Professor Margaret M Harding
Areas of expertise
- Medicinal And Biomolecular Chemistry 0304
- Proteins And Peptides 030406
- Biologically Active Molecules 030401
Biography
Ph.D. 1987 University of Sydney; D.Sc. 2002 University of Sydney;
Postdoctoral Fellow, Université Louis Pasteur, Strasbourg, France 1986-1988;
Ramsay Memorial Fellow, Cambridge University, UK, 1989-1989;
University of Sydney; DNA Programme Leader, CRC for Molecular Engineering, 1992-1998;
RACI Rennie Medal, , 1990-2005;
RACI Biota Medal for Medicinal Chemistry, 1995;
RACI Nyholm Youth Lecturer, 1999;
Member of ARC College of Experts, 2004-2006.
Dean of Graduate Research & Professor of Chemistry, UNSW, 2005-2009;
Pro Vice-Chancellor (Research), UNSW 2008-2012;
Visiting Professorial Fellow UNSW 2012-2015.
Deputy Vice-Chancellor (Research) at ANU June 2012 - December 2018
Publications
- Durai, C & Harding, P 2011, 'Targeting nucleic acids using dynamic combinatorial chemistry', Australian Journal of Chemistry, vol. 64, no. 6, pp. 671-680.
- C. Sherman Durai and M. M. Harding, Targeting Nucleic Acids Using Dynamic Combinatorial Chemistry, Aust. J. Chem. 2011, 64, 671-680.
- Schilter, D, Clegg, J, Harding, P et al 2010, 'Platinum(II) and palladium(II) metallomacrocycles derived from cationic 4,4'-bipyridinium, 3-aminopyrazinium and 2-aminopyrimidinium ligands', Dalton Transactions, vol. 39, no. 1, pp. 239-247.
- Schilter, D, Urathamakul, T, Harding, P et al 2010, 'ESI-MS and thermal melting studies of nanoscale platinum(II) metallomacrocycles with DNA', Dalton Transactions, vol. 39, no. 46, pp. 11263-11271.
- Hunter, L, Condie, G & Harding, P 2010, 'Reversible aqueous metathesis reactions for potential application in dynamic combinatorial chemistry', Tetrahedron Letters, vol. 51, no. 38, pp. 5064-5067.
- Garner, J & Harding, P 2010, 'Design and Synthesis of Antifreeze Glycoproteins and Mimics', ChemBioChem, vol. 11, no. 18, pp. 2489-2498.
- L. Hunter, G. Condie and M. M. Harding, Reversible Aqueous Metathesis Chemistry for potential applications in dynamic combinatorial chemistry, Tetrahedron Lett., 2010, 51, 5064-5067
- Manohari Abeysinghe, p, Han, Y & Harding, P 2009, 'Oxidation of threonine residues with IBX reagents', Tetrahedron Letters, vol. 50, no. 21, pp. 2601-2604.
- Garner, J, Jolliffe, K, Harding, P et al 2009, 'Synthesis of homogeneous antifreeze glycopeptides via a ligation-desulfurization strategy', Chemical Communications, vol. 45, no. 45, pp. 6925-6927.
- J. Garner, K. A. Jolliffe, M. M. Harding and R. J. Payne, Synthesis of homogeneous antifreeze glycopeptides via a ligation-desulfurisation strategy, Chem. Commun., 2009, 6925-6927
- P. M. Abeysinghe, Y. Han and M. M .Harding, Oxidation of Threonine residues in Peptides with Hypervalent Iodine Reagents, Tetrahedron Letters., 2009, 50, 2601-2604
- Garner, J, Inglis, S, Hook, J et al 2008, 'A solid-state NMR study of the interaction of fish antifreeze proteins with phospholipid membranes', European Biophysics Journal, vol. 37, no. 6, pp. 1031-1038.
- Buck, D, Manohari Abeysinghe, p, Cullinane, C et al 2008, 'Inclusion complexes of the antitumor metallocenes Cp2MCl2 (M = Mo, Ti) with cucurbit[n]urils', Dalton Transactions, vol. 1, no. 17, pp. 2328-2334.
- Harding, P & Manohari Abeysinghe, p 2007, 'Antitumor bis(cyclopentadienyl) metal complexes: titanocene and molybdocene dichloride and derivatives', Dalton Transactions, vol. 1, no. 32, pp. 3474-3482.
- Garner, J & Harding, P 2007, 'Design and synthesis of a-helical peptides and mimetics', Organic and Biomolecular Chemistry, vol. 5, no. 22, pp. 3557-3720.
- Campbell, K, Dillon, C, Smith, S et al 2007, 'Radiotracer studies of the antitumor metallocene molybdocene dichloride with biomolecules', Polyhedron, vol. 26, no. 2, pp. 456-459.
- Stok, J, Abeysinghe, P, Han, Y et al 2007, 'Antifreeze glycoproteins: Design of mimics and interaction with membranes', The 234th ACS National Meeting, American Chemical Society, Boston USA, pp. COMP-370.
- Inglis, S, Turner, J & Harding, P 2006, 'Applications of type I antifreeze proteins: Studies with model membranes & cryoprotectant properties', Current Protein and Peptide Science, vol. 7, no. 6, pp. 509-522.
- Inglis, S, McGann, M, Price, W et al 2006, 'Diffusion NMR studies on fish antifreeze proteins and synthetic analogues', FEBS Letters, vol. 580, no. 16, pp. 3911-3915.
- Lee, C, Groneman, J, Turner, P et al 2006, 'Synthesis and X-ray crystallographic analysis of chiral pyridyl substituted carbocyclic molecular clefts', Tetrahedron, vol. 62, no. 20, pp. 4870-4878.
- Waern, J, Turner, P & Harding, P 2006, 'Synthesis and Hydrolysis of Thiol Derivatives of Molybdocene Dichloride Incorporating Electron-Withdrawing Substituents', Organometallics, vol. 25, no. 14, pp. 3417-3421.
- Campbell, K, Foster, A, Dillon, C et al 2006, 'Genotoxicity and transmission electron microscopy studies of molybdocene dichloride', Journal of Inorganic Biochemistry, vol. 100, no. 7, pp. 1194-1198.
- Harding, P & Turner, J 2005, 'Synthesis and properties of chiral molecular clefts related to Troeger's base', Supramolecular Chemistry, vol. 17, no. 5, pp. 369-375.
- Waern, J, Harris, H, Lai, B et al 2005, 'Intracellular mapping of the distribution of metals derived from the antitumor metallocenes', Journal of Biological Inorganic Chemistry, vol. 10, no. 5, pp. 443-452.
- Kwan, A, Fairley, K, Anderberg, P et al. 2005, 'Solution Structure of a Recombinant Type I Sculpin Antifreeze Protein', Biochemistry, vol. 44, no. 6, pp. 1980-1988.
- Waern, J, Dillon, C & Harding, P 2005, 'Organometallic Anticancer Agents: Cellular Uptake and Cytotoxicity Studies on Thiol Derivatives of the Antitumor Agent Molybdocene Dichloride', Journal of Medicinal Chemistry, vol. 48, no. 6, pp. 2093-2099.
- Anderberg, P, Harding, P & Lay, P 2004, 'The effect of metal ions on the electrochemistry of the antitumor antibiotic streptonigrin', Journal of Inorganic Biochemistry, vol. 98, no. 5, pp. 720-726.
- Harding, P & Waern, J 2004, 'Bioorganometallic chemistry of molybdocene dichloride', Journal of Organometallic Chemistry, vol. 689, no. 25, pp. 4655-4668.
- Harding, P & Waern, J 2004, 'Coordination Chemistry of the Antitumor Metallocene Molybdocene Dichloride with Biological Ligands', Inorganic Chemistry, vol. 43, no. 1, pp. 206-213.
- Anderberg, P, Turner, J, Evans, K et al 2004, 'Ligand self-recognition in the stereoselective assembly of [2 + 2] metallomacrocycles from racemic chiral bisbipyridyl molecular clefts and zinc(II)', Dalton Transactions, vol. 1, no. 11, pp. 1708-1714.
- Harding, P & Grummitt, A 2003, '9-hydroxyellipticine and derivatives as chemotherapy agents', Mini-Reviews in Medicinal Chemistry, vol. 3, no. 2, pp. 67-76.
- Waern, J, Dillon, C & Harding, P 2003, 'Towards the determination of the mechanism of antitumour activity of molybdocene dichloride', Journal of Inorganic Biochemistry, vol. 96, p. 246.
- Grummitt, A, Harding, P, Anderberg, P et al 2003, 'Carbohydrate derivatives of the antitumor alkaloid 9-hydroxyellipticine', European Journal of Organic Chemistry, vol. 1, pp. 63-71.
- Tomczak, M, Hincha, D, Crowe, J et al 2003, 'The effect of hydrophobic analogues of the type I winter flounder antifreeze protein on lipid bilayers', FEBS Letters, vol. 551, no. 1-3, pp. 13-19.
- Harding, P, Anderberg, P & Luck, I 2002, 'Assignment of the 13C and 15N NMR spectra of the antitumour antibiotic streptonigrin', Magnetic Resonance in Chemistry, vol. 40, no. 4, pp. 313-315.
- Bonfantini, E, Burrell, A, Campbell, W et al 2002, 'Efficient synthesis of free-base 2-formyl-5,10,15,20-tetraarylporphyrins, their reduction and conversion to [(porphyrin-2-yl)methyl]phosphonium salts', Journal of Porphyrins and Phthalocyanines, vol. 6, no. 11 & 12, pp. 708-719.
- Liepinsh, E, Otting, G, Harding, P et al 2002, 'Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein', European Journal of Biochemistry, vol. 269, no. 4, pp. 1259-1266.
- Fairley, K, Westman, B, Pham, L et al 2002, 'Type I shorthorn sculpin antifreeze protein. Recombinant synthesis, solution conformation, and ice growth inhibition studies', Journal of Biological Chemistry, vol. 277, no. 27, pp. 24073-24080.
- Anderberg, P, Harding, P, Luck, I et al 2002, 'Ruthenium Complexes of Analogues of the Antitumor Antibiotic Streptonigrin', Inorganic Chemistry, vol. 41, no. 6, pp. 1365-1371.
- Field, J, Turner, P, Harding, P et al 2002, 'Carbocyclic molecular clefts incorporating hydrogen bonding features', New Journal of Chemistry, vol. 26, no. 6, pp. 720-725.
- Anderberg, P & Harding, P 2001, 'The role of ring D in the antitumor antibiotic streptonigrin: metal complexation, DNA binding and topoisomerase inhibition by ABC ring analogues of streptonigrin', Anti-Cancer Drug Design, vol. 16, no. 2/3, pp. 143-153.
- Haymet, A, Ward, L & Harding, P 2001, 'Hydrophobic analogues of the winter flounder 'antifreeze' protein', FEBS Letters, vol. 491, no. 3, pp. 285-288.
- Mokdsi, G & Harding, P 2001, 'Inhibition of human topoisomerase II by the antitumor metallocenes', Journal of Inorganic Biochemistry, vol. 83, no. 2-3, pp. 205-209.
- Mokdsi, G & Harding, P 2001, 'A 1H NMR study of the interaction of antitumor metallocenes with glutathione', Journal of Inorganic Biochemistry, vol. 86, no. 2-3, pp. 611-616.
- Long, G, Harding, P & Turner, P 2000, 'X-ray structure of the zinc complex of the central metal chelation site of the antitumour drug streptonigrin', Polyhedron, vol. 19, no. 9, pp. 1067-1071.
- Kimber, M, Anderberg, P & Harding, P 2000, 'Synthesis of ABC Analogues of the Antitumour Antibiotic Streptonigrin', Tetrahedron, vol. 56, no. 22, pp. 3575-3581.
- Wright Lucas, S & Harding, P 2000, 'Detection of DNA via an Ion Channel Switch Biosensor', Analytical Biochemistry, vol. 282, no. 1, pp. 70-79.
- Kimber, M, Try, A, Painter, L et al 2000, 'Synthesis of Functionalized Chiral Carbocyclic Cleft Molecules Complementary to Troeger's Base Derivatives', Journal of Organic Chemistry, vol. 65, no. 10, pp. 3042-3046.
- Harding, P & Mokdsi, G 2000, 'Antitumor metallocenes: structure-activity studies and interactions with biomolecules', Current Medicinal Chemistry, vol. 7, no. 12, pp. 1289-1303.
- Harding, P, Ward, L & Haymet, A 1999, 'Type I "antifreeze" proteins: structure-activity studies and mechanisms of ice growth inhibition', European Journal of Biochemistry, vol. 264, no. 3, pp. 653-665.
- Harding, P, Ward, L & Haymet, A 1999, 'Why fish do not freeze in polar waters', Chemistry in Australia, vol. 66, no. 2, pp. 31-33.
- Haymet, A, Ward, L & Harding, P 1999, 'Winter Flounder "Antifreeze" Proteins: Synthesis and Ice Growth Inhibition of Analogs that Probe the Relative Importance of Hydrophobic and Hydrogen-Bonding Interactions', Journal of the American Chemical Society, vol. 121, no. 5, pp. 941-948.
- Painter, L, Harding, P & Beeby, P 1998, 'Synthesis and interaction with human serum albumin of the first 3,18-disubstituted derivative of bilirubin', Journal of the Chemical Society, Perkin Transactions 1, vol. 18, pp. 3041-3044.
- Harding, P, Mokdsi, G, Mackay, J et al 1998, 'Interactions of the Antitumor Agent Molybdocene Dichloride with Oligonucleotides', Inorganic Chemistry, vol. 37, no. 10, pp. 2432-2437.
- Haymet, A, Ward, L, Harding, P et al 1998, 'Valine substituted winter flounder 'antifreeze': preservation of ice growth hysteresis', FEBS Letters, vol. 430, no. 3, pp. 301-306.
- Harding, P & Mokdsi, G 1998, 'Antitumor metallocenes: effect of DMSO on the stability of Cp2TiX2 and implications for anticancer activity', Metal-Based Drugs, vol. 5, no. 4, pp. 207-215.
- Baker, R, George, A & Harding, M 1998, 'Models and molecules - a workshop on stereoisomers', Journal of Chemical Education, vol. 75, no. 7, pp. 853-855.
- Mokdsi, G & Harding, P 1998, 'Water soluble, hydrolytically stable derivatives of the antitumor drug titanocene dichloride and binding studies with nucleotides', Journal of Organometallic Chemistry, vol. 565, no. 1-2, pp. 29-35.
- Try, A, Harding, P, Hamilton, D et al 1998, 'Reversible five-component assembly of a [2]catenane from a chiral metallomacrocycle and a dinaphtho-crown ether', Chemical Communications, vol. 6, pp. 723-724.
- Try, A, Painter, L & Harding, P 1998, 'Rigid chiral carbocyclic clefts as building blocks for the construction of new supramolecular hosts', Tetrahedron Letters, vol. 39, no. 52, pp. 9809-9812.
- Harding, P & Long, G 1997, 'Interaction of the antitumor antibiotic streptonigrin with metal ions and DNA', Current Medicinal Chemistry, vol. 4, no. 6, pp. 405-420.
- Houghton, M, Bilyk, A, Harding, P et al 1997, 'Effect of guest molecules, metal ions and linker length on the assembly of chiral [2+2] metallomacrocycles: solutions studies and crystal structures', Dalton Transactions, vol. 15, pp. 2725-2733.
- Long, G, Harding, P, Fan, J et al 1997, 'Interaction of the antitumor antibiotic streptonigrin with DNA and oligonucleotides', Anti-Cancer Drug Design, vol. 12, no. 6, pp. 453-472.
- Harding, P, Krippner, G, Shelton, C et al 1997, 'DNA-binding studies of XSPTSPSZ, derivatives of the intercalating heptad repeat of RNA polymerase II', Biopolymers, vol. 42, no. 4, pp. 387-398.
