Publications

• Yang, A, Alrosan, A, Sharpe, L et al. 2021, 'Regulation of ABCG4 transporter expression by sterols and LXR ligands', Biochimica et Biophysica Acta - General Subjects, vol. 1865, no. 1, pp. 8pp.
• Chai, A, Hartz, A, Gao, X et al. 2021, 'New evidence for p-gp-mediated export of amyloid-β peptides in molecular, blood-brain barrier and neuronal models', International Journal of Molecular Sciences, vol. 22, no. 1, pp. 1-20.
• Chai, A, Leung, G, Callaghan, R et al. 2020, 'P-glycoprotein: a role in the export of amyloid-beta in Alzheimer's disease?', The FEBS Journal, vol. 287, no. 4, pp. 612-625.
• Carey Hulyer, A, Briggs, D, O'Mara, M et al. 2020, 'Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane', Journal of Structural Biology, vol. 211, pp. 1-14.
• Rottet, S, Iqbal, S, Beales, P et al. 2020, 'Characterisation of Hybrid Polymersome Vesicles Containing the Efflux Pumps NaAtm1 or P-Glycoprotein', Polymers, vol. 12, no. 1049, pp. 1-22.
• Yong, C, Devine, S, Gao, X et al 2019, 'A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells', ChemMedChem, vol. 14, no. 33, pp. 1968-1981.
• Muthiah, D, Henshaw, G, DeBono, A et al 2019, 'Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives', Drug Metabolism and Disposition, vol. 47, no. 2, pp. 164-172.
• Yuan, Y, Cai, T, Callaghan, R et al 2019, 'Psoralen-loaded lipid-polymer hybrid nanoparticles enhance doxorubicin efficacy in multidrug-resistant HepG2 cells', International journal of nanomedicine, vol. 14, no. -, pp. 2207-2218.
• Skrzypek, R, Iqbal, S & Callaghan, R 2018, 'Methods of reconstitution to investigate membrane protein function', Methods, vol. 147, pp. 126-141pp.
• Devine, S, Yong, C, Amenuvegbe, D et al 2018, 'Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents', Journal of Medicinal Chemistry, vol. 61, no. 18, pp. 8444-8456pp.
• Yuan, Y, Chiba, P, Cai, T et al 2018, 'Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells', Oncology Reports, vol. 40, no. 2, pp. 1055-1063pp.
• Muthiah, D & Callaghan, R 2017, 'Dual effects of the PI3K inhibitor ZSTK474 on multidrug efflux pumps in resistant cancer cells', European Journal of Pharmacology, vol. 815, pp. 127-137.
• Board, M, Lopez, C, van den Bos, C et al 2017, 'Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species', The International Journal of Biochemistry and Cell Biology, vol. 88, pp. 75-83.
• Skrzypek, R & Callaghan, R 2017, 'The "pushmi-pullyu" of resistance to chloroquine in malaria', Essays in Biochemistry, vol. 61, no. 1, pp. 167-175.
• Mittra, R, Pavy, M, Subramanian, N et al 2017, 'Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein', Biochemical Pharmacology, vol. 123, pp. 19-28.
• Smith, H, Board, M, Pellagatti, A et al 2016, 'The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors', Journal of Celluar Biochemistry, vol. 117, no. 8, pp. 1890-1901.
• Mittra, R, Coyle, E & Callaghan, R 2016, 'Just How and Where Does P-glycoprotein Bind All Those Drugs?', in Anthony M George (ed.), ABC Transporters - 40 Years on, Springer International Publishing, Australia, pp. 153-194pp.
• Darby, R, Unsworth, A, Knapp, S et al 2015, 'Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors', Cancer Chemotherapy and Pharmacology, vol. 76, no. 4, pp. 853-864.
• Callaghan, R 2015, 'Providing a molecular mechanism for P-glycoprotein; Why would i bother?', Biochemical Society Transactions, vol. 43, no. 5, pp. 995-1002.
• van Wonderen, J, McMahon, R, O'Mara, M et al. 2014, 'The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis', The FEBS Journal, vol. 281, no. 9, pp. 2190-2201.
• Pollock, N, McDevitt, C, Collins, R et al 2014, 'Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids', Biochimica et Biophysica Acta: Biomembranes, vol. 1838, no. 1, pp. 134-147.
• DeBono, A, Mistry, S, Xie, J et al 2014, 'The Synthesis and Biological Evaluation of Multifunctionalised Derivatives of Noscapine as Cytotoxic Agents', ChemMedChem, vol. 9, no. 2, pp. 399-410.
• Callaghan, R, Bloch, K, Smith, H et al 2014, 'Metabolic Alterations During the Growth of Tumour Spheroids', Cell Biochemistry and Biophysics, vol. 68, no. 3, pp. 615-628.
• Callaghan, R, Luk, F & Bebawy, M 2014, 'Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?', Drug Metabolism and Disposition, vol. 42, no. 4, pp. 623-631.
• van Wonderen, J, McMahon, R, O'Mara, ML et al 2014, 'The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis', The FEBS Journal, vol. 281, no. 9, pp. 2190-2201
• Callaghan, R, Pluchino, K, Hall, M et al 2012, 'Collateral sensitivity as a strategy against cancer multidrug resistance', Drug Resistance Updates, vol. 15, no. 1-2, pp. 98-105.
• Callaghan, R, George, A & Kerr, I 2012, 'Molecular Aspects of the Translocation Process by ABC Proteins', in Edward H. Egelman (ed.), Comprehensive Biophysics, Vol 8, Bioenergetics, Academic Press, Oxford, pp. 145-173.
• Espinosa, M, Ceballos-Cancino, G, Callaghan, R et al 2012, 'Survivin isoform Delta Ex3 regulates tumor spheroid formation', Cancer Letters, vol. 318, no. 1, pp. 61-67.
• Pollock, N & Callaghan, R 2011, 'The lipid translocase, ABCA4: seeing is believings', The FEBS Journal, vol. 278, no. 18, pp. 3204-3214.
• Mellor, H & Callaghan, R 2011, 'Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein', Cancer Chemotherapy and Pharmacology, vol. 68, no. 5, pp. 1179-1190.
• Darby, R, Callaghan, R & McMahon, R 2011, 'P-glycoprotein Inhibition: The Past, the Present and the Future', Current Drug Metabolism, vol. 12, no. 8, pp. 722-731.
• Pollock, N, Niesten, P & Callaghan, R 2011, 'The flippase delusion', in Philippe F. Devaux & Andreas Herrmann (ed.), Transmembrane Dynamics of Lipids, John Wiley & Sons Inc, Hoboken, New Jersey, USA, pp. 225-249.
• Callaghan, R 2010, 'Multidrug efflux pumps: the big issues', The FEBS Journal, vol. 277, no. 3, p. 529.
• Crowley, E & Callaghan, R 2010, 'Multidrug efflux pumps: drug binding - gates or cavity?', The FEBS Journal, vol. 277, no. 3, pp. 530-539.
• Crowley, E, McDevitt, C & Callaghan, R 2010, 'Generating Inhibitors of P-Glycoprotein: Where to, Now?', Methods in Molecular Biology, vol. 596, pp. 405-432.
• Jeyabalan, J, Mesbit, M, Galvanovskis, J et al 2010, 'SEDLIN forms homodimers: Characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1', PLOS ONE (Public Library of Science), vol. 5, no. 5.
• Crowley, E, O'Mara, M, Kerr, I et al. 2010, 'Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1', The FEBS Journal, vol. 277, no. 19, pp. 3974-3985.
• McDevitt, C, Collins, R, Kerr, I et al 2009, 'Purification and structural analyses of ABCG2', Advanced Drug Delivery Reviews, vol. 61, no. 1, pp. 57-65.
• Heikal, A, Box, K, Rothnie, A et al 2009, 'The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides', Cryobiology, vol. 58, no. 1, pp. 37-44.
• Ford, R, Kamis, A, Kerr, I et al 2009, 'The ABC Transporters: Structural Insights into Drug Transport', in Gerhard Ecker & Peter Chiba (ed.), Transporters as Drug Carriers: Structure, Function, Substrates., Wiley-VCH Verlag GmbH & Co. KGaA., United States, pp. 1-48.
• Crowley, E, O'Mara, ML, Reynolds, C et al 2009, 'Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1', Biochemistry, vol. 48, no. 26, pp. 6249-6258.
• Callaghan, R, Crowley, E, Potter, S et al 2008, 'P-glycoprotein: So many ways to turn it on', Journal of Clinical Pharmacology, vol. 48, no. 3, pp. 365-378.
• Rivers, F, O'Brien, T & Callaghan, R 2008, 'Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations', European Journal of Pharmacology, vol. 598, no. 1-3, pp. 1-8.
• Carrier, D, Bakar, N, Napier, R et al 2008, 'The binding of auxin to the arabidopsis auxin influx transporter AUX1', Plant Physiology, vol. 148, no. 1, pp. 529-535.
• Mellor, H & Callaghan, R 2008, 'Resistance to chemotherapy in cancer: A complex and integrated cellular response', Pharmacology, vol. 81, no. 4, pp. 275-300.
• Callaghan, R & Crowley, E 2008, 'Chemoresistance in cancer', Horizons in Medicine, vol. 20, pp. 197-207.
• McDevitt, C, Crowley, E, Hobbs, G et al. 2008, 'Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?', The FEBS Journal, vol. 275, no. 17, pp. 4354-4362.
• Storm, J, Modok, S, O'Mara, M et al. 2008, 'Cytosolic region of TM6 in P-glycoprotein: Topographical analysis and functional perturbation by site directed labeling', Biochemistry, vol. 47, no. 12, pp. 3615-3624.
• McDevitt, C, Shintre, C, Grossmann, J et al 2008, 'Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography', FEBS Letters, vol. 582, no. 19, pp. 2950-2956.
• Modok, S, Scott, R, Alderden, R et al 2007, 'Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumour model', British Journal of Cancer, vol. 97, no. 2, pp. 194-200.
• Storm, J, O'Mara, ML, Crowley, E et al 2007, 'Residue G346 in Transmembrane Segment Six is Involved in Inter-Domain Communication in P-Glycoprotein', Biochemistry, vol. 46, no. 35, pp. 9899-9910.
• Callaghan, R, Ford, R & Kerr, I 2006, 'The translocation mechanism of P-glycoprotein', FEBS Letters, vol. 580, no. 4, pp. 1056-1063.
• Rosenberg, M, Callaghan, R, Modok, S et al 2005, 'Three-dimensional structure of P-glycoprotein: The transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state', Journal of Biological Chemistry, vol. 280, no. 4, pp. 2857-2862.

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

• What is the role of ABCA4 in vision and how does it contribute to retinopathies? (Primary Investigator)
• How do drugs bind to the multidrug resistance P-Glycoprotein? (Primary Investigator)
• The molecular process underlying multidrug efflux by P-glycoprotein (Primary Investigator)