Areas of expertise

• Animal Cell And Molecular Biology 060802
• Haematology 110202
• Cellular Immunology 110704
• Tumour Immunology 110709
• Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics) 110106

Publications

• Roco Alegre, J, Mesin, L, Binder, S et al. 2019, 'Class-Switch Recombination Occurs Infrequently in Germinal Centers', Immunity, vol. 51, no. 2, pp. 337-350.
• Jiang, S, Athanasopoulos, V, Ellyard, J et al. 2019, 'Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus', Nature Communications, vol. 10, no. 2201, pp. 1-12.
• Tavernier, S, Athanasopoulos, V, Verloo, P et al. 2019, 'A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation', Nature Communications, vol. 10, no. 4779, pp. 1-16.
• Ellyard, J, Tunningley, R, Lorenzo, A et al. 2019, 'Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders', Frontiers in Immunology, vol. 10, no. 2134, pp. 1-13.
• Ramiscal, R, Parish, I, Lee-Young, R et al. 2015, 'Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation', eLife, vol. 4, pp. e08698-e08698.
• Jiang, S, Athanasopoulos, V, Cappello, J et al. 2015, 'BANK1: A critical genetic determinant of B-Cell systemic lupus erythematosus', 51st Australian and New Zealand Society of Nephrology Annual Scientific Meeting, ed. Peter G Kerr, Asian Pacific Society of Nephrology, Canberra, Australia, pp. 22PP.
• Ellyard, J, Jerjen, R, Martin, J et al. 2014, 'Identification of a Pathogenic Variant in TREX1 in Early-Onset Cerebral Systemic Lupus Erythematosus by Whole-Exome Sequencing', Arthritis & Rheumatism, vol. 66, no. 12, pp. 3382-3386.
• Ellyard, J, Chia, T, Rodriguez-Pinilla, S et al. 2012, 'Heterozygosity for Roquin(san) leads to angioimmunoblastic T-cell lymphoma-like tumors in mice', Blood, vol. 120, no. 4, pp. 812-821.
• Ellyard, J, Benk, A, Taylor, B et al 2011, 'The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin', European Journal of Immunology, vol. 41, no. 2, pp. 485-490.
• Ellyard, JI, Vinuesa, CG, 2011, 'A BATF-ling connection between B cells and follicular helper T cells', Nature Immunology, vol. 12, no. 6, pp. 519-520.
• Simson, L, Ellyard, J & Parish, C 2010, 'The Role of Th2-Mediated Anti-Tumor Immunity in Tumor Surveillance and Clearance', in M. Penichet, E. Jensen-Jarolim (ed.), Cancer and IgE: Introducing the concept of AllergoOncology, Springer, New York, pp. 255-275.
• Ellyard, J, Quah, B, Simson, L et al 2010, 'Alternatively activated macrophage possess antitumor cytotoxicity that is induced by IL-4 and mediated by arginase-1', Journal of Immunotherapy, vol. 33, no. 5, pp. 443-452.
• Yu, D, Rao, S, Tsai, LM, Lee, SK, He, YQ, Sutcliffe, EL, Srivastava, M, Linterman, M, Zheng, L, Simpson, N, Ellyard,JI, Parish, IA, Ma, CS, Li, QJ, Parish, CR, Mackay, CR, Vinuesa, CG, 2009, 'The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment', Immunity, vol. 31, pp. 457-468.
• Simson, L, Ellyard, J, Dent, L et al. 2007, 'Potential role for eosinophils in tumor immune surveillance', in Jorge Kalil, Edecio Cinha-Neto and Luiz vicente Rizzo (ed.), Proceedings 13th International Congress of Immunology, Medimond, Bologna, Italy, pp. 161-165.
• Ellyard, J, Simson, L, Orlov, A et al. 2007, 'Eotaxin Selectively Binds Heparin: An interaction that protects eotaxin from proteolysis and potentiates chemotactic activity in vivo', Journal of Biological Chemistry, vol. 282, no. 29, pp. 15238-15247.
• Ellyard, J, Simson, L & Parish, C 2007, 'Th2-mediated anti-tumour immunity: Friend or foe?', Tissue Antigens, vol. 70, pp. 1-11.
• Simson, L, Ellyard, J, Dent, L et al. 2007, 'Regulation of Carcinogenesis by IL-5 and CCL11: A Potential Role for Eosinophils in Tumor Immune Surveillance', Journal of Immunology, vol. 178, pp. 4222-4229.
• Ellyard, J, Avery, D, Mackay, C et al 2005, 'Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54', European Journal of Immunology, vol. 35, no. 3, pp. 699-708.
• Avery, D, Ellyard, J, Mackay, F et al 2005, 'Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage', Journal of Immunology, vol. 174, pp. 4034-4042.
• Ellyard, J, Avery, D, Phan, T et al 2004, 'Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow', Blood, vol. 103, no. 10, pp. 3805-3812.
• Avery, D, Kalled, S, Ellyard, J et al 2003, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, vol. 112, no. 2, pp. 286-297.

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

• Novel pathways that regulate T cells (Secondary Investigator)
• The effect of follicular helper T cells on AID regulation and selection of high affinity germinal centre B cells (Primary Investigator)