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The Australian National University

Dr Rippei Hayashi

PhD in life science, University of Tokyo (2007)
Group Leader at JCSMR
ANU College of Health and Medicine
T: +61 2 6125 9396

Areas of expertise

  • Developmental Genetics (Incl. Sex Determination) 060403
  • Bioinformatics 060102
  • Invertebrate Biology 060808
  • Animal Developmental And Reproductive Biology 060803
  • Gene Expression (Incl. Microarray And Other Genome Wide Approaches) 060405

Research interests

small RNA-guided gene silencing, pre-mRNA splicing, transposon defence, organogenesis

Biography

Rippei Hayashi studied chemistry and biotechnology in the undergraduate (BSc, University of Tokyo, 2002). During his Masters/PhD, he studied the mechanism of orchestrated expression of nuclear-coded mitochondrial genes at transcriptional level, which led him to uncover the regulation of transcription factor's activity upon nuclear import (PhD, University of Tokyo, 2007). He was a Junior Research Fellow of Japan Society of Promotion of Science (JSPS, DC1). For his postdoc, he moved to Cancer Research UK (David Ish-Horowicz Group) in 2008 to study asymmetric mRNA localisation in developing Drosophila oocyte, mechanism of which was and still is largely unknown. This transition led him to get into RNA biology and Drosophila genetics, key combination for his current research. He developed and conducted live-cell imaging-based genetic screen for gurken mRNA localisation in Drosophila oocyte and identified a number of mutants related to transposon silencing, which affect the microtubule organisation thus the trafficking of gurken mRNA. He moved to the Institute of Molecular Biotechnology in Vienna, Austria (IMBA, Julius Brennecke Group) in 2013 to study the mechanism of small RNA-guided transposon silencing and uncovered an unexpected link between splicing regulation and transposon regulation, and clarified the biogenesis pathways of Piwi-interacting RNA (piRNA) in Drosophila. He started his own group in Jan 2018 in the Genome Science Department at the John Curtin School of Medical Researh in the Australian National University. His research interests include transposon silencing, post-transcriptional RNA processing, and organogenesis.

 

Researcher's projects

  • Uncover the mechanism of novel splicing “rescue” pathways
  • Molecular and functional characterisation of the terminal resection (trimming) of small RNA in animal development
  • Unravelling the role of transposon defence pathway in the development of gonads
  • Characterising the function of general transcription elongation factor Paf1 complex in transposon defence

 

Available student projects

  • Uncover the mechanism of novel splicing “rescue” pathways
  • Molecular and functional characterisation of the terminal resection (trimming) of small RNA in animal development
  • Unravelling the role of transposon defence pathway in the development of gonads
  • Characterising the function of general transcription elongation factor Paf1 complex in transposon defence

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Updated:  23 October 2018 / Responsible Officer:  Director (Research Services Division) / Page Contact:  Researchers