Areas of expertise

• Molecular Targets 111207
• Enzymes 060107
• Clinical Pharmacology And Therapeutics 111502
• Cell Metabolism 060104
• Cancer Genetics 111203
• Genetics 0604
• Oncology And Carcinogenesis 1112

Publications

• Mishra, AK, Parish, CR, Wong, ML, Licinio J, Blackburn AC 2017, 'Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer', PLOS ONE (Public Library of Science), vol. 12, no. 5, pp. 1-21pp.
• Tea, I, Martineau, E, Antheaume, I et al 2016, '¹³C and ¹⁵N natural isotope abundance reflects breast cancer cell metabolism', Scientific Reports, vol. 6, pp. 34251-34251.
• Galgamuwa Arachchige, R, Hardy, K, Dahlstrom, J et al 2016, 'Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties', Journal of the American Society of Nephrology, vol. 27, no. 11, pp. 3331-3344.
• Khan, A, Andrews, D & Blackburn, AC 2016, 'Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy', World Journal of Clinical Cases, vol. 4, no. 10, pp. 336-343.
• Rangasamy, D, Lenka, N, Ohms, S et al. 2015, 'Activation of LINE-1 retrotransposon increases the risk of epithelial-mesenchymal transition and metastasis in epithelial cancer', Current Molecular Medicine, vol. 15, no. 7, pp. 588-597.
• Gang, B, Dilda, P, Hogg, P et al 2014, 'Targeting of two aspects of metabolism in breast cancer treatment', Cancer Biology and Therapy, vol. 15, no. 11, pp. 1533-1541.
• Blackburn, A, Rooke, M, Li, Y et al 2014, 'Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in the Li-Fraumeni Syndrome model, Trp53 +/- mice', Cancer and Metabolism, vol. 2, no. S1, p. 10.
• Theodoratos, A, Blackburn, A, Coggan, M et al 2012, 'The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo', International Journal of Obesity, vol. 36, no. 10, pp. 1366-1369.
• Theodoratos, A, Blackburn, A, Cappello, J et al 2012, 'Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase', Biochemical Pharmacology, vol. 83, no. 3, pp. 427-433.
• Blackburn, A, Coggan, M, Shield, A et al 2011, 'Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress', Laboratory Investigation, vol. 91, no. 11, pp. 1572-1583.
• Sun, R, Board, P & Blackburn, A 2011, 'Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells', Molecular Cancer Therapeutics, vol. 10, no. Article #142, pp. 142-142.
• Blackburn, A 2011, 'Rats: Gnawing through the barriers to understanding genetic susceptibility and breast cancer', Breast Cancer Research (Online edition), vol. 13, no. 5, pp. 112-112.
• Blackburn, AC & Jerry, DJ 2011, 'Map Making in the 21st Century: Charting Breast Cancer Susceptibility Pathways in Rodent Models**', Journal of Mammary Gland Biology and Neoplasia, vol. 16, pp. 57-64.
• Tchatchou, S, Riedel, A, Lyer, S et al 2010, 'Identification of a DMBT1 Polymorphism Associated with Increased Breast Cancer Risk and Decreased Promoter Activity', Human Mutation, vol. 31, no. 1, pp. 60-66.
• Yan, H, Blackburn, A, McLary, S et al 2010, 'Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53^+/- mice', American Journal of Pathology, vol. 176, no. 3, pp. 1421-1432.
• Dunphy, K, Blackburn, A, Yan, H et al 2008, 'Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/-mice', Breast Cancer Research, vol. 10, no. 3.
• Sun, R, Fadia, M, Dahlstrom, J et al 2009, 'Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo', Breast Cancer Research and Treatment, vol. Online first, p. 8.
• Theodoratos, A, Tu, W, Cappello, J et al. 2009, 'Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta', Biochemical Pharmacology, vol. 77, no. 8, pp. 1358-1563.
• Schmuck, E, Cappello, J, Coggan, M et al 2008, 'Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs', The International Journal of Biochemistry and Cell Biology, vol. 40, no. 11, pp. 2553-9.
• Koch, J, Gu, X, Han, Y et al 2007, 'Mammary tumor modifiers in BALB/cJ mice heterozygous for p53', Mammalian Genome, vol. 18, no. 5, pp. 300-9.
• Blackburn, A, Hill, L, Roberts, A et al 2007, 'Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk', American Journal of Pathology, vol. 170, no. 6, pp. 2030-2041.
• Blackburn, A, Matthaei, K, Lim, C et al 2006, 'Deficiency of glutathione transferase Zeta causes oxidative stress and activation of antioxidant response pathways', Molecular Pharmacology, vol. 69, no. 2, pp. 650-657.
• Schmuck, E, Board, P, Whitbread, A et al 2005, 'Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimers and Parkinsons diseases', Pharmacogenetics and Genomics, vol. 12, pp. 493-501.
• Board, P, Anders, M & Blackburn, A 2005, 'Catalytic Function and Expression of Glutathione Transferase Zeta', in Lawrence H. Lash (ed.), Drug Metabolism and Transport, Humana Press Inc., USA, pp. 85-107.
• Lim, C, Matthaei, K, Blackburn, A et al 2004, 'Mice Deficient in Glutathione tranferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases', American Journal of Pathology, vol. 165, no. 2, pp. 679-693.
• Blackburn, A, McLary, S & Naaem, R 2004, 'Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain', Cancer Research, vol. 64, no. 15, pp. 5140-5147.
• Blackburn, A, Brown, J, Naber, S et al 2003, 'BALB/c Alleles for Prkdc and Cdkn2a Interact to Modify Tumor Susceptibility in Trp53+/- Mice', Cancer Research, vol. 63, pp. 2364-2368.
• Blackburn, A, Coggan, M, Tzeng, H et al 2001, 'GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase', Pharmacogenetics and Genomics, vol. 11, no. 8, pp. 671-678.
• Taylor, M, Board, P, Blackburn, A et al 2001, 'Zeta class glutathione transferase polymorphisms and Parkinsons disease', Journal of Neurology Neurosurgery and Psychiatry, vol. 70, pp. 406-425.
• Board, P, Chelvanayagam, G, Jermiin, L et al 2001, 'IDENTIFICATION OF NOVEL GLUTATHIONE TRANSFERASES AND POLYMORPHIC VARIANTS BY EXPRESSED SEQUENCE TAG DATABASE ANALYSIS', Drug Metabolism and Disposition, vol. 29, no. 4, pp. 544-547.
• Polekhina, G, Board, P, Blackburn, A et al. 2001, 'Crystal Structure of Maleylacetoacetate Isomerase/Glutathione Transferase Zeta Reveals the Molecular Basis for Its Remarkable Catalytic Promiscuity', Biochemistry, vol. 40, pp. 1567-1576.
• Tetlow, N, Blackburn, A, Chelvanayagam, G et al 2001, 'Alpha class glutathione transferase polymorphisms identified by EST database analysis', Chemico-Biological Interactions, vol. 133, pp. 123-125.
• Board, P, Chelvanayagam, G, Jermiin, L et al 2000, 'IDENTIFICATION AND CHARACTERIZATION OF THE ZETA CLASS OF GLUTATHIONE TRANSFERASES', Clinical Chemistry and Enzymology Communications, vol. 8, pp. 379-384.
• Blackburn, A, Tzeng, H, Anders, M et al 2000, 'Discovery of a functional polymorphism in human glutathione transferase Zeta by expressed sequence Tag database analysis', Pharmacogenetics and Genomics, vol. 10, pp. 49-57.
• Board, P, Tetlow, N, Blackburn, A et al 2000, 'Database Analysis and Gene Discovery in Parmacogenetics', Clinical Chemistry and Laboratory Medicine, vol. 38, no. 9, pp. 863-867.
• Tzeng, H, Blackburn, A, Board, P et al 2000, 'Polymorphism- and Species-Dependent Inactivation of Glutathione Transferase Zeta by Dichloroacetate', Chemical Research in Toxicology, vol. 13, pp. 231-236.

Projects and Grants

Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.

• Understanding and targeting metabolic regulators of cancer cell proliferation and death (Primary Investigator)
• Prevention of drug toxicities with dichloroacteic acid - the implication for cancer chemotherapy (Secondary Investigator)
• Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity (Secondary Investigator)