Associate Professor Tamás Fischer
Areas of expertise
- Epigenetics (Incl. Genome Methylation And Epigenomics) 060404
- Gene Expression (Incl. Microarray And Other Genome Wide Approaches) 060405
- Genome Structure And Regulation 060407
- Genomics 060408
- Biochemistry And Cell Biology Not Elsewhere Classified 060199
- Synthetic Biology 060113
- Cancer Genetics 111203
- Cancer Diagnosis 111202
- Cancer Therapy (Excl. Chemotherapy And Radiation Therapy) 111204
Research interests
The major research focus in the Fischer lab is to understand the connection between chromatin structure, pervasive transcription and RNA surveillance, and their influence on genomic stability and disease development, especially in cancer and aging-related diseases. In addition, the lab is pursuing synthetic biology approaches to develop early detection and novel treatment methods in cancer.
Biography
Tamás Fischer is an Associate Professor at The John Curtin School of Medical Research (JCSMR) at The Australian National University. He completed his PhD studies in 2005 at the University of Heidelberg, Germany, working on the nuclear export of mRNA and its coupling to transcription. Following his PhD, he was awarded a postdoctoral fellowship in epigenetics and chromatin biology at the National Cancer Institute (NCI, NIH) in the USA. He returned to Germany in 2010 to establish his own independent research group at the University of Heidelberg Biochemistry Center. He has recently moved his laboratory to Canberra, Australia to join the Department of Genome Sciences at JCSMR.
Publications
- Calviño, F, Kornprobst, M, Schermann, G et al 2017, 'Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis', PLOS ONE (Public Library of Science), vol. 12, no. 6, pp. e0178752-e0178752.
- Gumiero, A, Conz, C, Gese, G et al. 2016, 'Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain', Nature Communications, vol. 7, no. 13563, pp. 13563-13563.
- Tucker, J, Ohle, C, Schermann, G et al 2016, 'A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5 '-3 ' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe', PLoS Genetics, vol. 12, no. 2, pp. e1005873-e1005873.
- Ohle, C, Tesorero, R, Schermann, G et al 2016, 'Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair', Cell, vol. 167, no. 4, pp. 1001-1013.
- Zhou, Y, Zhu, J, Schermann, G et al. 2015, 'The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome', Nature Communications, vol. 6, no. 7050, pp. 1-11.
- Sancar, C, Ha, N, Yilmaz, R et al 2015, 'Combinatorial Control of Light Induced Chromatin Remodeling and Gene Activation in Neurospora', PLoS Genetics, vol. 11, no. 3, pp. e1005105-e1005105.
- Hoffmann, J, Symul, L, Shostak, A et al 2014, 'Non-circadian expression masking clock-driven weak transcription rhythms in U2OS Cells', PLOS ONE (Public Library of Science), vol. 9, no. 7, pp. e102238-e102238.
- Henning, B & Fischer, T 2013, 'The great repression: Chromatin and cryptic transcription', Transcription (Austin), vol. 4, no. 3, pp. 1-5.
- Henning, B, Bendrin, K, Zhou, Y et al 2012, 'Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription', EMBO Reports, vol. 13, no. 11, pp. 997 - 1003.
- Zhang, K, Fischer, T, Porter, R et al 2011, 'Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA', Science, vol. 331, no. 6024, pp. 1624 - 1627.
- Zofall, M, Fischer, T, Zhang, K et al 2009, 'Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs', Nature, vol. 461, no. 7262, pp. 419-422.
- Fischer, T, Cui, B, Dhakshnamoorthy, J et al 2009, 'Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 22, pp. 8998-9003.
- Jani, D, Lutz, S, Marshall, N et al 2009, 'Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export', Molecular Cell, vol. 33, no. 6, pp. 727 - 737.
- Roguev, A, Bandyopadhyay, S, Zofall, M et al 2008, 'Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast', Science, vol. 322, no. 5900, pp. 405-410.
- Grund, S, Fischer, T, Cabal, G et al 2008, 'The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression', Journal of Cell Biology, vol. 182, no. 5, pp. 897 - 910.
- Fischer, T, Rodriguez-Navarro, S, Pereira, G et al 2004, 'Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery', Nature Cell Biology, vol. 6, no. 9, pp. 840 - 849.
- Rodriguez-Navarro, S, Fischer, T, Luo, M et al 2004, 'Sus1, a Functional Component of the SAGA Histone Acetylase Complex and the Nuclear Pore-Associated mRNA Export Machinery', Cell, vol. 116, no. 1, pp. 75 - 86.
- Olasz, F, Fischer, T, Szabo, M et al 2003, 'Gene Conversion in Transposition of Escherichia coli Element IS30', Journal of Molecular Biology, vol. 334, no. 5, pp. 967-978.
- Fischer, T, Straber, K, Racz, A et al 2002, 'The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores', The EMBO Journal, vol. 21, no. 21, pp. 5843 - 5852.
- Czirjak, G, Fischer, T, Spat, A et al 2000, 'TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II', Molecular Endocrinology, vol. 14, no. 6, pp. 863-874.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Chromatin structure and pervasive transcription (Primary Investigator)
