Emeritus Professor Shin-Ho Chung
Areas of expertise
- Physical Organic Chemistry 030505
- Plasma Physics; Fusion Plasmas; Electrical Discharges 020204
- Protein Trafficking 060108
- Medical Biotechnology Diagnostics (Incl. Biosensors) 100402
- Cell Neurochemistry 060105
- Biological Physics 029901
- Catalysis And Mechanisms Of Reactions 030601
- Quantum Chemistry 030701
- Bioinformatics 060102
- Global Change Biology 069902
- Signal Transduction 060111
- Cell Metabolism 060104
- Chemical Thermodynamics And Energetics 030602
- Nanobiotechnology 100703
- Atomic And Molecular Physics 020201
- Applied Statistics 010401
- Analytical Biochemistry 060101
- Landscape Ecology 050104
- Complex Physical Systems 029902
- Nanoscale Characterisation 100712
- Receptors And Membrane Biology 060110
- Biochemistry And Cell Biology 0601
- Other Biological Sciences 0699
- Medical Biotechnology 1004
Available student projects
Several subfamilies of biological ion channels which allow sodium ions to move from outside of the cell to inside are important targets for alleviating chronic pain. Many small peptides isolated from venoms of cone snails, known as µ-conotoxins, are potent and specific blockers of sodium channels and thus are potential scaffolds for novel analgesics. Our group has developed reliable structural models for several subfamilies of sodium channels. In this project, using the state-of-the-art computational tools, we will attempt to elucidate in atomic detail how certain toxins extracted from cone snails interfere with sodium-transporting biological ion channels that are involved in the perception of pain. The ultimate goal of this in silico study is to design and synthesize toxin derivatives that can be used as novel pharmaceutical agents to combat persistent and chronic pain in human.
Publications
- Chung, S & Roper, M 2020, 'Generalized Langevin Equation: An Introductory Review for Biophysicists', Biophysical Reviews and Letters, vol. 14, no. 4, pp. 171 - 196.
- Chen, R & Chung, S 2018, 'Inhibition of Voltage-Gated K+ Channel Kv1.5 by Antiarrhythmic Drugs', Biochemistry, vol. 57, no. 18, pp. 2704-2710pp.
- Hilder, T, Robinson, A & Chung, S 2017, 'Functionalised Fullerene Targeting Human Voltage Gated Sodium Channel', ACS Chemical Neuroscience, doi: 10.1021/acschemneuro.7b00099
- Chen, R, Lu, D, Xie, Z et al 2016, 'Peptidomimetic star polymers for targeting biological ion channels', PLOS ONE (Public Library of Science), vol. 11, no. 3, pp. -.e0152169.
- Chen, R & Chung, S 2015, 'Computational Studies of Venom Peptides Targeting Potassium Channels', Toxins, vol. 7, no. 12, pp. 5194-5211.
- Thomas, M, Corry, B, Chung, S et al 2015, 'Modelling selective transport and desalination in nanotubes', in Ying (Ian) Chen (ed.), Nanotubes and Nonosheets, CRC Press, Taylor & Francis Group, London, pp. 305-330pp.
- Chen, R & Chung, S 2015, 'Molecular dynamics simulations of Na+ and leucine transport by LeuT', Biochemical and Biophysical Research Communications, vol. 464, no. 1, pp. 281-285.
- Chen, R, Gryn'ova, G, Wu, Y et al. 2014, 'Mechanisms and energetics of potassium channel block by local anesthetics and antifungal agents', Biochemistry, vol. 53, no. 43, pp. 6786-6792.
- Chen, R & Chung, S 2014, 'Mechanism of tetrodotoxin block and resistance in sodium channels', Biochemical and Biophysical Research Communications, vol. 446, no. 1, pp. 370-374.
- Hilder, T, Ridone, P, Nakayama, Y et al 2014, 'Binding of fullerenes and nanotubes to MscL', Scientific Reports, vol. 4, pp. 1-10.
- Hilder, T, Corry, B & Chung, S 2014, 'Multi-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels', Journal of Biological Physics, vol. 40, no. 2, pp. 109-119.
- Chen, R & Chung, S 2014, 'Binding Modes of Two Scorpion Toxins to the Voltage-Gated Potassium Channel Kv1.3 Revealed from Molecular Dynamics', Toxins, vol. 6, no. 7, pp. 2149-2161.
- Chen, R, Robinson, A & Chung, S 2014, 'Mechanism of µ-Conotoxin PIIIA Binding to the Voltage-Gated Na+ Channel Nav1.4', PLOS ONE (Public Library of Science), vol. 9, no. 3, pp. 1-8.
- Hilder, T & Chung, S 2013, 'Conduction and block of inward rectifier K+ channels: Predicted structure of a potent blocker of kir2.1', Biochemistry, vol. 52, no. 5, pp. 967-974.
- Chung, S & Chen, R 2013, 'Complex Structures between the N-Type Calcium Channel (Ca(V)2.2) and omega-Conotoxin GVIA Predicted via Molecular Dynamics', Analytical Biochemistry, vol. 52, no. 21, pp. 3765-3772.
- Chen, R & Chung, S 2013, 'Effect of gating modifier toxins on membrane thickness: Implications for toxin effect on gramicidin and mechanosensitive channels', Toxins, vol. 5, no. 2, pp. 456-471.
- Gordon, D, Chen, R & Chung, S 2013, 'Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications', Physiological Reviews, vol. 93, no. 2, pp. 767-802.
- Chen, R & Chung, S 2013, 'Molecular dynamics simulations of scorpion toxin recognition by the Ca2+-activated potassium channel KCa3.1', Biophysical Journal, vol. 105, no. 8, pp. 1829-1837.
- Hilder, T & Chung, S 2013, 'Designing a C-84 fullerene as a specific voltage-gated sodium channel blocker', Nanoscale Research Letters, vol. 8, no. 1, pp. 323-323.
- Hilder, T & Chung, S 2013, 'Conductance properties of the inwardly rectifying channel, Kir3.2: Molecular and Brownian dynamics study', Biochimica et Biophysica Acta: Biomembranes, vol. 1828, pp. 471-478.
- Hilder, T, Pace, R & Chung, S 2012, 'Computational design of a carbon nanotube fluorofullerene biosensor', Sensors, vol. 12, no. 10, pp. 13720-13735.
- Chen, R & Chung, S 2012, 'Structural Basis of the Selective Block of Kv1.2 by Maurotoxin from Computer Simulations', PLOS ONE (Public Library of Science), vol. 7, no. 10.
- Chen, R & Chung, S 2012, 'Binding modes and functional surface of anti-mammalian scorpion α-toxins to sodium channels', Biochemistry, vol. 51, no. 39, pp. 7775-7782.
- Gordon, D, Chen, R, Ho, J et al 2012, 'Rigid Body Brownian Dynamics as a Tool for Studying Ion Channel Blockers', Journal of Physical Chemistry B, vol. 116, no. 6, pp. 1933-1941.
- Hilder, T, Yang, R, Gordon, D et al 2012, 'Silicon carbide nanotube as a chloride-selective channel', Journal of Physical Chemistry C, vol. 116, no. 7, pp. 4465-4470.
- Chen, R & Chung, S 2012, 'Conserved functional surface of antimammalian scorpion β-toxins', Journal of Physical Chemistry B, vol. 116, no. 16, pp. 4796-4800.
- Chen, R & Chung, S 2012, 'Engineering a potent and specific blocker of voltage-gated potassium channel Kv1.3, a target for autoimmune diseases', Biochemistry, vol. 51, no. 9, pp. 1976-1982.
- Chen, R & Chung, S 2012, 'Binding Modes of mu-Conotoxin to the Bacterial Sodium Channel (Na(v)Ab)', Biophysical Journal, vol. 102, no. 3, pp. 483-488.
- Gordon, D & Chung, S 2012, 'Extension of Brownian Dynamics for Studying Blockers of Ion Channels', Journal of Physical Chemistry B, vol. 116, no. 49, pp. 14285-14294.
- Chen, R, Robinson, A & Chung, S 2012, 'Binding of hanatoxin to the voltage sensor of Kv2.1', Toxins, vol. 4, no. 12, pp. 1552-1564.
- Wanasundara, S, Krishnamurthy, V & Chung, S 2011, 'Free energy calculations of gramicidin dimer dissociation', Journal of Physical Chemistry B, vol. 115, no. 46, pp. 13765-13770.
- Hilder, T & Chung, S 2011, 'Carbon nanotube as a gramicidin analogue', Chemical Physics Letters, vol. 501, no. 4-6, pp. 423-426.
- Hilder, T, Gordon, D & Chung, S 2011, 'Computational modeling of transport in synthetic nanotubes', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 7, no. 6, pp. 702-709.
- Yang, R, Hilder, T, Chung, S et al 2011, 'First-Principles Study of Water Confined in Single-Walled Silicon Carbide Nanotubes', Journal of Physical Chemistry C, vol. 115, no. 35, pp. 17255-17264.
- Chen, R, Robinson, A, Gordon, D et al 2011, 'Modeling the Binding of Three Toxins to the Voltage-Gated Potassium Channel (Kv1.3)', Biophysical Journal, vol. 101, no. 11, pp. 2652-2660.
- Gordon, D & Chung, S 2011, 'Permeation and Block of the Kv1.2 Channel Examined Using Brownian and Molecular Dynamics', Biophysical Journal, vol. 101, no. 11, pp. 2671-2678.
- Hilder, T, Gordon, D & Chung, S 2011, 'Synthetic cation-selective nanotube: Permeant cations chaperoned by anions', Journal of Chemical Physics, vol. 134, no. 4, pp. 045103-1 - 045103-7.
- Hilder, T, Gordon, D & Chung, S 2010, 'Mimicking biological ion channels using boron nitride nanotubes', International Conference on Nanoscience and Nanotechnology (ICONN 2010), ed. Prof Andrew Dzurak, UNSW, Institute of Electrical and Electronics Engineers (IEEE Inc), Adelaide Australia, pp. 368-371.
- Hilder, T, Gordon, D & Chung, S 2010, 'Synthetic chloride-selective carbon nanotubes examined by using molecular and stochastic dynamics', Biophysical Journal, vol. 99, no. 6, pp. 1734-1742.
- Hilder, T, Yang, R, Venkateshwara, G et al. 2010, 'Validity of current force fields for simulations on boron nitride nanotubes', Micro and Nano Letters, vol. 5, no. 2, pp. 150-156.
- Gordon, D, Hoyles, M & Chung, S 2009, 'Algorithm for rigid-body Brownian dynamics', Physical Review E-Statistical, Nonlinear and Soft Matter Physics, vol. 80, pp. 066703/1-066703/12.
- Hilder, T, Gordon, D & Chung, S 2009, 'Salt Rejection and Water Transport Through Boron Nitride Nanotubes', Small, vol. 5, no. 19, pp. 2183-2190.
- Gordon, D, Krishnamurthy, V & Chung, S 2009, 'Generalized Langevin models of molecular dynamics simulations with applications to ion channels', Journal of Chemical Physics, vol. 131, pp. 134102-1 - 134102-11.
- Hilder, T, Gordon, D & Chung, S 2009, 'Boron Nitride Nanotubes Selectively Permeable to Cations or Anions', Small, vol. 5, no. 24, pp. 2870-2975.
- Ng, J, Vora, T, Krishnamurthy, V et al 2008, 'Estimating the dielectric constant of the channel protein and pore', European Biophysics Journal, vol. 37, pp. 213-222.
- Gordon, D, Krishnamurthy, V & Chung, S 2008, 'A generalized Langevin algorithm for studying permeation across biological ion channels', Molecular Physics, vol. 106, no. 11, pp. 1353-1361.
- Vora, T, Corry, B & Chung, S 2008, 'Brownian dynamics study of flux ratios in sodium channels', European Biophysics Journal, vol. 38, pp. 45-52.
- Vora, T, Bisset, D & Chung, S 2008, 'Conduction of Na+ and K+ through the NaK Channel: Molecular and Brownian Dynamics Studies', Biophysical Journal, vol. 95, no. 4, pp. 1600-1611.
- Bisset, D & Chung, S 2008, 'Efficacy of external tetraethylammonium block of the KcsA potassium channel: Molecular and Brownian dynamics studies', Biochimica et Biophysica Acta: Biomembranes, vol. 1778, no. 10, pp. 2273-2282.
- Krishnamurthy, V & Chung, S 2007, 'Large-scale Dynamical Models and Estimation for Permeation in Biological Membrane Ion Channels', Proceedings of the IEEE, vol. 95, no. 5, pp. 853-870.
- Hoyles, M, Krishnamurthy, V, Siksik, M et al 2007, 'Brownian Dynamics Theory for Predicting Internal and External Blockages of Tetraethylammonium in the KcsA Potassium Channel', Biophysical Journal, vol. 94, pp. 1-13.
- Chung, S & Corry, B 2007, 'Conduction properties of KcsA Measured Using Brownian Dynamics with Flexible Carbonyl Groups in the Selectivity Filter', Biophysical Journal, vol. 93, no. July, pp. 44-53.
- Krishnamurthy, V, Vora, T & Chung, S 2007, 'Adaptive Brownian Dynamics for Shape Estimation of Sodium Ion Channels', Journal of Nanoscience and Nanotechnology, vol. 7, no. 7, pp. 1-9.
- Chung, S 2007, 'Bionanotubes: the ultimate units of the physiology of life', Australian Physics, vol. April/May , pp. 16-17.
- Corry, B & Chung, S 2006, 'Mechanisms of Valence Selectivity in Biological Ion Channels', Cellular and Molecular Life Sciences, vol. 63, no. 3, pp. 301-315.
- Krishnamurthy, V & Chung, S 2006, 'Adaptive Brownian Dynamics Simulation for Estimating Potential Mean Force in Ion Channel Permeation', IEEE Transactions on Nanobioscience, vol. 5, no. 2, pp. 126-138.
- Chung, S & Krishnamurthy, V 2006, 'Brownian Dynamics: A powerful computational tool of Ion permeation in Bio-Nanotubes', in S.H. Chung, O.S. Anderson and V. Krishnamurthy (ed.), Biological membrane ion channels: dynamics, structure and applications, Springer, USA, pp. 507-543.
- Vora, T, Corry, B & Chung, S 2006, 'Brownian dynamics investigation into the conductance state of the MscS channel crystal structure', Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics, vol. 1758, pp. 730-737.
- Krishnamurthy, V, Hoyles, M, Saab, R et al 2006, 'Permeation in Gramicidin Ion Channels by Directly Estimating the Potential of Mean force Using Brownian Dynamics Simulations', Journal of Computational and Theoretical Nanoscience, vol. 35, pp. 702-711.
- Krishnamurthy, V & Chung, S 2006, 'Signal Processing Based on Hidden Markov models for Extracting Small Channel Currents', in S.H. Chung, O.S. Anderson and V. Krishnamurthy (ed.), Biological membrane ion channels: dynamics, structure and applications, Springer, USA, pp. 623-649.
- Chung, S, Anderson, O & Krishnamurthy, E, eds, 2006, Biological Membrane Ion Channels: Dynamics, Structure and Applications, Springer, USA.
- Corry, B, Vora, T & Chung, S 2005, 'Electrostatic Basis of Valence Selectivity in Cationic Channels', Biochimica et Biophysica Acta: Biomembranes, vol. 1711, pp. 72-86.
- Chung, S & Corry, B 2005, 'Three Computational Methods for Studying Permeation, Selectivity and Dynamics in Biological Ion Channels', Soft Matter, vol. 1, pp. 417-427.
- Krishnamurthy, V & Chung, S 2005, 'Brownian Dynamics Simulation for Modeling Ion Permeation Across Bionanotubes', IEEE Transactions on Nanobioscience, vol. 4, no. 1, pp. 102-111.
- Vora, T, Corry, B & Chung, S 2005, 'A Model of Sodium Channels', Biochimica et Biophysica Acta: Biomembranes, vol. 1668, pp. 106-116.
- Bisset, D, Corry, B & Chung, S 2005, 'The Fast Gating Mechanism in CIC-0 Channels', Biophysical Journal, vol. 89, pp. 179-186.
- Corry, B & Chung, S 2005, 'Influence of Protein Flexibility on the Electrostatic Energy Landscape in Gramicidin A', European Biophysics Journal, vol. 34, pp. 208-216.
- O'Mara, ML, Cromer, B, Parker, M et al 2005, 'Homology Model of the GABAA Receptor Examined Using Brownian Dynamics', Biophysical Journal, vol. 88, pp. 3286-3299.
- Corry, B, O'Mara, M & Chung, S 2004, 'Conduction Mechanisms of Chloride Ions in CIC-Type Channels', Biophysical Journal, vol. 86, pp. 846-860.
- Corry, B, O'Mara, M & Chung, S 2004, 'Permeation Dynamics of Chloride Ions in the CIC-O and CIC-1 Channels', Chemical Physics Letters, vol. 386, pp. 233-238.
- O'Mara, M, Barry, P & Chung, S 2003, 'A Model of the Glycine Receptor Deduced from Brownian Dynamics Studies', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 7, pp. 4310-4315.
- Allen, T, Bastug, T, Kuyucak, S et al 2003, 'Gramicidin A Channel as a Test Ground for Molecular Dynamics Force Fields', Biophysical Journal, vol. 84, pp. 2159-2168.
- Krishnamurthy, V & Chung, S 2003, 'Adaptive Learning Algorithms for Nernst Potential and I-V Curves in Nerve Cell Membrane Ion Channels Modelled as Hidden Markov Models', IEEE Transactions on Nanobioscience, vol. 2, no. 5, pp. 266-278.
- Edwards, S, Corry, B, Kuyucak, S et al 2002, 'Continuum Electrostatics Fails to Describe Ion Permeation in the Gramicidin Channel', Biophysical Journal, vol. 83, pp. 1348 - 1360.
- Chung, S, Allen, T & Kuyucak, S 2002, 'Conducting-State Properties of the KcsA Potassium Channel from Molecular and Brownian Dynamics Simulations', Biophysical Journal, vol. 82, pp. 628 - 645.
- Corry, B, Hoyles, M, Allen, T et al 2002, 'Reservoir Boundaries in Brownian Dynamics Simulations of Ion Channels', Biophysical Journal, vol. 82, pp. 1975 - 1984.
- Chung, S, Allen, T & Kuyucak, S 2002, 'Modeling Diverse Range of Potassium Channels with Brownian Dynamics', Biophysical Journal, vol. 83, pp. 263 - 277.
- Kuyucak, S & Chung, S 2002, 'Permeation Models and Structure-function Relationships in Ion Channels', Journal of Biological Physics, vol. 28, pp. 289-308.
- Chung, S & Kuyucak, S 2002, 'Recent Advances in Ion Channel Research', Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics, vol. 1565, pp. 267-286.
- Chung, S & Kuyucak, S 2002, 'Ion Channels: Recent Progress and Prospects', European Biophysics Journal, vol. 31, pp. 283-293.
- Bliznyuk, A, Rendell, A, Allen, T et al 2001, 'The Potassium Ion Channel: Comparison of Linear Scaling Semiempirical and Molecular Mechanics Representations of the Electrostatic Potential', Journal of Physical Chemistry B, vol. 105, pp. 12674-12679.
- Kuyucak, S, Andersen, O & Chung, S 2001, 'Models of Permeation in Ion Channels', Reports on Progress in Physics, vol. 64, pp. 1427-1472.
- Corry, B, Allen, T, Kuyucak, S et al 2001, 'Mechanisms of Permeation and Selectivity in Calcium Channels', Biophysical Journal, vol. 80, pp. 195-214.
- Chung, S & Kuyucak, S 2001, 'Predicting channel function from channel structure using Brownian dynamics simulations', Clinical and Experimental Pharmacology and Physiology, vol. 28, pp. 89-94.
- Moy, G, Corry, B, Kuyucak, S et al. 2000, 'Tests of Continuum Theories as Models of Ion Channels. I. Poisson-Boltzmann Theory versus Brownian Dynamics', Biophysical Journal, vol. 78, pp. 2349-2363.
- Corry, B, Kuyucak, S & Chung, S 2000, 'Invalidity of continuum theories of electrolytes in nanopores', Chemical Physics Letters, vol. 320, pp. 35-41.
- Corry, B, Kuyucak, S & Chung, S 2000, 'Tests of Continuum Theories as Models of Ion Channels. II. Poisson-Nernst-Planck Theory versus Brownian Dynamics', Biophysical Journal, vol. 78, pp. 2364-2381.
- Allen, T, Bliznyuk, A, Rendell, A et al 2000, 'The potassium channel: Structure, Selectivity and diffusion', Journal of Chemical Physics, vol. 112, pp. 8191-8204.
- Corry, B, Allen, T, Kuyucak, S et al 2000, 'A model of calcium channels', Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics, vol. 70883, pp. 1-6.
- Allen, T, Kuyucak, S & Chung, S 2000, 'Molecular dynamics estimates of ion diffusion in model hydrophobic and KcsA potassium channels', Biophysical Chemistry, vol. 86, pp. 1-14.
- Chung, S, Allen, T, Hoyles, M et al 1999, 'Permeation of ions across the potassium channel: Brownian dynamics studies', Biophysical Journal, vol. 77, pp. 2517-2533.
- Allen, T, Hoyles, M, Kuyucak, S et al 1999, 'Molecular and Brownian dynamics study of ion permeation across the potassium channel', Chemical Physics Letters, vol. 313, pp. 358-365.
- Allen, T, Kuyucak, S & Chung, S 1999, 'Molecular dynamics study of the KcsA potassium channel', Biophysical Journal, vol. 77, pp. 2502-2516.
- Allen, T, Kuyucak, S & Chung, S 1999, 'The effect of hydrophobic and hydrophilic channel walls on the structure and diffusion of water and ions', Journal of Chemical Physics, vol. 111, pp. 7985-7999.
- Poskitt, D, Dogancay, K & Chung, S 1999, 'A new analytical method of studying post-synaptic currents in the brain', Mathematical Biosciences, vol. 161, pp. 15-41.
- Poskitt, D, Dogancay, K & Chung, S 1999, 'Double blind deconvolution: the analysis of postsynaptic currents in nerve cells.', Journal of the Royal Statistical Society Series B, vol. B61, pp. 191-212.
- Saint, D & Chung, S 1999, 'Variability of channel subconductance states of the cardiac sodium channel induced by protease.', Receptors and Channels, vol. 6, pp. 283-294.
- Corry, B, Kuyucak, S & Chung, S 1999, 'Test of Poisson-Nernst-Planck theory of ion channels', Journal of General Physiology, vol. 114, pp. 597-600.
