Areas of expertise

• Epidemiology 111706
• Gene Expression (Incl. Microarray And Other Genome Wide Approaches) 060405
• Clinical Pharmacology And Therapeutics 111502
• Analytical Biochemistry 060101
• Molecular Targets 111207
• Receptors And Membrane Biology 060110
• Epigenetics (Incl. Genome Methylation And Epigenomics) 060404
• Enzymes 060107
• Respiratory Diseases 110203
• Developmental Genetics (Incl. Sex Determination) 060403
• Genetically Modified Animals 100104
• Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) 060106
• Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics) 110106
• Allergy 110701
• Veterinary Pathology 070709
• Genome Structure And Regulation 060407
• Molecular Evolution 060409
• Animal Physiology Biophysics 060601
• Toxicology (Incl. Clinical Toxicology) 111506
• Metabolic Medicine 110107
• Cell Metabolism 060104
• Pharmacogenomics 111505
• Numerical And Computational Mathematics 0103
• Medicinal And Biomolecular Chemistry 0304
• Biochemistry And Cell Biology 0601
• Genetics 0604
• Oncology And Carcinogenesis 1112
• Pharmacology And Pharmaceutical Sciences 1115

Publications

• Tummala, D, Rooke, M, Dahlstrom, J et al. 2021, 'Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation', Carcinogenesis, vol. 42, no. 6, pp. 853-863.
• Takemura, K, Board, P & Koga, F 2021, 'A systematic review of serum γ-glutamyltransferase as a prognostic biomarker in patients with genitourinary cancer', Antioxidants, vol. 10, no. 4.
• Chiou, P, Ohms, S, Board, P et al. 2020, 'Efavirenz as a potential drug for the treatment of triple-negative breast cancers', Clinical and Translational Oncology, vol. 23, pp. 353-363.
• Sokulsky, L, Goggins, B, Sherwin, S et al. 2020, 'GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1 alpha-induced eosinophilic airway inflammation', Clinical and Experimental Allergy, vol. 50, no. 5, pp. 609-624.
• Takemura, K, Yuasa, T, Inamura, K et al. 2020, 'Impact of Serum γ‑Glutamyltransferase on Overall Survival in Patients with Metastatic Renal Cell Carcinoma in the Era of Targeted Therapy', Targeted Oncology, vol. 15, no. 3, pp. 347-356.
• Xie, Y, Tummala, P, Oakley, A et al. 2020, 'Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors', Journal of Medicinal Chemistry, vol. 63, no. 6, pp. 2894-2914.
• Ogawa, T, Wada, Y, Takemura, K et al 2019, 'CHAC1 overexpression in human gastric parietal cells with Helicobacter pylori infection in the secretory canaliculi', Helicobacter (Oxford), vol. 24, no. 4, pp. 1-9.
• Hughes, M, Hughes, M, Hooftman, A et al 2019, 'Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation', Cell Reports, vol. 29, no. 1, pp. 151-161.
• Fernando, N, Wooff, Y, Aggio-Bruce, R et al 2018, 'Photoreceptor survival is regulated by GSTO1-1 in the degenerating retina', Investigative Ophthalmology and Visual Science, vol. 59, no. 11, pp. 4362-4374pp.
• Xie, Y, Dahlin, J, Oakley, A et al 2018, 'Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example', Journal of Medicinal Chemistry, vol. 61, no. 17, pp. 7448-7470pp.
• Wada, Y, Takemura, K, Tummala, P et al 2018, 'Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells', FEBS Open Bio, vol. 8, no. 4, pp. 671-679pp.
• Hughes, M, Lavrencic, P, Coll, R et al 2017, 'Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 32, pp. E6480-E6489.
• Richardson, S, Steele, G, Gallant, P et al. 2017, 'Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding', Journal of Cell Science, vol. 130, no. 20, pp. 3588-3600.
• Menon, D, Innes, A, Oakley, A et al 2017, 'GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity', Scientific Reports, vol. 7, no. 1, pp. 15pp.
• Norris, N, Joseph, S, Aditya, S et al 2017, 'Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability', Journal of Biological Chemistry, vol. 292, no. 20, pp. 8401-8411pp.
• Dulhunty, A, Board, P, Beard, N et al 2017, 'Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels', Advances in Pharmacology, vol. 79, pp. 287-324.
• Pok, S, Barn, V, Wong, D et al 2016, 'Testosterone regulation of cyclin E kinase: A key factor in determining gender differences in hepatocarcinogenesis', Journal of Gastroenterology and Hepatology, vol. 31, no. 6, pp. 1210-1219pp.
• Hewawasam, R, Liu, D, Casarotto, M et al 2016, 'The GSTM2 C-Terminal domain depresses contractility and Ca2+ transients in neonatal rat ventricular cardiomyocytes', PLOS ONE (Public Library of Science), vol. 11, no. 9, pp. e0162415-e0162415.
• Board, P & Menon, D 2016, 'Structure, function and disease relevance of Omega-class glutathione transferases', Archives of Toxicology, vol. 90, no. 5, pp. 1049-1067.
• Galgamuwa Arachchige, R, Hardy, K, Dahlstrom, J et al 2016, 'Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties', Journal of the American Society of Nephrology, vol. 27, no. 11, pp. 3331-3344.
• Rebbeck, R, van Zyl, H, Groom, L et al 2015, 'Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit', Skeletal Muscle, vol. 5, no. 23, pp. 1-15.
• Menon, D, Coll, R, O'Neill, L et al 2015, 'GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway', Journal of Cell Science, vol. 128, no. 10, pp. 1982-1990.
• Rebbeck, R, van Zyl, H, Groom, L et al 2015, 'Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit', Skeletal Muscle, vol. 5, no. 23, pp. 1-15.
• Samarasinghe, S, Liu, D, Tummala, D et al. 2015, 'Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes', Biochemical Pharmacology, vol. 97, no. 3, pp. 269-280.
• Rangasamy, D, Lenka, N, Ohms, S et al. 2015, 'Activation of LINE-1 retrotransposon increases the risk of epithelial-mesenchymal transition and metastasis in epithelial cancer', Current Molecular Medicine, vol. 15, no. 7, pp. 588-597.
• Blackburn, A, Rooke, M, Li, Y et al 2014, 'Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in the Li-Fraumeni Syndrome model, Trp53 +/- mice', Cancer and Metabolism, vol. 2, no. S1, p. 10.
• Rebbeck, R, Karunasekara, Y, Board, P et al 2014, 'Skeletal muscle excitation-contraction coupling: Who are the dancing partners?', The International Journal of Biochemistry and Cell Biology, vol. 48, no. 1, pp. 28-38.
• Lenka, N, Krishnan, S, Board, P et al 2014, 'Exploiting the power of LINE-1 retrotransposon mutagenesis for identification of genes involved in embryonic stem cell differentiation', Stem Cell Reviews, vol. 10, no. 3, pp. 408-416.
• Takemura, K, Kawachi, H, Eishi, Y et al 2014, 'γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors', Human Pathology, vol. 45, no. 2, pp. 331-341.
• Menon, D, Coll, R, O'Neill, L et al 2014, 'Glutathione transferase Omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages', Free Radical Biology and Medicine, vol. 73, pp. 318-327.
• Theodoratos, A, Dahlstrom, J, Galgamuwa Arachchige, R et al. 2014, 'Prevention of Cisplatin-Induced Nephrotoxicity by Dichloroacetate', Pathology, vol. 46, pp. S1.
• Menon, D & Board, P 2013, 'A fluorometric method to quantify protein glutathionylation using glutathione derivatization with 2,3-naphthalenedicarboxaldehyde', Analytical Biochemistry, vol. 433, no. 2, pp. 132-136.
• Yin, L, Song, J, Board, P et al 2013, 'Characterization of selenium-containing glutathione transferase zeta1-1 with high GPX activity prepared in eukaryotic cells', Journal of Molecular Recognition, vol. 26, no. 1, pp. 38-45.
• Brock, J, Board, P & Oakley, A 2013, 'Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of a non-catalytic ligandin site', PLOS ONE (Public Library of Science), vol. 8, no. 4, pp. e60324-e60324.
• Board, P & Menon, D 2013, 'Glutathione transferases, regulators of cellular metabolism and physiology', Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics, vol. 1830, no. 5, pp. 3267-3288.
• Menon, D & Board, P 2013, 'A role for glutathione transferase omega 1 (GSTO1-1) in the glutathionylation cycle', Journal of Biological Chemistry, vol. 288, no. 36, pp. 25769-25779.
• Bocedi, A, Fabrini, R, Farrotti, A et al 2013, 'The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily A PROPOSAL FOR AN EVOLUTIONARY DRIVING FORCE', Journal of Biological Chemistry, vol. 288, no. 34, pp. 24936-24947.
• Board, P & Hutchinson, I 2012, 'A fluorescence-based microtiter plate assay for γ-glutamylcyclotransferase', Analytical Biochemistry, vol. 420, no. 2, pp. 177-181.
• Amano, T, Eishi, Y, Yamada, T et al 2012, 'Widespread expression of γ-glutamyl cyclotransferase suggests it is not a general tumor marker', Journal of Histochemistry and Cytochemistry, vol. 60, no. 1, pp. 76-86.
• Theodoratos, A, Blackburn, A, Coggan, M et al 2012, 'The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo', International Journal of Obesity, vol. 36, no. 10, pp. 1366-1369.
• Liu, D, Hewawasam, R, Karunasekara, Y et al 2012, 'The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor', Biochemical Pharmacology, vol. 83, no. 11, pp. 1523-1529.
• Liu, H, Yin, L, Board, P et al 2012, 'Expression of selenocysteine-containing glutathione S-transferase in eukaryote', Protein Expression and Purification, vol. 84, no. 1, pp. 59-63.
• Lam , L, Zhang, Z, Board, P et al. 2012, 'Reduction of Benzoquinones to Hydroquinones via Spontaneous Reaction with Glutathione and Enzymatic Reaction by S-Glutathionyl-Hydroquinone Reductases', Biochemistry, vol. 51, no. 25, pp. 5014-5021.
• Takano, K, Liu, D, Tarpey, P et al. 2012, 'An X-linked Channelopathy with Cardiomegaly due to a CLIC2 Mutation Enhancing Ryanodine Receptor Channel Activity', Human Molecular Genetics, vol. 21, no. 20, pp. 4497-4507.
• Karunasekara, Y, Karunasekara, Y, Rebbeck, R et al 2012, 'An alpha-helical C-terminal tail segment of the skeletal L-type Ca2+ channel beta(1a) subunit activates ryanodine receptor type 1 via a hydrophobic surface', FASEB Journal, vol. 26, no. 12, pp. 5049-5059.
• Karunasekara, Y, Karunasekara, Y, Rebbeck, R et al 2012, 'An alpha-helical C-terminal tail segment of the skeletal L-type Ca2+ channel beta(1a) subunit activates ryanodine receptor type 1 via a hydrophobic surface', FASEB Journal, vol. 26, no. 12, pp. 5049-5059.
• Chen, L, Dahlstrom, J, Chandra, A et al 2012, 'Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer', Breast Cancer Research and Treatment, vol. 136, no. 1, pp. 129-142.
• Zhou, H, Brock, J, Liu, D et al 2012, 'Structural Insights into the Dehydroascorbate Reductase Activity of Human Omega-Class Glutathione Transferases', Journal of Molecular Biology, vol. 420, no. 3, pp. 190-203.
• Blackburn, A, Rooke, M, Li, Y et al 2012, 'Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in Trp53+/- mice', Hereditary Cancer in Clinical Practice, vol. 10, no. S2, pp. 1-2.
• Theodoratos, A, Blackburn, A, Cappello, J et al 2012, 'Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase', Biochemical Pharmacology, vol. 83, no. 3, pp. 427-433.
• Tae, H, Wei, L, van Zyl, H et al 2011, 'The elusive role of the SPRY2 domain in RyR1', Channels, vol. 5, no. 2, pp. 148-160.
• Zhou, H, Brock, J, Casarotto, M et al 2011, 'Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1', Journal of Biological Chemistry, vol. 286, no. 6, pp. 4271-4279.
• Board, P 2011, 'The omega-class glutathione transferases: Structure, function, and genetics', Drug Metabolism Reviews, vol. 43, no. 2, pp. 226-235.
• Board, P & Anders, M 2011, 'Glutathione transferase zeta: Discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1^-/- mice', Drug Metabolism Reviews, vol. 43, no. 2, pp. 215-225.
• Morris, M, Liu, D, Weaver, L et al 2011, 'A structural basis for cellular uptake of GST-fold proteins', PLoS ONE (Public Library of Science), vol. 6, no. 3, pp. e17864-e17864.
• Rebbeck, R, Karunasekara, Y, Gallant, E et al 2011, 'The β1a subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail', Biophysical Journal, vol. 100, no. 4, pp. 922-930.
• Dulhunty, A, Hewawasam, R, Liu, D et al 2011, 'Regulation of the cardiac muscle ryanodine receptor by glutathione transferases', Drug Metabolism Reviews, vol. 43, no. 2, pp. 236-252.
• Tae, H, Cui, Y, Karunasekara, Y et al. 2011, 'Cyclization of the intrinsically disordered α_1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function', Journal of Biological Chemistry, vol. 286, no. 25, pp. 22589-22599.
• Blackburn, A, Coggan, M, Shield, A et al 2011, 'Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress', Laboratory Investigation, vol. 91, no. 11, pp. 1572-1583.
• Peralvarez-Marin, A, Tae, H, Board, P et al. 2011, '3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM', PLOS ONE (Public Library of Science), vol. 6, no. 10, pp. e25813-e25813.
• Sun, R, Board, P & Blackburn, A 2011, 'Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells', Molecular Cancer Therapeutics, vol. 10, no. Article #142, pp. 142-142.
• Xun, L, Belchik, S, Xun, R et al 2010, 'S-Glutathionyl-(chloro)hydroquinone reductases: a novel class of glutathione transferases', Biochemical Journal, vol. 428, pp. 419-427.
• Oakley, A, Coggan, M & Board, P 2010, 'Identification and Characterization of gamma-Glutamylamine Cyclotransferase, an Enzyme Responsible for gamma-Glutamyl-epsilon-lysine Catabolism', Journal of Biological Chemistry, vol. 285, no. 13, pp. 9642-9648.
• Shield, A, Murray, T, Cappello, J et al 2010, 'Polymorphisms in the human glutathione transferase Kappa (GSTK1) promoter alter gene expression', Genomics, vol. 95, no. 5, pp. 299-305.
• Hewawasam, R, Liu, D, Casarotto, M et al 2010, 'The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor', Biochemical Pharmacology, vol. 80, no. 3, pp. 381-388.
• Weber, J, Oakley, A, Christ, A et al 2010, 'Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D₂ synthase', European Journal of Medicinal Chemistry, vol. 45, no. 2, pp. 447-454.
• Cui, Y, Tae, H, Norris, N et al. 2009, 'A dihydropyridine receptor alpha(1s) loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor', The International Journal of Biochemistry and Cell Biology, vol. 41, no. 3, pp. 677-686.
• Sun, R, Fadia, M, Dahlstrom, J et al 2009, 'Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo', Breast Cancer Research and Treatment, vol. Online first, p. 8.
• Liu, D, Hewawasam, R, Pace, S et al. 2009, 'Dissection of the inhibition of cardiac ryanodine receptors by human glutathione transferase GSTM2-2', Biochemical Pharmacology, vol. 77, no. 7, pp. 1181-1193.
• Morris, M, Craig, S, Sutherland, T et al 2009, 'Transport of glutathione transferase-fold structured proteins into living cells', Biochimica et Biophysica Acta: Biomembranes, vol. 1788, no. 1, pp. 676-685.
• Theodoratos, A, Tu, W, Cappello, J et al. 2009, 'Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta', Biochemical Pharmacology, vol. 77, no. 8, pp. 1358-1563.
• Tae, H, Norris, N, Cui, Y et al. 2009, 'Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor', Clinical and Experimental Pharmacology and Physiology, vol. 36, no. 3, pp. 346-349.
• Oakley, A, Yamada, T, Liu, D et al 2008, 'The identification and structural characterization of C7orf24 as γ-glutamyl cyclotransferase: an essential enzyme in the γ-glutamyl cycle', Journal of Biological Chemistry, vol. 283, no. 32, pp. 22031-22042.
• Zhou, J, Wolf, C, Henderson, C et al. 2008, 'Glutathione Transferase P1: An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma', American Journal of Respiratory and Critical Care Medicine, vol. 178, pp. 1202-1210.
• Wei, L, Abdellatif, Y, Liu, D et al 2008, 'Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity', The International Journal of Biochemistry and Cell Biology, vol. 40, no. 8, pp. 1616-28.
• Schmuck, E, Cappello, J, Coggan, M et al 2008, 'Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs', The International Journal of Biochemistry and Cell Biology, vol. 40, no. 11, pp. 2553-9.
• Zheng, K, Board, P, Fei, X et al 2008, 'A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases', The International Journal of Biochemistry and Cell Biology, vol. 40, pp. 2090-2097.
• Jalilian, C, Gallant, E, Board, P et al 2008, 'Redox potential and the response of cardiac ryanodine receptors to CLIC-2, a member of the glutathione S-transferase structural family', Antioxidants & redox signaling, vol. 10, no. 10, pp. 1675-86.
• Paiva, L, Marcos, R, Creus, A et al 2008, 'Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden', Pharmacogenetics and Genomics, vol. 18, no. 1, pp. 1-10.
• Board, P, Coggan, M, Cappello, J et al 2008, 'S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1', Analytical Biochemistry, vol. 374, no. 1, pp. 25-30.
• Board, P 2007, 'The use of glutathione transferase-knockout mice as pharmacological and toxicological models', Expert opinion on drug metabolism & toxicology, vol. 3, no. 3, pp. 421-33.
• Board, P & Anders, M 2007, 'Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones', Chemical Research in Toxicology, vol. 20, no. 1, pp. 149-54.
• Cromer, B, Gorman, M, Hansen, G et al 2007, 'Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2)', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, vol. F63, no. 11, pp. 961-3.
• Abdellatif, Y, Liu, D, Gallant, E et al 2007, 'The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels', Cell Calcium, vol. 41, no. 5, pp. 429-40.
• Cromer, B, Gorman, M, Hansen, G et al 2007, 'Structure of the Janus Protein Human CLIC2', Journal of Molecular Biology, vol. 374, no. 3, pp. 719-731.
• Harju, T, Peltoniemi, M, Rytila, P et al 2007, 'Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients', Respiratory research, vol. 8, p. 48.
• Blackburn, A, Matthaei, K, Lim, C et al 2006, 'Deficiency of glutathione transferase Zeta causes oxidative stress and activation of antioxidant response pathways', Molecular Pharmacology, vol. 69, no. 2, pp. 650-657.
• Board, P 2006, 'A class act - The discovery of the Theta class glutathione transferases', Biochemist, vol. October '06, pp. 35-38.
• Casarotto, M, Cui, Y, Karunasekara, Y et al. 2006, 'Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor', Clinical and Experimental Pharmacology and Physiology, vol. 33, no. 11, pp. 1114-17.
• Fang, Y, Kashkarov, U, Anders, M et al. 2006, 'Polymorphisms in the human glutathione transferase zeta promoter', Pharmacogenetics and Genomics, vol. 16, no. 5, pp. 307-13.
• Shield, A, Murray, T & Board, P 2006, 'Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase', Biochemical and Biophysical Research Communications, vol. 347, no. 4, pp. 859-66.
• Mannervik, B, Board, P, Hayes, J et al 2005, 'Nomenclature for Mammalian soluble glutathione transferases', in Helmut Sies and Lester Packer (ed.), Glutathione Transferases and Gamma-Glutamyl Transpeptidases, Elsevier, California, pp. 1-8.
• Dulhunty, A, Karunasekara, Y, Curtis, S et al 2005, 'Role of some unconserved residues in the C region of the skeletal DHPR II-III loop', Frontiers in Bioscience, vol. 10, pp. 1368-1381.
• Dulhunty, A, Karunasekara, Y, Curtis, S et al 2005, 'The recombinant dihydropyridine receptor II-III loop and partly structured C region peptides modify cardiac ryanodine receptor activity', Biochemical Journal, vol. 385, pp. 803-813.
• Cui, Y, Karunasekara, Y, Harvey, P et al. 2005, 'Letter to the editor: 1H, 13C and 15N assignments for the II-III loop region of the skeletal dyhydropyridine receptor', Journal of Biomolecular NMR, vol. 32, pp. 89-90.
• Baker, R, Catanzariti, A, Karunasekara, Y et al 2005, 'Using Deubiquitylating Enzymes as Research Tools', in Raymond J. Deshaies (ed.), Ubiquitin and Protein Degradation, Elsevier, California, pp. 540-554.
• Whitbread, A, Masoumi, A, Tetlow, N et al 2005, 'Characterization of the Omega Class of Glutathione Transferases', in Helmut Sies and Lester Packer (ed.), Glutathione Transferases and Gamma-Glutamyl Transpeptidases, Elsevier, California, pp. 78-99.
• Board, P & Anders, M 2005, 'Human Glutathione Transferase Zeta', in Helmut Sies and Lester Packer (ed.), Glutathione Transferases and Gamma-Glutamyl Transpeptidases, Elsevier, California, pp. 61-77.
• Dulhunty, A, Pouliquin, P, Coggan, M et al 2005, 'A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP', Biochemical Journal, vol. 390, pp. 333-343.
• Schmuck, E, Board, P, Whitbread, A et al 2005, 'Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimers and Parkinsons diseases', Pharmacogenetics and Genomics, vol. 12, pp. 493-501.
• Board, P, Anders, M & Blackburn, A 2005, 'Catalytic Function and Expression of Glutathione Transferase Zeta', in Lawrence H. Lash (ed.), Drug Metabolism and Transport, Humana Press Inc., USA, pp. 85-107.
• Whitbread, A, Mellick, G, Silburn, P et al 2004, 'Glutathione transferase Omega class polymorphisms in Parkinson disease', Neurology, vol. 62, pp. 1910-1911.
• Ricci, G, Turella, P, De Maria, F et al 2004, 'Binding and Kinetic Mechanisms of the Zeta Class Glutathione Transferase', Journal of Biological Chemistry, vol. 279, no. 32, pp. 33336-33342.
• Tetlow, N, Robinson, A, Mantle, T et al 2004, 'Polymorphism of human mu class glutathione transferases', Pharmacogenetics and Genomics, vol. 14, pp. 359-368.
• Lim, C, Matthaei, K, Blackburn, A et al 2004, 'Mice Deficient in Glutathione tranferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases', American Journal of Pathology, vol. 165, no. 2, pp. 679-693.
• Tetlow, N & Board, P 2004, 'Functional polymorphism of human glutathione transferase A2', Pharmacogenetics and Genomics, vol. 14, pp. 111-116.
• Board, P, Coggan, M, Watson, S et al 2004, 'CLIC-2 modulates cardiac ryanodine receptor Ca(2+) release channels', The International Journal of Biochemistry and Cell Biology, vol. 36, pp. 1599-1612.
• Robinson, A, Huttley, G, Booth, H et al 2004, 'Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases', Biochemical Journal, vol. 379, pp. 541-552.
• Catanzariti, A, Soboleva, T, Jans, D et al. 2004, 'An efficient system for high-level expression and easy purification of authentic recombinant proteins', Protein Science, vol. 13, pp. 1331-1339.
• Anderson, W, Board, P & Anders, M 2004, 'Glutathione Transferase Zeta-Catalyzed Bioactivation of Dichloroacetic Acid: Reaction of Glyoxylate with Amino Acid Nucleophiles', Chemical Research in Toxicology, vol. 17, pp. 650-662.
• Tetlow, N, Coggan, M, Casarotto, M et al 2004, 'Functional polymorphism of human glutathione transferase A3: effects on xenobiotic metabolism and steroid biosynthesis', Pharmacogenetics and Genomics, vol. 14, pp. 657-663.
• Board, P, Taylor, M, Coggan, M et al 2003, 'Clarification of the role of key active site residues of glutathione transferase Zeta/maleylacetoacetate isomerase by a new spectrophotometric technique', Biochemical Journal, vol. 374, pp. 731-737.
• Whitbread, A, Tetlow, N, Eyre, H et al 2003, 'Characterization of the human Omega class glutathione transferase genes and associated polymorphisms', Pharmacogenetics and Genomics, vol. 13, no. 3, pp. 131-144.
• Board, P 2002, 'Ligandin revisited: resolution of the alpha class glutathione transferase gene family', Pharmacogenetics and Genomics, vol. 12, no. 4, pp. 275-276.
• Melton, J, Ewart, G, Weir, R et al 2002, 'Alphavirus 6K proteins form ion channels', Journal of Biological Chemistry, vol. 277, no. 49., pp. 46923-46931.
• Coggan, M, Flanagan, J, Parker, M et al. 2002, 'Identification and characterization of GSTT3, a third murine Theta class glutathione transferase', Biochemical Journal, vol. 366, pp. 323-332.
• Dulhunty, A, Haarmann, C, Green, D et al 2002, 'Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle', Progress in Biophysics and Molecular Biology, vol. 79, pp. 45-75.
• Owczarek, C, Owczarek, A & Board, P 2002, 'Identification and characterization of polymorphisms at the HSA alpha1-acid glycoprotein (ORM*) gene locus in Caucasians', Genetics and Molecular Biology, vol. 25, no. 1, pp. 13-19.
• Lantum, H, Board, P & Anders, M 2002, 'Kinetics of the Biotransformation of Maleylacetone and Chlorofluoroacetic Acid by Polymorphic Variants of Human Glutathione Transferase Zeta (hGSTZ1-1)', Chemical Research in Toxicology, vol. 15, pp. 957-963.
• Cromer, B, Morton, C, Board, P et al 2002, 'From glutathione transferase to pore in a CLIC', European Biophysics Journal, vol. 31, pp. 356-364.
• Anderson, W, Liebler, D, Board, P et al 2002, 'Mass Spectral Characterization of Dichloroacetic Acid-Modified Human Glutathione Transferase Zeta', Chemical Research in Toxicology, vol. 15, no. 11, pp. 1387-1397.
• Lantum, H, Liebler, D, Board, P et al 2002, 'Alkylation and Inactivation of Human Glutathione Transferase Zeta (hGSTZ1-1) by Maleylacetone and Fumarylacetone', Chemical Research in Toxicology, vol. 15, no. January, pp. 707-716.
• Ren, X, Jemth, P, Board, P et al 2002, 'A Semisynthetic Glutathione Peroxidase with High Catalytic Efficiency: Selenoglutathione Transferase', Chemistry and Biology, vol. 9, no. July 2002, pp. 789-794.
• Lantum, H, Baggs, R, Krenitsky, D et al 2002, 'IMMUNOHISTOCHEMICAL LOCALIZATION AND ACTIVITY OF GLUTATHIONE TRANSFERASE ZETA (GSTZ1-1) IN RAT TISSUES', Drug Metabolism and Disposition, vol. 30, no. 6, pp. 616-625.
• Chelvanayagam, G, Parker, M & Board, P 2001, 'Fly fishing for GSTs: a unified nomenclature for mammalian and insect glutathione transferases', Chemico-Biological Interactions, vol. 133, pp. 256-260.
• Bamber, D, Board, P, Coggan, M et al 2001, 'Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer', Chemico-Biological Interactions, vol. 133, pp. 95-97.
• Board, P, Coggan, M, Chelvanayagam, G et al 2001, 'Characterization of the Omega class glutathione transferases', Chemico-Biological Interactions, vol. 133, pp. 204-206.
• Coggan, M, Liu, D, Chelvanayagam, G et al 2001, 'Evaluation of possible active site residues in GSTZ 1-1', Chemico-Biological Interactions, vol. 133, pp. 185-187.
• Caccuri, A, Antonini, G, Board, P et al. 2001, 'Evolutionary strategy for optimization of GSH binding and catalysis in Alpha, Pi, Mu and Theta glutathione transferases', Chemico-Biological Interactions, vol. 133, pp. 163-166.
• Harris, M, Kuwano, M, Webb, M et al. 2001, 'Identification of the Apical Membrane-targeting Signal of the Multidrug Resistance-associated Protein 2 (MRP2/cMOAT)', Journal of Biological Chemistry, vol. 276, no. 24, pp. 20676-20881.
• Nuccetelli, M, Evangelisti, C, Capo, C et al 2001, 'Limited proteolysis as a powerful tool for probing flexible oligopeptide portions among different classes of glutathione transferases', Chemico-Biological Interactions, vol. 133, pp. 43-48.
• Whitbread, A, Coggan, M & Board, P 2001, 'Genomic structure of human GST omega 1', Chemico-Biological Interactions, vol. 133, pp. 331-333.
• Tetlow, N, Blackburn, A, Chelvanayagam, G et al 2001, 'Alpha class glutathione transferase polymorphisms identified by EST database analysis', Chemico-Biological Interactions, vol. 133, pp. 123-125.
• Anders, M, Anderson, W, Tzeng, H et al 2001, 'Glutathione transferase zeta: novel xenobiotic substrates and enzyme inactivation', Chemico-Biological Interactions, vol. 133, pp. 211-216.
• Parker, M, McKinstry, W, Oakley, A et al 2001, 'Evolution of functional diversity as observed through structural studies of glutathione transferases', Chemico-Biological Interactions, vol. 133, pp. 8-12.
• Yin, Z, Dahlstrom, J, Le Couteur, D et al 2001, 'Immunohistochemistry of Omega Class Glutathione S-Transferase in Human Tissues', Journal of Histochemistry and Cytochemistry, vol. 49, no. 8, pp. 983-987.
• Tetlow, N, Liu, D & Board, P 2001, 'Polymorphism of human Alpha class glutathione transferases', Pharmacogenetics and Genomics, vol. 11, no. 7, pp. 609-617.
• Zakharyan, R, Sampayo-Reyes, A, Healy, S et al 2001, 'Human Monomethylarsonic Acid (MMA^v) Reductase Is a Member of the Glutathione-S-Transferase Superfamily', Chemical Research in Toxicology, vol. 14, pp. 1051-1057.
• Taylor, M, Board, P, Blackburn, A et al 2001, 'Zeta class glutathione transferase polymorphisms and Parkinsons disease', Journal of Neurology Neurosurgery and Psychiatry, vol. 70, pp. 406-425.
• Caccuri, A, Antonini, G, Board, P et al. 2001, 'Human Glutathione Transferase T2-2 Discloses Some Evolutionary Strategies for Optimization of Substrate Binding to the Active Site of Glutathione Transferases', Journal of Biological Chemistry, vol. 276, no. 8, pp. 5427-5431.
• Dulhunty, A, Gage, P, Curtis, S et al 2001, 'The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator', Journal of Biological Chemistry, vol. 276, no. 5, pp. 3319-3323.
• Board, P, Chelvanayagam, G, Jermiin, L et al 2001, 'IDENTIFICATION OF NOVEL GLUTATHIONE TRANSFERASES AND POLYMORPHIC VARIANTS BY EXPRESSED SEQUENCE TAG DATABASE ANALYSIS', Drug Metabolism and Disposition, vol. 29, no. 4, pp. 544-547.
• Gisi, D, Maillard, J, Flanagan, J et al. 2001, 'Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants', European Journal of Biochemistry, vol. 268, pp. 1-11.
• Blackburn, A, Coggan, M, Tzeng, H et al 2001, 'GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase', Pharmacogenetics and Genomics, vol. 11, no. 8, pp. 671-678.
• Caccuri, A, Antonini, G, Board, P et al. 2001, 'Human Glutathione Transferase T2-2 Discloses Some Evolutionary Strategies for Optimization of the Catalytic Activity of Glutathione Transferases', Journal of Biological Chemistry, vol. 276, no. 8, pp. 5432-5437.
• Polekhina, G, Board, P, Blackburn, A et al. 2001, 'Crystal Structure of Maleylacetoacetate Isomerase/Glutathione Transferase Zeta Reveals the Molecular Basis for Its Remarkable Catalytic Promiscuity', Biochemistry, vol. 40, pp. 1567-1576.
• Parker, M, McKinstry, W, Oakley, A et al. 2001, 'Evolution of functional diversity as observed through structural studies of glutathione transferases', Chemico-Biological Interactions, vol. 133, no. 1-3, pp. 8-12.
• Tzeng, H, Blackburn, A, Board, P et al 2000, 'Polymorphism- and Species-Dependent Inactivation of Glutathione Transferase Zeta by Dichloroacetate', Chemical Research in Toxicology, vol. 13, pp. 231-236.
• Njalsson, R, Carlsson, K, Olin, B et al. 2000, 'Kinetic properties of missense mutations in patients with glutathilone synthetase deficiency', Biochemical Journal, vol. 349, pp. 275-279.
• Flanagan, J, Chelvanayagam, G, Casarotto, M et al. 2000, 'A MUTAGENIC ANALYSIS OF THE ROLE OF Trp-115 IN THE HUMAN THETA CLASS GLUTATHIONE TRANSFERASE GSTT2-2', Clinical Chemistry and Enzymology Communications, vol. 8, pp. 261-269.
• Flanagan, J, King, W, Parker, W et al. 2000, 'Ab Initio Calculations on Hidden Modulators of Theta Class Glutathione Transferase Activity', Proteins: Structure Function and Genetics, vol. 39, no. ISI, pp. 235-243.
• Blackburn, A, Tzeng, H, Anders, M et al 2000, 'Discovery of a functional polymorphism in human glutathione transferase Zeta by expressed sequence Tag database analysis', Pharmacogenetics and Genomics, vol. 10, pp. 49-57.
• Board, P, Coggan, M, Chelvanayagam, G et al 2000, 'Identification, Characterization and Crystal Structure of the Omega Class Glutathione Transferases', Journal of Biological Chemistry, vol. 275, no. ISI, pp. 24798-24806.
• Board, P, Tetlow, N, Blackburn, A et al 2000, 'Database Analysis and Gene Discovery in Parmacogenetics', Clinical Chemistry and Laboratory Medicine, vol. 38, no. 9, pp. 863-867.
• Board, P, Chelvanayagam, G, Jermiin, L et al 2000, 'IDENTIFICATION AND CHARACTERIZATION OF THE ZETA CLASS OF GLUTATHIONE TRANSFERASES', Clinical Chemistry and Enzymology Communications, vol. 8, pp. 379-384.
• Taylor, M, Le Couteur, D, Mellick, G et al 2000, 'Paraoxonase polymorphisms, pesticide exposure and Parkinsons disease in a Caucasian population', Journal of Neural Transmission, vol. 107, no. ISI, pp. 979-983.
• Kangsadalampai, S, Yenchitsomanus, P, Chelvanayagam, G et al 2000, 'Identification of a new mutation (Gly420Ser), distal to the active site, that leads to factor XIII deficiency', European Journal of Haematology, vol. 65, pp. 279-284.
• Oakley, A, Rossjohn, J, McKinstry, W et al. 2000, 'STRUCTURE/FUNCTION STUDIES OF PI AND THETA CLASS GLUTATHIONE TRANSFERASES', Clinical Chemistry and Enzymology Communications, vol. 8, pp. 231-238.
• Le Couteur, D, McLean, A, Taylor, M et al 1999, 'Pesticides and Parkinsons disease', Biomedicine and Pharmacotherapy, vol. 53, no. 3, pp. 122-130.
• Kangsadalampai, S, Chelvanayagam, G, Baker, R et al. 1999, 'Identification and characterization of two missense mutations causing factor XIIIA deficiency', British Journal of Haematology, vol. 104, no. 1, pp. 37-43.
• Anderson, W, Board, P, Gargano, B et al 1999, 'Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking alpha-haloalkanoic acids', Chemical Research in Toxicology, vol. 12, no. 12, pp. 1144-1149.
• de Bruin, W, Wagenmans, M, Peters, W et al 1999, 'Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers', Carcinogenesis, vol. 20, no. 8, pp. 1453-1457.
• Board, P, Gali, R, Rossjohn, J et al 1999, 'Molecular basis of glutathione synthetase deficiency and a rare gene permutation event', The EMBO Journal, vol. 18, no. 12, pp. 3204-3213.
• Werkmeister, J, Anderson, W, Tzeng, H et al 1999, 'Glutathione transferase zeta-catalyzed biotransformation of deuterated dihaloacetic acids', Biochemical and Biophysical Research Communications, vol. 261, no. 3, pp. 779-783.
• Caccuri, A, Antonini, G, Board, P et al 1999, 'Proton release on binding of glutathione to alpha, Mu and delta class glutathione transferases [In Process Citation]', Biochemical Journal, vol. 344 Pt 2, pp. 419-425.
• Flanagan, J, Rossjohn, J, Parker, M et al. 1999, 'Mutagenic analysis of conserved arginine residues in and around the novel sulfate binding pocket of the human Theta class glutathione transferase T2-2 [In Process Citation]', Protein Science, vol. 8, no. 10, pp. 2205-2212.
• Whittington, A, Vichai, V, Webb, G et al. 1999, 'Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1', Biochemical Journal, vol. 337, no. Pt 1, pp. 141-151.

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

• Small molecule Inhibitors of glutathione transferase omega 1-1(GSTO1-1) for the treatment of inflammatory disease (Secondary Investigator)
• Decrypting the Excitation Contraction coupling machinery in skeletal muscle (Secondary Investigator)
• Glutathione transferase Omega 1 as a novel target for sepsis and other inflammatory disorders (Primary Investigator)
• Understanding and targeting metabolic regulators of cancer cell proliferation and death (Secondary Investigator)
• Glutathione transferase Zeta: A novel regulator of glucose and lipid metabolism (Primary Investigator)
• Prevention of drug toxicities with dichloroacteic acid - the implication for cancer chemotherapy (Primary Investigator)
• In-vivo, high-resolution, whole animal imaging (Secondary Investigator)
• The insertional mutagenesis system to identify epigenetic factors that control embryonic stem cell differentiation (Primary Investigator)
• DHPR a-B subunit interaction in skeletal muscle excitation contraction coupling and sarcopenia (Secondary Investigator)
• Targeting of two aspects of metabolic (TOTAM) for cancer therapy (Secondary Investigator)
• New cardiac ryanodine receptor inhibitors for the treatment of heart failure (Primary Investigator)
• DHPR β subunit binding to a variably spliced region of RyR1: a role in EC coupling and myotonic dystrophy (Secondary Investigator)
• Apparatus to determine mouse metabolic rate and movement (See 22085) (Primary Investigator)
• Chemoprevention of breast cancer with a non-hormonal, non-toxic anticancer agent (Secondary Investigator)
• Dichloroacetate: a novel anti-cancer agent (Secondary Investigator)
• The evaluation of gamma-gluamylcyclotransferase as a novel target for cancer therapy and diagnosis (Primary Investigator)
• Glutathione transferase-derived compounds as therapeutic agents (Primary Investigator)
• Communication between calcium ion channels in skeletal muscle excitation-contraction coupling (Secondary Investigator)
• The Role of Glutathione Transferase P1 in Regulating Allergic Airways Disease (Secondary Investigator)
• The role of gamma glutamyl cyclotransferase in glutathione homeostasis (Primary Investigator)
• Glutathione transferase deficient mice to probe for adverse drug reactions (Primary Investigator)