Areas of expertise

• Animal Physiology Biophysics 060601
• Structural Biology (Incl. Macromolecular Modelling) 060112
• Cell Metabolism 060104
• Signal Transduction 060111
• Characterisation Of Biological Macromolecules 030403
• Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics) 110106
• Receptors And Membrane Biology 060110
• Metabolic Medicine 110107
• Clinical Chemistry (Diagnostics) 110302
• Medicinal And Biomolecular Chemistry 0304
• Biochemistry And Cell Biology 0601
• Medical Biochemistry And Metabolomics 1101
• Paediatrics And Reproductive Medicine 1114
• Medical Physiology 1116

Publications

• O'Meara, C, Coupland, L, Kordbacheh, F et al. 2020, 'Neutralizing the pathological effects of extracellular histones with small polyanions', Nature Communications, vol. 11, no. 1.
• Salvage, S, Gallant, P, Beard, N et al. 2019, 'Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse', Journal of Cell Science, vol. 132, no. 10.
• Chakraborty, A, Gonano, L, Munro, M et al. 2019, 'Activation of RyR2 by class I kinase inhibitors', British Journal of Pharmacology, vol. 176, no. 6, pp. 773-786.
• Perez, C, Eltit, J, Lopez, J et al 2018, 'Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-β1a subunit (CACNB1)', American Journal of Physiology - Cell Physiology, vol. 314, no. 3, pp. 323-333pp.
• Denniss, A, Dulhunty, A & Beard, N 2018, 'Ryanodine receptor Ca2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease', The International Journal of Biochemistry and Cell Biology, vol. 101, pp. 49-53.
• Robinson, K, Easton, C, Dulhunty, A et al. 2018, 'Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels', ChemMedChem, vol. 13, no. 18, pp. 1957-1971pp.
• Walweel, K, Molenaar, P, Imtiaz, M et al 2017, 'Ryanodine receptor modification and regulation by intracellular Ca2?+ and Mg2?+ in healthy and failing human hearts', Journal of Molecular and Cellular Cardiology, vol. 104, no. March 2017, pp. 53-62pp.
• Dulhunty, A, Wei-LaPierre, L, Casarotto, M et al 2017, 'Core skeletal muscle ryanodine receptor calcium release complex', Clinical and Experimental Pharmacology and Physiology, vol. 44, no. 1, pp. 3-12pp.
• Dulhunty, A, Board, P, Beard, N et al 2017, 'Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels', Advances in Pharmacology, vol. 79, pp. 287-324.
• Norris, N, Joseph, S, Aditya, S et al 2017, 'Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability', Journal of Biological Chemistry, vol. 292, no. 20, pp. 8401-8411pp.
• Salvage, S, Chandrasekharan, K, Jeevaratnam, K et al 2017, 'Multiple targets for flecainide action: Implications for cardiac arrhythmogenesis', British Journal of Pharmacology, vol. 175, no. 8, pp. 1260-1278.
• Hanna, A, Lam, A, Thekkedam, C et al. 2017, 'The anthracycline metabolite doxorubicinol abolishes ryr2 sensitivity to physiological changes in luminal Ca21 through an interaction with calsequestrin', Molecular Pharmacology, vol. 92, no. 5, pp. 576-587.
• Richardson, S, Steele, G, Gallant, P et al. 2017, 'Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding', Journal of Cell Science, vol. 130, no. 20, pp. 3588-3600.
• van Zyl, H, Theodoratos, A, Smith, P et al 2016, 'Unexpected dependence of RyR1 splice variant expression in human lower limb muscles on fiber-type composition', Pflugers Archives European Journal of Physiology, vol. 468, no. 2, pp. 269-278.
• Hewawasam, R, Liu, D, Casarotto, M et al 2016, 'The GSTM2 C-Terminal domain depresses contractility and Ca2+ transients in neonatal rat ventricular cardiomyocytes', PLOS ONE (Public Library of Science), vol. 11, no. 9, pp. e0162415-e0162415.
• Wium, E, Dulhunty, A & Beard, N 2016, 'Three residues in the luminal domain of triadin impact on Trisk 95 activation of skeletal muscle ryanodine receptors', Pflugers Archives European Journal of Physiology, vol. 468, no. 11-12, pp. 1985-1994.
• Rebbeck, R, van Zyl, H, Groom, L et al 2015, 'Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit', Skeletal Muscle, vol. 5, no. 23, pp. 1-15.
• Li, L, Mirza, S, Richardson, S et al. 2015, 'A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels', Journal of Cell Science, vol. 128, no. 5, pp. 951-963.
• Beard, N & Dulhunty, A 2015, 'C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition', Skeletal Muscle, vol. 5, no. 1, pp. 1-12pp.
• Rebbeck, R, van Zyl, H, Groom, L et al 2015, 'Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit', Skeletal Muscle, vol. 5, no. 23, pp. 1-15.
• Samarasinghe, S, Liu, D, Tummala, D et al. 2015, 'Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes', Biochemical Pharmacology, vol. 97, no. 3, pp. 269-280.
• Walweel, K, Li, J, Molenaar, P et al 2014, 'Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum', Journal of General Physiology, vol. 144, no. 3, pp. 263-271.
• Rebbeck, R, Karunasekara, Y, Board, P et al 2014, 'Skeletal muscle excitation-contraction coupling: Who are the dancing partners?', The International Journal of Biochemistry and Cell Biology, vol. 48, no. 1, pp. 28-38.
• Hernandez-Ochoa, E, Olojo, R, Rebbeck, R et al 2014, 'β1a490-508, a 19-residue peptide from C-terminal tail of Cav1.1 β1a subunit, potentiates voltage-dependent calcium release in adult skeletal muscle fibers', Biophysical Journal, vol. 106, no. 3, pp. 535-547.
• Hanna, A, Lam, A, Thekkedam, C et al. 2014, 'Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment', Journal of Cell Science, vol. 127, no. 20, pp. 4531-4541.
• Hanna, A, Lam, A, Tham, S et al. 2014, 'Adverse Effects of Doxorubicin and Its Metabolic Product on Cardiac RyR2 and SERCA2A', Molecular Pharmacology, vol. 86, no. 4, pp. 438-449.
• Li, J, Imtiaz, M, Beard, N et al 2013, 'ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca²⁺ and Mg²⁺ Regulation', PLOS ONE (Public Library of Science), vol. 8, no. 3, pp. e58334-e58334.
• Smith, J, Vetter, I, Lewis, R et al. 2013, 'Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 22, pp. 8906-8911.
• Dulhunty, A, Wium, E, Li, L et al 2012, 'Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output', Clinical and Experimental Pharmacology and Physiology, vol. 39, no. 5, pp. 477-484.
• Liu, D, Hewawasam, R, Karunasekara, Y et al 2012, 'The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor', Biochemical Pharmacology, vol. 83, no. 11, pp. 1523-1529.
• Takano, K, Liu, D, Tarpey, P et al. 2012, 'An X-linked Channelopathy with Cardiomegaly due to a CLIC2 Mutation Enhancing Ryanodine Receptor Channel Activity', Human Molecular Genetics, vol. 21, no. 20, pp. 4497-4507.
• Dulhunty, A, Beard, N & Hanna, A 2012, 'Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease', Journal of General Physiology, vol. 140, no. 2, pp. 87-92.
• Wium, E, Dulhunty, A & Beard, N 2012, 'A skeletal muscle ryanodine receptor interaction domain in triadin', PLOS ONE (Public Library of Science), vol. 7, no. 8, pp. e43817-e43817.
• Karunasekara, Y, Karunasekara, Y, Rebbeck, R et al 2012, 'An alpha-helical C-terminal tail segment of the skeletal L-type Ca2+ channel beta(1a) subunit activates ryanodine receptor type 1 via a hydrophobic surface', FASEB Journal, vol. 26, no. 12, pp. 5049-5059.
• Karunasekara, Y, Karunasekara, Y, Rebbeck, R et al 2012, 'An alpha-helical C-terminal tail segment of the skeletal L-type Ca2+ channel beta(1a) subunit activates ryanodine receptor type 1 via a hydrophobic surface', FASEB Journal, vol. 26, no. 12, pp. 5049-5059.
• Peralvarez-Marin, A, Tae, H, Board, P et al. 2011, '3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM', PLOS ONE (Public Library of Science), vol. 6, no. 10, pp. e25813-e25813.
• Dulhunty, A, Casarotto, M & Beard, N 2011, 'The Ryanodine Receptor: A pivotal Ca²⁺ Regulatory Protein and Potential Therapeutic Drug Target', Current Drug Targets, vol. 12, no. 5, pp. 709-723.
• Dulhunty, A, Hewawasam, R, Liu, D et al 2011, 'Regulation of the cardiac muscle ryanodine receptor by glutathione transferases', Drug Metabolism Reviews, vol. 43, no. 2, pp. 236-252.
• Hanna, A, Janczura, M, Cho, E et al. 2011, 'Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors', Molecular Pharmacology, vol. 80, no. 3, pp. 538-549.
• Rebbeck, R, Karunasekara, Y, Gallant, E et al 2011, 'The β1a subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail', Biophysical Journal, vol. 100, no. 4, pp. 922-930.
• Tae, H, Cui, Y, Karunasekara, Y et al. 2011, 'Cyclization of the intrinsically disordered α_1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function', Journal of Biological Chemistry, vol. 286, no. 25, pp. 22589-22599.
• Tae, H, Wei, L, van Zyl, H et al 2011, 'The elusive role of the SPRY2 domain in RyR1', Channels, vol. 5, no. 2, pp. 148-160.
• Hewawasam, R, Liu, D, Casarotto, M et al 2010, 'The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor', Biochemical Pharmacology, vol. 80, no. 3, pp. 381-388.
• Beard, N, Wei, L, Cheung, S et al 2008, 'Phosphorylation of skeletal muscle calsequestrin enhances its Ca2+ binding capacity and promotes its association with junctin', Cell Calcium, vol. 44, no. 4, pp. 363-373.
• Cui, Y, Tae, H, Norris, N et al. 2009, 'A dihydropyridine receptor alpha(1s) loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor', The International Journal of Biochemistry and Cell Biology, vol. 41, no. 3, pp. 677-686.
• Dulhunty, A, Wei, L & Beard, N 2009, 'Junctin - the quiet achiever', Journal of Physiology, vol. 587, no. 13, pp. 3135-3137.
• Liu, D, Hewawasam, R, Pace, S et al. 2009, 'Dissection of the inhibition of cardiac ryanodine receptors by human glutathione transferase GSTM2-2', Biochemical Pharmacology, vol. 77, no. 7, pp. 1181-1193.
• Kimura, T, Lueck, J, Harvey, P et al. 2009, 'Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling', Cell Calcium, vol. 45, no. 3, pp. 264-274.
• Beard, N, Wei, L & Dulhunty, A 2009, 'Ca2+ signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin', European Biophysics Journal, vol. 39, no. 1, p. 10.
• Beard, N, Wei, L & Dulhunty, A 2009, 'Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen', Clinical and Experimental Pharmacology and Physiology, vol. 36, no. 3, pp. 340-345.
• Karunasekara, Y, Dulhunty, A & Casarotto, M 2009, 'The voltage-gated calcium-channel beta subunit: more than just an accessory', European Biophysics Journal, vol. 39, no. 1, pp. 79-81.
• Wei, L, Gallant, E, Dulhunty, A et al 2009, 'Junction and triadin each active skeletal ryanodine receptors but junction alone mediates functional interactions with calsequestrin', The International Journal of Biochemistry and Cell Biology, vol. 41, no. 11, pp. 2214-2224.
• Wei, L, Hanna, A, Beard, N et al 2009, 'Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle', Cell Calcium, vol. 45, no. 1, pp. 474-484.
• Pouliquin, P & Dulhunty, A 2009, 'Homer and the ryanodine receptor', European Biophysics Journal, vol. 39, no. 1, pp. 91-102.
• Pouliquin, P, Pace, S & Dulhunty, A 2009, 'In vitro modulation of the cardiac ryanodine receptor activity by Homer1', Pflugers Archives European Journal of Physiology, vol. 458, no. 4, pp. 723-732.
• Tae, H, Casarotto, M & Dulhunty, A 2009, 'Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor', European Biophysics Journal, vol. 39, no. 1, pp. 51-59.
• Tae, H, Norris, N, Cui, Y et al. 2009, 'Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor', Clinical and Experimental Pharmacology and Physiology, vol. 36, no. 3, pp. 346-349.
• Wei, L, Abdellatif, Y, Liu, D et al 2008, 'Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity', The International Journal of Biochemistry and Cell Biology, vol. 40, no. 8, pp. 1616-28.
• Feng, W, Tu, J, Pouliquin, P et al 2008, 'Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1', Cell Calcium, vol. 43, no. 3, pp. 307-314.
• Jalilian, C, Gallant, E, Board, P et al 2008, 'Redox potential and the response of cardiac ryanodine receptors to CLIC-2, a member of the glutathione S-transferase structural family', Antioxidants & redox signaling, vol. 10, no. 10, pp. 1675-86.
• Cromer, B, Gorman, M, Hansen, G et al 2007, 'Structure of the Janus Protein Human CLIC2', Journal of Molecular Biology, vol. 374, no. 3, pp. 719-731.
• Goonasekera, S, Beard, N, Groom, L et al 2007, 'Triadin Binding to the C-Terminal Luminal Loop of the Ryanodine Receptor is Important for Skeletal Muscle Excitation-Contraction Coupling', Journal of General Physiology, vol. 130, no. 4, pp. 365-78.
• Bannister, M, Hamada, T, Murayama, T et al 2007, 'Malignant hyperthermia mutation sites in the Leu(2442)-Pro(2477) (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area', Biochemical Journal, vol. 401, no. 1, pp. 333-9.
• Dulhunty, A, Beard, N, Pouliquin, P et al 2007, 'Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents?', Pharmacology and Therapeutics, vol. 113, no. 2, pp. 247-63.
• Abdellatif, Y, Liu, D, Gallant, E et al 2007, 'The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels', Cell Calcium, vol. 41, no. 5, pp. 429-40.
• Kimura, T, Pace, S, Wei, L et al. 2007, 'A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction', Biochemical Journal, vol. 401, no. 1, pp. 317-24.
• Casarotto, M, Cui, Y, Karunasekara, Y et al. 2006, 'Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor', Clinical and Experimental Pharmacology and Physiology, vol. 33, no. 11, pp. 1114-17.
• Dulhunty, A 2006, 'EXCITATION-CONTRACTION COUPLING FROM THE 1950s INTO THE NEW MILLENNIUM', Clinical and Experimental Pharmacology and Physiology, vol. 33, no. 9, pp. 763-72.
• Wei, L, Varsanyi, M, Dulhunty, A et al 2006, 'The conformation of calsequestrin determines its ability to regulate skeletal ryanodine receptors', Biophysical Journal, vol. 91, no. 4, pp. 1288-301.
• Dulhunty, A, Beard, N, Pouliquin, P et al 2006, 'Novel regulators of RyR Ca(2+) release channels: insight into molecular changes in genetically-linked myopathies', Journal of Muscle Research and Cell Motility, vol. 27, no. 5-7, pp. 351-65.
• Gibbs, G, Scanlon, M, Swarbrick, J et al 2006, 'The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling', Journal of Biological Chemistry, vol. 281, no. 7, pp. 4156-63.
• Pouliquin, P, Pace, S, Curtis, S et al. 2006, 'Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: modulation by Homer', The International Journal of Biochemistry and Cell Biology, vol. 38, no. 10, pp. 1700-15.
• Dulhunty, A, Pouliquin, P, Coggan, M et al 2005, 'A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP', Biochemical Journal, vol. 390, pp. 333-343.
• Beard, N, Casarotto, M, Wei, L et al 2005, 'Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation', Biophysical Journal, vol. 88, pp. 3444-3454.
• Kimura, T, Nakamori, M, Lueck, J et al 2005, 'Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1', Human Molecular Genetics, vol. 14, no. 15, pp. 2189-2200.
• Dulhunty, A, Karunasekara, Y, Curtis, S et al 2005, 'The recombinant dihydropyridine receptor II-III loop and partly structured C region peptides modify cardiac ryanodine receptor activity', Biochemical Journal, vol. 385, pp. 803-813.
• Cui, Y, Karunasekara, Y, Harvey, P et al. 2005, 'Letter to the editor: 1H, 13C and 15N assignments for the II-III loop region of the skeletal dyhydropyridine receptor', Journal of Biomolecular NMR, vol. 32, pp. 89-90.
• Dulhunty, A, Cengia, L, Young, J et al. 2005, 'Functional implications of modifying RyR-activating peptides for membrane permeability', British Journal of Pharmacology, vol. 144, pp. 743-754.
• Dulhunty, A, Karunasekara, Y, Curtis, S et al 2005, 'Role of some unconserved residues in the C region of the skeletal DHPR II-III loop', Frontiers in Bioscience, vol. 10, pp. 1368-1381.
• Haarmann, C, Dulhunty, A & Laver, D 2005, 'Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition', Biochemical Journal, vol. 387, pp. 429-436.
• Board, P, Coggan, M, Watson, S et al 2004, 'CLIC-2 modulates cardiac ryanodine receptor Ca(2+) release channels', The International Journal of Biochemistry and Cell Biology, vol. 36, pp. 1599-1612.
• Dulhunty, A, Curtis, S, Cengia, L et al 2004, 'Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release', Biochemical Journal, vol. 379, no. 1, pp. 161-172.
• Dulhunty, A, Curtis, S, Watson, S et al. 2004, 'Multiple Actions of Imperatoxin A on Ryanodine Receptors - Interactions with the II-III Loop A Fragment*', Journal of Biological Chemistry, vol. 279, no. 12, pp. 11853-11862.
• Gallant, E, Hart, J, Eager, K et al 2004, 'Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs: effects of a DHPR II-III loop peptide', American Journal of Physiology - Cell Physiology, vol. 286, pp. C821-C830.
• Beard, N, Laver, D & Dulhunty, A 2004, 'Calesquestrin and the calcium release channel of skeletal and cardiac muscle', Progress in Biophysics and Molecular Biology, vol. 85, pp. 33-69.
• Casarotto, M, Green, D, Pace, S et al. 2004, 'ACTIVATING THE RYANODINE RECEPTOR WITH DIHYDROPYRIDINE RECEPTOR II-III LOOP SEGMENTS: SIZE AND CHARGE DO MATTER', Frontiers in Bioscience, vol. 9, pp. 2860-2872.
• Haarmann, C, Green, D, Casarotto, M et al. 2003, 'The random-coil C fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors', Journal of Biochemistry, vol. 372, pp. 305-316.
• Dulhunty, A & Pouliquin, P 2003, 'What we dont know about the Structure of Ryanodine receptor Calcium release channels', Clinical and Experimental Pharmacology and Physiology, vol. 30, pp. 713-723.
• Green, D, Pace, S, Curtis, S et al. 2003, 'The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha helical dihydropyridine receptor segment', Biochemical Journal, vol. 370, pp. 517-527.
• Dulhunty, A, Haarmann, C, Green, D et al 2002, 'Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle', Progress in Biophysics and Molecular Biology, vol. 79, pp. 45-75.
• Beard, N, Sakowska, M, Dulhunty, A et al. 2002, 'Calsequestrin Is an Inhibitor of Skeletal Muscle Ryanodine Receptor Calcium Release Channels', Biophysical Journal, vol. 82, pp. 310-320.
• Dulhunty, A & Laver, D 2002, 'A Ca2+-Activated Anion Channel in the Sarcoplasmic Reticulum of Skeletal Muscle', in Catherine Mary Fuller (ed.), Calcuim-Activated Chloride Channels, Academic Press, USA, pp. 59-80.
• Dulhunty, A, Gage, P, Curtis, S et al 2001, 'The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator', Journal of Biological Chemistry, vol. 276, no. 5, pp. 3319-3323.
• Dulhunty, A, Laver, D, Curtis, S et al. 2001, 'Characteristics of Irreversible ATP Activation Suggest that Native Skeletal Ryanodine Receptors Can Be Phosphorylated via an Endogenous CaMKII', Biophysical Journal, vol. 81, pp. 3240-3252.
• Casarotto, M, Green, D, Pace, S et al. 2001, 'Structural Determinants for Activation or Inhibition of Ryanodine Receptors by Basis Residues in the Dihydropyridine Receptor II-III Loop', Biophysical Journal, vol. 80, pp. 2715-2726.
• Gallant, P, Curtis, S, Pace, S et al. 2001, 'Arg⁶¹⁵Cys substitution in pig skeletal ryanodine receptors increases activation of single channels by a segment of the skeletal DHPR II-III loop.', Biophysical Journal, vol. 80, pp. 1769-1782.
• Laver, D, Lenz, G & Dulhunty, A 2001, 'Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle', Journal of Physiology, vol. 535, no. 3, pp. 715-728.
• Hart, J & Dulhunty, A 2000, 'Nitrix oxide activates or inhibits skeletal muscle ryandine receptors depending on its concentration, membrane potential and ligand binding', Journal of Membrane Biology, vol. 173, pp. 227-236.
• Green, D, Pace, S, Hurne, A et al. 2000, 'Skeletal muscle ryanodine receptor channels are activated by the fungal metabolite, gliotoxin', Journal of Membrane Biology, vol. 175, pp. 223-233.
• Casarotto, M, Gibson, F, Pace, S et al. 2000, 'A Structural Requirement for Activation of Skeletal Ryanodine Receptors by Peptides of the Dihydropyridine Receptor II-III Loop', Journal of Biological Chemistry, vol. 275, pp. 11631-11637.
• Mould, J & Dulhunty, A 2000, 'Cadmuim withdrawal contractures in rat soleus muscle fibres.', Pflugers Archives European Journal of Physiology, vol. 440, no. 1, pp. 68-74.
• Mould, J & Dulhunty, A 2000, 'Delayed contractures induced by external cadimium ions rat soleus muscle fibres', Pflugers Archives European Journal of Physiology, vol. 439, no. 3, pp. 263-270.
• Dulhunty, A, Haarmann, C, Green, D et al 2000, 'How Many Cysteine Residues Regulate Ryanodine Receptor Channel Activity', Antioxidants and Redox Signaling, vol. 2, no. 1, pp. 27-34.
• Mould, J & Dulhunty, A 1999, 'Pflugers Archiv slow contractures induced by external cadmim ions in rat soleus fibres', Pflugers Archives European Journal of Physiology.
• Dulhunty, A, Laver, D, Gallant, E et al. 1999, 'Activation and Inhibition of Skeletal RyR Channels by a Part of the Skeletal DHPR II-III Loop: Effects of DHPR Ser 687 and FKBP12', Biophysical Journal, vol. 77, pp. 189-203.
• Eager, K & Dulhunty, A 1999, 'Cardiac Ryanodine Receptor Activity is Altered by Oxidising Reagents in Either the Luminal or Cytoplasmic Solutions', Journal of Membrane Biology, vol. 167, pp. 205-214.
• Mould, J & Dulhunty, A 1999, 'Effects of external cadmium ions on excitation-contraction coupling in rat soleus fibres', Pflugers Archives European Journal of Physiology, vol. 437, pp. 197-203.
• Haarmann, C, Fink, R & Dulhunty, A 1999, 'Oxidation and Reduction of Pig Skeletal Muscle Ryanodine Receptors', Biophysical Journal, vol. 77, pp. 3010-3022.

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

• Calcium signalling by intracellular calcium stores in rabbit, mouse and man: implications for muscle performance and athletic ability (Primary Investigator)
• Scintillation Counter (See 26118) (Primary Investigator)
• Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity (Secondary Investigator)
• Prep Cell, Pump and Fraction Collector (See 23912) (Primary Investigator)
• C02 Incubator (See 22803) (Primary Investigator)
• How triadin and junctin communicate with ryanodine receptors deep within a calcium store to determine skeletal muscle contraction (Primary Investigator)
• DHPR β subunit binding to a variably spliced region of RyR1: a role in EC coupling and myotonic dystrophy (Primary Investigator)
• New cardiac ryanodine receptor inhibitors for the treatment of heart failure (Secondary Investigator)