Dr Ehsan Kheradpezhouh
Areas of expertise
- Cellular Nervous System 110902
- Sensory Systems 110906
- Cell Physiology 320801
- Neurosciences 3209
- Central Nervous System 320903
Research interests
I am interested in studying the physiological and pathological role of Transient Receptor Potential (TRP) channels in rodent cortex.
Biography
I am a group leader at the Eccles Institute of Neuroscience, JCSMR. I studied medicine in Shiraz University and received my PhD in Physiology from the Adelaide University in 2015. My research has focused on the physiological and pathological role of transient receptor potential channels (TRPs) in the mammalian cortex. TRPs comprise a superfamily of nonselective cation channels that are well preserved throughout evolution and across species from yeasts to humans.
Recently, my research identified high expression of TRP Ankyrin 1 (TRPA1) in rodent cortical neurons. Currently, I combine in vivo and in vitro electrophysiology, two-photon calcium imaging, and behavioural assays to investigate how TRPA1 modulates sensory processing in rodent cortex across modalities of whisker-touch and vision. We expand this knowledge to understand the role of TRP channels in brain pathologies such as Multiple Sclerosis and Epilepsy.
Available student projects
Understanding the role of TRPA1 in the development and progression of Multiple Sclerosis in mice
Current student projects
1. Understanding the role of Muscarinic 1 cholinergic receptor in mouse sensory processing and detection behaviour
2. Characterising the co-localisation and functional interaction between TRPA1 and TRPV1 in the mammalian cortex and understanding how this interaction affects sensory processing and detection behaviour
The role of M1 Muscarinic modulation on mouse behaviour
Publications
- Kheradpezhouh, E, Mishra, W & Arabzadeh, E 2021, 'A protocol for simultaneous in vivo juxtacellular electrophysiology and local pharmacological manipulation in mouse cortex', STAR Protocols, vol. 2, no. 1, pp. 1-13.
- Lee, C, Kheradpezhouh, E, Diamond, M et al. 2020, 'State-Dependent Changes in Perception and Coding in the Mouse Somatosensory Cortex', Cell Reports, vol. 32, no. 13, pp. 1-15.
- Kheradpezhouh, E, Tang, M, Mattingley, J et al. 2020, 'Enhanced Sensory Coding in Mouse Vibrissal and Visual Cortex through TRPA1', Cell Reports, vol. 32, no. 3, pp. 1-18.
- Kheradpezhouh, E, Choy, J, Arabzadeh, E et al. 2019, 'Localized two-photon photoswitching of Optovin in rat cortical neurons', Journal of Physics D: Applied Physics, vol. 52, no. 25, pp. 1-7.
- Kheradpezhouh, E, Zhou, F, Barritt, G et al 2018, 'Oxidative stress promotes redistribution of TRPM2 channels to the plasma membrane in hepatocytes', Biochemical and Biophysical Research Communications, vol. 503, no. 3, pp. 1891-1896pp.
- Kheradpezhouh, E, Choy, J, Daria, V et al. 2017, 'TRPA1 expression and its functional activation in rodent cortex', Open Biology, vol. 7, no. 4, pp. 160314-160314.
- Kheradpezhouh, E, Adibi, M & Arabzadeh, E 2017, 'Response dynamics of rat barrel cortex neurons to repeated sensory stimulation', Scientific Reports, vol. 7, no. 1, pp. 11445 (10pp).
- Kheradpezhouh, E, Barritt, G & Rychkov, G 2016, 'Curcumin inhibits activation of TRPM2 channels in rat hepatocytes', Redox Biology, vol. 7, pp. 1-7pp.
- Kheradpezhouh, E, Ma, L, Morphett, A, Barritt, G et al 2014, 'TRPM2 channels mediate acetaminophen-induced liver damage', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. 3176-3818.
- Kheradpezhouh, E, Panjehshahin, M, Miri, R et al 2010, 'Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine', European Journal of Pharmacology, vol. 628, no. 1-3, pp. 274-281.
- Kheradpezhouh, E, Miri, R, Motevaselian, M et al 2009, 'Effect of cimetidine on antinociceptive properties of Morphine in Mice', Journal of Applied Animal Research, vol. 36, no. 1, pp. 129-132.
- Kheradpezhouh, E, Miri, R, Noorafshan, A et al 2008, 'A New Method of Brain Staining with Triphenyltetrazolium Chloride to Determine Infarct Size in Rats', Journal of Applied Animal Research, vol. 33, no. 2, pp. 149-152.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- The contribution of cortical TRPA1 to sensory perception and behaviour of mammalians (Primary Investigator)
