Associate Professor Simon Jiang
Areas of expertise
- Humoural Immunology And Immunochemistry 110705
- Autoimmunity 110703
- Rheumatology And Arthritis 110322
- Nephrology And Urology 110312
- Immunogenetics (Incl. Genetic Immunology) 110706
- Medical Genetics (Excl. Cancer Genetics) 110311
Biography
Simon completed his undergraduate medical training at the University of Newcastle and specialist training in Nephrology at The Canberra and Royal Prince Alfred Hospitals. He received his Masters in Medicine(Hons) from the University of Sydney and his PhD at the ANU as an NHMRC/RACP scholar investigating the role of genetic variation in systemic lupus erythematosus.
Simon’s laboratory investigates the genetic and molecular mechanisms of systemic autoimmunity and kidney disease. He leads a national translational personalised medicine program centred at The Canberra Hospital and ANU which investigates complex autoimmunity by identifying potential pathogenic gene variants and demonstrating the molecular and immune consequence of these variants. In collaboration with the National Centre for Indigenous Genomics, he also uses this personalised medicine approach to investigate the unique genetic basis of kidney disease in Indigenous Australians.
Current student projects
Role of IRF7 variation in autoimmunity and immunodeficiency
Genetic variation and risk of kidney disease in the Tiwi Islanders
Artificial intelligence in unbiased diagnosis and prognosis of glomerulonephritis
Predicting outcomes of glomerulonephritis and chronic kidney disease
Publications
- McKeon, K & Jiang, S 2020, 'Treatment of systemic lupus erythematosus', Australian Prescriber, vol. 43, no. 3, pp. 85-90.
- Jiang, S, Stanley, M & Garcia de Vinuesa, C 2020, 'Rare genetic variants in systemic autoimmunity', Immunology and Cell Biology, vol. 98, no. 5.
- Jiang, S, Athanasopoulos, V, Ellyard, J et al. 2019, 'Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus', Nature Communications, vol. 10, no. 2201, pp. 1-12.
- Ellyard, J, Tunningley, R, Lorenzo, A et al. 2019, 'Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders', Frontiers in Immunology, vol. 10, no. 2134, pp. 1-13.
- Kennard, A, Jiang, S & Walters, G 2017, 'Increased glomerulonephritis recurrence after living related donation', BMC Nephrology, vol. 18, no. 25, pp. 1-9pp.
- Jiang, S & Lea-Henry, T 2016, 'Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre', Annals of Translational Medicine, vol. 4, no. 24, pp. 1-3.
- Jiang, S, Shen, N & Garcia de Vinuesa, C 2015, 'Posttranscriptional T cell gene regulation to limit Tfh cells and autoimmunity', Current Opinion in Immunology, vol. 37, pp. 21-27.
- Ellyard, J, Jerjen, R, Martin, J et al. 2014, 'Identification of a Pathogenic Variant in TREX1 in Early-Onset Cerebral Systemic Lupus Erythematosus by Whole-Exome Sequencing', Arthritis & Rheumatism, vol. 66, no. 12, pp. 3382-3386.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Investigating the genetic and molecular basis of autoimmune kidney disease (Primary Investigator)
- Investigating the genetic basis of chronic kidney disease in Tiwi Islanders (Primary Investigator)
- How BANK1 pathway defects in B cells cause human lupus (Secondary Investigator)
- Investigating the effect of single nucleotide polymorphisms on the development of systemic lupus erythematosus (Primary Investigator)
