Dr Joe Kaczmarski
Areas of expertise
- Biomolecular Modelling And Design 030402
- Characterisation Of Biological Macromolecules 030403
- Proteins And Peptides 030406
- Medicinal And Biomolecular Chemistry Not Elsewhere Classified 030499
- Enzymes 060107
- Signal Transduction 060111
- Structural Biology (Incl. Macromolecular Modelling) 060112
- Host Parasite Interactions 060307
- Phylogeny And Comparative Analysis 060309
Research interests
Protein Engineering
Protein Evolution
Host-Pathogen Interactions
Solute-binding protein
Isothermal Titration Calorimetry
Macromolecular X-ray Crystallography
Biography
2020 Australian National University - Doctor of Philosophy (Structural Biology, Jackson Lab)
2014 Australian National University - Bachelor of Philosophy (First Class Honours)
2009 The Friends' School
Researcher's projects
- Engineering of ligand-gated ion channels for neuroscience
- Evolution of enzymes from solute-binding proteins
- Structural biology of non-ribosomal peptide synethesis proteins
- Drug interactions with the Plasmodium falciparum Chloroquine-Reistance Transporter
Publications
- Kaczmarski, J, Mahawaththage Don, M, Feintuch, A et al. 2020, 'Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme', Nature Communications, vol. 11, no. 1.
- Kaczmarski, J, Hong, N, Mukherjee, B et al. 2019, 'Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the P-II-like Protein, SbtB, from Cyanobium sp. PCC7001', Biochemistry, vol. 58, no. 50, pp. 5030-5039.
- Kaczmarski, J, Mitchell, J, Spence, M et al 2019, 'Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors', Current Opinion in Structural Biology, vol. 57, pp. 31-38.
- Greule, A, Izoré, T, Iftime, D et al 2019, 'Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics', Nature Communications, vol. 10.
- Izoré, T, Tailhades, J, Hansen, M et al 2019, 'Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 8, pp. 2913-2918.
- Clifton, B, Kaczmarski, J, Carr, P et al. 2018, 'Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein', Nature Chemical Biology, vol. 14, no. 6, pp. 542-547pp.
- Fisher, C, Sutton, H, Kaczmarski, J et al. 2017, 'T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein', PLoS Pathogens, vol. 13, no. 7, pp. 23pp.
- Kaczmarski, J & Corry, B 2014, 'Investigating the size and dynamics of voltage-gated sodium channel fenestrations A molecular dynamics study', Channels, vol. 8, no. 3, pp. 264-277.