Professor Ruth Arkell
Areas of expertise
- Developmental Genetics (Incl. Sex Determination) 310503
- Biochemistry And Cell Biology 3101
- Foetal Development And Medicine 321501
Publications
- Barratt, K, Drover, K, Thomas, Z et al. 2022, 'Patterning of the antero-ventral mammalian brain: Lessons from holoprosencephaly comparative biology in man and mouse', WIREs Mechanisms of Disease, vol. 14, no. 4.
- Bellchambers, H, Barratt, K, Diamand, K et al. 2021, 'SUMOylation potentiates ZIC protein activity to influence murine neural crest cell specification', International Journal of Molecular Sciences, vol. 22, no. 19, pp. 1-22.
- Ali, R, Bellchambers, H, Warr, N et al. 2021, 'WNT-responsive SUMOylation of ZIC5 promotes murine neural crest cell development, having multiple effects on transcription', Journal of Cell Science, vol. 134, no. 9, pp. 1-13.
- Dinh, T, Iseki, H, Mizuno, S et al. 2021, 'Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway', eLife, vol. 10.
- Ahmed, J, Ahmed, J, Diamand, K et al. 2020, 'Systematized reporter assays reveal ZIC protein regulatory abilities are Subclass-specific and dependent upon transcription factor binding site context', Scientific Reports, vol. 10, no. 1, pp. -.
- Barratt, K & Arkell, R 2020, 'Whole-Mount In Situ Hybridization in Post-Implantation Staged Mouse Embryos', Current Protocols in Mouse Biology, vol. 10, no. 2, pp. -.
- Easteal, S, Arkell, R, Balboa, R et al. 2020, 'Equitable Expanded Carrier Screening Needs Indigenous Clinical and Population Genomic Data', American Journal of Human Genetics, vol. 107, no. 2, pp. 175-182.
- Barratt, K & Arkell, R 2020, 'Production of Digoxigenin-Labeled Riboprobes for In Situ Hybridization Experiments', Current Protocols in Mouse Biology, vol. 10, no. 2.
- Easteal, S, Arkell, R, Balboa, R et al. 2020, 'Equitable Expanded Carrier Screening Needs Indigenous Clinical and Population Genomic Data', American Journal of Human Genetics, vol. 107, no. 2, pp. 175-182.
- Barratt, K, Diamand, K & Arkell, R 2018, 'Identification of reference genes suitable for RT-qPCR studies of murine gastrulation and patterning', Mammalian Genome, vol. 29, no. 9, pp. 656-662pp.
- Diamand, K, Barratt, K & Arkell, R 2018, 'Overview of Rodent Zic Genes', in J Aruga (ed.), Zic family, Springer, Singapore, pp. 179-207.
- Barratt, K & Arkell, R 2018, 'ZIC2 in Holoprosencephaly', in J Aruga (ed.), Zic family, Springer, Singapore, pp. 269-299pp.
- Diamand, K, Alzahrani, A, Ahmed, J et al 2017, 'Elevated canonical Wnt signalling disrupts development of the embryonic midline and may underlie cases of ZIC3-associated Heterotaxy', 18th International Congress of Developmental Biology, ISDB 2017, ed. David Wilkinson, Elsevier Science, Netherlands, pp. S28-S29.
- Cameron, A, Turner, C, Adams, D et al 2016, 'Flightless I is a key regulator of the fibroproliferative process in hypertrophic scarring and a target for a novel antiscarring therapy', British Journal of Dermatology, vol. 174, no. 4, pp. 786-794.
- Houtmeyers, R, Gainkam, O, Glanville-Jones, H et al 2016, 'Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling', Human Molecular Genetics, vol. 25, no. 18, pp. 3946-3959.
- Velez Valbuena, J, Lopera, F, Falla, D et al. 2015, 'APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease', Molecular Psychiatry, vol. 21, no. 7, pp. 916-924.
- Turner, C, Waters, J, Jackson, J et al 2015, 'Fibroblast-specific upregulation of Flightless I impairs wound healing', Experimental Dermatology, vol. 24, no. 9, pp. 692-697.
- Chan, H, Kopecki, Z, Waters, J et al 2014, 'Cytoskeletal protein Flightless I differentially affects TGF-beta isoform expression in both in vitro and in vivo wound models', Wound Practice and Research, vol. 22, no. 3, pp. 169-181.
- Ruzehaji, N, Kopecki, Z, Melville, E et al 2014, 'Attenuation of flightless i improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes', Diabetologia, vol. 57, no. 2, pp. 402-412.
- Barratt, K, Glanville-Jones, H & Arkell, R 2014, 'The Zic2 Gene Directs the Formation and Function of Node Cilia to Control Cardiac Situs', Genesis, vol. 52, no. 6, pp. 626-635.
- Kopecki, Z, Yang, G, Arkell, R et al 2014, 'Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering', Journal of Pathology, vol. 232, no. 5, pp. 541-552.
- Chervenak, A, Bank, L, Thomsen, N et al 2014, 'The Role of Zic Genes in Inner Ear Development in the Mouse: Exploring Mutant Mouse Phenotypes', Developmental Dynamics, vol. 243, no. 11, pp. 1487-1498.
- Caruana, G, Farlie, P, Hart, A et al 2013, 'Genome-Wide ENU Mutagenesis in Combination with High Density SNP Analysis and Exome Sequencing Provides Rapid Identification of Novel Mouse Models of Developmental Disease', PLOS ONE (Public Library of Science), vol. 8, no. 3, pp. e55429-e55429.
- Arkell, R, Glanville-Jones, H & Woo, N 2013, 'Successful whole embryo culture with commercially available reagents', International Journal of Developmental Biology, vol. 57, no. 1, pp. 61-67.
- Watkins-Chow, D, Cooke, J, Pidsley, R et al 2013, 'Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes', PLoS Genetics, vol. 9, no. 1, pp. e1003094-e1003094.
- Ruzehaji, N, Mills, S, Melville, E et al 2013, 'The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing', BioMed Research International, vol. 2013, no. 389792, pp. 389792-389792.
- Houtmeyers, R, Souopgui, J, Tejpar, S et al 2013, 'The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis', Cellular and Molecular Life Sciences, vol. 70, no. 20, pp. 3791-3811.
- Arkell, R, Fossat, N & Tam, P 2013, 'Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output', Current Opinion in Genetics and Development, vol. 23, no. 4, pp. 454-460.
- Ahmed, J, Ali, R et al 2013, 'A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation', Disease Models and Mechanisms, vol. 6, no. 3, pp. 755-767.
- Ali, R, Bellchambers, H & Arkell, R 2012, 'Zinc fingers of the cerebellum (Zic): Transcription factors and co-factors', The International Journal of Biochemistry and Cell Biology, vol. 44, no. 11, pp. 2065-2068.
- Arkell, R, Arkell, R & Tam, P 2012, 'Initiating head development in mouse embryos: Integrating signalling and transcriptional activity', Open Biology, vol. 2, pp. 120030-120030.
- Arkell, R, Arkell, R & Tam, P 2012, 'Initiating head development in mouse embryos: Integrating signalling and transcriptional activity', Open Biology, vol. 2, pp. 120030-120030.
- Thomsen, N, Ali, R, Ahmed, J et al 2012, 'High Resolution Melt Analysis (HRMA); a Viable Alternative to Agarose Gel Electrophoresis for Mouse Genotyping', PLOS ONE (Public Library of Science), vol. 7, no. 9, pp. e45252-e45252.
- Fossat, N, Jones, V, Khoo, P et al 2011, 'Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo', Development, vol. 138, no. 4, pp. 667-676.
- Arkell, R, Waters, J, Lindo, J et al 2011, 'Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model', The Journal of Investigative Dermatology, vol. 131, no. 4, pp. 838-847.
- Lin, C, Waters, J, Powell, B et al 2011, 'Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing', Mammalian Genome, vol. 22, no. 5-6, pp. 341-352.
- Kopecki, Z, O'Neill, G, Arkell, R et al 2011, 'Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a rac1-dependent pathway', The Journal of Investigative Dermatology, vol. 131, no. 7, pp. 1450-1459.
- Kopecki, Z, Arkell, R, Strudwick, X et al 2011, 'Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita', Journal of Pathology, vol. 225, no. 3, pp. 401-413.
- Thomsen N, Chappell A, Ali RG, Jones T, Adams DH, Matthaei KI, Campbell HD, Cowin AJ & Arkell R 2011, 'Mouse Strains for the Ubiquitous or Conditional Overexpression of the Flii Gene**', Genesis, vol. 49, pp. 681-688.
- Adams, D, Ruzehaji, N, Strudwick, X et al 2009, 'Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-b1 and TGF-b3', British Journal of Dermatology, vol. 161, no. 2, pp. 1-11.
- Mackenzie, F, Romero, R, Williams, D et al 2009, 'Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse', Human Molecular Genetics, vol. 18, no. 19, pp. 3553-3566.
- Kopecki, Z, Arkell, R, Powell, B et al 2009, 'Flightless I Regulates Hemidesmosome Formation and Integrin-Mediated Cellular Adhesion and Migration during Wound Repair', The Journal of Investigative Dermatology, vol. Online 12 Feb 2009, pp. 1-15.
- Warr, N, Powles-Glover, N, Chappell, A et al 2008, 'Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation', Human Molecular Genetics, vol. 17, no. 19, pp. 2986-2996.
- Goldsworthy, M, Hugill, A, Freeman, H et al 2008, 'Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance', Diabetes, vol. 57, pp. 2234-2244.
- Ybot-Gonzalez, P, Gaston-Massuet, C, Girdler, G et al 2007, 'Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling', Development, vol. 134, pp. 3203-3211.
- Garrick, D, Sharpe, J, Arkell, R et al 2006, 'Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues', PLoS Genetics, vol. 2, no. 4, pp. 438-450.
- Blewitt, M, Vickaryous, N, Hemley, S et al 2005, 'An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 21, pp. 7629-7634.
- Bogani, D, Willoughby, C, Davies, J et al 2005, 'Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 35, pp. 12477-12482.
- Mallon, A, Wilming, L, Weekes, J et al 2004, 'Organization and Evolution of a Gene-rich Region of the Mouse Genome: A 12.7Mb Region Deleted in the Del(13) Svea36H Mouse', Genome Research, vol. 14, pp. 1888-1901.
- Elms, P, Scurry, A, Davies, J et al 2004, 'Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation', Gene Expression, vol. 4, pp. 505-511.
- Bogani, D, Warr, N, Elms, P et al 2004, 'New Semidominant Mutations that affect Mouse Development', Genesis, vol. 40, pp. 109-117.
- Brown, L, Paraso, M, Arkell, R et al 2004, 'In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation', Human Molecular Genetics, vol. 14, no. 3, pp. 411-420.
- Curtin, J, Quint, E, Tsipouri, V et al 2003, 'Mutation of Celsr1 Disrupts Planar Polarity of Inner Ear Hair Cells and Causes Severe Neural Tube Defects in the Mouse', Current Biology, vol. 13, pp. 1129-1133.
- Elms, P, Siggers, P, Napper, D et al 2003, 'Zic2 is required for neural crest formation and hindbrain patterning during mouse development', Developmental Biology, vol. 264, no. 2, pp. 391-406.
- Murdoch, J, Henderson, D, Doudney, K et al 2003, 'Disruption of scribble (Scrib1) causes severe neural tube defects in the circletail mouse', Human Molecular Genetics, vol. 12, no. 2, pp. 87-98.
- Grimmond, S, Larder, R, Van Hateren, N et al 2001, 'Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development', Mechanisms of Development, vol. 102, pp. 209-211.
- Epikopou, V, Arkell, R, Timmons, P et al. 2001, 'Induction of the mammalian node requires Arkadia function in the extraembryonic lineages', Nature, vol. 410, pp. 825-830.
- Arkell, R, Cadman, M, Marsland, T et al 2001, 'Genetic, physical and phenotypic characterization of the Del(13)Svea36H mouse', Mammalian Genome, vol. 12, pp. 687-694.
Projects and Grants
Grants information is drawn from ARIES. To add or update Projects or Grants information please contact your College Research Office.
- The influence of genetic variation on foetal alcohol spectrum disorder (Primary Investigator)
- The ZIC3 Heterotaxy-associated transcription factor: a new player in nuclear control of canonical Wnt signalling (Primary Investigator)
- Elevated Wnt signalling underlies ZIC3-associated Heterotaxy (Primary Investigator)
- The role of the actin remodelling protein, Flightless i, in tissue regeneration (Primary Investigator)
- Mechanism of Flightless i function in burn injury and scar formation (Primary Investigator)
- Zic Gene Function During the Development of the Embryonic Midline (Primary Investigator)
