Emeritus Professor Simon Easteal
Areas of expertise
- Anthropological Genetics 060401
- Bioinformatics 060102
- Biological Adaptation 060303
- Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) 170101
- Developmental Psychology And Ageing 170102
- Epidemiology 111706
- Gene Expression (Incl. Microarray And Other Genome Wide Approaches) 060405
- Genomics 060408
- Mental Health 111714
- Molecular Evolution 060409
- Population, Ecological And Evolutionary Genetics 060411
- Quantitative Genetics (Incl. Disease And Trait Mapping Genetics) 060412
Research interests
My research focuses on the evolution of human diversity and the influence of our evolutionary past on our current heath and wellbeing. I research: how environmental factors influence the function of the human genome; how the human genome has evolved in response to environmental change; how individual differences in genome structure modify environmental influences on development, ageing, performance and health; how differences in genome structure and function can indicate health status and biological functioning.
Biography
I was appointed Head of the Human Genetics Group, JCSMR in 1994 and Professor in 2000. From 2002 to 2003 I worked part-time as Director of the Genetic Epidemiology Unit at the Menzies Institute of Population Health Research at the University of Tasmania and from 2004 to 2005 worked as one of the foundation Trusted Intermediaries in the InnovationXchange Network. From 2008 to 2011 I was appointed as Deputy Director, JCSMR.
I have received over $22,000,000 in external research funding to support his research from a wide range of agencies including the Australian Research Council and The National Health and Medical Research Council. I have published 2 books and ~175 articles and I have been invited to give numerous international seminar and conference presentations.
I have supervised 25 PhD students and has been an advisor to many more, and 12 masters-by-research and honours students.
From 1998 to 2003 I was Editor-in-Chief of Molecular Biology and Evolution and I have served on the Editorial Boards of a number of other journals. I was a member of the Scientific Advisory Board of Entigen Inc. (a bioinformatics start-up company based in Sunnyvale, California; 2001), the Scientific Advisory Committee of Genetic Technologies Ltd. (a Melbourne-based genetics testing company; 2003-07), the Research Committee of the Australian Institute of Sport (2001-03), the Selection Advisory Committee of the Australian Research Council Future Fellowships Scheme (2010), the National Selection Committee of the Australian-American Fulbright Commission (2009-10) and the ARC Bioinformatics Centre of Excellence, University of Queensland (2003-10).
I have been a consultant to the Defence Science and Technology Organisation (DSTO), The Australian Industry Group, the Commonwealth Department of Education, Science and Training and the University of Tasmania. I have provided expert testimony in relation to DNA evidence in the ACT, New South Wales, the Northern Territory, Queensland, Tasmania and Victoria, and I have provided expert advice to a wide range of organisations and agencies.
Researcher's projects
Gene-environment interactions affecting mental health and cognitive decline in late age.
Gene-environment interactions in human social and affiliative behaviour.
Genetics and evolution of human psychological diveristy.
Genomic responses to environmental change in humans.
Human genome diversity and evolution.
Available student projects
Gene environment interactions associated with mental health and age-related cognitive decline.
Evoultionary analysis of haplotype variation in the human genome.
Development and application of novel approaches to mapping human genome sequence variation associated with continuous traits and disease phenotypes.
Gene-environment interactions associated with social and affilative behaviour.
Evolutionary analysis of tandem repeat variation.
Current student projects
The effect of cooperative behaviour on the evolution of senescence.
The role of argenine vasopressin receptor gene variation in male social and affiliative behaviour.
Variation in human AVPR1a and OXTR genes: cellular function and influence on social behaviour, personality and health.
Mapping genes associated with sex-specific survivorship in humans.
Bioinformatic approaches to characterizing transfusion transmitted viruses: occult hepatitis B virus.
Development, implementation and application of new algorithms for genotyping tandem repeat variation from human genome sequencing.
Past student projects
Telomere length variation and age-related decline in a large population sample.
Genotype-environment interations in determining common forms of mental illness associated with anxiety and depression.
The functional effects and evolutionary history of a common null allele in the human ACTN3 gene.
Patterns of genetic variation in peoples of mainland Papua New Guinea.
Genetic and environmental determinants of antisocial behaviour patterns in humans.
Evolution of the Gerbich negative allele of glycophorin C: Co-evolution of malaria and its human hosts.
Analysis of the relationship between the 7-repeat allele of the DRD4 gene and ADHD with comorbid depression.
Variation in Natural Selection in 647 Environmental Health Related Genes.
Evolution of Genetic Loci Associated with the Size of the Neurocranium and Brain: Results from the Alpha Thalassaemia/ Mental Retardation X-linked Gene ATRX
The role of oxytocin in affiliative behaviour: A study of naturally occurring variation in the human oxytocin receptor gene (OXTR).
A role for Apoptosis and Mitochondrial Haplogroup J in Human Ageing.
Effect of Microsatellite Variation on the Expression of the Human Arginine-Vasopressin Receptor-1a (AVPR1a) gene.
Association of Polymorphisms of the Estrogen Receptor Gene with Human Behaviour Traits.
Publications
- Culverhouse, R, Saccone, N, Horton, A et al 2018, 'Collaborative meta-Analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression', Molecular Psychiatry, vol. 23, no. 1, pp. 133-142pp.
- Hawi, Z, Cummins, T, Tong, J et al. 2017, 'Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study', Molecular Psychiatry, vol. 22, no. 4, pp. 580-584.
- Newman, S & Easteal, S 2017, 'The dynamic upper limit of human lifespan [version 2; referees: 1 approved, 2 approved with reservations]', F1000 Research, vol. 6, no. 569, pp. 20pp.
- Andrews, S, Das, D, Anstey, K et al 2017, 'Association of AKAP6 and MIR2113 with cognitive performance in a population based sample of older adults', Genes, Brain and Behavior, vol. 16, no. 4, pp. 472-478pp.
- Andrews, S, Eramudugolla, R, Velez Valbuena, J et al. 2017, 'Validating the role of the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years', Alzheimer's Research and Therapy, vol. 9, no. 1, pp. 16-16.
- Culverhouse, R, Saccone, N, Horton, A et al. 2017, 'Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression', Molecular Psychiatry, vol. Online, pp. 10pp.
- Andrews, S, Das, D, Anstey, K et al 2017, 'Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study', Journal of Alzheimer's Disease, vol. 57, no. 2, pp. 423-436pp.
- Das, D, Cherbuin, N, Anstey, K et al 2017, 'Regional Brain Volumes and ADHD Symptoms in Middle-Aged Adults: The PATH Through Life Study', Journal of Attention Disorders, vol. 21, no. 13, pp. 1073-1086.
- Velez Valbuena, J, Rivera, D, Mastronardi, C et al. 2016, 'A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer's Disease', Neural Plasticity, vol. 2016, pp. 9760314-9760314.
- Mastronardi, C, Pillai, E, Pineda, D et al. 2016, 'Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate', Molecular Psychiatry, vol. 21, no. 10, pp. 1434-1440.
- Das, D, Velez Valbuena, J, Acosta, M et al. 2016, 'Retrospective assessment of childhood ADHD symptoms for diagnosis in adults: validity of a short 8-item version of the Wender-Utah Rating Scale', Attention Deficit and Hyperactivity Disorders - ADHD, vol. 8, no. 4, pp. 215-223.
- Velez Valbuena, J, Lopera, F, Patel, H et al. 2016, 'Mutations modifying sporadic Alzheimer's disease age of onset', American Journal of Medical Genetics, Part B: Neuropsychiatric, vol. 171, no. 8, pp. 1116-1130.
- Newman, S, Eyre, S, Kimble, C et al. 2016, 'REPRODUCTIVE SUCCESS IS PREDICTED BY SOCIAL DYNAMICS AND KINSHIP IN MANAGED ANIMAL POPULATIONS', F1000 Research, vol. 5, no. 870, pp. 870-870.
- Lueders, E, Kurth, F, Das, D et al. 2016, 'Associations between corpus callosum size and ADHD symptoms in older adults: The PATH through life study', Psychiatry Research: Neuroimaging, vol. 256, pp. 8-14pp.
- Andrews, S, Das, D, Cherbuin, N et al 2016, 'Association of genetic risk factors with cognitive decline: the PATH through life project', Neurobiology of Aging, vol. 41, pp. 150-158.
- Velez Valbuena, J, Jack, C, Chuah, A et al. 2015, 'Cross validation of pooling/resampling GWAS using the WTCCC data', Molecular Biology and Genetic Engineering, vol. 3, no. 1, pp. 1-10.
- Gyngell, C & Easteal, S 2015, 'Cognitive Diversity and Moral Enhancement', Cambridge Quarterly of Healthcare Ethics, vol. 24, no. 1, pp. 66-74.
- Newman, S & Easteal, S 2015, 'A new metric of inclusive fitness predicts the human mortality profile', PLOS ONE (Public Library of Science), vol. 10, no. 1, pp. e0117019-e0117019.
- Cherbuin, N, Sargent, K, Easteal, S et al. 2015, 'Hippocampal atrophy is associated with subjective memory decline: The PATH Through Life study', American Journal of Geriatric Psychiatry, vol. 23, no. 5, pp. 446-455.
- Andrews, S, Das, D, Anstey, K et al 2015, 'Interactive effect of APOE genotype and blood pressure on cognitive decline: The PATH Through Life Study', Journal of Alzheimer's Disease, vol. 44, no. 4, pp. 1087-1098.
- Velez Valbuena, J, Lopera, F, Falla, D et al. 2015, 'APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease', Molecular Psychiatry, vol. 21, no. 7, pp. 916-924.
- Das, D, Cherbuin, N, Anstey, K et al 2015, 'ADHD Symptoms and Cognitive Abilities in the Midlife Cohort of the PATH Through Life Study', Journal of Attention Disorders, vol. 19, no. 5, pp. 414-424.
- Bunce, D, Bielak, A, Anstey, K et al 2014, 'APOE Genotype and Cognitive Change in Young, Middle-Aged, and Older Adults Living in the Community', Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 69, no. 4, pp. 379-386.
- Bunce, D, Bielak, A, Anstey, K et al 2014, 'APOE Genotype and Cognitive Change in Young, Middle-Aged, and Older Adults Living in the Community', Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 69, no. 4, pp. 379-386.
- Eramudugolla, R, Bielak, A, Bunce, D et al 2014, 'Long-Term Cognitive Correlates of Traumatic Brain Injury across Adulthood and Interactions with APOE Genotype, Sex, and Age Cohorts', Journal of International Neuropsychological Society, vol. 20, no. 4, pp. 444-454.
- Das, D, Cherbuin, N, Easteal, S et al 2014, 'Attention deficit/hyperactivity disorder symptoms and cognitive abilities in the late-life cohort of the PATH Through Life Study', PLOS ONE (Public Library of Science), vol. 9, no. 1, pp. e86552-e86552.
- Assareh, A, Mather, K, Crawford, J et al. 2014, 'Renin-Angiotensin system genetic polymorphisms and brain white matter lesions in older Australians', American Journal of Hypertension, vol. 27, no. 9, pp. 1191-1198.
- Das D, Tan X, Bielak AAM et al 2014, 'Cognitive ability, intraindividual variability and common genetic variants of COMT and BDNF: a longitudinal study in a population-based sample of old adults', Psychology and Aging.
- Londono, A, Castellanos, F, Andres, A et al 2013, 'An 1H-MRS framework predicts the onset of Alzheimer's disease symptoms in PSEN1 mutation carriers', Alzheimer's & Dementia, vol. 2013, pp. 1-10.
- Culverhouse, R, Bowes, L, Breslau, N et al 2013, 'Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression', BMC Psychiatry, vol. 13, no. 13, pp. 304-304.
- Anstey, KJ, Cherbuin, N, Eramudugolla, R et al 2013, 'Characterizing Mild Cognitive Disorders in the young-old over 8 years: Prevalence, estimated incidence, stability of diagnosis, and impact on IADLs**', Alzheimer's & Dementia.
- Shang, G, Easteal, S, Ohms, S et al 2013, 'Predicting the presence of hepatitis B virus surface antigen in Chinese patients by pathology data mining', Journal of Medical Virology, vol. 85, no. 8, pp. 1334-1339.
- Eramudugolla, R, Cherbuin, N, Easteal, S et al 2012, 'Self-Reported Cognitive Decline on the Informant Questionnaire on Cognitive Decline in the Elderly Is Associated with Dementia, Instrumental Activities of Daily Living and Depression but Not Longitudinal Cognitive Change', Dementia and Geriatric Cognitive Disorders, vol. 34, no. 5-6, pp. 282-291.
- Das, D, Cherbuin, N, Butterworth, P et al 2012, 'A Population-Based Study of Attention Deficit/Hyperactivity Disorder Symptoms and Associated Impairment in Middle-Aged Adults', PLOS ONE (Public Library of Science), vol. 7, no. 2, pp. e31500-e31500.
- Anstey, KJ, Christensen, H, Butterworth, P et al 2011, 'Cohort Profile: The PATH through life project', International Journal of Epidemiology, pp. 1-10.
- Bunce, D, Anstey, KJ, Cherbuin, N et al 2012, 'APOE genotype and entorhinal cortex volume in non-demented community-dwelling adults in midlife and early old age', Journal of Alzheimer's Disease, vol. Epub ahead of print, no. 30, pp. 1-8.
- Das, D, Cherbuin, N, Anstey, KJ, Sachdev, PS & Easteal, S 2011, 'Lifetime cigarette smoking is associated with striatal volume measures', Addiction Biology, vol. Online.
- Das, D, Tan, X & Easteal, S 2011, 'Effect of Model Choice in Genetic Association Studies: DRD4 Exon III VNTR and Cigarette Use in Young Adults', American Journal of Medical Genetics, Part B: Neuropsychiatric, vol. 156B, no. 3, pp. 346-351.
- Das, D, Cherbuin, N, Tan, X et al. 2011, 'DRD4-exonIII-VNTR Moderates the Effect of Childhood Adversities on Emotional Resilience in Young-Adults', PLOS ONE (Public Library of Science), vol. 6, no. 5, pp. e20177-e20177.
- Bunce, D., Anstey, K.J., Burns, R.A., Christensen, H. & Eastel, S. (2011). Does possession of apolipoprotein E varepsilon4 benefit cognitive function in healthy young adults?, Neuropsychologia, vol. 49, pp. 1693-1697.
- Licinio, J, Easteal, S & Wong, M 2010, 'Concrete helix recalls smallpox win', Nature, vol. 468, no. 7321, p. 173.
- Arnold, B, Easteal, P, Easteal, S, Rice, S, 2010, 'It just doesn't ADD Up: ADHD/ADD, the Workplace and Discrimination', Melbourne University Law Review, vol. 34, no. 2, p. 359.
- Sachdev, P, Parslow, R, Wen, W et al 2005, 'Why do women have more white matter hyperintensities? Sex differences in the extent, aetiology and consequences of leukoaraiosis', 2nd International Society on Brain and Behaviour, BioMed Central Ltd., London, p. 1.
- Adcock, G, Easteal, S, Huttley, G et al 2001, 'Human origins and ancient human DNA [3]', Science, vol. 292, no. 5522, pp. 1655-1656.
- Smith, A, Box, N, Marks, L et al 2001, 'The human melanocortin-1 receptor locus: Analysis of transcription unit, locus polymorphism and haplotype evolution', Gene, vol. 281, no. 1-2, pp. 81-94.
- Huttley, G, Easteal, S, Southey, M et al 2000, 'Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees', Nature Genetics, vol. 25, no. 4, pp. 410-413.
- Mather, K, Jorm, A, Milburn, P et al. 2010, 'No associations between telomere length and age-sensitive indicators of physical function in mid and later life', Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 65, no. 8, pp. 792-799.
- Yap, V, Lindsay, H, Easteal, S et al 2010, 'Estimates of the effect of natural selection on protein-coding content', Molecular Biology and Evolution, vol. 27, no. 3, pp. 726-734.
- Chipman, P, Jorm, A, Tan, X et al. 2010, 'No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life even', Psychiatric Genetics, vol. 20, no. 1, pp. 8-13.
- Mather, K, Jorm, A, Anstey, K et al 2010, 'Cognitive performance and leukocyte telomere length in two narrow age-range cohorts: a population study', BMC geriatrics, vol. 10, pp. 62-62.
- Sachdev, P, Parslow, R, Wen, W et al 2009, 'Sex differences in the causes and consequences of white matter hyperintensities', Neurobiology of Aging, vol. 30, no. 6, pp. 946-56.
- Cherbuin, N, Meslin, C, Kumar, R et al. 2009, 'Risk factors of transition from normal cognition to mild cognitive disorder: The PATH trough Life study.', Dementia and Geriatric Cognitive Disorders, vol. 28, no. 1, pp. 47-55.
- Christensen, H, Batterham, P, Mackinnon, A et al 2008, 'The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample', BMC geriatrics, vol. 8, no. 14, pp. 1-10.
- Cherbuin, N, Anstey, K, Sachdev, P et al. 2008, 'Total and Regional Gray Matter Volume Is Not Related to APOE*E4 Status in a Community Sample of Middle-Aged Individuals', Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 63, no. 5, pp. 501-504.
- Schranz, H, Yap, V, Easteal, S et al 2008, 'Pathological rate matrices: from primates to pathogens', BMC Bioinformatics, vol. 9, no. 1, pp. 1-10.
- Scott, B & Easteal, S 2008, 'A single-step assay for the Gerbich-negative allele of glycophorin C', Blood cells, Molecules and Diseases, vol. 41, no. 1, pp. 1-4.
- Prichard, Z, Mackinnon, A, Jorm, A et al 2008, 'No evidence for interaction between MAOA and childhood adversity for antisocial behavior', American Journal of Medical Genetics, Part B: Neuropsychiatric, vol. 147, pp. 228-232.
- Easteal, S 2007, 'Long distance linkage disequilibrium between HLA microsatellites in two human populations', in John A. Hansen (ed.), Immunobiology of the Human MHC: Proceedings of the 13th International Histocompatibility Workshop and Conference, IHWG Press, Seattle, US, pp. 33-36.
- Jorm, A, Mather, K, Butterworth, P et al. 2007, 'APOE Genotype and Cognitive Functioning in a Large Age-Stratified Population Sample.', Neuropsychology, vol. 21, no. 1, pp. 1-8.
- Prichard, Z, Jorm, A, Mackinnon, A et al 2007, 'Association analysis of 15 polymorphisms within 10 candidate genes for antisocial behavioural traits', Psychiatric Genetics, vol. 17, pp. 299-303.
- Golubchik, T, Wise, M, Easteal, S et al 2007, 'Mind the gaps: evidence of bias in estimates of multiple sequence alignments', Molecular Biology and Evolution, vol. 24, no. 11, pp. 2433-42.
- MacArthur, D, Seto, J, Raftery, J et al 2007, 'Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans', Nature Genetics, vol. 39, no. 10, pp. 1261-5.
- Prichard, Z, Mackinnon, A, Jorm, A et al 2007, 'AVPR1A and OXTR polymorphisms are associated with sexual and reproductive behavioral phenotypes in humans.', Human Mutation, vol. 28, no. 11, p. 1150.
- Huttley, G, Wakefield, M & Easteal, S 2007, 'Rates of genome evolution and branching order from whole genome analysis', Molecular Biology and Evolution, vol. 24, no. 8, pp. 1722-30.
- Chipman, P, Jorm, A, Prior, M et al. 2007, 'No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: results from two community surveys', American Journal of Medical Genetics, Part B: Neuropsychiatric, vol. 144, no. 4, pp. 561-5.
- Ng, C, Easteal, S, Schweitzer, I et al. 2006, 'Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities', Progress in neuro-psychopharmacology and biological psychiatry, vol. 30, no. 5, pp. 953-7.
- Prichard, Z & Easteal, S 2006, 'Characterization of simple sequence repeat variants linked to candidate genes for behavioral phenotypes', Human Mutation, vol. 27, no. 1, p. 120.
- Ho, J, Adams, C, Lew, J et al 2006, 'SeqVis: visualization of compositional heterogeneity in large alignments of nucleotides', Bioinformatics, vol. 22, no. 17, pp. 2162-3.
- Harley, N, Attenborough, R, Alpers, M et al 2005, 'The importance of social structure for patterns of human genetic diversity: Y-chromosome and mitochondrial genome variation in Papuan speaking people of mainland Papua New Guinea', in Andrew Pawley, Robert Attenborough, Jack Golson and Robin Hide (ed.), Papuan pasts: Cultural, linguistic and biological histories of Papuan-speaking peoples, Pacific Linguistics, Canberra Australia, pp. 729-756.
- Easteal, S, Whittle, B, Mettenmeyer, A et al 2005, 'Mitochondrial genome diversity among Papuan-speaking people of Papua New Guinea', in Andrew Pawley, Robert Attenborough, Jack Golson and Robin Hide (ed.), Papuan pasts: Cultural, linguistic and biological histories of Papuan-speaking peoples, Pacific Linguistics, Canberra Australia, pp. 717-728.
- Jorm, A, Christensen, H, Rodgers, B et al. 2004, 'Association of Adverse Childhood Experiences, Age of Menarche, and Adult Reproductive Behavior: Does the Androgen Receptor Gene Play a Role?', American Journal of Medical Genetics, Part A, vol. 125B, pp. 105-111.
- Ng, C, Schweitzer, I, Norman, T et al 2004, 'The emerging role of pharmacogenetics: implications for clinical psychiatry', Australian and New Zealand Journal of Psychiatry, vol. 38, no. 7, pp. 483-489.
- Dwyer, T, Ponsonby, A, Stankovich, J et al 2004, 'Measuring environmental factors can enhance the search for disease causing genes?', Journal of Epidemiology and Community Health, vol. 58, pp. 613-615.
- Jorm, A, Butterworth, P, Anstey, K et al. 2004, 'Memory complaints in a community sample aged 60-64: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white matter hperintensities.', Psychological Medicine, vol. 34, pp. 1495-1506.
- Torpy, D, Bachmann, A, Gartside, M et al 2004, 'Association between chronic fatigue syndrome and the corticosteroid-binding globulingene ALA SER224 polymorphism', Endocrine Research, vol. 30, no. 3, pp. 417-429.
- Turakulov, R, Jorm, A, Jacomb, P et al. 2004, 'Association of dopamine-β-hydroxylase and androgen receptor gene polymorphisms with Eysencks P and other personality traits', Personality and Individual Differences, vol. 37, pp. 191-202.
- Easteal, S, Bhatia, K & Kirk, R 2004, 'A Study of Genetic Distance and the Austronesian/ Non-Austonesian Dichotomy', in Peter Bellwood (ed.), The Austronesians: Historical and Comparative Perspectives, ANU ePress, Australia, pp. 195-206.
- Turakulov, R & Easteal, S 2003, 'Number of SNPS loci needed to detect population structure', Human Heredity, vol. 55, pp. 37-45.
- Jorm, A, Prior, M, Sanson, A et al. 2003, 'Apolipoprotein E genotype and temperament: A longitudinal study from infancy to the late teens', Psychosomatic Medicine, vol. 65, pp. 662-664.
- Yang, N, MacArthur, D, Gulbin, J et al 2003, 'ACTN3 Genotype is Associated with Human Elite Athletic Performance', American Journal of Human Genetics, vol. 73, no. 3, pp. 627-631.
- Hofer, S, Christensen, H, MacKinnon, A et al. 2002, 'Change in cognitive functioning associated with apoE genotype in a community sample of older adults', Psychology and Aging, vol. 17, no. 2, pp. 194-208.
- Prichard, Z, Jorm, A, Prior, M et al. 2002, 'Association of polymorphisms of the estrogen receptor gene with anxiety-related traits in children and adolescents: A longitudinal study', American Journal of Medical Genetics, Part A, vol. 114, no. 2, pp. 169-176.
- Jorm, A, Prior, M, Sanson, A et al. 2002, 'Lack of Association of a Single-Nucleotide Polymorphism of the mu-Opioid Receptor Gene With Anxiety-Related Traits: Results From a Cross-Sectional Study of Adults and a Longitudinal Study of Children', American Journal of Medical Genetics, Part A, vol. 114, no. 6, pp. 659-664.
- Hofer, S, Christensen, H, Mackinnon, A et al. 2002, 'Change in cognitive functioning associated with apoE genotype in a community sample of older adults', Psychology and Aging, vol. 17, pp. 194-208.
- Cooper, A, Rambaut, A, Macaulay, V et al 2001, 'Human Origins and Ancient Human DNA', Science, vol. 292, no. 2001, pp. 1656-1656.
- Peacock, W, Dennis, E, Easteal, S et al 2001, 'Lake Mungo 3: A response to recent critiques', Archaeology in Oceania, vol. 36, pp. 163-174.
- Board, P, Coggan, M, Chelvanayagam, G et al 2001, 'Characterization of the Omega class glutathione transferases', Chemico-Biological Interactions, vol. 133, pp. 204-206.
- Adcock, G, Dennis, E, Easteal, S et al 2001, 'Mitochondrial DNA sequences in ancient Australians: Implications for modern human origins', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 2, pp. 537-542.
- Mills, M, Yang, N, Weinberger, R et al 2001, 'Differential expression of the actin-binding proteins, α-actinin-2 and -3, in different species: implications for the evolution of functional redundancy', Human Molecular Genetics, vol. 10, no. 13, pp. 1335-1346.
- Jorm, A, Prior, M, Sanson, A et al. 2001, 'Association of a Polymorphism of the Dopamine Transporter Gene With Externalizing Behavior Problems and Associated Temperament Traits: A Longitudinal Study From Infancy to the Mid-Teens', American Journal of Medical Genetics, Part A, vol. 105, pp. 105-346.
- Watson, E, Easteal, S & Penny, D 2001, 'Homo Genus: A Review of the Classification of Humans and the Great Apes', in Phillip V. Tobias, Michael A. Raath, Jacopo Moggi-Cecchi and Gerald A. Doyle (ed.), Humanity from Africa Naissance to Coming Millennia: Colloquia in Human Biology and Palaeoanthropology, Firenze University Press, Firenze, Italy, pp. 307-318.
- Wolf, M, Easteal, S, Kahn, M et al. 2000, 'TrExML: a maximum-likelihood approach for extensive tree-space exploration', Bioinformatics, vol. 16, no. 4, pp. 383-394.
- Jorm, A, Prior, M, Sanson, A et al. 2000, 'Association of a functional polymorphism of the serotonin transporter gene with anxiety-related temperament and behavior problems in children: a longitudinal study from infancy to the mid-teens', Molecular Psychiatry, vol. 5, pp. 542-547.
- Henderson, A, Jorm, A, Christensen, H et al. 2000, 'COMT and DRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders', American Journal of Medical Genetics, Part A, vol. 96, pp. 102-107.
- Huttley, G, Jakobsen, I, Wilson, S et al. 2000, 'How important is DNA replication for mutagenesis?', Molecular Biology and Evolution, vol. 17, pp. 929 - 937.
- Huttley, G, Jakobsen, I & Easteal, S 2000, 'How important is DNA replication for mutagenesis?', Molecular Biology and Evolution, vol. 17, pp. 929-937.
- Jorm, A & Easteal, S 2000, 'Assessing candidate genes as risk factors for mental disorders: the value of population-based epidemiological studies', Social Psychiatry and Psychiatric Epidemiology, vol. 35, pp. 1-4.
- Andrews, T & Easteal, S 2000, 'Evolutionary Rate Acceleration of Cytochrome c Oxidase Subunit I in Simian Primates', Journal of Molecular Evolution, vol. 50, no. ISI, pp. 562-568.
- Jorm, A, Henderson, A, Jacomb, P et al. 2000, 'Association of smoking and personality with a polymorphism of the dopamine transporter gene: results from a community survey', American Journal of Medical Genetics, Part A, vol. 96, pp. 331-334.
- Board, P, Coggan, M, Chelvanayagam, G et al 2000, 'Identification, Characterization and Crystal Structure of the Omega Class Glutathione Transferases', Journal of Biological Chemistry, vol. 275, no. ISI, pp. 24798-24806.
- Jorm, A, Henderson, A, Jacomb, P et al. 2000, 'Association of a functional polymorphism of the monoamine oxdiase A gene promoter with personality and psychiatric symptoms', Psychiatric Genetics, vol. 10, pp. 87-90.
- Easteal, S 1999, 'Reply to benton [In Process Citation]', Bioessays, vol. 21, no. 12, p. 1060.
- Holmes, R, Easteal, S & Beacham, I 1999, 'Evolution of class I alcohol dehydrogenase genes in catarrhine primates: gene conversion, substitution rates, and gene regulation', Molecular Biology and Evolution, vol. 16, no. 1, pp. 23-36.
- Jacomb, P, Jorm, A, Croft, L et al. 1999, 'HLA-A and CTGB33 polymorphisms and variation in IQ scores', Personality and Individual Differences, vol. 26.
- North, K, Yang, N, Wattanasirichaigoon, D et al 1999, 'A common nonsense mutation results in alpha-actinin-3 deficiency in the general population', Nature Genetics, vol. 21, no. 4, pp. 353-544.
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Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Freezerworks Sample Management Software (See 30857) (Primary Investigator)
- Variation in the arginine vasopressin 1a receptor (AVPR1a) gene, the social environment, general health and wellbeing (Primary Investigator)
- Genetic variants and environmental factors in depression (Secondary Investigator)
- OpenArray Block upgrade for QuantStudio 12K Flex Instrument (See 26118) (Primary Investigator)
- Functional and phenotypic effect of dopamine transporter gene variation (Primary Investigator)
- MultiNA MCE-202 microchip electrophoresis system for DNA/RNA analysis, including 8 reusable microchips and 10 reagent kits (See 22803) (Primary Investigator)
- Causes and consequences of mental disorders, cognitive decline and dementia over the adult life course and the implications for mental health services: PATH Through Life Wave 4 (Secondary Investigator)
- Confirmation of differently expressed genes associated with autologous transfusion (Primary Investigator)
