
Research interests
Kiaran's major research interests are in the biology of the malaria parasite, with a particular focus on the mechanism of action of, and mechanisms of resistance to, antimalarial drugs, and in the physiology of the (related) apicomplexan parasite Toxoplasma gondii.
Biography
Kiaran Kirk carried out his PhD in the Department of Biochemistry at the University of Sydney (1985-1988). In 1989 he went to the Oxford University Laboratory of Physiology where he held an Oxford Nuffield Medical Fellowship, the Staines Medical Research Fellowship (Exeter College) and a Lister Institute Senior Research Fellowship. He returned to Australia in 1996 to head the Department of Biochemistry and Molecular Biology in the ANU Faculty of Science, holding this post until June 2009 when he took up the position of Director of the newly-created ANU Research School of Biology. From 2014 to 2017 Kiaran served as the Dean of the ANU College of Medicine, Biology and Environment. Since August 2017 he has been Dean of the ANU College of Science.
Kiaran was elected a Fellow of the Australian Academy of Health and Medical Sciences (FAHMS) in 2017 and appointed Member of the Order of Australia (AM) in the 2023 Australia Day Honours.
Publications
- Qiu, D, Pei, J, Rosling, J et al. 2022, 'A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin', Nature Communications, https://www.nature.com/articles/s41467-022-33403-9
- Fairweather, S, Rajendran, E, Blume, M et al. 2021, 'Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii, PLoS Pathogens, 17, https://doi.org/10.1371/journal.ppat.1009835
- Rajendran, E, Clark, M, Goulart, C et al. 2021, 'Substrate-mediated regulation of the arginine transporter of Toxoplasma gondii', PLoS Pathogens, https://orcid.org/0000-0002-8036-9531
- Tse, E, Aithani, L, Anderson, M et al. 2021, 'An open drug discovery competition: Experimental validation of predictive models in a series of novel antimalarials', Journal of Medicinal Chemistry, 64, 16450-16463.
- Zeng, J, Hapuarachchi, S, Shafik, S et al. 2021, 'Identifying the major lactate transporter of Toxoplasma gondii tachyzoites', Scientific Reports, 11, 1-11.
- Rajendran, E, Kirk, K & van Dooren, G 2020, 'Measuring Solute Transport in Toxoplasma gondii Parasites', in Christopher J. Tonkin (ed.), Toxoplasma gondii: Methods and Protocols, Humana Press, New York, NY, pp. 245-268.
- Gilson, P, Kumarasingha, R, Thompson, J et al. 2019, 'A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4', Scientific Reports, 9, 1-15.
- Lehane, A, Dennis, A, Bray, K et al. 2019, 'Characterization of the ATP4 ion pump in Toxoplasma gondii', Journal of Biological Chemistry, 294, 5720-5734.
- Parker, K *, Fairweather, S *, Rajendran, E et al. 2019, 'The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family', PLoS Pathogens, 15, e1007577. * Co-first authors
- Dennis, A, Lehane, A, Ridgway, M et al. 2018, 'Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials', Antimicrobial Agents and Chemotherapy, 62, 1-17.
- Dennis, A, Rosling, J, Lehane, A et al. 2018, 'Diverse antimalarials from whole cell phenotypic screens disrupt malaria parasite ion and volume homeostasis', Scientific Reports, 8, 1-15.
- Kuchel, PW, Kirk, K & Shishmarev, D 2018, 'The NMR 'split peak effect' in cell suspensions: Historical perspective, explanation and applications', Progress in Nuclear Magnetic Resonance Spectroscopy, 104, 1-11.
- Rosling, J, Ridgway, M, Summers, R et al 2018, 'Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes', Journal of Biological Chemistry, 293, 13327-13337.
- Hapuarachchi, S, Cobbold, S, Shafik, S et al 2017, 'The malaria parasite's lactate transporter PfFNT is the target of antiplasmodial compounds identified in whole cell phenotypic screens', PLoS Pathogens, 13:e1006180. doi: 10.1371/journal.ppat.1006180
- Nakazawa Hewitt, S, Dranow, D, Horst, B et al 2016, 'Biochemical and structural characterization of selective allosteric inhibitors of the Plasmodium falciparum drug target, Prolyl-tRNA-synthetase', ACS Infectious Diseases, 3, 34-44.
- Rajendran, E, Hapuarachchi, S, Miller, C et al 2017, 'Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites', Nature Communications, 8:14455. doi: 10.1038/ncomms14455.
- Cobbold, S, Llinas, M & Kirk, K 2016, 'Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum', Cellular Microbiology, 18, 820-830.
- Tran, P, Tate, C, Ridgway, M et al 2016, 'Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen? A cautionary tale in screening transgenic parasites', International Journal for Parasitology: Drugs and Drug Resistance, 6,179-183.
- Van Voorhis, W, Adams, J, Adelfio, R et al 2016, 'Open source drug discovery with the Malaria Box compound collection for neglected diseases and beyond', PLoS Pathogens, 12: e1005763. doi:10.1371/journal.ppat.1005763
- Williamson, A, Ylioja, P, Robertson, M et al 2016, 'Open source drug discovery: highly potent antimalarial compounds derived from the Tres Cantos arylpyrroles', ACS Central Science, 4, e06416. doi: 10.7554/eLife.06416
- Winterberg, M & Kirk, K 2016, 'A high-sensitivity HPLC assay for measuring intracellular Na+ and K+ and its application to Plasmodium falciparum infected erythrocytes', Scientific Reports, 6, 29241; doi: 10.1038/srep29241
- Kirk, K & Martin, R 2015, 'Membrane transport in the malaria parasite', in Marcel Hommel & Peter Kremsner (ed.), Encyclopedia of Malaria, Springer New York, Online.
- Kirk, K 2015, 'Ion regulation in the malaria parasite', Annual Review of Microbiology, 69, 341-359.
- Spillman, N & Kirk, K 2015, 'The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs', International Journal for Parasitology: Drugs and Drug Resistance, 5, 149-162.
- Marchetti, R, Lehane, A, Shafik, S et al 2015, 'A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum'. Nature Communications, 6, 6721.
- Teng, R, Lehane, A, Winterberg, M et al 2014, '1H-NMR metabolite profiles of different strains of Plasmodium falciparum', Bioscience Reports, 34, 685-699.
- Jimenez-Diaz, M, Ebert, D, Salinas, Y et al 2014, '(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium', Proceedings of the National Academy of Sciences USA, 111, E5455-E5462.
- Vaidya, A, Morrisey, J, Zhang, Z et al 2014, 'Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum', Nature Communications, 5, 5521
- Lehane, A, Ridgway, M, Baker, E et al 2014, 'Diverse chemotypes disrupt ion homeostasis in the malaria parasite', Molecular Microbiology, 94, 327-339.
- Tran, P, Brown, S, Mitchell, T et al 2014, 'A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite', Nature Communications, 5, 4773.
- Summers, R, Dave, A, Dolstra, T et al 2014, 'Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter', Proceedings of the National Academy of Sciences USA, 111, E1759-E1767.
- Yabas, M, Coupland, L.A., Cromer, D., Winterberg, M., Teoh, N.C. D'Rozario, J., Kirk, K., Bröer, S., Paris, C.R. and A. Enders 2014, 'Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span', Journal of Biological Chemistry, 289, 19531-19537.
- Kirk, K & Lehane, A 2014, 'Membrane transport in the malaria parasite and its host erythrocyte', Biochemical Journal, 457, 1-18.
- Hrycyna, C, Summers, R, Lehane, A et al 2014, 'Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum', ACS Chemical Biology, 9, 722-730.
- Niemand, J, Burger, P, Verlinden, B et al 2013, 'Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites', Antimicrobial Agents and Chemotherapy, 57, 2874-2877.
- Spillman, N, Allen, R & Kirk, K 2013, 'Na+ extrusion imposes an acid load on the intraerythrocytic malaria parasite', Molecular and Biochemical Parasitology, 189, 1-4
- Spillman, N, Allen, R, McNamara, C et al 2013, 'Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials', Cell Host and Microbe, 13, 227-237.
- Van Schalkwyk, D, Saliba, K, Biagini, G et al 2013, 'Loss of pH Control in Plasmodium falciparum Parasites Subjected to Oxidative Stress', PLoS ONE, 8(3), e58933/1-8.
- Martin, R, Butterworth, A, Gardiner, D et al 2012, 'Saquinavir Inhibits the malaria parasite's chloroquine resistance transporter', Antimicrobial Agents and Chemotherapy, 56, 2283-2289.
- Barrand, M, Winterberg, M, Ng, F et al 2012, 'Glutathione export from human erythrocytes and Plasmodium falciparum malaria parasites', Biochemical Journal, 448, 1-24.
- Lehane, A, McDevitt, C, Kirk, K et al 2012, 'Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?', International Journal for Parasitology: Drugs & Drug Resistance, 2, 47-57.
- Niemand, J, Louw, A, Birkholtz, L et al 2012, 'Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum', International Journal for Parasitology, 42, 921-929.
- Winterberg, M, Rajendran, E, Baumeister, S et al 2012, 'Chemical activation of a high-affinity glutamate transporter in human erythrocytes and its implications for malaria-parasite-induced glutamate uptake', Blood, 119, 3604-3612.
- Cobbold, S, Martin, R & Kirk, K 2011, 'Methionine transport in the malaria parasite Plasmodium falciparum', International Journal for Parasitology, 41, 125-135.
- Lehane, A, Van Schalkwyk, D, Valderramos, S et al 2011, 'Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT', Antimicrobial Agents and Chemotherapy, 55, 2310-2318.
- Tilley, L, Dixon, M & Kirk, K 2011, 'The Plasmodium falciparum-infected red blood cell', The International Journal of Biochemistry and Cell Biology, 43, 839-842.
- Zishiri, V, Hunter, R, Smith, P et al 2011, 'A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT', European Journal of Medicinal Chemistry, 46, 1729-42.
- Lehane, A & Kirk, K 2010, 'Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT', Molecular Microbiology, 77, 1039-1051.
- Henry, R, Cobbold, S, Allen, R et al 2010, 'An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum', Journal of Biological Chemistry, 285, 18615-18626.
- Downie, M, El Bissati, K, Bobenchik, A et al 2010, 'PfNT2, a Permease of the Equilibrative Nuceloside Transporter Family in the Endoplasmic Reticulum of Plasmodium falciparum', Journal of Biological Chemistry, 285, 20827-20833.
- Allen, R & Kirk, K 2010, 'Plasmodium falciparum culture: The benefits of shaking', Molecular and Biochemical Parasitology, 169, 63-65.
- Spillman, N, Allen, R & Kirk, K 2009, 'Na+-dependent acid efflux from P. falciparum: PfNHE or residual nigericin?', Molecular and Biochemical Parasitology, 166, 3.
- Martin, R, Ginsburg, H & Kirk, K 2009, 'Membrane transport proteins of the malaria parasite', Molecular Microbiology, 74, 519-528.
- Dean, S, Marchetti, R, Kirk, K et al 2009, 'A surface transporter family conveys the trypanosome differentiation signal', Nature, 459, 213-217.
- Kirk, K, Howitt, S, Broer, S et al 2009, 'Purine uptake in Plasmodium: transport versus metabolism', Trends in Parasitology, 25, 246-249.
- Teng, R, Junankar, P, Bubb, W et al 2009, 'Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by 1H NMR spectroscopy', NMR in Biomedicine, vol. 22, no. 3, pp. 292-302.
- Martin, R, Marchetti, R, Cowen, A et al. 2009, 'Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter', Science, vol. 325, pp. 1680-1682.
- Downie, M, Saliba, K, Broer, S et al 2008, 'Purine nucleobase transport in the intraerythrocytic malaria parasite', International Journal for Parasitology, 38, 203-209.
- Lehane, A & Kirk, K 2008, 'Chloroquine-resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.', Antimicrobial Agents and Chemotherapy, vol. 52, no. 12, pp. 4374-4380.
- Spry, C, Kirk, K & Saliba, K 2008, 'Coenzyme A biosynthesis: an antimicrobial drug target', FEMS Microbiology Reviews, vol. 32, pp. 56-106.
- Saliba, K, Lehane, A & Kirk, K 2008, 'A polymorphic drug pump in the malaria parasite', Molecular Microbiology, vol. 70, no. 4, pp. 775-779.
- Lehane, A, Hayward, R, Saliba, K et al 2008, 'A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites', Journal of Cell Science, vol. 121, no. 10, pp. 1624-1632.
- Spillman, N, Allen, R & Kirk, K 2008, 'Acid extrusion from the intraerythrocytic malaria parasite is not via a Na+/H+ exchanger', Molecular and Biochemical Parasitology, vol. 162, no. 1, pp. 96-99.
- Downie, M, Kirk, K & Mamoun, C 2008, 'Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum', Eukaryotic Cell, 7, 1231-1237.
- Kirk, K & Saliba, K 2007, 'Targeting Nutrient Uptake Mechanisms in Plasmodium', Current Drug Targets, vol. 8, no. 1, pp. 75-88.
- Staines, H, Alkhalil, A, Allen, R et al 2007, 'Electrophysiological studies of malaria parasite-infected erythrocytes: Current status', International Journal for Parasitology, vol. 37, no. 5, pp. 475-482.
- Henry, R, Martin, R, Howitt, S et al 2007, 'Localisation of a candidate anion transporter to the surface of the malaria parasite', Biochemical and Biophysical Research Communications, vol. 363, no. 2, pp. 288-291.
- Martin, R & Kirk, K 2007, 'Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum', Blood, 109, 2217-2224.
- Lehane, A, Marchetti, R, Spry, C et al 2007, 'Feedback Inhibition of Pantothenate Kinase Regulates Pantothenol Uptake by the Malaria Parasite', Journal of Biological Chemistry, vol. 282, no. 35, pp. 25395-25405.
- Baumeister, S, Winterberg, M, Duranton, C et al 2006, 'Evidence for the involvement of Plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane', Molecular Microbiology, vol. 60, no. 2, pp. 493-504.
- Downie, M, Saliba, K, Howitt, S et al 2006, 'Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1', Molecular Microbiology, 60, 738-748.
- Hayward, R, Saliba, K & Kirk, K 2006, 'The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance', Journal of Cell Science, 119, 1016-1025.
- Saliba, K (co-first author), Martin, R (co-first author), Broer, A et al 2006, 'Sodium-dependent uptake of inorganic phosphate by the intracelluar malaria parasite', Nature, vol. 443, pp. 582-585.
- Kirk, K, Martin, R, Broer, S et al 2005, 'Plasmodium permeomics: membrane transport proteins in the malaria parasite.', Current Topics in Microbiology and Immunology, vol. 295, pp. 325-56.
- Martin, R, Henry, R, Abbey, J et al. 2005, 'The permeome of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum', Genome Biology, vol. 6, no. 3, pp. R26.
- Hayward, R, Saliba, K & Kirk, K 2005, 'pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum', Molecular Microbiology, vol. 55, no. 4, pp. 1285-1295.
- Hayward, R, Saliba, K & Kirk, K 2005, 'Mutations in pfmdr1 Modulate the Sensitivity of Plasmodium falciparum to the Intrinsic Antiplasmodial Activity of Verapamil', Antimicrobial Agents and Chemotherapy, vol. 49, no. 2, pp. 840-842.
- Saliba, K & Kirk, K 2005, 'CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation', Molecular and Biochemical Parasitology, vol. 141, no. 1, pp. 129-131.
- Spry, C, Chai, C, Kirk, K et al 2005, 'A Class of Pantothenic Acid Analogs Inhibits Plasmodium falciparum Pantothenate Kinase and Represses the Proliferation of Malaria Parasites', Antimicrobial Agents and Chemotherapy, vol. 49, no. 11, pp. 4649-4657.
- Saliba, K, Ferru, I & Kirk, K 2005, 'Provitamin B5 (Pantothenol) Inhibits Growth of the Intraerythrocytic Malaria Parasite', Antimicrobial Agents and Chemotherapy, vol. 49, no. 2, pp. 632-637.
- Bray, P (co-first author), Martin, R (co-first author), Tilley, L et al 2005, 'Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance', Molecular Microbiology, vol. 56, no. 2, pp. 323-333.
- Becker, K & Kirk, K 2004, 'Of malaria, metabolism and membrane transport', Trends in Parasitology, vol. 20, no. 12, pp. 590-596.
- Martin, R & Kirk, K 2004, 'The Malaria Parasites Chloroquine Resistance Transporter is a Member of the Drug/Metabolite Transporter Superfamily', Molecular Biology and Evolution, vol. 21, no. 10, pp. 1938-1949.
- Junankar, P, Karjalainen, A & Kirk, K 2004, 'Osmotic swelling activates two pathways for K+ efflux in a rat hepatoma cell line', Cellular Physiology and Biochemistry, vol. 14, no. 3, pp. 143-154.
- Saliba, K, Krishna, S & Kirk, K 2004, 'Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative', FEBS Letters, vol. 570, no. 1-3, pp. 93-96.
- Lehane, A, Saliba, K, Allen, R et al 2004, 'Choline uptake into the malaria parasite is engergized by the membrane potential', Biochemical and Biophysical Research Communications, vol. 320, no. 2, pp. 311-317.
- Kirk, K 2004, 'Channels and transporters as drug targets in the Plasmodium-infected erythrocyte', Acta Tropica, vol. 89, no. 3, pp. 285-298.
- Allen, R & Kirk, K 2004, 'Cell volume control in the Plasmodium-infected erythrocyte', Trends in Parasitology, vol. 20, no. 1, pp. 7-10.
- Allen, R & Kirk, K 2004, 'The Membrane Potential of the Intraerythrocytic Malaria Parasite Plasmodium falciparum', Journal of Biological Chemistry, vol. 279, no. 12, pp. 11264-11272.
- Staines, H, Dee, B, O'Brien, M et al 2004, 'Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes', Molecular and Biochemical Parasitology, vol. 133, no. 2, pp. 315-318.
- Lingelbach, K, Kirk, K, Rogerson, S et al 2004, 'Molecular approaches to malaria', Molecular Microbiology, vol. 54, no. 3, pp. 575-587.
- Go, M, Liu, M, Wilairat, P et al 2004, 'Antiplasmodial Chalcones Inhibit Sorbitol-Induced Hemolysis of Plasmodium falciparum-Infected Erythrocytes', Antimicrobial Agents and Chemotherapy, vol. 48, no. 9, pp. 3241-3245.
- Baumeister, S, Endermann, T, Charpian, S et al 2003, 'A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes', Molecular and Biochemical Parasitology, vol. 132, pp. 35-45.
- Kirk, K & Saliba, K 2003, 'The Membrane Physiology of the Malaria-Infected Red Cell', in Ingolf Bernhardt & J Clive Ellory (ed.), Red Cell Membrane Transport in Health and Disease, Springer, Germany, pp. 569-585.
- Saliba, K, Allen, R, Zissis, S et al. 2003, 'Acidification of the Malaria Parasites Digestive Vacuole by a H+-ATPase and a H+-pyrophosphatase', Journal of Biological Chemistry, vol. 278, no. 8, pp. 5605-5612.
- Bray, P, Saliba, K, Davies, J et al 2002, 'Further comments on the distribution of acridine orange fluorescence in P. falciparum-infected erythrocytes', Molecular and Biochemical Parasitology, vol. 119, no. 2, pp. 311-313.
- Junankar, P, Karjalainen, A & Kirk, K 2002, 'The Role of P2Y1 Purinergic Receptors and Cytosolic Ca2+ Hypotonically Activated Osmolyte Efflux from a Rat Hepatoma Cell Line', Journal of Biological Chemistry, vol. 277, no. 43, pp. 40324-40334.
- Bray, P, Saliba, K, Davies, J et al 2002, 'Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH', Molecular and Biochemical Parasitology, vol. 119, no. 2, pp. 301-304.
- Kirk, K & Saliba, K 2002, 'Chloroquine resistance and the pH of the malaria parasites digestive vacuole', Drug Resistance Updates, vol. 4, no. 6, pp. 335-338.
- Kirk, K 2001, 'Membrane Transport in the Malaria-Infected Erythrocyte', Physiological Reviews, vol. 81, no. 2, pp. 495-537.
- Biagini, G, Knodler, L, Saliba, K et al 2001, 'Na+-dependent pH Regulation by the Amitochondriate Protozoan Parasite Giardia intestinalis', Journal of Biological Chemistry, vol. 276, no. 31, pp. 29157-29162.
- Saliba, K & Kirk, K 2001, 'Nutrient acquisition by intracellular apicomplexan parasites: staying in for dinner', International Journal for Parasitology, vol. 31, no. 12, pp. 1321-1330.
- Alleva, L & Kirk, K 2001, 'Calcium regulation in the intraerythrocytic malaria parasite Plasmodium falciparum', Molecular and Biochemical Parasitology, vol. 117, no. 2, pp. 121-128.
- Saliba, K & Kirk, K 2001, 'H+-coupled Pantothenate Transport in the Intracellular Malaria Parasite', Journal of Biological Chemistry, 276, 18115-18121.
- Kirk, K 2001, 'A voracious creature', The Lancet, 358, Supplementary Issue No 1, 41.
- Elliott, J, Saliba, K & Kirk, K 2001, 'Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparum', Biochemical Journal, vol. 355, pp. 733-739.
- Staines, H, Ellory, J & Kirk, K 2001, 'Perturbation of the pump-leak balance for Na+ and K+ in malaria-infected erythrocytes', American Journal of Physiology - Cell Physiology, vol. 280, pp. C1576-C1587.
- Reed, M, Saliba, K, Caruana, S et al. 2000, 'Pgh modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum', Nature, vol. 403, pp. 906-909.
- Staines, H, Rae, C & Kirk, K 2000, 'Increased permeability of the malaria-infected erythrocyte to organic cations', Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics, vol. 1463, pp. 88-98.
- Junankar, P & Kirk, K 2000, 'Organic Osmolyte Channels: A Comparative View', Cellular Physiology and Biochemistry, vol. 10, no. 5-6, pp. 355-360.
- Krishna, S, Woodrow, C, Burchmore, R et al 2000, 'Hexose Transport in Asexual Stages of Plasmodium falciparum and Kinetoplastidae', Parasitology Today, vol. 16, no. 12, pp. 516-521.
- Biagini, G, Kirk, K, Schofield, P et al 2000, 'Role of K+ and amino acids in osmoregulation by the free-living microaerophilic protozoon Hexamita inflata', Microbiology (UK), vol. 146, pp. 427-433.
- Biagini, G, Lloyd, D, Kirk, K et al 2000, 'The Membrane Potential of Giardia intestinalis', FEMS Microbiology Letters, vol. 192, pp. 153-157.
- Kirk, K 2000, 'Malaria: Channelling nutrients', Nature, vol. 406, no. 6799, p. 949.
- Rickards, R, Smith, G & Kirk, K 2000, Compounds and therapeutic methods, WO0069856, Australia.
- Rickards, R, Rothschild, J, Willis, A et al. 1999, 'Calothrixins A and B, Novel Pentacyclic Metabolites from Calothrix Cyanobacteria with Potent Activity against Malaria Parasites and Human Cancer Cells', Tetrahedron, vol. 55, pp. 13513-13520.
- Saliba, K & Kirk, K 1999, 'pH Regulation in the Intracellular Malaria Parasite, Plasmodium falciparum: H+ extrusion via a V-Type H+-ATPase', Journal of Biological Chemistry, vol. 274, no. 47, pp. 33213-33219.
- Staines, H, Chang, W, Ellory, J et al 1999, 'Passive Ca2+ Transport and Ca2-dependent K+ transport in Plasmodium falciparum-infected red cells', Journal of Membrane Biology, vol. 172, pp. 13-24.
- Kirk, K, Tilley, L & Ginsburg, H 1999, 'Transport and Trafficking in the Malaria-infected Erythrocyte', Parasitology Today, vol. 15, no. 9, pp. 355-357.
- Kirk, K, Staines, H, Martin, R et al 1999, 'Transport properties of the host cell membrane', in Gregory R. Bock, Gail Cardew (ed.), Novartis Foundation Symposium 226 - Transport and Trafficking in the Malaria-Infected Erythrocyte, John Wiley & Sons, Inc., England.
- Saliba, K & Kirk, K 1998, 'Clotrimazole inhibits the growth of the malaria parasite Plasmodium falciparum in vitro'. Transactions of the Royal Society of Tropical Medicine and Hygiene, 92, 666-667.
- Saliba, K, Horner, H & Kirk, K 1998, 'Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum', Journal of Biological Chemistry, 273, 10190-10195.
- Saliba, K & Kirk, K 1998, 'Uptake of an antiplasmodial protease inhibitor into Plasmodium falciparum-infected human erythrocytes via a parasite-induced pathway', Molecular and Biochemical Parasitology, 94, 297-301.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- How do apicomplexan parasites steal amino acids from their hosts? (Secondary Investigator)
- Regulating nutrient uptake in intracellular parasites (Secondary Investigator)
- Understanding high-level resistance to antimalarial PfATP4 inhibitors (Secondary Investigator)
- An open source approach to understanding an important parasite ion pump (Secondary Investigator)
- A novel family of amino acid transporters in Apicomplexan parasites (Primary Investigator)
- PfATP4 Compounds Screening (Primary Investigator)
- Targeting an ion pump in the malaria parasite with multiple compound classes (Primary Investigator)
- Testing the MMV Malaria Box on malaria parasite ion regulation (Primary Investigator)
- The Na/H exchanger and V-type pyrophosphatases of the malaria parasite (Secondary Investigator)
- Transport of amino acids and polyamines in the malaria parasite (Primary Investigator)
- Molecular identification of novel permeation pathways induced by malaria parasites (Primary Investigator)
- Characterization of the chloroquine resistance transporter of the malaria parasite (Secondary Investigator)
- Chloroquine resistance and the physiology of the malaria parasite's digestive vacuole (Primary Investigator)
- Ion transport in the malaria parasite and parasitised erythrocyte (Primary Investigator)
