Dr Amee George
BSc (Hons), PhD
Research Fellow (ACRF Department of Cancer Biology and Therapeutics) and Manager, ANU Centre for Therapeutic Discovery (ACTD), Biomolecular Resource Facility, JCSMR
ANU College of Health and Medicine
Research interests
- High throughput screening
- siRNA screening (high content and high throughput)
- Compound screening
- High content imaging
- Ribosome biogenesis
- Ribosomopathies (Diamond Blackfan Anaemia)
- Cancer cell biology
- Cell signalling
- Cell biology
Publications
- Chan, K, Blake, S, Zhu, H et al. 2020, 'A functional genetic screen defines the AKT-induced senescence signaling network', Cell Death and Differentiation, vol. 27, pp. 725-741.
- Nunez Villacis, L, Wong, M, Ferguson, L et al. 2018, 'New Roles for the Nucleolus in Health and Disease', Bioessays, vol. 40, no. 5, pp. 11pp.
- He, J, Soo, H, Evers, M et al. 2018, 'High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology', Assay and Drug Development Technologies, vol. 16, no. 6, pp. 320-332pp.
- Coulson, R, Liew, S, Connelly, A et al 2017, 'The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma', Oncotarget, vol. 8, no. 12, pp. 18640-18656pp.
- Hein, N, Cameron, D, Hannan, K et al. 2017, 'Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population', Blood, vol. 129, no. 21, pp. 2882-2895pp.
- George, A, Allen, A & Chand, A 2017, 'Repurposing ARBs as treatments for breast cancer', Aging, vol. 9, no. 5, pp. 1357-1358pp.
- Venugopal, P, Moore, S, Lawrence, D et al 2017, 'Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan Anemia patient', Haematologica, vol. 102, no. 12, pp. e506-e509pp.
- Devlin, J, Hannan, K, Hein, N et al. 2016, 'Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma', Cancer Discovery, vol. 6, no. 1, pp. 59-70.
- Quin, J, Chan, K, Devlin, J et al. 2016, 'Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling', Oncotarget, vol. 7, no. 31, pp. 49800-49818.
- Chan, K, Paavolainen, L, Hannan, K et al. 2016, 'Combining high-content imaging and phenotypic classification analysis of senescence-associated beta-galactosidase staining to identify regulators of oncogene-induced senescence', Assay and Drug Development Technologies, vol. 14, no. 7, pp. 416-428.
- Harrison, S, George, A & Hannan, R 2015, 'Commentary - A new window on cancer therapy? Targeting the nucleolus and ribosome biogenesis using the small molecule inhibitor of polymerase I transcription, CX-5461', International Journal of Hematologic Oncology, vol. 4, no. 2, pp. 61-65pp.
- Sjogren, S, Siva, K, Soneji, S et al 2015, 'Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia', British Journal of Haematology, vol. 171, no. 4, pp. 517-529.
- Hein, N, Hannan, K, George, A et al. 2013, 'The nucleolus: An emerging target for cancer therapy', Trends in Molecular Medicine, vol. 19, no. 11, pp. 643-654.
- George, A, Purdue, B, Gould, C et al 2013, 'A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation', Journal of Cell Science, vol. 126, no. 23, pp. 5377-5390.
- George, A, Hannan, R & Thomas, W 2013, 'Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches', The FEBS Journal, vol. 280, no. 21, pp. 5258-5268.
- George, A, Purdue, B, Gould, K et al 2012, 'A Functional SiRNA Screening Approach to Investigate the Mechanism Underlying GPCR-mediated EGFR Transactivation in Malignancy', European Journal of Cancer, vol. 48, no. 5, pp. S149-S149.
- Astle, M, Hannan, K, Ng, P et al. 2012, 'AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: Implications for targeting mTOR during malignancy', Oncogene, vol. 31, no. 15, pp. 1949-1962.
- George, A, Thomas, W & Hannan, R 2010, 'The renin-angiotensin system and cancer: Old dog, new tricks', Nature Reviews Cancer, vol. 10, no. 11, pp. 745-759.
- George, A, Gordon, L, Beissbarth, T et al 2010, 'A Serial Analysis of Gene Expression Profile of the Alzheimer's Disease Tg2576 Mouse Model', Neurotoxicity Research, vol. 17, no. 4, pp. 360-379.
- Wong, L, McGhie, J, Sim, M et al 2010, 'ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells', Genome Research, vol. 20, no. 3, pp. 351-360.
