Professor Matthew Cook
Areas of expertise
- Immunogenetics (Incl. Genetic Immunology) 110706
- Humoural Immunology And Immunochemistry 110705
- Rheumatology And Arthritis 110322
- Infectious Diseases 110309
- Cellular Immunology 110704
- Autoimmunity 110703
- Immunology 1107
Research interests
Genetic and cellular basis of human immunological disease
Our laboratory operates within the Centre for Personalised Immunology. We operate at the interface between contemporary clinical practice and discovery, with overarching aims of improving diagnostic accuracy and devising more precise treatments through better understanding of disease mechanisms.
Characterising human genetic variation is a potentially powerful method for discovering mechanisms of disease. In some cases, a diagnosis of Mendelian disease can be made through WGS, and therefore we have implemented a diagnostic genomics service (Canberra Clinical Genomics). In other cases, whole genome sequencing identifies genetic variants that provide clues to mechanisms of disease. Our lab investigates the functional consequences of genetic variants using biochemistry and cellular immunology. In order to understand how genetically encoded changes in immunity cause pathology, we also develop bespoke models of human disease by engineering orthologous gene variants in mouse models using CRISPR/cas9. We have been applying this approach to many different types of immunological disease, but particularly primary antibody deficiency, autoimmunity and sarcoidosis.
Biography
Matthew Cook is Professor of Medicine at Australian National University (ANU), Director of Immunology at Canberra Hospital and Co-Director of the Centre for Personalised Immunology. He is also medical director of Canberra Clinical Genomics, which is a NATA-accredited diagnostic genomics facility, established as a joint venture between ACT Health and ANU. He is a clinician-scientist with more than 20 years of experience using genetic analysis to elucidate disease pathways, focussing on autoimmune and immune deficiency diseases. He has been chief investigator on numerous NHMRC project grants and three NHMRC program grants. He was elected as a foundation fellow of the RCPA Faculty of Science.
Researcher's projects
How do genetic variants affecting NF-kB cause autoimmunity and immune deficiency?
In this project we are investigating several rare Mendelian disorders of NF-kB to understand how defects in these transcription factors alter central T cell tolerance, T and B cell development, and normal immune responses to infection.
AUTOCheck: immune related adverse events from checkpoint inhibitors
Immune checkpoint inhibitors have transformed the management of many forms of cancer but sometimes treatment is complicated by development of organ-specific autoimmune diseases. In this study, we are investigating the genetic and cellular basis for susceptibility to these side effects. Insights gained from this study will help refine use of checkpoint inhibitors and potentially advance understanding of autoimmune disease.
Genetic and cellular basis of antibody deficiency
A large discovery program that aims to identify new causes of primary antibody deficiency (including CVID) beginning with WGS but encompassing functional analysis in model organisms to prove causation.
Australian Genomics Health Alliance Genetic Immunology rare disease flagship
AGHA aims to improve the implementation of genomics into routine clinical practice. The GI rare disease flagship is a national collaboration of scientists and clinicians working to improve diagnosis of patients with early onset autoimmunity. Immune deficiency and autoinflammatory diseases.
Mechanisms of sarcoidosis
Sarcoidosis is a chronic inflammatory disorder but curiously overlaps with immune deficiency. Sarcoidosis patients often exhibit low white cell counts and defective immune responses, but also experience inflammatory complications that sometimes lead to organ damage. The cause of sarcoidosis remans obscure and we are tackling this problem using genomics and cellular analysis.
Our Health in Our Hands (OHIOH) ANU Grand Challenge
OHIOH was funded as the inaugural ANU Grand challenge and is a collaboration between biomedicine, engineering, physics and computer science that is tackling the challenges of deep personalisation of medicine through genomics, wearables, nanodiagnostics and machine learning.
Available student projects
Projects are available in all research projects. If you are interested in joining the lab, please contact me by email.
Current student projects
- Investigating the role of NOD2 variants in auto-inflammatory diseases.
- Analysis of a novel heterozygous missense mutation in IKBKB.
- Investigation of molecular and cellular determinants of immune related adverse events following treatment with immune checkpoint inhibitors.
- CTLA4 deficiency with autoimmunity and immunodeficiency together in human.
- The Role of NFKB2 in B cell development and activation
Past student projects
- Characterisation of a novel mutation in IKBKB implicated in a primary immunodeficiency disease.
- Regulation of T cell differentiation by CTLA4 .
- Investigation of a novel mutation in IL21R implicated in a primary immunodeficiency disorder.
- Regulation of immune tolerance and autoimmunity by NFKB2.
- Investigation of genetic mechanisms of sarcoidosis
Publications
- Al Sukaiti, N, Ahmed, K, Alshekaili, J et al. 2021, 'A Decade Experience on Severe Combined Immunodeficiency Phenotype in Oman, Bridging to Newborn Screening', Frontiers in Immunology, vol. 11.
- Hicks, S, Pohl, K, Neeman, T et al. 2021, 'A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting', Journal of Infectious Diseases, vol. 223, no. 1, pp. 10-14.
- Arsov, T, Kelecic, J, Frkovic, S et al. 2021, 'Expanding the clinical spectrum of pathogenic variation in NR2F2: Asplenia', European Journal of Medical Genetics, vol. 64, no. 12.
- Lee, W, Talaulikar, D & Cook, M 2021, 'Retrospective single-centre analysis of diagnostic approach to adult-onset haemophagocytic lymphohistiocytosis', Internal Medicine Journal, vol. 51, no. 6, pp. 939-947.
- Henschke, A, Desborough, J, Parkinson, A et al. 2021, 'Personalizing Medicine and Technologies to Address the Experiences and Needs of People with Multiple Sclerosis', Journal of Personalized Medicine, vol. 11, no. 8, pp. 1-9.
- Lea-Henry, T, Chuah, A, Stanley, M et al. 2021, 'Increased burden of rare variants in genes of the endosomal Toll-like receptor pathway in patients with systemic lupus erythematosus', LUPUS, vol. 30, no. 11, pp. 1756-1763.
- Howson, L, Awad, W, von Borstel, A et al. 2020, 'Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1', Science Immunology, vol. 5, no. 49.
- Brohus, M, Arsov, T, Wallace, D et al. 2020, 'Infanticide vs. inherited cardiac arrhythmias', Europace, vol. 23, no. 3, pp. 441-450.
- Wirasinha, R, Davies, A, Srivastava, M et al. 2020, 'Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility', Journal of Experimental Medicine, vol. 218, no. 2.
- Lorenzini, T, Fliegauf, M, Klammer, N et al. 2020, 'Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations', Journal of Allergy and Clinical Immunology, vol. 146, no. 4, pp. 901-911.
- Desborough, J, Brunoro, C, Parkinson, A et al. 2020, 'It struck at the heart of who I thought I was: A meta-synthesis of the qualitative literature examining the experiences of people with multiple sclerosis', Health Expectations, vol. 23, no. 5, pp. 1007-1027.
- Ellyard, J, Tunningley, R, Lorenzo, A et al. 2019, 'Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders', Frontiers in Immunology, vol. 10, no. 2134, pp. 1-13.
- Field, M, Burgio, G, Chuah, A et al. 2019, 'Recurrent miscalling of missense variation from short-read genome sequence data', BMC Genomics, vol. 20, no. 8, pp. 1-9.
- Lee, W, Calma, A, Drummond, C et al 2019, 'Xanthoma and paraproteinaemia: A spot diagnosis', BMJ Case Reports, vol. 12, no. 2, pp. 1-2.
- Jiang, S, Athanasopoulos, V, Ellyard, J et al. 2019, 'Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus', Nature Communications, vol. 10, no. 2201, pp. 1-12.
- Dorjbal, B, Stinson, J, Ma, C et al 2019, 'Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease', Journal of Allergy and Clinical Immunology, vol. 143, no. 4, pp. 1482-1495.
- Fernandez De Canete Nieto, P, Sweet, R, Gonzalez Figueroa, P et al 2019, 'Regulatory roles of IL-10 producing human follicular T cells', Journal of Experimental Medicine, vol. 216, no. 8, p. 14.
- Swaminathan, A, Harrison, S, Ketheesan, N et al 2018, 'Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity Study', The Journal of Investigative Dermatology, vol. 139, no. 7, pp. 1545-1553.e6.
- Haas, M, Boughtwood, T, Quinn, M et al. 2018, 'The ethics approval process for multisite research studies in Australia: changes sought by the Australian Genomics initiative', The Medical Journal of Australia, vol. 211, no. 10, pp. 440-444.
- Miraghazadeh, B, Cardinez, C, da Silva, E et al. 2018, 'Modelling human immune deficiency from novel missense mutations with orthologous heterozygous mutations engineered in mice by CRISPR/Cas9', CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference, IMDDNAC 2018, Springer New York LLC, United States, pp. 440-440.
- McKinnon, R, Cook, M, Liauw, W et al. 2018, 'Biosimilarity and Interchangeability: Principles and Evidence: A Systematic Review', BioDrugs, vol. 32, no. 1, pp. 27-52.
- Alshekaili, J, Chand, R, Lee, E et al. 2018, 'STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles', Scientific Reports, vol. 8, no. 3529, pp. 1-11.
- Hosking, L, Bannister, E, Cook, M et al 2018, 'Trichohepatoenteric Syndrome Presenting with Severe Infection and Later Onset Diarrhoea', Journal of Clinical Immunology, vol. 38, no. 1, pp. 3pp.
- Miraghazadeh, B & Cook, M 2018, 'Nuclear Factor-kappaB in Autoimmunity: Man and Mouse', Frontiers in Immunology, vol. 9, no. 613, pp. 1-16pp.
- Da Silva, E, Baker, A, Alshekaili, J et al. 2018, 'A randomized trial of serological and cellular responses to hepatitis B vaccination in chronic kidney disease', PLOS ONE (Public Library of Science), vol. 13, no. 10, pp. 1-20.
- Cardinez, C, Miraghazadeh, B, Tanita, K et al 2018, 'Gain-of-function IKBKB mutation causes human combined immune deficiency', https://www.ncbi.nlm.nih.gov/pubmed/30337470
- Anantharajah, A, Khoo, K, Downes, M et al. 2017, 'A CURIOUS CASE OF PERIODIC FEVERS, AVASCULAR NECROSIS AND INFLAMMATORY NODULES', Australasian Society of Clinical Immunology and Allergy (ASCIA), 28th Annual Conference, Wiley-Blackwell Publishing Asia, Australia, pp. 35-35.
- Al Sukaiti, N, AbdelRahman, K, Al Shekaili, J et al. 2017, 'Agammaglobulinaemia despite terminal B-cell differentiation in a patient with a novel LRBA mutation', Clinical and Translational Immunology, vol. 6, no. e144, pp. 1-5.
- Pucar, P, Hawkins, C, Randall, K et al 2017, 'Comparison of enzyme-linked immunosorbent assay and rapid chemiluminescent analyser in the detection of myeloperoxidase and proteinase 3 autoantibodies', Pathology, vol. 49, no. 4, pp. 413-418.
- Lee, W, Watson, D, Chand, R et al. 2017, 'A case of recurrent Onychomycosis without autoimmunity', Internal Medicine Journal, vol. 47, no. 5, pp. 1pp.
- Wu, Z, Liang, R, Ohnesorg, T et al. 2016, 'Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion', PLoS Genetics, vol. 12, no. 5, pp. e1006067-e1006067.
- Ma, C, Wong, N, Rao, G et al 2016, 'Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4(+) T cells into distinct effector subsets', Journal of Experimental Medicine, vol. 213, no. 8, pp. 1589-1608.
- Ma, C, Wong, N, Rao, G et al 2016, 'Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4(+) T cells into distinct effector subsets', Journal of Experimental Medicine, vol. 213, no. 8, pp. 1589-1608.
- Pucar, P, Da Silva, E, Hawkins, C et al 2016, 'Keeping Fevers In The Family', 27th Annual Conference of the Australasian Society of Clinical Immunology and Allergy (ASCIA), ed. Jeff Szer, Wiley-Blackwell Publishing Asia, Australia, pp. 33-33.
- Hew, M, Gillman, A, Sutherland, M et al 2016, 'Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria', Clinical and Experimental Allergy, vol. 46, no. 11, pp. 1407-1415.
- Gibson, P, Reddel, H, McDonald, V et al 2016, 'Effectiveness and response predictors of omalizumab in a severe allergic asthma population with a high prevalence of comorbidities: the Australian Xolair Registry', Internal Medicine Journal, vol. 46, no. 9, pp. 1054-1062.
- Fernandez De Canete Nieto, P, Sweet, R, Papa, I et al. 2016, 'Human Foxp3-negative follicular regulatory T cells control IgE responses', European Journal of Immunology, vol. 46, no. S1, pp. 13-13.
- Jerjen, R, Kreft, L, McEwan, E et al. 2016, 'Elucidating genetic pathways in SLE and stratifying patients via whole genome sequencing', ICI 2016 International Congress of Immunology, Wiley - VCH Verlag GmbH & CO. KGaA, Germany, pp. 313-313.
- Hew, M, Gillman, A, Sutherland, M et al 2016, 'Clinical Effectiveness Of Omalizumab In Severe Allergic Asthma Above The Recommended Dosing Range: The Australian Xolair Registry', International Conference of the American-Thoracic-Society (ATS), American Thoracic Society, United States, pp. A1407.
- Wu, Z, Liang, R, Ohnesorg, T et al 2016, 'Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion', PLoS Genetics, vol. 12, no. 5, pp. -.
- Jiang, S, Mercan, S, Papa, I et al. 2015, 'Vangl1 copy number variation predisposes to nephritis in systemic lupus erythmatosus'.
- Taupin, D, Lam, W, Rangiah, D et al 2015, 'A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred', Human Genome Variation, vol. 2, pp. 15013 (3 pp).
- Baynam, G, overkov, A, Davis, M et al 2015, 'A germline MTOR mutation in Aboriginal Australian siblings with intellectual disability, dysmorphism, macrocephaly, and small thoraces', American Journal of Medical Genetics, Part A, vol. 167, no. 7, pp. 1659-1667.
- Ma, C, Wong, N, Rao, G et al 2015, 'Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies', Journal of Allergy and Clinical Immunology, vol. 136, no. 4, pp. 993-+.
- Taupin, D, Lam, W, Rangiah, D et al. 2015, 'A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred', Human Genome Variation, vol. 2, pp. 15013 (3 pp).
- Subramaniam, K, Fallon, K, Ruut, T et al. 2015, 'Infliximab reverses inflammatory muscle wasting (sarcopenia) in Crohn's disease', Alimentary pharmacology & therapeutics, vol. 41, no. 5, pp. 419-428.
- Garcia de Vinuesa, C & Cook, M 2015, The promise and challenges of genomic medicine, pp. 17-18pp.
- Field, M.A., Cho, V., Cook, M.A., Enders, A., Vinuesa, C.G., Whittle, B., Andrews, T.D. and C.C. Goodnow 2015, 'Reducing the search space for causal genetic variants with VASP', Bioinformatics, pp. 1-3.
- Lee, E, Fulcher, D, Whittle, B et al. 2014, 'Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100', Blood, vol. 124, no. 19, pp. 2964-2972.
- Kane, A, Deenick, E, Ma, C et al 2014, 'STAT3 is a central regulator of lymphocyte differentiation and function', Current Opinion in Immunology, vol. 28, pp. 49-57.
- Pandya, V, Hooper, C, Essex, R et al 2014, 'Tattoo-associated uveitis', American Journal of Ophthalmology, vol. 158, no. 6, pp. 1355-1356.
- Subramaniam, K, Fallon, K, Ruut, T et al. 2014, 'Mo1249 The Anti-TNF Agent Infliximab Reverses Inflammatory Sarcopenia in Crohn's Disease', Gastroenterology, vol. 146, no. 5, pp. S597-S597.
- Altin, J, Daley, S, Howitt, J et al. 2014, 'Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells', National Academy of Sciences. Proceedings, vol. 111, no. 6, pp. 2067-2074.
- Ellyard, J, Jerjen, R, Martin, J et al. 2014, 'Identification of a Pathogenic Variant in TREX1 in Early-Onset Cerebral Systemic Lupus Erythematosus by Whole-Exome Sequencing', Arthritis & Rheumatism, vol. 66, no. 12, pp. 3382-3386.
- Chew, G, Gatenby, P, Mercan, S et al. 2014, 'TNFRSF13B Variants in SLE and Immunodeficiency', Journal of Clinical & Cellular Immunology, vol. 5, no. 4, pp. 1-8.
- Pratama, A, Ramiscal, R, Silva-Galindo, D et al. 2013, 'Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation', Immunity, vol. 38, no. 4, pp. 669-680.
- Ives, M, Ma, C, Palendira, U et al 2013, 'Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T-cell memory formation and function', Journal of Allergy and Clinical Immunology, vol. 132, no. 2, pp. 400-411.
- Berglund, L, Avery, D, Ma, C et al 2013, 'L-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts', Blood, vol. 122, no. 24, pp. 3940-3950.
- He, J, Tsai, L, Leong, Y et al. 2013, 'Circulating precursor CCR7loPD-1hi CXCR5+ CD4+ T cells indicate tfh cell activity and promote antibody responses upon antigen reexposure', Immunity, vol. 39, no. 4, pp. 770-781.
- Deenick, E, Avery, D, Chan, A et al 2013, 'Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells', Journal of Experimental Medicine, vol. 210, no. 12, pp. 2739-2753.
- Baird, M, Woon Ang, P, Clark, I et al 2013, 'The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner', Laboratory Investigation, vol. 93, no. 1, pp. 112-122.
- Chew, G, Srivastava, U, Gatenby, P et al 2013, 'Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22)', Journal of Allergy and Clinical Immunology, vol. 131, no. 4, pp. 1130-+.
- Ellyard, J, Chia, T, Rodriguez-Pinilla, S et al. 2012, 'Heterozygosity for Roquin(san) leads to angioimmunoblastic T-cell lymphoma-like tumors in mice', Blood, vol. 120, no. 4, pp. 812-821.
- Altin, J, Goodnow, C & Cook, M 2012, 'IL-10+CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation', Journal of Immunology, vol. 188, no. 11, pp. 5478-5488.
- Ma, C, Avery, D, Chan, A et al 2012, 'Functional STAT3 deficiency compromises the generation of human T follicular helper cells', Blood, vol. 119, no. 17, pp. 3997-4008.
- Hayter, S & Cook, M 2012, 'Updated assessment of the prevalence, spectrum and case definition of autoimmune disease', Autoimmunity Reviews, vol. 11, no. 10, pp. 754-765.
- Tian, L, Altin, J, Makaroff, L et al 2011, 'Foxp3(+) regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis', Blood, vol. 118, no. 7, pp. 1845-1853.
- Palendira, U, Low, C, Chan, A et al 2011, 'Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP', PLoS Biology, vol. 9, no. 11, pp. e1001187-e1001187.
- Altin, J, Tian, L, Liston, A et al. 2011, 'Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus TH2 effector cells to cause allergy', Journal of Allergy and Clinical Immunology, vol. 127, no. 5, pp. 1277-U296.
- Eri, R, Adams, R, Tran, T et al 2011, 'An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity', Mucosal Immunology, vol. 4, no. 3, pp. 354-364.
- Vinuesa, C.G. & Cook, M 2011, 'Blood Relatives of Follicular Helper T Cells', Immunity, vol. 34, no. 1, pp. 10-12.
- Alshekaili, J, Li, C & Cook, M 2010, 'Heterophile interference accounts for method-specific dsDNA antibodies in patients receiving anti-TNF treatment', Rheumatology, vol. 49, no. 5, pp. 891-897.
- Avery, D, Deenick, E, Ma, C et al. 2010, 'B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans', Journal of Experimental Medicine, vol. 207, no. 1, pp. 155-171.
- Alshekaili, J, Reynolds, G & Cook, M 2010, 'De novo infantile primary antiphospholipid antibody syndrome', LUPUS, vol. 19, no. 13, pp. 1565-1568.
- Ma, C, Batten, M, Ramamoorthi, N et al 2010, 'IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells', Journal of Experimental Medicine, vol. 207, no. 13, pp. 2895-2906.
- Simpson, N, Gatenby, P, Wilson, A, Malik, S, Fulcher, DA, Tangye, SG, Manku, H,Vyse, TJ, Roncador, G, Huttley, G, Goodnow, CC, Vinuesa, CG, Cook, MC, 2010, 'Expansion of Circulating T Cells Resembling Follicular Helper T Cells Is a Fixed Phenotype That Identifies a Subset of Severe Systemic Lupus Erythematosus', Arthritis & Rheumatism, vol. 62, no. 1, pp. 234-244.
- Cook, M & Tangye, S 2009, 'Primary immune deficiencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections', International Immunology, vol. 21, no. 9, pp. 1003-1011.
- Tangye, S, Cook, M & Fulcher, D 2009, 'Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome', Journal of Immunology, vol. 182, no. 1, pp. 21-28.
- Linterman, M, Rigby, R, Wong, R, Yu, D, Brink, R, Cannons, JL, Schwartzberg, PL, Cook, MC, Walters, GD, Vinuesa, CG, 2009, 'Follicular helper T cells are required for systemic autoimmunity', Journal of Experimental Medicine, vol. 206, no. 3, pp. 561-576.
- Vinuesa, C.G., Sanz, I & Cook, M 2009, 'Dysregulation of germinal centres in autoimmune disease', Nature Reviews, Immunology, vol. 9, pp. 845-857.
- Ma, C, Chew, G, Simpson, N et al. 2008, 'Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3', Journal of Experimental Medicine, vol. 205, no. 7, pp. 1551-1557.
- Heazlewood, C, Cook, M, Rajaraman, E et al 2008, 'Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis', PLoS Medicine, vol. 5, no. 3, pp. 0440-0460.
- Ormerod, A & Cook, M 2008, 'Epidemiology of primary systemic vasculitis in the Australian Capital Territory and south-eastern New South Wales', Internal Medicine Journal, vol. 38, pp. 816-823.
- Cook, M 2008, 'B cell back catalogue', Immunology and Cell Biology, vol. 86, pp. 109-110.
- Avery, D, Ma, C, Bryant, V et al 2008, 'STAT3 is required for IL-21-induced secretion of IgE from human naive B cells', Blood, vol. 112, no. 5, pp. 1784-93.
- Yu, D, Cook, M, Shin, D, Silva, DG, Marshall, J, Toellner, KM, Havran, WL, Caroni, P, Cooke, MP, Morse, HC, MacLennan, ICM, Goodnow, CC, Vinuesa, CG, 2008, 'Axon growth and guidance genes identify T-dependent germinal centre B cells', Immunology and Cell Biology, vol. 86, pp. 3-14.
- Vinuesa, C.G., & Cook, M 2007, 'Genetic analysis of systemic autoimmunity', in George Bock and Jamie Goode (ed.), Decoding the genomic control of immune reactions: Novartis Foundation Symposium, No 281, John Wiley & Sons Inc, Chichester, U.K., pp. 103-120.
- Vinuesa, C.G., & Cook, M 2007, 'The Molecular Basis of Lymphoid Architecture in the Mouse', in James Fox,S Barthold,M Davisson.C Newcomer,F Quimby,A Smith (ed.), The Mouse in Biomedical Research (2nd ed), Academic Press, USA, pp. 57-108.
- Hawkins, C, Collignon, P, Adams, D et al 2006, 'Profound lymphopenia and bacteraemia', Internal Medicine Journal, vol. 36, pp. 385-388.
- Cook, M, Vinuesa, C.G., & Goodnow, C 2006, 'ENU-mutagenesis: insight into immune function and pathology', Current Opinion in Immunology, vol. 18, pp. 627-633.
- Vinuesa, C.G., Cook, M, Angelucci, C et al 2005, 'A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity', Nature, vol. 435, pp. 452-458.
- Cook, M 2004, 'B Cell biology, apoptosis, and autoantibodies to phospholipids', Thrombosis Research, vol. 114, pp. 307-319.
- MacLennan, ICM, Toellner, KM, Cunningham, AF, Serre, K, Sze, DMY, Zuniga, E, Cook, MC, Vinuesa, CG, 2003, 'Extrafollicular antibody responses', Immunological Reviews, vol. 194, pp. 8-18.
- Vinuesa, C.G., Sze, D, Cook, M et al 2003, 'Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide-antigens', European Journal of Immunology, vol. 33, pp. 297-305.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- Missed opportunities in clinical practice: Tools to enhance clinician awareness and diagnosis of rare diseases in Australia (Secondary Investigator)
- Australian Genomics Grant Program (Secondary Investigator)
- AUTO-CHECK study: Molecular determinants of autoimmunity and immune related adverse events in advanced cancer patients treated with immune checkpoint inhibitors (Primary Investigator)
- Establishment of the Canberra Clinical Genomic Service and Research Service Agreement July 2020 - June 2025 (Secondary Investigator)
- How BANK1 pathway defects in B cells cause human lupus (Secondary Investigator)
- Regulation of Haemopoietic and Immune Cells in Health and Disease (Secondary Investigator)
- How does NF-kB2 regulate central T cell tolerance to prevent organ-specific autoimmune disease (Primary Investigator)
- Preparing Australia for Genomic Medicine: A proposal by the Australian Genomics Health Alliance (Secondary Investigator)
- Novel pathways that regulate T cells (Secondary Investigator)
- Centre for Personalised Immunology (Secondary Investigator)
- Flow cytometry for primary immune deficiency (Primary Investigator)
- Genomic medicine for human immune deficiency (Primary Investigator)
- Molecular and Cellular basis of inflammatory and immunodeficiency diseases (Secondary Investigator)
- Genotypes and phenotypes of human primary non-congenital antibody deficiency (Secondary Investigator)
- Assessing the impact of solar ultraviolet radiation on the immune response to primary vaccination: the AusUVI Study (Secondary Investigator)
- Genetic pathology of Roquin in human autoimmune disease (Secondary Investigator)