Professor Angela Dulhunty
Areas of expertise
- Animal Physiology Biophysics 060601
- Structural Biology (Incl. Macromolecular Modelling) 060112
- Signal Transduction 060111
- Characterisation Of Biological Macromolecules 030403
- Receptors And Membrane Biology 060110
- Biochemistry And Cell Biology 0601
Research interests
The focus of the Muscle Research Group is on the dynamic calcium signalling in skeletal and cardiac muscle that regulates contraction. My particular interest is in the complex regulation of the ryanodine receptor calcium release channel which releases the Ca2+ ions required for contraction during excitation-contraction coupling. Many myopathies are linked to mutations in the ryanodine receptor or in its associated regulatory proteins which alter its ion channel function and lead to disorders such as malignant hyperthermia, central core disease and myotonic dystrophy in skeletal muscle or cause arrhythmias in the heart that can lead to sudden death. Our aims are (a) to understand how myopathy-associated mutations alter the function of ryanodine receptor channels to lead to muscle weakness and (b) to understand the interactions between the surface membrane dihydropyridine receptor and ryanodine receptor that enables excitation-contraction coupling in skeletal muscle.
Biography
Dulhunty graduated from The University of Sydney, Australia, in 1969 with a Bachelor of Science degree and Honours in Physiology. She obtained a PhD from the University of NSW in 1973 presenting a thesis describing muscle electrophysiology studies carried out with Professor Peter Gage. She was then awarded a Muscular Dystrophy Postdoctoral Fellowship to work at the University of Rochester (NY) with Professors Paul Horowicz, Clara Franzini-Armstrong and Camillo Peracchia. She returned to Australia in 1975 and established a Muscle Research Laboratory in the Department of Anatomy at The University of Sydney. In 1982 Dulhunty, with Professors Peter Gage and Peter Parry, was awarded and a Centre of Excellence for Nerve Muscle Research at the University of NSW. The Centre moved to the Australian National University in Canberra in 1984, where Dulhunty re-established the Muscle Research Laboratory. She was awarded a DSc degree by the University of NSW in 1988 for her extensive research into muscle excitation-contraction coupling (ECC). Dulhunty was appointed to an Emeritus position at the ANU in 2017. In 2022, she was awarded an AM (Australian Medal) for contributions to Medical Research and Student training
Dulhunty’s research has focussed on the translation of electrical signals in the surface membrane of muscle fibres into the release of the calcium ions from their internal in the sarcoplasmic reticulum (SR), to enable muscle contraction in the process of excitation contraction coupling (ECC). In her PhD studies she explored the complex nature of transverse (T-) tubule extensions of the surface membrane which conduct the surface electrical signal throughout the fibre cross-section. The discovery of asymmetric charge movement arising from dihydropyridine receptors in T-tubules allowed her to examine this voltage sensor for ECC in fast and slow-twitch mammalian muscle and to apply this to her subsequent studies of the voltage dependence for ECC. The other major component of ECC, the ryanodine receptor (RyR) calcium release channel in the SR, was identified in the late 1980s. Dulhunty was amongst the first researchers to study single RyR ion channels from skeletal and cardiac muscle using lipid bilayer electrophysiology. She has continued to study RyR channels, combining electrophysiology, biochemistry, protein chemistry, structural biology and molecular biology to explore normal RyR function and pathological changes that reduce skeletal muscle function and which can compromise cardiac muscle to the extent of causing heart attack.
Publications
- Richardson, S, Thekkedam, C, Casarotto, M et al. 2023, 'FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease', Philosophical Transactions of the Royal Society of London Series B, vol. 378, no. 1879.
- Shishmarev, D, Rowland, E, Aditya, S et al. 2022, 'Molecular interactions of STAC proteins with skeletal muscle dihydropyridine receptor and excitation-contraction coupling', Protein Science, vol. 31, no. 5, pp. 1-11.
- Dulhunty, A, Fraser, J, Huang, C et al. 2022, 'Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide', <>.
- Dulhunty, A 2022, 'Molecular Changes in the Cardiac RyR2 With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)', Frontiers in Physiology, vol. 13, pp. 1-7.
- Salvage, S, Huang, C, Fraser, J et al. 2022, 'How does flecainide impact RyR2 channel function?', Journal of General Physiology, vol. 154, no. 9, pp. 1-23.
- Salvage, S, Gallant, P, Fraser, J et al. 2021, 'Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action', Cells, vol. 10, no. 8.
- Robinson, K, Culley, D, Waring, S et al. 2020, 'Peptide mimetic compounds can activate or inhibit cardiac and skeletal ryanodine receptors', Life Sciences, vol. 260, pp. 1-16.
- O'Meara, C, Coupland, L, Kordbacheh, F et al. 2020, 'Neutralizing the pathological effects of extracellular histones with small polyanions', Nature Communications, vol. 11, no. 1.
- Salvage, S, Gallant, P, Beard, N et al. 2019, 'Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse', Journal of Cell Science, vol. 132, no. 10.
- Chakraborty, A, Gonano, L, Munro, M et al. 2019, 'Activation of RyR2 by class I kinase inhibitors', British Journal of Pharmacology, vol. 176, no. 6, pp. 773-786.
- Perez, C, Eltit, J, Lopez, J et al 2018, 'Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-β1a subunit (CACNB1)', American Journal of Physiology - Cell Physiology, vol. 314, no. 3, pp. 323-333pp.
- Denniss, A, Dulhunty, A & Beard, N 2018, 'Ryanodine receptor Ca2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease', The International Journal of Biochemistry and Cell Biology, vol. 101, pp. 49-53.
- Robinson, K, Easton, C, Dulhunty, A et al. 2018, 'Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels', ChemMedChem, vol. 13, no. 18, pp. 1957-1971pp.
- Dulhunty, A, Beard, N & Casarotto, M 2018, 'Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling [version 1; peer review: 4 approved]', F1000 Research, vol. 7, pp. -.
- Walweel, K, Molenaar, P, Imtiaz, M et al 2017, 'Ryanodine receptor modification and regulation by intracellular Ca2?+ and Mg2?+ in healthy and failing human hearts', Journal of Molecular and Cellular Cardiology, vol. 104, no. March 2017, pp. 53-62pp.
- Dulhunty, A, Wei-LaPierre, L, Casarotto, M et al 2017, 'Core skeletal muscle ryanodine receptor calcium release complex', Clinical and Experimental Pharmacology and Physiology, vol. 44, no. 1, pp. 3-12pp.
- Dulhunty, A, Board, P, Beard, N et al 2017, 'Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels', Advances in Pharmacology, vol. 79, pp. 287-324.
- Norris, N, Joseph, S, Aditya, S et al 2017, 'Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability', Journal of Biological Chemistry, vol. 292, no. 20, pp. 8401-8411pp.
- Salvage, S, Chandrasekharan, K, Jeevaratnam, K et al 2017, 'Multiple targets for flecainide action: Implications for cardiac arrhythmogenesis', British Journal of Pharmacology, vol. 175, no. 8, pp. 1260-1278.
- Hanna, A, Lam, A, Thekkedam, C et al. 2017, 'The anthracycline metabolite doxorubicinol abolishes ryr2 sensitivity to physiological changes in luminal Ca21 through an interaction with calsequestrin', Molecular Pharmacology, vol. 92, no. 5, pp. 576-587.
- Richardson, S, Steele, G, Gallant, P et al. 2017, 'Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding', Journal of Cell Science, vol. 130, no. 20, pp. 3588-3600.
- van Zyl, H, Theodoratos, A, Smith, P et al 2016, 'Unexpected dependence of RyR1 splice variant expression in human lower limb muscles on fiber-type composition', Pflugers Archives European Journal of Physiology, vol. 468, no. 2, pp. 269-278.
- Hewawasam, R, Liu, D, Casarotto, M et al 2016, 'The GSTM2 C-Terminal domain depresses contractility and Ca2+ transients in neonatal rat ventricular cardiomyocytes', PLOS ONE (Public Library of Science), vol. 11, no. 9, pp. e0162415-e0162415.
- Wium, E, Dulhunty, A & Beard, N 2016, 'Three residues in the luminal domain of triadin impact on Trisk 95 activation of skeletal muscle ryanodine receptors', Pflugers Archives European Journal of Physiology, vol. 468, no. 11-12, pp. 1985-1994.
- Rebbeck, R, van Zyl, H, Groom, L et al 2015, 'Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit', Skeletal Muscle, vol. 5, no. 23, pp. 1-15.
- Li, L, Mirza, S, Richardson, S et al. 2015, 'A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels', Journal of Cell Science, vol. 128, no. 5, pp. 951-963.
- Beard, N & Dulhunty, A 2015, 'C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition', Skeletal Muscle, vol. 5, no. 1, pp. 1-12pp.
- Rebbeck, R, van Zyl, H, Groom, L et al 2015, 'Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit', Skeletal Muscle, vol. 5, no. 23, pp. 1-15.
- Samarasinghe, S, Liu, D, Tummala, D et al. 2015, 'Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes', Biochemical Pharmacology, vol. 97, no. 3, pp. 269-280.
- Walweel, K, Li, J, Molenaar, P et al 2014, 'Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum', Journal of General Physiology, vol. 144, no. 3, pp. 263-271.
- Rebbeck, R, Karunasekara, Y, Board, P et al 2014, 'Skeletal muscle excitation-contraction coupling: Who are the dancing partners?', The International Journal of Biochemistry and Cell Biology, vol. 48, no. 1, pp. 28-38.
- Hernandez-Ochoa, E, Olojo, R, Rebbeck, R et al 2014, 'β1a490-508, a 19-residue peptide from C-terminal tail of Cav1.1 β1a subunit, potentiates voltage-dependent calcium release in adult skeletal muscle fibers', Biophysical Journal, vol. 106, no. 3, pp. 535-547.
- Hanna, A, Lam, A, Thekkedam, C et al. 2014, 'Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment', Journal of Cell Science, vol. 127, no. 20, pp. 4531-4541.
- Hanna, A, Lam, A, Tham, S et al. 2014, 'Adverse Effects of Doxorubicin and Its Metabolic Product on Cardiac RyR2 and SERCA2A', Molecular Pharmacology, vol. 86, no. 4, pp. 438-449.
- Li, J, Imtiaz, M, Beard, N et al 2013, 'ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca2+ and Mg2+ Regulation', PLOS ONE (Public Library of Science), vol. 8, no. 3, pp. e58334-e58334.
- Smith, J, Vetter, I, Lewis, R et al. 2013, 'Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 22, pp. 8906-8911.
- Dulhunty, A, Wium, E, Li, L et al 2012, 'Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output', Clinical and Experimental Pharmacology and Physiology, vol. 39, no. 5, pp. 477-484.
- Liu, D, Hewawasam, R, Karunasekara, Y et al 2012, 'The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor', Biochemical Pharmacology, vol. 83, no. 11, pp. 1523-1529.
- Takano, K, Liu, D, Tarpey, P et al. 2012, 'An X-linked Channelopathy with Cardiomegaly due to a CLIC2 Mutation Enhancing Ryanodine Receptor Channel Activity', Human Molecular Genetics, vol. 21, no. 20, pp. 4497-4507.
- Dulhunty, A, Beard, N & Hanna, A 2012, 'Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease', Journal of General Physiology, vol. 140, no. 2, pp. 87-92.
- Wium, E, Dulhunty, A & Beard, N 2012, 'A skeletal muscle ryanodine receptor interaction domain in triadin', PLOS ONE (Public Library of Science), vol. 7, no. 8, pp. e43817-e43817.
- Karunasekara, Y, Karunasekara, Y, Rebbeck, R et al 2012, 'An alpha-helical C-terminal tail segment of the skeletal L-type Ca2+ channel beta(1a) subunit activates ryanodine receptor type 1 via a hydrophobic surface', FASEB Journal, vol. 26, no. 12, pp. 5049-5059.
- Karunasekara, Y, Karunasekara, Y, Rebbeck, R et al 2012, 'An alpha-helical C-terminal tail segment of the skeletal L-type Ca2+ channel beta(1a) subunit activates ryanodine receptor type 1 via a hydrophobic surface', FASEB Journal, vol. 26, no. 12, pp. 5049-5059.
- Peralvarez-Marin, A, Tae, H, Board, P et al. 2011, '3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM', PLOS ONE (Public Library of Science), vol. 6, no. 10, pp. e25813-e25813.
- Dulhunty, A, Casarotto, M & Beard, N 2011, 'The Ryanodine Receptor: A pivotal Ca2+ Regulatory Protein and Potential Therapeutic Drug Target', Current Drug Targets, vol. 12, no. 5, pp. 709-723.
- Dulhunty, A, Hewawasam, R, Liu, D et al 2011, 'Regulation of the cardiac muscle ryanodine receptor by glutathione transferases', Drug Metabolism Reviews, vol. 43, no. 2, pp. 236-252.
- Hanna, A, Janczura, M, Cho, E et al. 2011, 'Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors', Molecular Pharmacology, vol. 80, no. 3, pp. 538-549.
- Rebbeck, R, Karunasekara, Y, Gallant, E et al 2011, 'The β1a subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail', Biophysical Journal, vol. 100, no. 4, pp. 922-930.
- Tae, H, Cui, Y, Karunasekara, Y et al. 2011, 'Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function', Journal of Biological Chemistry, vol. 286, no. 25, pp. 22589-22599.
- Tae, H, Wei, L, van Zyl, H et al 2011, 'The elusive role of the SPRY2 domain in RyR1', Channels, vol. 5, no. 2, pp. 148-160.
- Hewawasam, R, Liu, D, Casarotto, M et al 2010, 'The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor', Biochemical Pharmacology, vol. 80, no. 3, pp. 381-388.
- Beard, N, Wei, L, Cheung, S et al 2008, 'Phosphorylation of skeletal muscle calsequestrin enhances its Ca2+ binding capacity and promotes its association with junctin', Cell Calcium, vol. 44, no. 4, pp. 363-373.
- Cui, Y, Tae, H, Norris, N et al. 2009, 'A dihydropyridine receptor alpha(1s) loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor', The International Journal of Biochemistry and Cell Biology, vol. 41, no. 3, pp. 677-686.
- Dulhunty, A, Wei, L & Beard, N 2009, 'Junctin - the quiet achiever', Journal of Physiology, vol. 587, no. 13, pp. 3135-3137.
- Liu, D, Hewawasam, R, Pace, S et al. 2009, 'Dissection of the inhibition of cardiac ryanodine receptors by human glutathione transferase GSTM2-2', Biochemical Pharmacology, vol. 77, no. 7, pp. 1181-1193.
- Kimura, T, Lueck, J, Harvey, P et al. 2009, 'Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling', Cell Calcium, vol. 45, no. 3, pp. 264-274.
- Beard, N, Wei, L & Dulhunty, A 2009, 'Ca2+ signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin', European Biophysics Journal, vol. 39, no. 1, p. 10.
- Beard, N, Wei, L & Dulhunty, A 2009, 'Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen', Clinical and Experimental Pharmacology and Physiology, vol. 36, no. 3, pp. 340-345.
- Karunasekara, Y, Dulhunty, A & Casarotto, M 2009, 'The voltage-gated calcium-channel beta subunit: more than just an accessory', European Biophysics Journal, vol. 39, no. 1, pp. 79-81.
- Wei, L, Gallant, E, Dulhunty, A et al 2009, 'Junction and triadin each active skeletal ryanodine receptors but junction alone mediates functional interactions with calsequestrin', The International Journal of Biochemistry and Cell Biology, vol. 41, no. 11, pp. 2214-2224.
- Wei, L, Hanna, A, Beard, N et al 2009, 'Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle', Cell Calcium, vol. 45, no. 1, pp. 474-484.
- Pouliquin, P & Dulhunty, A 2009, 'Homer and the ryanodine receptor', European Biophysics Journal, vol. 39, no. 1, pp. 91-102.
- Pouliquin, P, Pace, S & Dulhunty, A 2009, 'In vitro modulation of the cardiac ryanodine receptor activity by Homer1', Pflugers Archives European Journal of Physiology, vol. 458, no. 4, pp. 723-732.
- Tae, H, Casarotto, M & Dulhunty, A 2009, 'Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor', European Biophysics Journal, vol. 39, no. 1, pp. 51-59.
- Tae, H, Norris, N, Cui, Y et al. 2009, 'Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor', Clinical and Experimental Pharmacology and Physiology, vol. 36, no. 3, pp. 346-349.
- Wei, L, Abdellatif, Y, Liu, D et al 2008, 'Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity', The International Journal of Biochemistry and Cell Biology, vol. 40, no. 8, pp. 1616-28.
- Feng, W, Tu, J, Pouliquin, P et al 2008, 'Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1', Cell Calcium, vol. 43, no. 3, pp. 307-314.
- Jalilian, C, Gallant, E, Board, P et al 2008, 'Redox potential and the response of cardiac ryanodine receptors to CLIC-2, a member of the glutathione S-transferase structural family', Antioxidants & redox signaling, vol. 10, no. 10, pp. 1675-86.
- Cromer, B, Gorman, M, Hansen, G et al 2007, 'Structure of the Janus Protein Human CLIC2', Journal of Molecular Biology, vol. 374, no. 3, pp. 719-731.
- Goonasekera, S, Beard, N, Groom, L et al 2007, 'Triadin Binding to the C-Terminal Luminal Loop of the Ryanodine Receptor is Important for Skeletal Muscle Excitation-Contraction Coupling', Journal of General Physiology, vol. 130, no. 4, pp. 365-78.
- Bannister, M, Hamada, T, Murayama, T et al 2007, 'Malignant hyperthermia mutation sites in the Leu(2442)-Pro(2477) (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area', Biochemical Journal, vol. 401, no. 1, pp. 333-9.
- Dulhunty, A, Beard, N, Pouliquin, P et al 2007, 'Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents?', Pharmacology and Therapeutics, vol. 113, no. 2, pp. 247-63.
- Abdellatif, Y, Liu, D, Gallant, E et al 2007, 'The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels', Cell Calcium, vol. 41, no. 5, pp. 429-40.
- Kimura, T, Pace, S, Wei, L et al. 2007, 'A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction', Biochemical Journal, vol. 401, no. 1, pp. 317-24.
- Casarotto, M, Cui, Y, Karunasekara, Y et al. 2006, 'Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor', Clinical and Experimental Pharmacology and Physiology, vol. 33, no. 11, pp. 1114-17.
- Dulhunty, A 2006, 'EXCITATION-CONTRACTION COUPLING FROM THE 1950s INTO THE NEW MILLENNIUM', Clinical and Experimental Pharmacology and Physiology, vol. 33, no. 9, pp. 763-72.
- Wei, L, Varsanyi, M, Dulhunty, A et al 2006, 'The conformation of calsequestrin determines its ability to regulate skeletal ryanodine receptors', Biophysical Journal, vol. 91, no. 4, pp. 1288-301.
- Dulhunty, A, Beard, N, Pouliquin, P et al 2006, 'Novel regulators of RyR Ca(2+) release channels: insight into molecular changes in genetically-linked myopathies', Journal of Muscle Research and Cell Motility, vol. 27, no. 5-7, pp. 351-65.
- Gibbs, G, Scanlon, M, Swarbrick, J et al 2006, 'The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling', Journal of Biological Chemistry, vol. 281, no. 7, pp. 4156-63.
- Pouliquin, P, Pace, S, Curtis, S et al. 2006, 'Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: modulation by Homer', The International Journal of Biochemistry and Cell Biology, vol. 38, no. 10, pp. 1700-15.
- Dulhunty, A, Pouliquin, P, Coggan, M et al 2005, 'A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP', Biochemical Journal, vol. 390, pp. 333-343.
- Beard, N, Casarotto, M, Wei, L et al 2005, 'Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation', Biophysical Journal, vol. 88, pp. 3444-3454.
- Kimura, T, Nakamori, M, Lueck, J et al 2005, 'Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1', Human Molecular Genetics, vol. 14, no. 15, pp. 2189-2200.
- Dulhunty, A, Karunasekara, Y, Curtis, S et al 2005, 'The recombinant dihydropyridine receptor II-III loop and partly structured C region peptides modify cardiac ryanodine receptor activity', Biochemical Journal, vol. 385, pp. 803-813.
- Cui, Y, Karunasekara, Y, Harvey, P et al. 2005, 'Letter to the editor: 1H, 13C and 15N assignments for the II-III loop region of the skeletal dyhydropyridine receptor', Journal of Biomolecular NMR, vol. 32, pp. 89-90.
- Dulhunty, A, Cengia, L, Young, J et al. 2005, 'Functional implications of modifying RyR-activating peptides for membrane permeability', British Journal of Pharmacology, vol. 144, pp. 743-754.
- Dulhunty, A, Karunasekara, Y, Curtis, S et al 2005, 'Role of some unconserved residues in the C region of the skeletal DHPR II-III loop', Frontiers in Bioscience, vol. 10, pp. 1368-1381.
- Haarmann, C, Dulhunty, A & Laver, D 2005, 'Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition', Biochemical Journal, vol. 387, pp. 429-436.
- Board, P, Coggan, M, Watson, S et al 2004, 'CLIC-2 modulates cardiac ryanodine receptor Ca(2+) release channels', The International Journal of Biochemistry and Cell Biology, vol. 36, pp. 1599-1612.
- Dulhunty, A, Curtis, S, Cengia, L et al 2004, 'Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release', Biochemical Journal, vol. 379, no. 1, pp. 161-172.
- Dulhunty, A, Curtis, S, Watson, S et al. 2004, 'Multiple Actions of Imperatoxin A on Ryanodine Receptors - Interactions with the II-III Loop A Fragment*', Journal of Biological Chemistry, vol. 279, no. 12, pp. 11853-11862.
- Gallant, E, Hart, J, Eager, K et al 2004, 'Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs: effects of a DHPR II-III loop peptide', American Journal of Physiology - Cell Physiology, vol. 286, pp. C821-C830.
- Beard, N, Laver, D & Dulhunty, A 2004, 'Calesquestrin and the calcium release channel of skeletal and cardiac muscle', Progress in Biophysics and Molecular Biology, vol. 85, pp. 33-69.
- Casarotto, M, Green, D, Pace, S et al. 2004, 'ACTIVATING THE RYANODINE RECEPTOR WITH DIHYDROPYRIDINE RECEPTOR II-III LOOP SEGMENTS: SIZE AND CHARGE DO MATTER', Frontiers in Bioscience, vol. 9, pp. 2860-2872.
- Haarmann, C, Green, D, Casarotto, M et al. 2003, 'The random-coil C fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors', Journal of Biochemistry, vol. 372, pp. 305-316.
- Dulhunty, A & Pouliquin, P 2003, 'What we dont know about the Structure of Ryanodine receptor Calcium release channels', Clinical and Experimental Pharmacology and Physiology, vol. 30, pp. 713-723.
- Green, D, Pace, S, Curtis, S et al. 2003, 'The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha helical dihydropyridine receptor segment', Biochemical Journal, vol. 370, pp. 517-527.
- Dulhunty, A, Haarmann, C, Green, D et al 2002, 'Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle', Progress in Biophysics and Molecular Biology, vol. 79, pp. 45-75.
- Beard, N, Sakowska, M, Dulhunty, A et al. 2002, 'Calsequestrin Is an Inhibitor of Skeletal Muscle Ryanodine Receptor Calcium Release Channels', Biophysical Journal, vol. 82, pp. 310-320.
- Dulhunty, A & Laver, D 2002, 'A Ca2+-Activated Anion Channel in the Sarcoplasmic Reticulum of Skeletal Muscle', in Catherine Mary Fuller (ed.), Calcuim-Activated Chloride Channels, Academic Press, USA, pp. 59-80.
- Dulhunty, A, Gage, P, Curtis, S et al 2001, 'The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator', Journal of Biological Chemistry, vol. 276, no. 5, pp. 3319-3323.
- Dulhunty, A, Laver, D, Curtis, S et al. 2001, 'Characteristics of Irreversible ATP Activation Suggest that Native Skeletal Ryanodine Receptors Can Be Phosphorylated via an Endogenous CaMKII', Biophysical Journal, vol. 81, pp. 3240-3252.
- Casarotto, M, Green, D, Pace, S et al. 2001, 'Structural Determinants for Activation or Inhibition of Ryanodine Receptors by Basis Residues in the Dihydropyridine Receptor II-III Loop', Biophysical Journal, vol. 80, pp. 2715-2726.
- Gallant, P, Curtis, S, Pace, S et al. 2001, 'Arg615Cys substitution in pig skeletal ryanodine receptors increases activation of single channels by a segment of the skeletal DHPR II-III loop.', Biophysical Journal, vol. 80, pp. 1769-1782.
- Laver, D, Lenz, G & Dulhunty, A 2001, 'Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle', Journal of Physiology, vol. 535, no. 3, pp. 715-728.
- Hart, J & Dulhunty, A 2000, 'Nitrix oxide activates or inhibits skeletal muscle ryandine receptors depending on its concentration, membrane potential and ligand binding', Journal of Membrane Biology, vol. 173, pp. 227-236.
- Green, D, Pace, S, Hurne, A et al. 2000, 'Skeletal muscle ryanodine receptor channels are activated by the fungal metabolite, gliotoxin', Journal of Membrane Biology, vol. 175, pp. 223-233.
- Casarotto, M, Gibson, F, Pace, S et al. 2000, 'A Structural Requirement for Activation of Skeletal Ryanodine Receptors by Peptides of the Dihydropyridine Receptor II-III Loop', Journal of Biological Chemistry, vol. 275, pp. 11631-11637.
- Mould, J & Dulhunty, A 2000, 'Cadmuim withdrawal contractures in rat soleus muscle fibres.', Pflugers Archives European Journal of Physiology, vol. 440, no. 1, pp. 68-74.
- Mould, J & Dulhunty, A 2000, 'Delayed contractures induced by external cadimium ions rat soleus muscle fibres', Pflugers Archives European Journal of Physiology, vol. 439, no. 3, pp. 263-270.
- Dulhunty, A, Haarmann, C, Green, D et al 2000, 'How Many Cysteine Residues Regulate Ryanodine Receptor Channel Activity', Antioxidants and Redox Signaling, vol. 2, no. 1, pp. 27-34.
- Mould, J & Dulhunty, A 1999, 'Pflugers Archiv slow contractures induced by external cadmim ions in rat soleus fibres', Pflugers Archives European Journal of Physiology.
- Dulhunty, A, Laver, D, Gallant, E et al. 1999, 'Activation and Inhibition of Skeletal RyR Channels by a Part of the Skeletal DHPR II-III Loop: Effects of DHPR Ser 687 and FKBP12', Biophysical Journal, vol. 77, pp. 189-203.
- Eager, K & Dulhunty, A 1999, 'Cardiac Ryanodine Receptor Activity is Altered by Oxidising Reagents in Either the Luminal or Cytoplasmic Solutions', Journal of Membrane Biology, vol. 167, pp. 205-214.
- Mould, J & Dulhunty, A 1999, 'Effects of external cadmium ions on excitation-contraction coupling in rat soleus fibres', Pflugers Archives European Journal of Physiology, vol. 437, pp. 197-203.
- Haarmann, C, Fink, R & Dulhunty, A 1999, 'Oxidation and Reduction of Pig Skeletal Muscle Ryanodine Receptors', Biophysical Journal, vol. 77, pp. 3010-3022.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Developing animal models with an RYR-1 mutation and clinical phenotype for the purpose of evaluating cell and modecular mechanisms of RYR-1 disease (Primary Investigator)
- Decrypting the Excitation Contraction coupling machinery in skeletal muscle (Secondary Investigator)
- Calcium signalling by intracellular calcium stores in rabbit, mouse and man: implications for muscle performance and athletic ability (Primary Investigator)
- Scintillation Counter (See 26118) (Primary Investigator)
- Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity (Secondary Investigator)
- DHPR a-B subunit interaction in skeletal muscle excitation contraction coupling and sarcopenia (Primary Investigator)
- Payment for services around and attendance at the ARC College as a College member at the selection meetings - Angela Dulhunty (Primary Investigator)
- Prep Cell, Pump and Fraction Collector (See 23912) (Primary Investigator)
- C02 Incubator (See 22803) (Primary Investigator)
- How triadin and junctin communicate with ryanodine receptors deep within a calcium store to determine skeletal muscle contraction (Primary Investigator)
- DHPR β subunit binding to a variably spliced region of RyR1: a role in EC coupling and myotonic dystrophy (Primary Investigator)
- New cardiac ryanodine receptor inhibitors for the treatment of heart failure (Secondary Investigator)
- Unique isoform-specific regulation of cardiac ryanodine receptors by calcium store proteins (Primary Investigator)
- Regulation of calcium release channels (RyR2) in healthy and failing hearts (Secondary Investigator)
- Glutathione transferase-derived compounds as therapeutic agents (Secondary Investigator)
- Communication between calcium ion channels in skeletal muscle excitation-contraction coupling (Primary Investigator)
- Control of Calcium Movements in Muscle (Secondary Investigator)
- Structural Determinants of an Intracellular Calcium Store (Primary Investigator)